• Proceedings of the Korean Society of Precision Engineering Conference
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• 2010.11a
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• pp.479-480
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• 2010

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2010.11a
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• pp.467-468
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• 2010

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2005.05a
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• pp.207-214
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• 2005

Productivity and quality stability are very important competitive factors in PCB manufacturing lines that process the multiple types of products with the mixed process flows under frequent order information changes. MES is an appropriate IT solution to solve these problems in the medium-sized PCB manufacturing company. This paper introduces the MES development and its effects for a medium-sized PCB manufacturing company. The main functions of an implemented MES are delivery simulation, production scheduling, and production process monitoring. Productivity are improved up to $10{\sim}20%$ and manufacturing lead times per order are shortened up to 2 days according to the manufacturing scenarios.

• Proceedings of the Safety Management and Science Conference
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• 2007.04a
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• pp.73-80
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• 2007

Recently, the strategy of the age of limitless competition for existence of manufacturing company appears for the enhancement of productivity through the automatic system, the reduction for the cost for standardization and the decision making process for the information system. Especially the critical success factors in manufacturing company can be summarized for the establishment of production visibility through the production management, material & work-in-process management, the establish of the flexible manufacturing system for the changed order priority and the establish of the quality system for improvement of product and process quality. The existing production management systems supply only simple information about production results on real time, can delay quick decision making. And it can prevent acquiring the information about various customer needs and the communication problems with other systems. In this paper, it will show MES system, a solution for the problems of existing production management systems. And through a case study of D company, it will reveal improvement effect on shipment error using MES system and economic analysis for MES itself.

• Journal of the Korea Safety Management & Science
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• v.14 no.4
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• pp.265-270
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• 2012

This paper deals with the application and effects of MES for H automobile plant in China. There existed the production planning and the different work order in PL painting plant, but we can simultaneously prepare the painting parts and parts delivery and assembly according to painting color by introducing MES. We can respond the change of production planning and operate integratively the PL painting, parts storage and parts delivery and then we can results in reasonable logistics. We obtained the exact production information, correct work order, precise delivery order. We obtained not only the improvement of logistics but also the reduction of inventory.

• Journal of the Korea Safety Management & Science
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• v.9 no.2
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• pp.113-122
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• 2007

Recently, the strategy of the age of limitless competition for existence of manufacturing company appears for the enhancement of productivity through the automatic system, the reduction for the cost for standardization and the decision making process for the information system. Especially the critical success factors in manufacturing company can be summarized for the establishment of production visibility through the production management, material & work-in-process management, the establish of the flexible manufacturing system for the changed order priority and the establish of the quality system for improvement of product and process quality. The existing production management systems supply only simple information about production results on real time, can delay quick decision making. And it can prevent acquiring the information about various customer needs and the communication problems with other systems. In this paper, it will show MES system, a solution for the problems of existing production management systems. And through a case study of D company, it will reveal improvement effect on shipment error using MES system and economic analysis for MES itself.

• Journal of the Korea Safety Management & Science
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• v.24 no.2
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• pp.127-134
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• 2022

Production management in the automobile parts industry is carried out according to the production plan of the customer, so it is important to prevent shortages in product supply. As the product composition became increasingly complex, the MES System was built for the purpose of efficient production plan management and inventory management, but its utilization is low. This study analyzed the problems of the MES system and sought to improve it. Through previous studies, it was confirmed that the inventory management of the pull approach that actually occurred in the warehouse is more suitable than the push approach based on the forecast of the warehouse for the volatility, complexity, and uncertainty of orders in the auto parts industry. To realize this, we tried distributed MRP by using the ADO function of VBA to link the standard information of the MES system with Excel and change the structure of the BOM table. Through this, it can help increase the accuracy of production planning and realize efficient inventory management, thereby increasing the utilization of the MES system in the auto parts industry and enhancing the competitiveness of the company.

