• Journal of Pharmaceutical Investigation
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• v.18 no.2
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• pp.43-47
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• 1988

In order to increase the dissolution characteristics of relatively water-insoluble metoclopramide (MCP), coprecipitates of MCP with polyvinylpyrrolidone (PVP), polyethylene glycol (PEG) 1000, 4000 or 6000 were prepared in various drug to polymer ratios. The dissolution rate of MCP-PVP coprecipitate was greater than those of MCP alone, MCP-PVP physical mixture and MCP-PEG coprecipitates. The dissolution rate of MCP-PEG 6000 coprecipitate was greater than those of MCP-PEG 1000 and MCP-PEG 4000 coprecipitates. The dissolution half-lives $(T_{50%})$ for MCP alone and 1:5 (w/w) MCP-PEG 6000 coprecipitate were determined by the log-probit method at $37^{\circ}C$ and found to be 4.17 and 0.98 min, respectively.

• The KIPS Transactions:PartB
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• v.10B no.7
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• pp.769-776
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• 2003

DNA computing has used to solve MCP (Maximal Clique Problem). However, when current DNA computing is applied to MCP. it can't efficiently express vertices and edges and it has a problem that can't look for solutions, by misusing wrong restriction enzyme. In this paper we proposed ACO (Algorithm for Code Optimization) that applies DNA coding method to DNA computing to solve MCP's problem. We applied ACO to MCP and as a result ACO could express DNA codes of variable lengths and generate codes without unnecessary vertices than Adleman's DNA computing algorithm could. In addition, compared to Adleman's DNA computing algorithm, ACO could get about four times as many as Adleman's final solutions by reducing search time and biological error rate by 15%.

• Korean Journal of Environment and Ecology
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• v.25 no.1
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• pp.1-9
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• 2011

In order to analyze the change in home ranges depending on the reproductive stage of Pipistrellus abramus, radio-tracking was carried out for a total of 9 individuals, 3 individuals each, by dividing stages into a pregnancy stage, lactation stage, and post-lactation stage from May to August 2009. For radio-telemetry, 0.38g transmitters, R2000 receivers and 3-element Yagi antennas were used. Pipistrellus abramus were captured using a double-stacked mist net and a harp-trap. Analysis of home ranges used a SHP File and ArcGIS 3.3 for GIS, and used a Kernel Home Range Method(KHR) and a Minimum Convex Polygon(MCP) Method for analysis. Home ranges at the pregnancy stage were MCP 100% $13.46{\pm}1.84ha$, MCP 95% $12.28{\pm}2.15ha$, KHR 50% $3.00{\pm}0.71ha$, and home ranges at the lactation stage were MCP 100% $8.13{\pm}0.23ha$, MCP 95% $7.73{\pm}0.63ha$, KHR 50%$1.84{\pm}1.05ha$. Home ranges at the post-lactation stage were MCP 100% $125.58{\pm}97.77ha$, MCP 95% $123.89{\pm}97.73ha$, KHR 50% $28.61{\pm}26.78ha$. As a result, home ranges of pipistrellus abramus showed a significant difference in all of the MCP 100%, MCP 95%, KHR 50% depending on reproductive stages, being largest in the post-lactation stage and smallest in the lactation stage.

• The Korean Journal of Applied Statistics
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• v.28 no.1
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• pp.75-82
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• 2015

We discuss confidence intervals for sensitive binomial attributes obtained by a direct question method and indirect question method. The Randomized Response Technique(RRT) by Warner (1965) is an indirect question method that uses a randomization device to reduce the response burden of respondents. We used the mean coverage probability (MCP), root mean squared error (RMSE), and mean expected width (MEW) to compare the confidence intervals by the two methods. The numerical comparisons indicated found that the MEW of RRT is too large and the RRT is so conservative that the MCP exceeds a nominal level(${\alpha}$); therefore, it is necessary to complement these problem in order to increase the utility of the indirect question method.

