• Advances in nano research
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• v.12 no.6
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• pp.639-652
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• 2022

The prolyl 3-hydroxylase family member 4 (P3H4), is associated with post-translational modification of fibrillar collagens and aberrantly activated in cancer leading to tumor progression. However, its role in clear cell renal cell carcinoma (ccRCC) is still unknown. Here we reported that P3H4 was highly expressed in renal cancer tissues and significantly positive correlated with poor prognosis. Knockdown of P3H4 inhibited the proliferation, migration and metastasis of renal cancer cells in vitro and in vivo, and also, overexpression of it enhanced the oncogenic process. Mechanistically, P3H4 depletion decreased the levels of GDF15-MMP9 axis and repressed its downstream signaling. Further functional studies revealed that inhibition of GDF15 suppressed renal cancer cell growth and GDF15 recombinant human protein (rhGDF15) supplementation effectively rescued the inhibitory effect induced by P3H4 knockdown. Moreover, decreased levels of MMP9 caused by inhibition of P3H4-GDF15 signaling constrained the expression of PD-L1 and suppression of P3H4 accordingly promoted anti-tumor immunity via stimulating the infiltration of CD4+ and CD8+ T cells in syngeneic mice model. Taken together, our findings firstly demonstrated that P3H4 promotes ccRCC progression by activating GDF15-MMP9-PD-L1 axis and targeting P3H4-GDF15-MMP9 signaling pathway can be a novel strategy of controlling ccRCC malignancy.

• Journal of Practical Engineering Education
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• v.14 no.1
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• pp.205-217
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• 2022

For high school students in Jeonbuk, this study aims to identify the problems caused by outflow of local youth population and their preference factors to enter university in Seoul-metropolitan area, and to draw out the direction of local human resources program, through questionnaire investigation and focused group interview. The main findings are as follows: First, 68.8% of high school students, especially the top grade students prefer to enter university in metropolitan area. The metropolitan cultural characteristics, such as reputation of universities and ranking, openness and anonymity, and urban infrastructure attract students. Second, there is a close relationship between the individual background, growth area - enrollment area - employment area, and the location dependency without return migration is very strong. Third, local human resources program was evaluated as a meaningful activity for high school students, in order to understand the further education and career, and have an interest in local universities. Therefore, it is necessary to discover industries consistent with local identity, create networks, develop and implement programs considering the actual educational conditions. The gender-free program, supplement program for the integrated curriculum, and contents that to supplement science subjects should be developed. Additionally, this issue could be resolved expanding the perspective of balanced national development and improve the local environment to enhance the urban attraction points.

• Journal of Life Science
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• v.32 no.2
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• pp.148-154
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• 2022

Focal adhesion kinase (FAK) is known to regulate cell adhesion, migration, and mechanotransduction in focal adhesions (FAs). However, studies on how FAK activity is regulated in the plasma membrane microdomains according to the composition of extracellular matrix (ECM) proteins are still lacking. A genetically encoded fluorescence resonance energy transfer (FRET)-based biosensor can provide useful information on the activity of intracellular signals with high spatiotemporal resolution. In this study, we analyzed the FAK activities in lipid raft (detergent-resistant membrane) and non-lipid raft (non-detergent-resistant membrane) microdomains using FRET-based membrane targeting FAK biosensors (FAK-Lyn and FAK-KRas biosensors) under four different ECM protein compositions: glass, type 1 collagen, fibronectin, and laminin. Interestingly, FAK activity in response to laminin in a lipid raft microdomain was lower than that in other ECM conditions. Cells subjected to fibronectin showed higher FAK activity in a lipid raft microdomain than that in a non-lipid raft microdomain. Therefore, this study demonstrates that the FAK activity can be distinctively regulated according to the ECM type and the environment of the plasma membrane microdomains.

• International Journal of Computer Science & Network Security
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• v.21 no.11
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• pp.345-353
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• 2021

