• The Journal of the Korea Contents Association
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• v.15 no.8
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• pp.579-587
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• 2015

The purpose of this study is to investigate how Korean learners perceive English vowels and further to test SLM which claims that new L2 vowel categories are more easily acquired than similar L2 vowel categories. Twenty Korean learners participated in English-to-Korean mapping test and English vowel identification test with target vowels /i, ɪ, u, ʊ, ɛ, æ/. The result revealed that Korean participants mapped the English pairs /i/-/ɪ/ and /u/-/ʊ/ onto single Korean vowel /i/ and /u/, respectively. in addition, both of English /ɛ/ and /æ/ were simultaneously mapped onto Korean /e/ and /ɛ/. This indicated that the Korean participants seemed to have perceptual difficulty for the pairs /i-ɪ/, /u-ʊ/, and /ɛ-æ/. The result of the forced-choice identification test showed that the accuracy of /ɪ, ʊ, æ/(ɪ: 81.3%, ʊ: 62.5%, æ: 60.0%) was significantly higher than that of /i, u, ɛ/(i: 28,8%, u: 28.8%, ɛ: 32.4%). Thus, the claim of SLM is confirmed given that /ɪ, ʊ, æ/ are new vowel categories whereas /i, u, ɛ/ are similar vowel categories. Further, the conspicuously low accuracy of the similar L2 vowel categories /i, u, ɛ/ was accounted for by over-generalization whereby the Korean participants excessively replaced L2 similar /i, u, ɛ/ with L2 new /ɪ, ʊ, æ/ as the participants were learning the L2 new vowel categories in the process of acquisition. Based on the findings this study, pedagogical suggestions are provided.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.2
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• pp.591-598
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• 2012

Aim and background: MicroRNAs (miRNAs) are a class of naturally occurring small noncoding RNAs that regulate gene expression, cell growth, differentiation and apoptosis by targeting mRNAs for translational repression or cleavage. The present study was conducted to study miRNAs in Egyptian breast cancer (BC) and their relation to metastasis, tumor invasion and apoptosis in addition to their association with the ER and PR statuses. Methods: Real Time RT-PCR was performed to identify the miRNA expression level of eight miRNAs and eight metastatic-related genes in 40 breast cancer samples and their adjacent non-neoplastic tissues. The expression levels of each miRNA relative to U6 RNA were determined using the $^{2-{\Delta}}CT$ method. Also, miRNA expression profiles of the BC and their corresponding ANT were evaluated. Results: The BC patients showed an up-regulation in miRNAs (mir-155, mir-10, mir-21 and mir-373) with an upregulation in MMP2, MMp9 and VEGF genes. We found down regulation in mir-17p, mir-126, mir-335, mir-30b and also TIMP3, TMP1 and PDCD4 genes in the cancer tissue compared to the adjacent non-neoplastic tissues. Mir -10b, mir -21, mir-155 and mir373 and the metastatic genes MMP2, MMP9 and VEGF were significantly associated with an increase in tumor size (P < 0.05). No significant difference was observed between any of the studied miRNAs regarding lymph node metastasis. Mir-21 was significantly over-expressed in ER-/PR-cases. Conclusion: Specific miRNAs (mir-10, mir-21, mir-155, mir-373, mir-30b, mir-126, mir-17p, mir-335) are associated with tumor metastasis and other clinical characteristics for BC, facilitating identification of individuals who are at risk.

