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Association Between Single Nucleotide Polymorphisms in the XRCC1 Gene and Susceptibility to Prostate Cancer in Chinese Men

  • Zhou, Yun-Feng;Zhang, Guang-Bo;Qu, Ping;Zhou, Jian;Pan, Hui-Xin;Hou, Jian-Quan
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.10
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    • pp.5241-5243
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    • 2012
  • Background: Prostate cancer (Pca) is one of the most common complex and polygenic diseases in men. The X-ray repair complementing group 1 gene (XRCC1) is an important candidate in the pathogenesis of Pca. The purpose of this study was to evaluate the association between single nucleotide polymorphisms in the XRCC1 gene and susceptibility to Pca. Materials and Methods: XRCC1 gene polymorphisms and associations with susceptibility to Pca were investigated in 193 prostate patients and 188 cancer-free Chinese men. Results: The c.910A>G variant in the exon9 of XRCC1 gene could be detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing methods. Significantly increased susceptibility to prostate cancer was noted in the homozygote comparison (GG versus AA: OR=2.95, 95% CI 1.46-5.42, ${\chi}^2$=12.36, P=0.001), heterozygote comparison (AG versus AA: OR=1.76, 95% CI 1.12-2.51, ${\chi}^2$=4.04, P=0.045), dominant model (GG/AG versus AA: OR=1.93, 95% CI 1.19-2.97, ${\chi}^2$=9.12, P=0.003), recessive model (GG versus AG+AA: OR=2.17, 95% CI 1.33-4.06, ${\chi}^2$=8.86, P=0.003) and with allele contrast (G versus A: OR=1.89, 95% CI 1.56-2.42, ${\chi}^2$=14.67, P<0.000). Conclusions: These findings suggest that the c.910A>G polymorphism of the XRCC1 gene is associated with susceptibility to Pca in Chinese men, the G-allele conferring higher risk.

A Study on Body Types Characteristics of Mongolian Men (몽골 남성의 체형특성에 관한 연구 - 18~24세를 중심으로 -)

  • Im, Soon;Kim, Sang-Hee
    • Journal of the Korea Fashion and Costume Design Association
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    • v.12 no.1
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    • pp.141-151
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    • 2010
  • The purpose of the study was to offer basic documents to the textile fashion industry by investigating changes of figures by various factors as each other social and environment. This study analyzes characterization and classification of body types of Mongolian men. 100 adult subjects within the 18 to 24 age group were studied. The physical measurements of the research subjects come up to a total of 63 items. Data was statistically analyzed with SPSS program using basic statistics, t-test, one-way ANOVA, Duncan-test, factor analysis and cluster analysis. The conclusions are as follows. In the result of factors analysis in physical measurements of Mongolian men, 10 factors such as the vertical size of body, on the obesity of body, the leg size, the bust from back length, the bust from front length, the shoulder size were extracted. The accumulated contributory rate of these was 73.86%. The cluster analysis for the comparison of the body types, by categorizing the body types produced three types. The comparison of 45 items in physical measurements between Korean men and Mongolian men resulted in the differences in 20 items. While the height items including stature between them showed negligible differences.

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Orientalism in Modern Men's Skirt Fashion (현대 남성 스커트에 나타난 오리엔탈리즘)

  • Lee, Young-Min;Lee, Youn-Hee
    • The Research Journal of the Costume Culture
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    • v.13 no.1
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    • pp.133-149
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    • 2005
  • Western designers have long been inspired by exotic and mysterious looks and feelings of non-western countries in their design works. The influence of Orientalism has been prevalent not only in fashion but also in overall aspects of Western cultures ad it dated back to the B.C period. Orientalism has been interpreted differently in different ages. Orientalism has been in effect since the strong emergence of Western powers beginning in the 13th century. There have been produced many studies to analyze the tradition of Western fashion under the framework of Orientalism, but most of them have focused on women's wear and the researches on men's wear have hardly been productive, particularly on men's skirts. This paper aims to analyze the restoration movement of men's skirt fashion in Western societies such as tin America and European countries from the standpoint of Orientalism and attempts to forecast its future. The paper shows how we can reveal the identity of the tradition of men's skirt in Western fashion by making a critical comparison between the pictures of western men's skirts and those found in the folk fashion tradition in non-western countries.