Cloud computing represent a new era of computing that's forms through the combination of service-oriented architecture (SOA), Internet and grid computing with virtualization technology. Virtualization is a concept through which every cloud is enable to provide on-demand services to the users. Most IT service provider adopt cloud based services for their users to meet the high demand of computation, as it is most flexible, reliable and scalable technology. Energy based performance tradeoff become the main challenge in cloud computing, as its acceptance and popularity increases day by day. Cloud data centers required a huge amount of power supply to the virtualization of servers for maintain on- demand high computing. High power demand increase the energy cost of service providers as well as it also harm the environment through the emission of CO₂. An optimization of cloud computing based on energy-performance tradeoff is required to obtain the balance between energy saving and QoS (quality of services) policies of cloud. A study about power usage of resources in cloud data centers based on workload assign to them, says that an idle server consume near about 50% of its peak utilization power [1]. Therefore, more number of underutilized servers in any cloud data center is responsible to reduce the energy performance tradeoff. To handle this issue, a lots of research proposed as energy efficient algorithms for minimize the consumption of energy and also maintain the SLA (service level agreement) at a satisfactory level. VM (virtual machine) consolidation is one such technique that ensured about the balance of energy based SLA. In the scope of this paper, we explore reinforcement with fuzzy logic (RFL) for VM consolidation to achieve energy based SLA. In this proposed RFL based active VM consolidation, the primary objective is to manage physical server (PS) nodes in order to avoid over-utilized and under-utilized, and to optimize the placement of VMs. A dynamic threshold (based on RFL) is proposed for over-utilized PS detection. For over-utilized PS, a VM selection policy based on fuzzy logic is proposed, which selects VM for migration to maintain the balance of SLA. Additionally, it incorporate VM placement policy through categorization of non-overutilized servers as- balanced, under-utilized and critical. CloudSim toolkit is used to simulate the proposed work on real-world work load traces of CoMon Project define by PlanetLab. Simulation results shows that the proposed policies is most energy efficient compared to others in terms of reduction in both electricity usage and SLA violation.

• Smart Media Journal
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• v.12 no.2
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• pp.66-75
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• 2023

Recently, the number of cloud web applications is increasing owing to the accelerated migration of enterprises and public sector information systems to the cloud. Traditional network attacks on cloud web applications are characterized by Denial of Service (DoS) attacks, which consume network resources with a large number of packets. However, HTTP DoS attacks, which consume application resources, are also increasing recently; as such, developing security technologies to prevent them is necessary. In particular, since low-bandwidth HTTP DoS attacks do not consume network resources, they are difficult to identify using traditional security solutions that monitor network metrics. In this paper, we propose a new detection model for detecting HTTP DoS attacks on cloud web applications by collecting the application metrics of web servers and learning them using machine learning. We collected 18 types of application metrics from an Apache web server and used five machine learning and two deep learning models to train the collected data. Further, we confirmed the superiority of the application metrics-based machine learning model by collecting and training 6 additional network metrics and comparing their performance with the proposed models. Among HTTP DoS attacks, we injected the RUDY and HULK attacks, which are low- and high-bandwidth attacks, respectively. As a result of detecting these two attacks using the proposed model, we found out that the F1 scores of the application metrics-based machine learning model were about 0.3 and 0.1 higher than that of the network metrics-based model, respectively.

• The Journal of Korean Academy of Prosthodontics
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• v.61 no.1
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• pp.33-43
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• 2023

Pathological wear across the entire dentition causes problems such as collapsed occlusal plane, reduced vertical dimension, anterior premature contact, inadequate anterior guidance, and tooth migration, thereby induce symptoms such as temporomandibular joint disorder, reduced masticatory efficiency, and tooth hypersensitivity. For the treatment of patients with excessive wear, evaluation of vertical dimension should be preceded along with analysis of the cause. The patient in this case was a 45-year-old female with a history of orthognathic surgery. Through clinical examination, radiographic examination, and model analysis, overall tooth wear, interdental spacing in the anterior maxillary region, retruded condylar position, and insufficient interocclusal space for prosthetic restoration were confirmed. Full mouth rehabilitation with increased vertical dimension was planned, the patient's adaptation to the new vertical dimension was evaluated with a removable occlusal splint and temporary prosthesis, and cross-mounting was performed based on the temporary restoration to fabricate the definitive zirconia prosthesis, maintaining the adjusted vertical dimension. It showed satisfactory functional and esthetic results through stable restoration of the occlusal relationship.

• Journal of Internet of Things and Convergence
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• v.9 no.1
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• pp.105-115
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• 2023

This study seeks to find a way to induce users to expand their direct participation in sports through the acceptance of digital technology. From July 1 to August 30, 2022, a survey was conducted targeting home training users who applied the Internet of Things (IoT). 129 people participated in the survey through non-face-to-face self-administration method. For data processing, frequency analysis, exploratory factor analysis, reliability analysis, correlation analysis, multiple regression analysis, and 3-step mediation regression analysis were conducted using IBM's SPSS 21.0 program. The results of the study are as follows. First, in the relationship between the home training PPM model and direct participation in sports, ease appeared to have a mediating effect. In the factors of push, simple functionality showed a complete mediating effect, and inefficiency showed a partial mediating effect. Among pull factors, enjoyment and possibility of experience showed a complete mediating effect. In the mooring factors, individual innovativeness showed a complete mediating effect. Second, in the relationship between home training PPM model and direct participation in sports, usefulness showed a mediating effect. In the factors of push, simple functionality showed a complete mediating effect, and inefficiency showed a partial mediating effect. Among pull factors, enjoyment and possibility of experience showed a complete mediating effect. Among the mooring factors, individual innovativeness showed a partial mediating effect. Through this research, it is expected that the sports industry will contribute to the expansion of consumption expenditure and economic growth through the expansion of digital technologies such as NFT, Metaverse, and virtual/augmented reality.