• Korean Journal of Food Science and Technology
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• v.41 no.5
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• pp.536-540
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• 2009

The principal objective of this study was to develop a method to prolong the freshness and maintain the quality of muskmelon (Cucumis melo L.) treated with 1-methylcyclopropene (1-MCP). The rate of weight loss increased with storage time for all samples, but the rates were lower in the 1-MCP treated samples than in the control samples. The hardness of muskmelons treated with 1-MCP differed significantly from that of the controls. The soluble solid contents in the control were highest on day 4 at 15.1%, and evidenced a decreasing trend as the storage period elapsed. Conversely, the soluble solid contents of the 1-MCP-treated samples remained steady at 14% until day 16. The acidity of 1-MCP-treated samples was higher than that of the control over 10 days of storage. The respiration rate of the 1-MCP-treated samples increased less and was lower than that of the controls. Based on the results of our sensory evaluation, muskmelon treated with 1-MCP gas remained fresh for more than 25 days, whereas the control samples remained fresh for only 13 days.

• Journal of the Korean Society of Marine Environment & Safety
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• v.18 no.6
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• pp.545-550
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• 2012

Wind resource assessment is necessary when designing wind farm. To get the assessment, we must use a long term(20 years) observed wind data but it is so hard. so that we usually measured more than a year on the planned site. From the wind data, we can calculate wind energy related with the wind farm site. However, it calculate wind energy to collect the long term data from Met-mast(Meteorology Mast) station on the site since the Met-mast is unstable from strong wind such as Typhoon or storm surge which is Non-periodic. To solve the lack of the long term data of the site, we usually derive new data from the long term observed data of AWS(Automatic Weather Station) around the wind farm area using mathematical interpolation method. The interpolation method is called MCP(Measure-Correlative-Predict). In this study, based on the MCP Regression Model proposed by us, we estimated the wind energy at Handong site using AEP(Annual Energy Production) from Gujwa AWS data in Jeju. The calculated wind energy at Handong was shown a good agreement between the predicted and the measured results based on the linear regression MCP. Short term AEP was about 7,475MW/year. Long term AEP was about 7,205MW/year. it showed an 3.6% of annual prediction different. It represents difference of 271MW in annual energy production. In comparison with 20years, it shows difference of 5,420MW, and this is about 9 months of energy production. From the results, we found that the proposed linear regression MCP method was very reasonable to estimate the wind resource of wind farm.

• Archives of Pharmacal Research
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• v.25 no.5
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• pp.709-717
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• 2002

Hypoxemia is known to induce various physiological changes which can result in alteration in drug pharmacokinetics. To examine the effect of acute moderate hypoxemia on metoclopramide (MCP) pharmacokinetics, a continuous 14-hour infusion of MCP during a normoxemic, hypoxemic and subsequent normoxemic period was conducted in eight adult sheep. Arterial blood and urine samples were collected to examine the effects on the pharmacokinetics of MCP and its deethylated metabolites. MCP and its mono- and di-deethylated metabolites were quantitated using a GC/MS method. Steady-state concentrations of MCP were achieved in each of the three periods. During hypoxemia, MCP plasma steady-state concentration increased significantly from 50.72$\pm$1.06 to 63.62$\pm$1.79 ng/mL, and later decreased to 55.83$\pm$1.15 ng/mL during the post-hypoxemic recovery period. Total body clearance ($CL_{TB}$) of MCP was significantly decreased from 274.2$\pm$48.0 L/h to 205.40$\pm$28.2 L/h during hypoxemia, and later restored to 245.8$\pm$44.2 L/h during the post-hypoxemic period. Plasma mono-deethylated MCP concentration (32.78$\pm$1.73 ng/mL) also increased, compared to the control group (21.20$\\pm$1.39 ng/mL), during hypoxemia and subsequent normoxemic period. Renal excretion of MCP and its metabolites was also decreased during hypoxemia, while urine flow was increased with a concomitant decrease in urine osmolality. Thus, the results indicate that acute moderate hypoxemia affects MCP pharmacokinetics.