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Predictors of Coronary Heart Disease Risk in Healthy Men and Women (건강한 남녀의 관상동맥질환 위험 예측요인)

  • Kim, Kyeung-Ae;Kim, Jung-Soon;Kim, Myoung-Soo
    • Journal of Korean Academy of Nursing
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    • v.37 no.7
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    • pp.1039-1048
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    • 2007
  • Objective: The purpose of this study was to identify predictors of coronary heart disease risk factors in healthy men and women. Method: The subjects of this study were 346 people (173 men and women aged 20 years and over) who received health screenings. Data was collected from December 1, 2005 to February 28, 2006. The FANTASTIC Lifestyle Assessment Inventory except smoking and the Framingham risk score of subjects were investigated. Data was analyzed by descriptive analysis, t-test, ANOVA, pearson correlation coefficients and stepwise multiple regression using the SPSS 10.0 program. Results: The mean score of the lifestyle of the women (64.24) was higher than that of the men (59.12). The mean score of the risk of coronary heart disease of the men (5.28%) was higher than that of the women (0.28%). The framingham risk for men was significantly related to lifestyle such as dietary habit, use of caffeine and drugs, anxiety and depression, job satisfaction, and closeness with family. The main predictors of framingham risk for men and women were 'use of caffeine and drugs', and 'menopause' which explained 16.5%, and 30.7% respectively. Conclusion: Since lifestyles can be changed with effort, coronary heart disease can be prevented while people are healthy.

A Review of Men's Body Image Literature: What We Know, and Need to Know

  • Bradley, Linda Arthu;Rudd, Nancy;Reilly, Andy;Freson, Tim
    • International Journal of Costume and Fashion
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    • v.14 no.1
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    • pp.29-45
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    • 2014
  • In the contemporary world, fashionable bodies are socially constructed in light of current idealized images. Media portrayal of such images can have negative health implications. This issue has long been problematic for women. Nowadays, men are subject to more scrutiny regarding their bodies, although male body image has been studied far less than female body image. In this position paper based on a review of the major studies that have been conducted on men and body image, we summarize the findings from these state-of-the-art studies that have been recently published in academic journals. Three themes related to male body image were extracted: socio-cultural ideals, masculinity, and minority men. This study adds to the literature I that it demonstrates that men experience and view their bodies differently from women, though some behaviors, such as disordered eating, are similar. Other behaviors, such as the drive for muscularity, are couched in the context of the social construction of gender and power. Most of the studies were done on white, heterosexual populations of young men, and nearly all used quantitative research methods. Little research has been conducted on ethnic and sexual minorities. We conclude with a discussion of what we need to know, and to that end, we suggest future avenues of research.

Relationship Between Cigarette Smoking and Muscle Strength in Japanese Men

  • Saito, Takeshi;Miyatake, Nobuyuki;Sakano, Noriko;Oda, Kanae;Katayama, Akihiko;Nishii, Kenji;Numata, Takeyuki
    • Journal of Preventive Medicine and Public Health
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    • v.45 no.6
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    • pp.381-386
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    • 2012
  • Objectives: To investigate the link between cigarette smoking and muscle strength in Japanese men. Methods: We used data on 4249 Japanese men, aged $43.3{\pm}13.9$ years, in this cross-sectional investigation study. Grip strength and leg strength were measured as indicators of overall muscle strength. Meanwhile, subjects' cigarette smoking habits were recorded by trained medical staff. The effect of cigarette smoking on muscle strength was evaluated. Results: A total of 1618 men (38.1%) were smokers and 1481 men (34.9%) exercised regularly. Significant differences in muscle strength were noted between men with and without a Brinkman index of 400 or greater, after adjusting for age. After adjusting for age, height, body weight and exercise habits, associations between the Brinkman index and leg strength and the ratio of leg strength to body weight were attenuated. Conclusions: Cigarette smoking might be negatively associated with muscle strength, especially grip strength in Japanese men.

