• 생물정신의학
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• 제25권3호
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• pp.60-71
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• 2018

Objectives A growing body of evidence has suggested that morphologic changes in cerebellum may be implicated with pathophysiology of major depressive disorder (MDD). The aim of this study is to investigate a difference in the volume and cortical thickness of the specific region of cerebellum between patients with MDD and healthy controls (HC). Methods A total of 127 patients with MDD and 105 HC participated in this study and underwent T1-weighted structural magnetic resonance imaging. We analyzed volume and cortical thickness of each twelve cerebellum regions divided by left and right and the volume and cortical thickness of the whole cerebellum from T1-weigted image of participants. One-way analysis of covariance was used to investigate the volume and cortical thickness difference of total and specific regions between two groups adjusting for age, gender, medication, and total intracranial cavity volume. Results We found that the patients with MDD had significantly greater volume in the left cerebellum lobule III region [false discovery rate (FDR)-corrected p = 0.034] compared to HC. Also, our findings indicate that cortical thickness of left lobule VIIB (FDR-corrected p = 0.032) and lobule VIIIB (FDR-corrected p = 0.032) are significantly thinner in the patients with MDD compared with the HC. No significant volume and cortical thickness differences were observed in other sub-regions of the cerebellum. The volumes and cortical thickness of whole cerebellum between patients with MDD and HC did not differ significantly. Conclusions We observed the region-specific volume and cortical thickness difference in cerebellum between the patients with MDD and HC. The results of our study implicate that the information about structural alterations in cerebellum with further replicative studies might provide a stepping stone toward a specific marker to diagnose MDD.

• 전기전자학회논문지
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• 제8권1호
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• pp.22-32
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• 2004

본 논문에서는 Honghai Jiang에 의해 제안된 OVAG(Output value array graphs)를 기초로 MOVAG(Multi output value array graphs)를 이용한 다치논리함수의 구성방법을 제안하였다. D.M.Miller에 의해 제안된 MDD(Multiple-valued Decision Diagram)는 주어진 다변수의 함수에서 회로 설계까지 많은 처리시간과 노력이 요구되므로 본 논문에서는 MDD의 단점을 보완하여 데이터 처리시간의 단축과 적은 복잡도를 갖도록 MOVAG를 설계하였다. 또한 MOVAG의 구성 알고리즘과 입력행렬선정 알고리즘을 제안하고 T-gate를 사용하여 다치 논리 회로를 설계, 모의 실험을 통해 그 결과를 검증하였다.

• Clinical Psychopharmacology and Neuroscience
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• 제16권4호
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• pp.461-468
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• 2018

Objective: Cognitive disturbance is one of the major symptoms of depression and may be improved by treatment with antidepressants. This study aimed to investigate the predictors of cognitive improvement in patients with major depressive disorder (MDD) who were taking antidepressants. Methods: This study included 86 patients with MDD who completed 12 weeks of antidepressant monotherapy. Cognitive symptoms were assessed using the Perceived Deficits Questionnaire-Korean version (PDQ-K), which addresses four domains of cognitive functioning (attention/concentration, retrospective memory, prospective memory, and organization/planning) and was administered at study entry and at the 12-week end point. A variety of demographic, clinical, and treatment-related variables were evaluated as predictors of changes in total and domain scores. Results: All PDQ-K domains showed significant improvement after 12 weeks of antidepressant treatment. More severe initial depressive symptoms, fewer sick-leave days at study entry, and reduced use of concomitant anxiolytics/hypnotics during treatment were significantly associated with greater cognitive improvement. Conclusion: Cognitive symptoms are more responsive to antidepressant treatment in patients with severe MDD. Reduced use of anxiolytics and hypnotics could improve the cognitive functioning of patients with MDD taking antidepressants.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2010년도 추계학술발표대회
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• pp.287-290
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• 2010