• Journal of agriculture & life science
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• v.53 no.2
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• pp.65-75
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• 2019

Stem and root of elm trees have used as traditional medical materials, but there is little information on the distribution and resources of habitats. Korean native growing Ulmus spp. (U. davidiana var. Japonica, U. parvifolia, U. davidiana, and U. macrocarpa) genetic resources studied through The National Forest Inventory of Korea data and field survey. The distributions of U. davidiana var. japonica according to elevation distributed evenly. Both U. parvifolia and U. davidiana were inhabited mostly at less than 200 m of altitude. Each Ulmaceae species widely were distributed nationwide, but a dominant species was different depending on locals. It observed that Ulmaceae inhabits mainly in steep slopes of 31-45 degrees. Most of the habitats regenerated by natural seeding and the most abundant species were a codominant tree. Distribution of trees in U davidiana var. japonica was 7 m-13 m, and in young U. parvifolia and U. macrocarpa, more than 25% of young trees less than 7 m observed. The distribution of the diameter of breast height of the U. davidiana var. japonica was 46.4% for 11-20 cm, 52.6% for 11-20 cm in U. parvifolia. The average T/R ratio was 0.83, and the mean weight ratio of root bark was 62%. As the results of this study, the domestic Ulmaceae biomassare very small. It is difficult to harvest in that the habitat on the slope. Thus, it is too hard to develop functional materials using biomass at present. Therefore, it is necessary to develop technology for the selection and propagation of elite trees of Ulmaceae.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.17
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• pp.7589-7594
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• 2015

Background: MicroRNAs (miRNAs) are small non-coding RNA molecules, implicated in several activities like initiation, progression and prognosis of various cancers. Single nucleotide polymorphisms (SNPs) in miRNA genes can lead to alteration in mRNA expression, resulting in diverse functional consequences. The aim of our study was to investigate the association of miR-149C>T and miR-196a2C>T SNPs with susceptibility to development of oral squamous cell carcinoma (OSCC) in South Indian subjects. Materials and Methods: 100 OSCC patients and 102 healthy controls from the general population were recruited for the study. Genetic analysis was performed by polymerase chain reaction/restriction fragment length polymorphism (PCR/RFLP) as per a standard protocol. Results: The genotype frequencies in miR-196a2 polymorphism, of TT, CT and CC in the OSCC patients were 69%,10% and 22% respectively while for control group it was 80%, 15% and 5% respectively. The CC genotype of miR196a2 polymorphism was significantly associated with oral squamous cell carcinoma. The genotype frequencies in miR-149 polymorphisms of CC, CT and TT in the oral squamous cell carcinoma (OSCC) patients were 72%, 22% and 6% respectively and for control group 88%, 12% and 0% respectively. CT and TT genotypes of miR149 polymorphism were found to be significantly associated with OSCC (p = 0.05 and 0.07). Conclusions: Our study suggests that miR-196a2C>T and miR-149C>T polymorphisms may play crucial roles in the development of OSCC in South Indian subjects.

• The Korean Journal of Malacology
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• v.27 no.4
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• pp.371-376
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• 2011

Digestive enzymatic compositions and activities in digestive diverticula of the three species of bivalves were investigated in this study. Mytilus galloprovincialis, Saxidomus purpuratus and Tegillarca granosa which were collected from southern coast of Korea on November 2010, were used for analysis. Amylase and cellulase occupied approximately 95% of digestive enzymes in digestive diverticula of M. galloprovincialis, S. purpuratus and T. granosa. The amylase and cellulase activities were 2.6 and 0.8 U/mg in M. galloprovincialis, 2.4 and 8.8 U/mg in S. purpuratus and 7.3 and 11.8 U/mg in T. granosa. And protease activities in digestive diverticula of M. galloprovincialis, S. purpuratus and T. granosa showed the lowest values to 0.00019, 0.00028 and 0.00022 U/mg, respectively.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.10 no.2
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• pp.123-128
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• 2010

ularly, a points of view Health-care system, it can reduce costs and efforts in order to management of patients. However, Health-care system keep a level of service for person and extends of hospital inner parts system. Although the rate of an addict grow by alcoholic but it is difficult to manage and diagnosis because of patient data gathering. Therefore in this thesis, it is proposed to patient data gathering and monitering method in u-zone. It can collect patient data by pulse, temperature and acceleration sensor and it can diagnosis correct based on emotion change data.