• Journal of Life Science
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• v.33 no.9
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• pp.703-712
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• 2023

Angiogenesis, the formation of blood vessels from pre-existing vessels, is a multistep process regulated by modulators of angiogenesis. It is essential for various physiological processes, such as embryonic development, chronic inflammation, and wound repair. Dysregulation of angiogenesis causes many diseases, such as cancer, autoimmune diseases, rheumatoid arthritis, cardiovascular disease, and delayed wound healing. However, the number of effective anti-angiogenic drugs is limited. Recent research has focused on identifying potential drug candidates from natural sources. For example, marine natural products have been shown to have anti-cancer, anti-oxidant, anti-inflammatory, antiviral, and wound-healing effects. Thus, this study aimed to describe the angiogenesis inhibitory effect of Hizikia fusiforms (brown algae) extract. The hexane extract of H. fusiformis has shown inhibitory effects on in vitro angiogenesis assays, such as cell migration, invasion, and tube formation in human umbilical vein endothelial cells (HUVECs). The hexane extract of H. fusiformis (HFH) inhibited in vivo angiogenesis in a mouse Matrigel gel plug assay. In addition, the protein expression of vascular endothelial growth factor (VEGF), mitogen-activated protein kinase (MAPK)/extracellular signal kinase, and AKT serine/threonine kinase 1 decreased following treatment with H. fusiformis extracts. Our results demonstrated that the hexane extract of H. fusiformis (HFH) inhibits angiogenesis in vitro and in vivo.

• Women's Studies Review
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• v.26 no.1
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• pp.183-206
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• 2009

This study attempts to explore a phenomenon of an expansion of emotional capitalism in the context of marriage migration. Emphasizing that 'emotion,' 'love,' 'affection,' 'intimacy,' and 'care' are neither materialistic nor a work, and noting that they are social roles attached to natural femininity and that they are separated from the economic realm, modern myth has been challenged by the increase of marriage industry, emotional/service work, and care industry. This study discusses the ways in which individual desires for love and intimacy and her/his economical needs are combined or negotiated. Specifically, this study 1) reviews existing literature on how 'love' and 'intimacy' has been combined with economy under capitalism in general, 2) discusses the ways in which a marriage has been commercially negotiated within the context of South Korea, 3) analyzes combined aspects of 'love' and 'economy' within cross-border marriages and suggests that cross-border marriages, even though they are highly commercially negotiated, may not be fully explained by 'economy' only as other marriages have both aspects of 'love' and 'economy.' An analysis on 'love' and 'economy,' not only separated from each other but also controversial, is essential for understanding 'intimacy' and transitions of Korean families in post-modern era. However, the evaluation criteria for commercial trades in 'love' and 'intimacy' have not developed yet. Whereas a certain trade is inevitable or essential, others may threaten our lives. Developing the ethical and political evaluation criteria on such commercial trades requires future study.

• Journal of International Area Studies (JIAS)
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• v.12 no.4
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• pp.395-420
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• 2009

Academic discourses on Swahili identity have been focused on either its Bantu or Arabic-originated theories. Both theories, nevertheless, have a common feature: a unilineal origin of Swahili identity. This paper questions on this Swahili identity and argues that Swahili identity has been developed through historical experience and discourses. For this, the paper utilizes Barth's theory of situationalism. Barth(1998(1969)) suggests that maintaining an ethnic identity is a personal or group choice out of multiple layers of social identities according to his or their social environments. Tanzanian Swahili identity is a good case for this analysis. Based on fieldwork conducted at Magomeni and Msasani in Dar es Salaam, a capital of Tanzania, the paper shows that residents in both areas hold strong Swahili identities although they have different social and historical experience. In case of Magomeni, most of the residents came from Zanzibar, a core Swahili cultural area. They trace their original genealogy from Arabia peninsular. Besides, they argue that they speak a proper kiSwahili(Swahili language) distinguishable from inland kiSwahili. On the contrary, residents of Msasani show variety of ethnic identities, far from a proper Swahili. They have adapted Swahili identities since the independence of Tanzania. With the help of strong socialist policies, including a language policy, most of Tanzanian ethnic groups have ignored their own identities and accommodated a national identity, Tanzanian(waTanzania) or Swahili people(waSwahili). Makonde immigrants from Mozambique who consists the majority of residents in Msasani also easily accommodate Swahili identity in the course. Therefore, Makonde have began to rebirth as waSwahili by claiming that they are living in Tanzania and speak kiSwahili as a mother tongue.