오늘날 모바일 시장을 중심으로 다양한 플랫폼이 등장하면서 모바일 어플리케이션 개발 시 여러 플랫폼을 고려해야 하는 부담이 증대되고 있다. 이러한 상황에서 Model-Driven Development(MDD) 는 멀티플랫폼에 대응하는 어플리케이션 개발의 효율성을 높여줄 수 있다. 하지만 이 기법을 이용하는 대다수의 연구 결과들은 해당 방법론을 통해 생성된 결과물의 질을 객관적으로 평가할 수 없고, 이 때문에 해당 방법론의 성능 평가가 힘들다. 본 연구에서는 대상 플랫폼들이 제공하는 API 를 분석한 결과에 근거하여 공통 요소를 추출하고 이를 이용하여 MDD 기반으로 개발을 진행할 수 있는 개발 프로세스를 소개하고, 이를 통해 생성된 소스 코드의 기능적 유사도 및 코드 생성률과 기능적 유사도를 평가할 수 있는 방법을 제안한다. 이 방법은 코드를 AST 로 바꾸고 API 맵핑 테이블에 근거하여 동일한 키워드로 변환하고 유사도를 측정하여 설계 시 의도한 기능이 얼마나 잘 코드로 생성되었는 지 평가할 수 있는 방법이다. 본 연구에서는 이 방법을 이용하여 생성된 코드의 기능적 유사도와 코드 생성률을 측정하였다.

• 생물정신의학
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• 제15권2호
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• pp.92-100
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• 2008

Objectives : The purpose of this study was to investigate 1) the neuropsychological deficits with major depressive disorder(MDD) in depressed state and 2) the changes of neuropsychological dysfunctions during depressed episodes and remitted periods in the MDD group. Methods : 12 patients with MDD and 70 normal controls who were diagnosed and classified by DSM-IV and SCID-IV interview participated in this study. The psychopathology was measured using the Hamilton rating scale for depression(HAM-D) and Brief Psychiatric Rating Scale(BPRS). The memory function, executive function, and sustained attention were measured by a trained psychologist using the Korean version of Memory Assessment Scale(K-MAS), Wisconsin Card Sorting Test(WCST), and Vigilance(VIG) and Cognitrone (COG) in Vienna Test System. After 6 weeks of treatment, we retested the cognitive tests in order to measure the cognitive functions in remitted states. Results : Patients with MDD achieved significantly lower score in sentence immediately recall, verbal memory score and total memory score of the K-MAS, total errors of the WCST, response time of Vigilance and response time at "Yes" response of Cognitrone than normal controls at baseline. After 6 weeks of medication, the psychiatric symptoms in the patient group were attenuated, and most of the neuropsychological functions including attention, memory, and frontal/executive function were improved except for response time of Cognitrone. Conclusions : This study provides evidence for distinct neuropsychological deficits in patients with MDD on their depressed states and remitted periods. The impairment on response time remains after remission, and this would be a trait marker of major depressive disorder.

• 한국인터넷방송통신학회논문지
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• 제11권5호
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• pp.27-33
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• 2011

디지털 통신 시스템에서 채널에서 발생되는 ISI(Inter-Symbol Interference)를 줄이기 위해 사용되는 적응 등화기의 알고리즘으로 MCMA(Constant Modulus Algorithm)가 있다. MCMA는 비교적 간단한 연산량을 갖지만 어느 정도 적당한 수렴율과 정상 상태의 MSE(mean square error)를 가지므로 본 논문에서는 이를 개선키 위해 병렬 구조를 갖는 등화 방식을 제안하며, MCMA(Modified Constant Modulus Algorithm)과 MDD(Modified Decision Directed Algorithm)으로 구성이 되어있다. 제안 방식에서는 4-QAM 좌표와 16-QAM 좌표의 관계를 이용한, 새로운 비용 함수를 정의 하고, 만약 수신된 신호에 오프셋이 발생할 때, MCMA의 성능이 저하되므로 이를 극복하기 위해서 본 논문에서는 MDD(Modified Decision Direct) 알고리즘과 결합한 병렬형 구조를 적용하므로서 기존의 MCMA보다 빠른 수렴 속도와 낮은 MSE를 갖는 개선된 성능을 얻을 수 있음을 컴퓨터 시뮬레이션으로 확인하였다.

• Molecular & Cellular Toxicology
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• 제4권4호
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• pp.355-359
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• 2008

This study aimed to determine the relationship between the C825T polymorphism in the G-protein ${\beta}$3-subunit (GNB3) gene and the response to citalopram in a Korean population with major depressive disorder (MDD). Citalopram was administered for 8 weeks to the 84 MDD patients who completed this study. All subjects were examined using the Structured Clinical Interview for DSM-IV, and the severity of depression was assessed using the 21-item Hamilton Depression Rating (HAMD-21) scale. A main effect of an interaction of genotype with time on the decrease in the HAMD-21 score during the 8-week study period was not found. ANOVA revealed no significant effects of the GNB3 C825T polymorphism on the decrease in the HAMD-21 score at each time period. Although the C825T polymorphism of the GNB3 gene may affect the pathogenesis of MDD, our results do not support the hypothesis that this polymorphism is involved in the therapeutic response to citalopram in Korean patients with MDD.

