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http://dx.doi.org/10.24986/anxmod.2021.17.2.006

Comparison of Mismatch Negativity According to Suicidal Ideation in Patients With Major Depressive Disorder  

Lee, Minji (Department of Psychiatry, Soonchunhyang University Seoul Hospital, College of Medicine)
Lee, Yeon Jung (Department of Psychiatry, Soonchunhyang University Seoul Hospital, College of Medicine)
Hwang, Jaeuk (Department of Psychiatry, Soonchunhyang University Seoul Hospital, College of Medicine)
Woo, Sung-il (Department of Psychiatry, Soonchunhyang University Seoul Hospital, College of Medicine)
Kim, Min Jae (Department of Psychiatry, Soonchunhyang University Seoul Hospital, College of Medicine)
Kang, Byungjoo (Department of Psychiatry, Soonchunhyang University Seoul Hospital, College of Medicine)
Kim, Younggeun (Department of Psychiatry, Soonchunhyang University Seoul Hospital, College of Medicine)
Hahn, Sang-Woo (Department of Psychiatry, Soonchunhyang University Seoul Hospital, College of Medicine)
Publication Information
Anxiety and mood / v.17, no.2, 2021 , pp. 84-91 More about this Journal
Abstract
Objective : Mismatch negativity (MMN) is known to reflect several abnormalities of cognitive functioning. This study is aimed to investigate the differences in MMN among major depressive disorder (MDD) patients with or without suicidal ideation. Methods : Sixty-seven patients with MDD were recruited into this study. MMN was measured by a 64-channel electroencephalography (EEG) using oddball paradigm over the front-central area. Clinical characteristics were assessed using the Beck Anxiety Inventory (BAI), the Beck Depression Inventory-II (BDI-II), and the Beck Scale for Suicide ideation (SSI-BECK). Patients were divided into two groups, no suicidal ideation (N=12) and suicidal ideation (N=55), depending on the presence of suicide ideation in SSI-BECK questionnaires. Results : The MMN latencies were significantly longer in the MDD patients with suicidal ideation than in the MDD patents without suicidal ideation (p<0.05). The MMN amplitudes were not significantly different between the two groups. Conclusion : Suicidal ideation may be associated with longer MMN latencies, and it suggests that MMN may play a potential role in assessing the suicidal risk among MDD patients.
Keywords
Mismatch negativity; Suicidal ideation; Major depressive disorder;
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