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http://dx.doi.org/10.3961/jpmph.15.055

Associations of Sarcopenia and Sarcopenic Obesity With Metabolic Syndrome Considering Both Muscle Mass and Muscle Strength  

Lee, Jihye (Department of Preventive Medicine, Chung-Ang University College of Medicine)
Hong, Yeon-pyo (Department of Preventive Medicine, Chung-Ang University College of Medicine)
Shin, Hyun Ju (Namyangju City Hall)
Lee, Weonyoung (Department of Preventive Medicine, Chung-Ang University College of Medicine)
Publication Information
Journal of Preventive Medicine and Public Health / v.49, no.1, 2016 , pp. 35-44 More about this Journal
Abstract
Objectives: We investigated the associations of sarcopenia-defined both in terms of muscle mass and muscle strength-and sarcopenic obesity with metabolic syndrome. Methods: Secondary data pertaining to 309 subjects (85 men and 224 women) were collected from participants in exercise programs at a health center in a suburban area. Muscle mass was measured using bioelectrical impedance analysis, and muscle strength was measured via handgrip strength. Sarcopenia based on muscle mass alone was defined as a weight-adjusted skeletal muscle mass index more than two standard deviations below the mean of a sex-specific young reference group (class II sarcopenia). Two cut-off values for low handgrip strength were used: the first criteria were <26 kg for men and <18 kg for women, and the second criteria were the lowest quintile of handgrip strength among the study subjects. Sarcopenic obesity was defined as the combination of class II sarcopenia and being in the two highest quintiles of total body fat percentage among the subjects. The associations of sarcopenia and sarcopenic obesity with metabolic syndrome were evaluated using logistic regression models. Results: The age-adjusted risk ratios (RRs) of metabolic syndrome being compared in people with or without sarcopenia defined in terms of muscle mass were 1.25 (95% confidence interval [CI], 1.06 to 1.47, p=0.008) in men and 1.12 (95% CI, 1.06 to 1.19, p<0.001) in women, which were found to be statistically significant relationships. The RRs of metabolic syndrome being compared in people with or without sarcopenic obesity were 1.31 in men (95% CI, 1.10 to 1.56, p=0.003) and 1.17 in women (95% CI, 1.10 to 1.25, p<0.001), which were likewise found to be statistically significant relationships. Conclusions: The associations of sarcopenia defined in terms of muscle mass and sarcopenic obesity with metabolic syndrome were statistically significant in both men and women. Therefore, sarcopenia and sarcopenic obesity must be considered as part of the community-based management of non-communicable diseases.
Keywords
Sarcopenia; Metabolic syndrome X; Association; Muscle strength;
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1 Shim MS, Lee MS, Oh NR, Kang KH. A study on duty awareness of public health-center workers. J Korea Conver Soc 2010;1(1): 83-91 (Korean).
2 Byun DH, Kim EJ, Park MB, Son HR, Park HK, Kim CB. Accessible strategy of the registration & management of hypertension and diabetes mellitus patients through the public-private partnership: policy implications fron the Hongcheon-gun case. Korean J Health Educ Promot 2013;30(4):111-123 (Korean).   DOI
3 Ministry of Health and Welfare. Korea health statistics 2013: Korea National Health and Nutrition Examination Survey (KNHANES VI-1). Sejong: Ministry of Health and Welfare; 2014, p. 52 (Korean).
4 Korea University Research and Business Foundation. Ansan community-based cohort study. Cheongju: Korea Centers for Disease Control and Prevention; 2013, p. 84 (Korean).
5 Statistics Korea. Annual report on the causes of death statistics 2013. Daejeon: Statistics Korea; 2014, p. 12 (Korean).
6 Hong S, Choi WH. Clinical and physiopathological mechanism of sarcopenia. Korean J Med 2012;83(4):444-454 (Korean).   DOI
7 Prado CM, Wells JC, Smith SR, Stephan BC, Siervo M. Sarcopenic obesity: a critical appraisal of the current evidence. Clin Nutr 2012;31(5):583-601.   DOI
8 Rosenberg IH. Sarcopenia: origins and clinical relevance. J Nutr 1997;127(5 Suppl):990S-991S.   DOI
9 Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, et al. Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on Sarcopenia in Older People. Age Ageing 2010;39(4):412-423.   DOI
10 Balagopal P, Rooyackers OE, Adey DB, Ades PA, Nair KS. Effects of aging on in vivo synthesis of skeletal muscle myosin heavy-chain and sarcoplasmic protein in humans. Am J Physiol 1997; 273(4 Pt 1):E790-E800.   DOI
11 Hwang J, Lee W. Aging and sarcopenia: resistance exercise and protein intake in the elderly. Ewha J Human Move Sci 2009;12:15-20 (Korean).
12 Zoico E, Di Francesco V, Guralnik JM, Mazzali G, Bortolani A, Guariento S, et al. Physical disability and muscular strength in relation to obesity and different body composition indexes in a sample of healthy elderly women. Int J Obes Relat Metab Disord 2004;28(2):234-241.   DOI
13 Stenholm S, Harris TB, Rantanen T, Visser M, Kritchevsky SB, Ferrucci L. Sarcopenic obesity: definition, cause and consequences. Curr Opin Clin Nutr Metab Care 2008;11(6):693-700.   DOI