• Journal of Korean Society for Atmospheric Environment
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• v.26 no.2
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• pp.137-150
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• 2010

A meso-urban meteorological model (Urbanized MM5; uMM5) with urban canopy parameterization (UCP) was applied to the high-resolution simulation of meteorological fields in a complex coastal urban area and the assessment of urban impacts. Multi-scale simulations with the uMM5 in the innermost domain (1-km resolution) covering the Busan metropolitan region were performed during a typical sea breeze episode (4~8 August 2006) with detailed fine-resolution inputs (urban morphology, land-use/land-cover sub-grid distribution, and high-quality digital elevation model data sets). An additional simulation using the standard MM5 was also conducted to identify the effects of urban surface properties under urban meteorological conditions. Results showed that the uMM5 reproduced well the urban thermal and dynamic environment and captured well the observed feature of sea breeze. When comparison with simulations of the standard MM5, it was found that the uMM5 better reproduced urban impacts on temperature (especially at nighttime) and urban wind flows: roughness-induced deceleration and UHI (Urban Heat Island)-induced convergence.

• Ocean and Polar Research
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• v.37 no.1
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• pp.23-35
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• 2015

A 450 m-long sediment section was recovered from Hole U1359D located at the eastern levee of the Jussieau submarine channel on the Wilkes Land continental rise (East Antarctica) during IODP Expedition 318. The age model for Hole U1359D was established by paleomagnetic stratigraphy and biostratigraphy, and the ages of core-top and core-bottom were estimated to be about 5 Ma and 13 Ma, respectively. Biogenic opal content during this period varied between 3% and 60%. In the Southern Ocean, high biogenic opal content generally represents warm climate characterized by the increased light availability due to the decrease of sea-ice distribution. The surface water productivity change in terms of biogenic opal content at about 10.2 Ma in the Wilkes Land continental rise was related to the development of Northern Component Water. After about 10.2 Ma, more production of Northern Component Water in the North Atlantic caused to increase heat transport to the Southern Ocean, resulting in the enhanced diatom production. Miocene isotope events (Mi4~Mi7), which are intermittent cooling intervals during the Miocene, appeared to be correlated to the low biogenic opal contents, but further refinement was required for precise correlation. Biogenic opal content decreased abruptly during 6 Ma to 5.5 Ma, which most likely corresponds to the Messinian salinity crisis. Short-term variation of biogenic opal content was related to the extent of sea-ice distribution associated with the location of Antarctic Polar Front that was controlled by glacial-interglacial paleoclimate change, although more precise dating and correlation will be necessary. Diatom production in the Wilkes Land continental rise increased during the interglacial periods because of the reduced sea-ice distribution and the southward movement of Antarctic Polar Front.

• Transactions of the Korean hydrogen and new energy society
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• v.19 no.2
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• pp.124-131
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• 2008

Crude cytoplasmic fraction of phototrophic purple sulfur bacterium, Thiocapsa roseopersicina NCIB 8347, were initially prepared and purified by sonication, ultracentrifugation, ammonium sulfate fractionation and heat-treatment and it has been previously reported. Using various applications of chromatography far the purification of membrane-bound and soluble hydrogenases from heat-treated enzyme fraction were studied at present report. When the heat-treated enzyme preparation was applied to the anion column chromatography using Q-sepharose, Fraction I and II, which were extracted with the KCl 0-0.5 M gradient, showed the specific evolution hydrogenase activity 3.86 and 2.27 U/mg-protein respectively. Specific hydrogenase activitys of Fraction I and II were further increased to 4.35 and 7.46 U/mg-protein for Fraction I and to 2.49 and 4.41 U/mg-protein fur Fraction II respectively, when hydrophobic interaction column, Phenyl superose, and anion exchange column, Mono-Q, were applied. Size exclusion chromatography using superdex 200 concentrated the hydrogenase Fraction I and II to 9.19 and 7.84 U/mg-protein respectively at the final step of purification.

• Communications of the Korean Institute of Information Scientists and Engineers
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• v.32 no.2
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• pp.52-58
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• 2014