• Journal of Life Science
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• v.31 no.2
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• pp.192-198
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• 2021

Red yeast rice has been extensively used as food and traditional medicine for thousands of years in East Asian countries. It is produced by the fermentation of a particular yeast (in general, Monascus purpureus) as rice and various cereals (barley, soybean, etc.). Monascus sp. produces many secondary metabolites during its growth, including pigments, monacolins, and γ-aminobutyric acid. Some metabolites―specifically, monacolin K, γ-aminobutyric acid, dimerumic acid, and monascus pigments―have been reported to lower cholesterol and blood pressure while showing anti-obesity effects. In this study, we investigated the anti-obesity effect of ethanol extract from red yeast barley (RYB) fermented with Monascus sp. BHN-MK 2 on 3T3-L1 cells. The anti-obesity effects of RYB extract were examined: its lipid accumulation inhibitory effect was tested by Oil Red O staining, and obesity-related mRNA expression levels were tested by real-time RT-PCR in MDI stimulated 3T3-L1 cells. The intracellular lipid content of MDI-stimulated 3T3-L1 cells decreased significantly to 5.04%, 12.24%, and 23.52% in response to 200, 400, and 800 ㎍/ml RYB, respectively. Moreovers, we evaluated that RYB extract significantly downregulated the expression of C/EBPα, SREBP-1, and PPAR-γ gene in a dose-dependent manner. As a result, red yeast barley ethanol extracts exerted the strongest anti-obesity effects. Also, the results indicate that red yeast barley could be used as a functional anti-obesity food material.

• Journal of Life Science
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• v.32 no.7
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• pp.523-531
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• 2022

The purpose of this study was to evaluate the effect of antioxidant and anti-adipogenic activities in ethanol extracts from herb mixture (Ephedra sinica, Atractylodes lance, Gypsum fibrosum, and Theobroma cacao). DPPH, ABTS⁺ radical and xanthine oxidase scavenging activities were measured for antioxidant activity. Extracts of the herb mixture had 75.0, 100.8, and 79.5% scavenging activities at 1,000 ㎍/ml concentration, respectively. We investigated the inhibition of adipogenesis and adipocyte differentiation with an extract of an herb mixture in 3T3-L1 preadipocytes. An extract from the herb mixture at concentrations between 0 and 50 ㎍/ml did not affect 3T3-L1 cell viability. Treatment with herb mixture extracts of 25, 50, and 75 ㎍/ml in 3T3-L1 preadipocytes inhibited lipid accumulation in a dose-dependent manner. As a result of a Western blot experiment, it was shown that the herb mixture inhibited the differentiation transcription factors, PPARγ and C/EBPa, by 44.2 and 77.6%, respectively, at a concentration of 75 ㎍/ml in MDI-induced differentiated 3T3-L1 cells. As a result of RT-PCR, the gene expression of C/EBPa, SREBP-1c, and PPARγ was significantly inhibited by 43.4%, 59.6%, and 55.3%, respectively, at the concentration of 75 ㎍/ml of the herb mixture compared with the MDI-treated group. In addition, the expression of fatty acid synthase (FAS), a fatty acid synthesis regulator, was suppressed. These results can be applied to develop a functional food for anti-obesity with a herb mixture.

• Bulletin of the Korean Chemical Society
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• v.33 no.2
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• pp.692-694
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• 2012

• The Bulletin of The Korean Astronomical Society
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• v.26 no.1
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• pp.34.2-34.2
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• 2001

• The Bulletin of The Korean Astronomical Society
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• v.33 no.1
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• pp.38.1-38.1
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• 2008

• 한국가스학회:학술대회논문집
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• 1998.09a
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• pp.183-187
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• 1998

• Proceedings of the Korean Institute of Industrial Safety Conference
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• 2003.10a
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• pp.60-65
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• 2003

Semi-Rigid 폴리우레탄 foam의 한 종류인 PIR(Polyisocyanurate) foam은 당량적으로 과량의 MDI가 투입되어 생성된 Isocyanate Trimer(Isocyanurate)가 높은 Char Formation을 형성, 우수한 난연특성, 낮은 SMOKE INDEX, 높은 OXYGEN INDEX를 나타낸다. 국내엔 1988년 단열재용 폴리우레탄 foam으로는 최초로 미국의 UL Mark를 획득하여 건설, 건축등 관련업계에서 요구하는 난연특성 및 단열제로서의 제반요건에 부응하며 꾸준히 연구 개발되어 왔다.(중략)

• Proceedings of the Korean Statistical Society Conference
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• 2003.05a
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• pp.103-108
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• 2003

데이터마이닝을 위한 대용량 데이터베이스를 축소시키는 방법 중에 속성선택 방법이 많이 사용되고 있다. 본 논문에서는 세 가지 속성선택 방법을 사용하여 조건속성 수를 60%이상 축소시켜 결정나무와 로지스틱 회귀모형에 적용시켜보고 이들의 효율을 비교해 본다. 세 가지 속성선택 방법은 MDI, 정보획득, ReliefF 방법이다. 결정나무 방법은 QUEST, CART, C4.5를 사용하였다. 속성선택 방법들의 분류 정확성은 UCI 데이터베이스에 주어진 Credit 승인 데이터베이스와 German Credit 데이터베이스를 사용하여 10층-교차확인 방법으로 평가하였다.

• CDE review
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• v.4 no.2
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• pp.36-41
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• 1998

To survive in the intensive world wide automotive market, more and more automotive companies are investing their resources into concurrent engineering systems (CE) based on the combined CAD/CAM/CAE/ PDM technology. The main objectives of CE in automotive companies are the quality improvement of products and the reduction of cost and time to market. Remarkable effects are appearing from some of these companies. As shown in this paper, these successful automotive companies have been focusing on establishing the new process and methodology in applying CE into their car development process.

• Proceedings of the Korean Information Science Society Conference
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• 1998.10b
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• pp.638-640
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• 1998

본 논문은 교통 신호 제어 알고리즘들의 성능을 비교하기 위한 복수 교차로 시뮬레이터를 구현하였다. 기존의 교통 시뮬레이터들은 단일교차로를 대상으로 하거나 텍스트 모드로 동작하는 경우가 많았다. 논문의 시뮬레이터는 Visual C++의 MFC 라이브러리를 사용하여 n$\times$n 형태를 갖는 복수 교차로에 적합하도록 객체 지향적으로 구현되었으며, 성능 비교를 위하여 제어 알고리즘들을 별개의 윈도우에서 처리하기 쉽도록 MDI 방식을 사용하였다. 객체지향 프로그래밍 기술로 시뮬레이터를 설계하였기 때문에 편리할 뿐만 아니라 확장이나 수정이 용이하다는 장점을 갖는다.