The Relationship between Health Promoting Behaviors and Anger in Middle-Aged Men (일 도시지역 중년 남성의 건강증진행위와 분노와의 관계)

  • Kim Jong-Im;Park Mi-Young
    • Journal of Korean Academy of Fundamentals of Nursing
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    • v.12 no.1
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    • pp.38-45
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    • 2005
  • Purpose: The purpose of this study was to identify health promoting behaviors and the relationship between health promoting behaviors and state and trait anger in middle-aged men. Method: In this descriptive correlational study, the participants were 143 middle-aged men who lived in D city. Data were collected from November, 2004 to January. 2005. Personal interviews with a structured questionnaire were used. The data were analyzed using descriptive statistics, and Pearson correlation coefficients with SPSS Win 11.0 program. Results: The score for health promoting behavior in the middle-aged men was above the mean score. The highest dimension was self-actualization and the lowest dimension of health promoting behaviors was exercise. A significant negative correlation was found between health promoting behaviors and state anger in middle-aged men. But there was no significant correlation between health promoting behaviors and trait anger. Conclusion: These results suggest that state anger should be considered as an important factor when nurses develop educational programs to enhance health promoting behavior in middle-aged men.

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Associations of Sarcopenia and Sarcopenic Obesity With Metabolic Syndrome Considering Both Muscle Mass and Muscle Strength

  • Lee, Jihye;Hong, Yeon-pyo;Shin, Hyun Ju;Lee, Weonyoung
    • Journal of Preventive Medicine and Public Health
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    • v.49 no.1
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    • pp.35-44
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    • 2016
  • Objectives: We investigated the associations of sarcopenia-defined both in terms of muscle mass and muscle strength-and sarcopenic obesity with metabolic syndrome. Methods: Secondary data pertaining to 309 subjects (85 men and 224 women) were collected from participants in exercise programs at a health center in a suburban area. Muscle mass was measured using bioelectrical impedance analysis, and muscle strength was measured via handgrip strength. Sarcopenia based on muscle mass alone was defined as a weight-adjusted skeletal muscle mass index more than two standard deviations below the mean of a sex-specific young reference group (class II sarcopenia). Two cut-off values for low handgrip strength were used: the first criteria were <26 kg for men and <18 kg for women, and the second criteria were the lowest quintile of handgrip strength among the study subjects. Sarcopenic obesity was defined as the combination of class II sarcopenia and being in the two highest quintiles of total body fat percentage among the subjects. The associations of sarcopenia and sarcopenic obesity with metabolic syndrome were evaluated using logistic regression models. Results: The age-adjusted risk ratios (RRs) of metabolic syndrome being compared in people with or without sarcopenia defined in terms of muscle mass were 1.25 (95% confidence interval [CI], 1.06 to 1.47, p=0.008) in men and 1.12 (95% CI, 1.06 to 1.19, p<0.001) in women, which were found to be statistically significant relationships. The RRs of metabolic syndrome being compared in people with or without sarcopenic obesity were 1.31 in men (95% CI, 1.10 to 1.56, p=0.003) and 1.17 in women (95% CI, 1.10 to 1.25, p<0.001), which were likewise found to be statistically significant relationships. Conclusions: The associations of sarcopenia defined in terms of muscle mass and sarcopenic obesity with metabolic syndrome were statistically significant in both men and women. Therefore, sarcopenia and sarcopenic obesity must be considered as part of the community-based management of non-communicable diseases.

