• The Journal of Korean Academy of Prosthodontics
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• v.55 no.4
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• pp.381-388
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• 2017

Purpose: Unpredictable shrinkage of zirconia during sintering process causes discrepancy. Therefore, there have been attempts to reduce discrepancy by milling zirconia after sintering. However, due to the hardness of sintered zirconia, milling takes longer time, causes damage to the machine and causes chip formation. With customized zirconia block using the mean dimension of prepared natural dentition, it is expected to overcome these shortcomings. Materials and methods: The mean dimension of prepared natural dentition was analyzed as STL file after scanning of prepared teeth treated at SNUDH. The transverse, frontal and sagittal planes were set using Mimics and Photoshop. 3D volume was projected on each plane, and the outer line was measured through external tangent line, and the inner line was measured through inflection point of tangent line. Results: The mean height of prepared incisal (N = 57) is $6.60{\pm}1.05mm$, mesiodistal length is $2.98{\pm}0.73mm$, buccolingual length is $2.04{\pm}0.73mm$. The mean height of prepared premolar (N = 15) is $5.37{\pm}1.49mm$, mesiodistal length is $4.10{\pm}1.78mm$, buccolingual length is $5.86{\pm}1.55mm$. And the mean height of prepared molar (N = 13) is $5.11{\pm}1.29mm$, mesiodistal length is $6.80{\pm}1.18mm$, buccolingual length is $7.34{\pm}1.40mm$. Conclusion: Using the mean dimension of prepared natural dentition, it is expected to be able to fabricate customized zirconia block.

• Clinical and Experimental Pediatrics
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• v.57 no.5
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• pp.226-231
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• 2014

Purpose: Kikuchi-Fujimoto disease (KFD) is a benign disease, which is characterized by a cervical lymphadenopathy with fever, and it often mimics malignant lymphoma (ML). 2-[$^{18}F$]fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography ($^{18}F$-FDG PET/CT) is a powerful imaging modality for the diagnosis, staging and monitoring of ML, with the limitations including the nonspecific FDG uptake in infectious or inflammatory processes. This study compared clinical manifestations and PET/CT findings between KFD and ML patients. Methods: We retrospectively reviewed the medical records of 23 patients with KFD and 33 patients with ML, diagnosed histopathologically, between January 2000 and May 2013 at the Department of Pediatrics, Yeungnam University Medical Center. Among them, we analyzed the clinical manifestations, laboratory findings and characteristics, and the amount of $^{18}F$-FDG uptake between 8 KFD and 9 ML patients who had $^{18}F$-FDG PET/CT. Results: The $^{18}F$-FDG PET/CT maximum standardized uptake values ($SUV_{max}$) ranged from 8.3 to 22.5 (mean, 12.0) in KFDs, and from 5.8 to 34.3 (mean, 15.9) in MLs. There were no significant differences in $SUV_{max}$ between KFDs and MLs. $^{18}F$-FDG PET/CT with ML patients showed hot uptakes in the extranodal organs, such as bone marrow, small bowel, thymus, kidney, orbit and pleura. However, none of the KFD cases showed extranodal uptake (P<0.001). $^{18}F$-FDG PET/CT findings of KFD with nodal involvement only were indistinguishable from those of ML. Conclusion: Patients who had extranodal involvement on PET/CT were more likely to have malignancy than KFD.

• Journal of the Institute of Electronics and Information Engineers
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• v.49 no.9
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• pp.104-112
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• 2012

Recently, the HDR imaging technique that mimics human eye is incorporated with LCD/LED display devices to deal with mismatch between the real world scene and the displayed image. However, HDR image has a veiling glare limit as well as a scale of the local contrast problem. In order to overcome these problems, several color correction methods, CSR(center/surround Retinex), MSR (Multi-Scale Retinex), tone-mapping method, iCAM06 and so on, are proposed. However, these methods have a dominated color throughout the entire resulting image after performing color correction. Accordingly, this paper presents a new color correction method using dynamic cone response function. The proposed color correction method consists of tone-mapping and dynamic cone response. The tone-mapping is obtained by using a linear interpolation between chromatic and achromatic. Thereafter, the resulting image is processed through the dynamic cone response function, which estimates the dynamic responses of human visual system as well as deals with mismatch between the real scene image and the rendered image. The experiment results show that the proposed method yields better performance of color correction over the conventional methods.