• 대한불안의학회지
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• 제17권2호
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• pp.84-91
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• 2021

Objective : Mismatch negativity (MMN) is known to reflect several abnormalities of cognitive functioning. This study is aimed to investigate the differences in MMN among major depressive disorder (MDD) patients with or without suicidal ideation. Methods : Sixty-seven patients with MDD were recruited into this study. MMN was measured by a 64-channel electroencephalography (EEG) using oddball paradigm over the front-central area. Clinical characteristics were assessed using the Beck Anxiety Inventory (BAI), the Beck Depression Inventory-II (BDI-II), and the Beck Scale for Suicide ideation (SSI-BECK). Patients were divided into two groups, no suicidal ideation (N=12) and suicidal ideation (N=55), depending on the presence of suicide ideation in SSI-BECK questionnaires. Results : The MMN latencies were significantly longer in the MDD patients with suicidal ideation than in the MDD patents without suicidal ideation (p<0.05). The MMN amplitudes were not significantly different between the two groups. Conclusion : Suicidal ideation may be associated with longer MMN latencies, and it suggests that MMN may play a potential role in assessing the suicidal risk among MDD patients.

• Journal of Preventive Medicine and Public Health
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• 제55권6호
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• pp.549-558
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• 2022

Objectives: Poor complementary feeding practices have consistently contributed to the burden of child undernutrition in Indonesia. This study aimed to estimate the prevalence and predictors of the time of the introduction of solid, semi-solid, and soft foods (ISSSF), minimum dietary diversity (MDD), minimum meal frequency (MMF), and minimum acceptable diet (MAD). Methods: We analyzed 4804 last-born infants aged 6-23 months from the 2017 Indonesia Demographic and Health Survey, which employed multistage cluster random sampling. The outcomes were calculated based on the 2021 World Health Organization/United Nations Children's Fund guidelines. The predictors of the 4 complementary feeding indicators were assessed using multivariate Poisson regression with robust variance adjusting for potential confounders and study design. Results: The prevalence of ISSSF, MDD, MMF, and MAD was 86.1%, 54.3%, 71.8%, and 37.6%, respectively, with younger children less likely to meet 3 out of the 4 outcomes. Parental education, the presence of a birth attendant, and maternal media consumption were among the predictors of MDD and MAD. Children from families with higher income were more likely to meet MDD than those from low-income households (adjusted prevalence ratio [aPR], 1.16; 95% confidence interval [CI], 1.05 to 1.28). Living in an urban area was positively associated with MMF (aPR, 1.09; 95% CI, 1.04 to 1.15) and MAD (aPR, 1.12; 95% CI 1.02 to 1.24). In eastern regions, the prevalence of children achieving MDD and MAD was lower than in those living in Java and Bali. Conclusions: It is crucial that more attention and efforts are made to improve the recommended practices throughout Indonesia, since the prevalence of adequate complementary feeding practices remains low.

• 문화기술의 융합
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• 제8권5호
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• pp.29-37
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• 2022

2017년 새롭게 제정된 유럽의 새 의료기기 규제법인 MDR은 기존의 CE 적합성 인증을 받은 의료기기 제품들이 새로운 CE의 MDR규정에 맞춰 2024년 5월까지 인증을 받도록 요구하고 있다. 새로운 MDR 적합성 요구사항은 기존보다 강화된 의료기기 임상평가 및 임상 조사를 요구하며 또한 문서화된 시판후 임상 추적 자료의 제출을 요구한다. 한국의 의료기기 업체들도 새로운 MDR 요구사항을 맞춰 적합인정을 받아야 하나, 새로우 규정을 정확히 이해하지 못하여 산업계의 혼란은 계속 되고 있다. 본 연구에서는 한국과 미국의 의료기기 관련 규정을 알아보고, 또한유럽의 의료기기법인 MDR을 기존의 유럽 의료기기 지침인 MDD와 비교함으로써 유럽 의료기기법의 요구 사항들을 이해하는데 도움이 되고자 한다.