• Journal of Life Science
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• v.12 no.5
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• pp.505-514
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• 2002

The aim of this study was to evaluate the anticonvulsant activity of four agents derived from tropinone (T-1: 2,4-dipyrrolylmethenylnortropinone, T-2: 2,4-diphenylmethenylnortropinone, T-3 : 2,4-difurfurylmethenylnortropinone, T-4 : 2,4-dimethoxyphenylmethenylnortropinone) in NIH Swiss mouse. Pentylenetetrazole (nZ) was injected via intraperi-toniurn in mouse and Maximal Electroshock (MES) stimulation was through both conjunctivas by electrodes. Tropinone derivatives were treated at 15 minutes before PTZ or MES procedure. PIZ of 25 mg/kg induced generalized seizure in mouse, effects of tropinone derivatives on PTZ-induced seizure were monitored. Compared with control group, T-4 decreased seizure grade most effectively. Also T-4 increased onset time of PTZ-induced seizure. This result showed that T-4 is most effective on PTZ-induced seizure. In MES-induced seizure, T-1 decreased seizure grade and recovery time. nNOS expression in hippocampus and cortex were increased in nZ- and MES-induced seizure animals compared with control. Pretreatment of tropinone derivatives in PTZ-induced seizure did not affected nNOS expression in brain tissues, but T-1 and T-4 decreased nNOS expression in cortex of MES-induced seizure animals. These findings suggest that tropinone derivatives have specific anticonvulsant activities according to PTZ- and MES-induced seizure. 2,4- dimethoxyphenylmethenylnoroopinone is most effective in PTZ-induced seizure and 2,4-di methoxyphenylmethenylnortropinone is most effective in MES-induced seizure.

• Journal of Life Science
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• v.29 no.5
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• pp.530-536
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• 2019

Glioblastoma (GBM) is the most incurable brain cancer derived from the transformed glial cells. Standard anti-GBM treatment, including surgery and chemoradiotherapy, does not ensure good prognosis for the patients with GBM, because successful therapy is often impeded by presence of glioma stem cells (GSCs). GSCs, which is generally divided into proneural (PN) and mesenchymal (MES) subtype, are understood as subpopulation of cancer cells responsible for GBM initiation, progression and recurrence after standard treatments. In the present study, we demonstrate that PN subtype GSCs differentially transit to MES subtype GSCs by specific cytokines. The expression of CD44, a marker of MES subtype GSCs, was observed when GSC11 PN subtype GSCs were exposed to tumor necrosis factor alpha ($TNF-{\alpha}$) cytokine and GSC23 PN subtype GSCs were treated to transforming growth factor beta 1 ($TGF-{\beta}1$) cytokine. Ivy glioblastoma atlas project (Ivy GAP) bioinformatics database showed that $TNF-{\alpha}$ and $TGF-{\beta}1$ were highly expressed in necrotic region and perivascular region, respectively. In addition, $TNF-{\alpha}$ signaling was relatively upregulated in necrotic region, while $TGF-{\beta}$ signaling was increased in perivascular region. Taken together, our observations suggest that MES subtype GSCs can be derived from various PN subtype GSCs by multimodal cytokine stimuli provided by neighboring tumor microenvironment.

• KSCI Review
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• v.14 no.2
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• pp.159-164
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• 2006

MES(Manufacturing Execution System) is a control system which supports basic activities(scheduling, working process and qualify management, etc) to execute working on the shop floor. As especially MES is a system to decrease the gap between production planning and operating, it executes functions that make decision between management and labor using real-time data. MES for real-time information processing requires certain conditions such as data modeling of RFID, which has recently attracted attentions, and monitoring of each product unit from manufacture to sales. However, in the middle of processing the unit with a RFID tag, transponders(readers) can't often read the tag due to reader's malfunctions, intentional damages, loss and the circumstantial effects; for that reason, users are unable to confirm the location of the product unit. In this case, users cannot avoid tracing the path of units with uncertain clues. In this paper, we suggest that the unique MES based on RFID and Bayesian Network can immediately track the product unit, and show how to evaluate it.