• Journal of Life Science
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• v.28 no.8
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• pp.931-937
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• 2018

Triptolide is a compound found in Tripterygium wilfordii and reported to have an anti-inflammatory and anti-oxidant activities. A previous study shows that the dietary supplementation with triptolide increases resistance to environmental stressors, including oxidative stress, heat shock, and ultraviolet irradiation, and extends lifespan in C. elegans. Here, we investigated the underlying mechanisms involved in the lifespan-extending effect of triptolide. The effect of triptolide on age-related diseases, such as diabetes mellitus and Alzheimer's disease, was also examined using animal disease models. The longevity phenotype conferred by triptolide was not observed in the eat-2 mutant, a well-known genetic model of dietary restriction, while there was an additional lifespan extension with triptolide in age-1 and clk-1 mutants. The long lifespan of age-1 mutant is resulted from a reduced insulin/IGF-1-like signaling and the clk-1 mutant lives longer than wild-type due to dysfunction of mitochondrial electron transport chain reaction. The effect of dietary restriction using bacterial dilution on lifespan also overlapped with that of triptolide. The toxicity of high glucose diet or transgenic human amyloid beta gene was significantly suppressed by the supplementation with triptolide. These findings suggest that triptolide can mimic the effect of dietary restriction on lifespan and onset of age-related diseases. We conclude that triptolide can be a strong candidate for the development of dietary restriction mimetics.

• BMB Reports
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• v.51 no.11
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• pp.602-607
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• 2018

Aberrant expression of microRNAs (miRNAs) plays important roles in carcinogenesis and tumor progression. However, the expression and biological role of miR-301b in triple-negative breast cancer (TNBC) remains unclear. Here we aimed to evaluate the roles and mechanisms of miR-301b in TNBC cells. miR-301b expression was assessed in TNBC specimens and cell lines by quantitative Real-Time PCR (qRT-PCR). TNBC cells were transfected with miR-301b mimics, inhibitors or Cylindromatosis (CYLD) small interfering RNA (siRNA) using Lipofectamine 2000. The functional roles of miR-301b were determined by cell proliferation, colony formation, and apoptosis assays. Western blots and qRT-PCR were used to measure the expression of mRNAs and proteins in the cells. We found that miR-301b was upregulated in TNBC specimens and cell lines. Overexpression of miR-301b promoted cell proliferation in TNBC cells, while inhibited the apoptosis induced by 5-FU. CYLD was downregulated by miR-301b at both mRNA and protein levels in TNBC cells. Dual-luciferase report assay confirmed that miR-301b downregulated CYLD by direct interaction with the 3'-untranslated region(3'-UTR) of CYLD mRNA. $NF-{\kappa}B$ activation was mechanistically associated with miR-301b-mediated downregulation of CYLD. However, inhibition of miR-301b reversed all the effects of miR-301b. In conclusion, miR-301b plays an oncogenic role in TNBC possibly by downregulating CYLD and subsequently activating $NF-{\kappa}B$ p65, and this may provide a novel therapeutic approach for TNBC.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.33 no.5
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• pp.1999-2007
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• 2013

The key characteristics of two-lane-and-two-way traffic flow are platoon and overtaking caused by low-speed vehicle such as truck. In order to develop two-way traffic flow model comprised of CF(car-following) and overtaking model, it is essential to develop a car-following model which is suitable to two-way traffic flow. Short distance between vehicles is caused when a high-speed vehicle tailgates and overtakes foregoing low-speed vehicle on two-way road system. And a vehicle following low-speed vehicle decides to overtake the front low-speed vehicle using suitable space within the headway distribution of opposite traffic flow. For this reason, a two-way CF model should describes not only running within short gap but also headway distribution. Additionally considering domestic two-way-road size, there is a on-going need for large-network simulation, but there are few studies for two-way CF model. In this paper, a two-way CA model is developed, which explains two-way CF behavior more realistic and can be applied for large road network. The experimental results show that the developed model mimics stop-and-go phenomenon, one of features of congested traffic flow, and efficiently generates the distribution of headway. When the CF model is integrated with overtaking model, it is, therefore, expected that two-way traffic flow can be explained more realistically than before.