• Journal of Radiation Industry
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• v.10 no.4
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• pp.205-210
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• 2016

This study was conducted to evaluate the combined effect of gamma irradiation and different conditions (vacuum packaging, antioxidant and freezing) on the microbiological and sensory characteristics of freeze dried Manila clam porridge (MCP) for immuno-compromised patient food. MCP can be sterilized at 1 kGy to 10 kGy. The initial counts of total aerobic bacteria and yeast molds in the non-irradiated MCP were $2.4{\pm}0.5$ and $1.2{\pm}0.3{\log}\;CFU\;g^{-1}$, respectively, but gamma irradiation significantly decreased the total aerobic bacteria to below the detection limit ($1{\log}\;CFU\;g^{-1}$) (5 kGy). Moreover, gamma irradiation effectively eliminated yeasts/molds at dose below than 1 kGy. However, gamma irradiation accelerated the increase of lipid oxidation and therefore, decreased the sensory characteristics of MCP as irradiation dose increased. To improve the sensory qualities of gamma irradiated MCP, combination treatment (vacuum packaging, 0.1% vitamin C) were applied. There was no significant difference in the overall acceptance scores between the combined-treatment sample (5.6 points) and the non-irradiated samples (6.0). The results indicate that combination treatment (vacuum packaging, 0.1% vitamin C) may help to maintain the quality of MCP. Therefore, it considered that irradiation of MCP with combined treatment and this is an effective method for the consumption as a special purpose food such as for space travel or immuno-compromised patients.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 1994.10a
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• pp.46-51
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• 1994

자동차용 MCP(Multi Changer Player)는 조용하고 깨끗한 음악을 감상하고 싶어하는 소비자들에게 큰 호응을 얻고 있다. 그러나 주행중에 외력이 자동차용 MCP 데크를 통하여 클렘핑부(Clamping부 : 이하 방진부라 함)에 전달되어 방진부에 진동이 발생할 수 있다. 이때 방진부에 장착되어 있는 CD(Compact Disc)의 음재생에 영향을 줄 수 있다. 따라서 본 연구에서는 자동차용 MCP 데크 메카니즘의 중요 구성 부분인 방진부를 설계 및 실험 해석에 의해 진동 저감 대책을 세움으로써 기초 자료를 확보하고 제품의 성능을 향상시키고자 한다. 자동차용 MCP 데크에 장착된 방진부의 진동 저감 문제를 해결하기 위해 먼저 다음과 같은 사항이 방진부에 미치는 영향도를 알아본다. 1) 아이들링(Idling) 중일때의 자동차의 특성과 주행중일때의 자동차의 특성 및 노면 외란이 진장부에 미치는 영향도를 파악한다. 2) CD가 클램핌되어 있을 때의 CD의 모드를 해석해 본다. 그리고 방진재로 사용된 스프링의 설계 및 방진 고무의 물성치 변화에 따른 방진부의 특성변화를 실험에 의해 해석하여 적절한 방진재를 선정한다. 또한 결정된 방진재를 사용한 MCP의 음비(Sound Skip) 특성을 측정해본다.

• Biomolecules & Therapeutics
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• v.18 no.1
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• pp.71-76
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• 2010

Skin irritation caused by retinol and retinoic acid results in mild erythema called as retinoid dermatitis. To develop compounds modulating the retinoid dermatitis, we tried to establish the screening method for retinoid dermatitis. At first we examined the inflammatory cytokine profile in neonatal human dermal fibroblasts which are known to be one of main site of retinoid action. As a result, interleukin-8 (IL-8) and monocytes chemoattractant protein-1 (MCP-1) were significantly produced by all trans retinoic acid (ATRA) and all trans retinol (ATROL) in dermal fibroblasts. Especially the production of MCP-1 was more than that of IL-8. The production of MCP-1 by retinoid was dose-dependently increased, continuing up to 24 hrs. After then using ethacrynic acid (ECA) known to reduce mouse ear edema induced by ATRA, we checked whether ECA suppressed the production of MCP-1. As a result, ECA effectively suppressed the production of MCP-1 in the ATRA- or ATROL-treated-fibroblasts. These results suggested that screening method effectively reflects the in vivo anti-inflammatory activity of ECA. It was reported that citral inhibited the enzyme involved in the conversion of ATROL to ATRA. We showed that citral suppressed the production of MCP-1 in ATROL-treated fibroblasts. We expect these finding might be helpful to find useful compounds modulating the side effects of retinoid or retinoid dermatitis.