The Association between Physical Activity and Metabolic Syndrome Index in Middle-aged Adults (중년 성인의 신체활동과 대사증후군 지표의 관계)

  • So Youn Bang
    • Journal of Information Technology Applications and Management
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    • v.30 no.1
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    • pp.71-80
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    • 2023
  • The purpose of this study is to promote understanding of physical activity and metabolic syndrome in middle-aged adults and to provide basic data of interventions development for the prevention and management of metabolic syndrome. Using the 2020 data for Korea National Health and Nutrition Examination Survey, 1,786 middle-aged adults between the ages of 40 and 64 with no missing data were analyzed. As a result of the study, 56.5(±2.1)% of men and 52.9(±1.81)% of women were sufficient activity group among physical activity, and the proportion of men was higher than that of women, but it was not statistically significant(t=1.27, p=.207). The prevalence of metabolic syndrome was 38.9(±2.1%) of men and 25.4(±1.5)% of women, the prevalence of men was significantly higher than that of women(t=5.12, p<.001). Compared to the insufficient activity group, the sufficient activity group had a 0.71(95% CI: 0.57~0.88) times the risk of developing low HDL(high density lipoprotein)- cholesterol(p=.002), and this pattern was maintained even after adjusting for age, education level, body mass index, smoking status, and drinking status(p=.002). Based on the results of this study, a physical activity and metabolic syndrome risk group in middle-aged adults should be selected, and physical activity promotion program to improve high density lipoprotein-cholesterol among metabolic syndrome indicators should be developed.

Decisional balance corresponding to the Stage of Change of Smoking Cessation in Middle Aged Men (중년 흡연남성의 금연 변화단계에 따른 의사결정 균형에 대한 연구)

  • Chang Sung-Ok;Park Chang-Seung;Min In-Sun
    • Journal of Korean Academy of Fundamentals of Nursing
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    • v.7 no.2
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    • pp.164-176
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    • 2000
  • Purpose : This study was done to identify the factors of decisional balance for smoking cessation among middle aged men in Korea. This was composed of a set of variables at the level of decision making when middle aged men decide to stop smoking. It was used to classify and identify the characteristics of the stages of change for smoking cessation to which the middle aged men belong, and was used to identify the variables of decisional balance which influenced the stages of change for smoking cessation in middle aged men. Methods : A convenience sample of 169 men who had smoked and were smoking, were between age 30 and 60 and lived in Seoul(mean age=44), were selected from the community. The data was collected from December 10, 1999 to February 28, 2000. The research instrument was the Decisional Balance Measure for Smoking Cessation (Velicer et al., 1985). and Stage of Change Measure(DiClemente et al., 1991). The data were analyzed using the SAS Program. Results : 1. According to stage of change measure, the 169 subjects were distributed in each stage of change for smoking cessation: in the pre-contemplation stage 63 subjects(32.7%), contemplation stage 60 subjects (35.5%), preparation stage 17 subjects(10.1%), and maintenance stage 29 subjects(17.2%). 2. Factor analysis identified 4 factors of decisional balance as appropriate factors for smoking cessation of middle aged men. There were named by the researchers; 1)'Perceived Burden to Self', 2)'Perceived Benefit to Others' 3)'Perceived Approval to Others', and 4)'Perceived Disapproval to Self'. 3. Analysis of variance showed that the three components, 1)'Perceived Burden to Self(F=8.50, P=.0001)', 2)'Perceived Benefit to Others(F=3.19, P=.025)' and 3)'Perceived DisApproval to Self(F=2.87, P=.038)were significantly associated with stage of change. 4. Through discriminant analysis, it was found that 'Perceived Burden to self' was the most influential variable in discriminating the four stages of change(pre-contemplation, contemplation, preparation, and maintenance). Conclusion : The results are consistent with the application of the Transtheoretical model, which has been used to understand how people change health behavior. Even though this study is a cross-sectional, not a longitudinal study, the findings of this study give useful information for smoking cessation intervention for the middle aged men.

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