• Progress in Medical Physics
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• v.21 no.3
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• pp.281-290
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• 2010

Cone-beam digital tomosynthesis (CBDT) has greatly been paid attention in the image-guided radiation therapy because of its attractive advantages such as low patient dose and less motion artifact. Image quality of tomograms is, however, dependent on the imaging conditions such as the scan angle (${\beta}_{scan}$) and the number of projection views. In this paper, we describe the principle of CBDT based on filtered-backprojection technique and investigate the optimization of imaging conditions. As a system performance, we have defined the figure-of-merit with a combination of signal difference-to-noise ratio, artifact spread function and floating-point operations which determine the computational load of image reconstruction procedures. From the measurements of disc phantom, which mimics an impulse signal and thus their analyses, it is concluded that the image quality of tomograms obtained from CBDT is improved as the scan angle is wider than 60 degrees with a larger step scan angle (${\Delta}{\beta}$). As a rule of thumb, the system performance is dependent on $\sqrt{{\Delta}{\beta}}{\times}{\beta}^{2.5}_{scan}$. If the exact weighting factors could be assigned to each image-quality metric, we would find the better quantitative imaging conditions.

• Journal of KIISE:Software and Applications
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• v.28 no.9
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• pp.669-680
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• 2001

Genetic Algorithms are optimization algorithm that mimics biological evolution to solve optimization problems. Genetic algorithms provide an alternative to traditional optimization techniques by using directed random searches to locate optimal solutions in complex fitness landscapes. Hybrid genetic algorithm that is combined with local search called learning can sustain the balance between exploration and exploitation. The genetic traits that each individual in the population learns through evolution are transferred back to the next generation, and when this learning is combined with genetic algorithm we can expect the improvement of the search speed. This paper proposes a genetic algorithm based Cellular Learning with accelerated learning capability for function optimization. Proposed Cellular Learning strategy is based on periodic and convergent behaviors in cellular automata, and on the theory of transmitting to offspring the knowledge and experience that organisms acquire in their lifetime. We compared the search efficiency of Cellular Learning strategy with those of Lamarckian and Baldwin Effect in hybrid genetic algorithm. We showed that the local improvement by cellular learning could enhance the global performance higher by evaluating their performance through the experiment of various test bed functions and also showed that proposed learning strategy could find out the better global optima than conventional method.

• Journal of Korean Society of Transportation
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• v.22 no.4 s.75
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• pp.147-158
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• 2004

A class of SWP(Stochastic Wane Propagation) models microscopically mimics individual vehicles' stochastic behavior and traffic jam propagation with simplified car-following models based on CA(Cellular Automata) theory and macroscopically captures dynamic traffic flow relationships based on statistical physics. SWP model, a program-oriented model using both discrete time-space and integer data structure, can simulate a huge road network with high-speed computing time. However, the model has shortcomings to both the capturing of low speed within a jam microscopically and that of the density and back propagation speed of traffic congestion macroscopically because of the generation of spontaneous jam through unrealistic collision avoidance. In this paper, two additional rules are integrated into the NaSch model. The one is SMR(Stopping Maneuver Rule) to mimic vehicles' stopping process more realistically in the tail of traffic jams. the other is LAR(Low Acceleration Rule) for the explanation of low speed characteristics within traffic jams. Therefore, the CA car-following model with the two rules prevents the lockup condition within a heavily traffic density capturing both the stopping maneuver behavior in the tail of traffic jam and the low acceleration behavior within jam microscopically, and generates more various macroscopic traffic flow mechanism than NaSch model's with the explanation of propagation speed and density of traffic jam.

• Development and Reproduction
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• v.9 no.2
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• pp.135-142
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• 2005

Vitellogenins(VTGs) are the precursor of egg-yolk proteins in most oviparous species from invertebrates to vertebrates. In oviparose vertebrates, VTGs are synthesized in the liver and transported through the blood to oocytes. In female fish, concentrations of plasma VTG increase rapidly at onset of vitellogenesis in the normal reproductive cycle. Male fishes also possess the gene for VTG, but plasma concentrations of the protein typically remain small, presumably due to low levels of endogenous estrogens. However, exposure of males to exogenous estrogenic mimics can result elevated. Therefore, the VTG in fish can be used as a useful biomarker for appropriate tools of endocrine disrupting compounds effects. In this studies, we prepared the test methods that can measure the plasma VTG level in the gobies that live in polluted area with mimic estrogen. For the purpose, we purified VTG of floating goby(Chaenogobius annularis) and prepared specific monoclonal and polyclonal antisera to yolk protein, then developed a sandwich competitive ELISA system for measurement of plasma VTG levels. Validation for the ELISA system using monoclonal and polyclonal antibodies against VTG was tested. The absorbance curve of serial dilutions of serum from vitellogenic female was paralleled to the standard curve of VTG, but normal male was not paralleled. The developed sandwich ELISA system was measured for VTG levels in plasma of common goby(Acanthogobius flaviman) and javeline goby(A. hasta) as well as in plasma of floating goby(C. annularis).