14 World Health Organization. Ageing and life-course [cited 2009 Apr 30]. Available from: http://www.who.int/ageing/en/.
15 Sayer AA, Dennison EM, Syddall HE, Gilbody HJ, Phillips DI, Cooper C. Type 2 diabetes, muscle strength, and impaired physical function: the tip of the iceberg? Diabetes Care 2005;28(10): 2541-2542.   DOI
16 Janssen I, Heymsfield SB, Ross R. Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability. J Am Geriatr Soc 2002;50(5):889-896.   DOI
17 Janssen I, Shepard DS, Katzmarzyk PT, Roubenoff R. The healthcare costs of sarcopenia in the United States. J Am Geriatr Soc 2004;52(1):80-85.   DOI
18 Gale CR, Martyn CN, Cooper C, Sayer AA. Grip strength, body composition, and mortality. Int J Epidemiol 2007;36(1):228-235.   DOI
19 Klip A, Pâquet MR. Glucose transport and glucose transporters in muscle and their metabolic regulation. Diabetes Care 1990;13(3):228-243.   DOI
20 Reaven GM. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes 1988;37(12):1595-1607.   DOI
21 Walsh K. Adipokines, myokines and cardiovascular disease. Circ J 2009;73(1):13-18.   DOI
22 Solerte SB, Gazzaruso C, Bonacasa R, Rondanelli M, Zamboni M, Basso C, et al. Nutritional supplements with oral amino acid mixtures increases whole-body lean mass and insulin sensitivity in elderly subjects with sarcopenia. Am J Cardiol 2008; 101(11A):69E-77E.
23 Kim TN, Yang SJ, Yoo HJ, Lim KI, Kang HJ, Song W, et al. Prevalence of sarcopenia and sarcopenic obesity in Korean adults: the Korean sarcopenic obesity study. Int J Obes (Lond) 2009; 33(8):885-892.   DOI
24 Sanada K, Miyachi M, Tanimoto M, Yamamoto K, Murakami H, Okumura S, et al. A cross-sectional study of sarcopenia in Japanese men and women: reference values and association with cardiovascular risk factors. Eur J Appl Physiol 2010;110(1): 57-65.   DOI
25 Chien MY, Huang TY, Wu YT. Prevalence of sarcopenia estimated using a bioelectrical impedance analysis prediction equation in community-dwelling elderly people in Taiwan. J Am Geriatr Soc 2008;56(9):1710-1715.   DOI
26 Chen LK, Liu LK, Woo J, Assantachai P, Auyeung TW, Bahyah KS, et al. Sarcopenia in Asia: consensus report of the Asian Working Group for Sarcopenia. J Am Med Dir Assoc 2014;15(2): 95-101.   DOI
27 Srikanthan P, Hevener AL, Karlamangla AS. Sarcopenia exacerbates obesity-associated insulin resistance and dysglycemia: findings from the National Health and Nutrition Examination Survey III. PLoS One 2010;5(5):e10805.   DOI
28 Moon SS. Low skeletal muscle mass is associated with insulin resistance, diabetes, and metabolic syndrome in the Korean population: the Korea National Health and Nutrition Examination Survey (KNHANES) 2009-2010. Endocr J 2014;61(1):61-70.   DOI
29 Lauretani F, Russo CR, Bandinelli S, Bartali B, Cavazzini C, Di Iorio A, et al. Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia. J Appl Physiol (1985) 2003;95(5):1851-1860.   DOI
30 Janssen I, Heymsfield SB, Baumgartner RN, Ross R. Estimation of skeletal muscle mass by bioelectrical impedance analysis. J Appl Physiol (1985) 2000;89(2):465-471.   DOI
31 Janssen I, Baumgartner RN, Ross R, Rosenberg IH, Roubenoff R. Skeletal muscle cutpoints associated with elevated physical disability risk in older men and women. Am J Epidemiol 2004; 159(4):413-421.   DOI
32 Roubenoff R. Sarcopenic obesity: the confluence of two epidemics. Obes Res 2004;12(6):887-888.   DOI
33 Kim YS, Lee Y, Chung YS, Lee DJ, Joo NS, Hong D, et al. Prevalence of sarcopenia and sarcopenic obesity in the Korean population based on the Fourth Korean National Health and Nutritional Examination Surveys. J Gerontol A Biol Sci Med Sci 2012; 67(10):1107-1113.   DOI
34 Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, et al. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 2005; 112(17):2735-2752.   DOI
35 Park E, Choi SJ, Lee HY. The prevalence of metabolic syndrome and related risk factors based on the KNHANES V 2010. J Agric Med Community Health 2013;38(1):1-13 (Korean).   DOI
36 Sayer AA, Syddall HE, Dennison EM, Martin HJ, Phillips DI, Cooper C, et al. Grip strength and the metabolic syndrome: findings from the Hertfordshire Cohort Study. QJM 2007;100(11): 707-713.   DOI
37 Gaster M, Vach W, Beck-Nielsen H, Schroder HD. GLUT4 expression at the plasma membrane is related to fibre volume in human skeletal muscle fibres. APMIS 2002;110(9):611-619.   DOI
38 Roubenoff R. Catabolism of aging: is it an inflammatory process? Curr Opin Clin Nutr Metab Care 2003;6(3):295-299.   DOI
39 Tanimoto Y, Watanabe M, Sun W, Sugiura Y, Tsuda Y, Kimura M, et al. Association between sarcopenia and higher-level functional capacity in daily living in community-dwelling elderly subjects in Japan. Arch Gerontol Geriatr 2012;55(2):e9-e13.   DOI
40 Tieland M, Dirks ML, van der Zwaluw N, Verdijk LB, van de Rest O, de Groot LC, et al. Protein supplementation increases muscle mass gain during prolonged resistance-type exercise training in frail elderly people: a randomized, double-blind, placebo-controlled trial. J Am Med Dir Assoc 2012;13(8):713-719.   DOI