• Title/Summary/Keyword: MC-1

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Prevalence and Intensity of Clonorchis sinensis Metacercariae in Freshwater Fish from Wicheon Stream in Gunwi-gun, Gyeongsangbuk-do, Korea

  • Sohn, Woon-Mok;Na, Byoung-Kuk;Cho, Shin-Hyeong;Ju, Jung-Won;Son, Dong-Chul
    • Parasites, Hosts and Diseases
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    • v.56 no.1
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    • pp.41-48
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    • 2018
  • The infection status of Clonorchis sinensis metacercariae (CsMc) was examined in freshwater fish from a highly prevalent site, Wicheon (a branch of Nakdong-gang), which is located in Gunwi-gun, Gyeongsangbuk-do, the Republic of Korea. Total 1,162 fish in 32 species were examined by the artificial digestion method through 6 years. CsMc were detected in 720 (67.5%) out of 1,067 fish (26 spp.) and their density was 610 per fish infected. In the susceptible gobioninid fish group, i.e., Pungtungia herzi, Squalidus gracilis majimae, Squalidus japonicus coreanus, Sarcocheilichthys variegatus wakiyae and Pseudorasbora parva, all of 323 fish were infected with an average of 1,310 CsMc. Total 23 (95.8%) gobioninid fish, i.e., Pseudogobio esocinus, Abbottina springeri, Hemibarbus longirostris, Microphysogobio koreensis, and Microphysogobio jeoni, were infected with 127 CsMc in average. In the acheilognathinid fish (bitterlings) group, the prevalence was 77.0%, and the density was 50 CsMc per fish infected. In the rasborinid fish (chubs) group, i.e., Zacco platypus, Zacco temminckii, Zacco koreanus, and Opsariichthys uncirostris amurensis, 147 (36.5%) out of 403 fish examined were infected with 15 CsMc in average. The susceptibility indices of CsMc were 412 in the overall positive fish group, 1,310 in the gobioninid group-1, 122 in the gobioninid group-2, 38.5 in the acheilognathinid group, and 5.5 in the rasborinid fish group. Conclusively, it was confirmed that CsMc are highly prevalent in fish from Wicheon, and their infection tendency varied according to the subfamily groups in Cyprinidae fish hosts.

Effects of Wild Simulated Ginseng on the Proliferation, Differentiation and Mineralization of Osteoblastic MC3T3-E1 Cells (산양삼의 조골세포 활성화에 미치는 영향)

  • Jin Boo Jeong
    • Proceedings of the Plant Resources Society of Korea Conference
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    • 2020.08a
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    • pp.90-90
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    • 2020
  • Panax ginseng C.A. Meyer (P. ginseng) is known to exert a wide range of pharmacological effects both in vitro and in vivo. Although studies on ginsenoside, antioxidant activity, and anticancer effect of wild simulated ginseng (WSG) have been conducted, there is little research on the effect of WSG on bone metabolism. In this study, we investigated the potential anti-osteoporotic properties of WSG on the growth and differentiation of MC3T3-E1 cells. WSG significantly increased the viability and proliferation of MC3T3-E1 cells. WSG activated intracellular alkaline phosphatase (ALP) activity in MC3T3-E1 cells. In addition, WSG increased the mineralized nodules in MC3T3-E1 cells. Furthermore, WSG increased the expression of genes such as Runx2, ALP, OPN and OCN associated with osteoblast growth and differentiation in a dose-dependent manner.

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Unique Cartilage Matrix-Associated Protein Alleviates Hyperglycemic Stress in MC3T3-E1 Osteoblasts (Unique cartilage matrix-associated proteins에 의한 MC3T3-E1 조골세포에서의 고혈당 스트레스 완화 효과)

  • Hyeon Yeong Ju;Na Rae Park;Jung-Eun Kim
    • Journal of Life Science
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    • v.33 no.11
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    • pp.851-858
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    • 2023
  • Unique cartilage matrix-associated protein (UCMA) is an extrahepatic vitamin K-dependent protein rich in γ-carboxylated (Gla) residues. UCMA has been recognized for its ability to promote osteoblast differentiation and enhance bone formation; however, its impact on osteoblasts under hyperglycemic stress remains unknown. In this paper, we investigated the effect of UCMA on MC3T3-E1 osteoblastic cells under hyperglycemic conditions. After exposure to high glucose, the MC3T3-E1 cells were treated with recombinant UCMA proteins. CellROX and MitoSOX staining showed that the production of reactive oxygen species (ROS), which initially increased under high-glucose conditions in MC3T3-E1 cells, decreased after UCMA treatment. Additionally, quantitative polymerase chain reaction revealed increased expression of antioxidant genes, nuclear factor erythroid 2-related factor 2 and superoxide dismutase 1, in the MC3T3-E1 cells exposed to both high glucose and UCMA. UCMA treatment downregulated the expression of heme oxygenase-1, which reduced its translocation from the cytosol to the nucleus. Moreover, the expression of dynamin-related protein 1, a mitochondrial fission marker, was upregulated, and AKT signaling was inhibited after UCMA treatment. Overall, UCMA appears to mitigate ROS production, increase antioxidant gene expression, impact mitochondrial dynamics, and modulate AKT signaling in osteoblasts exposed to high-glucose conditions. This study advances our understanding of the cellular mechanism of UCMA and suggests its potential use as a novel therapeutic agent for bone complications related to metabolic disorders.

Use of the Texas Eye Research and Technology Center Dry Eye Questionaire (TERTC-DEQ) as a Screening Survey for Contact Lens Wearers and Nonwearers (콘택트렌즈 착용자와 비착용자의 건성안 설문조사 TERTC-DEQ의 활용)

  • Kim, Jai-Min;Kim, Yong-Hwan;Jung, Ju-Hyun
    • Journal of Korean Ophthalmic Optics Society
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    • v.12 no.4
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    • pp.127-131
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    • 2007
  • This study was designed to demonstrate the ability of Texas Eye Research and Technology Center Dry Eye Questionaire (TERTC-DEQ) to examine the distribution of self-reported dry eye symptoms and their diurnal intensity in university students and compare it with McMonnies & Ho DEQ. Two dry eye questionnaires were administered to 46 contact lens wearers and 47 nonwearers. Contact lens wearers scored higher on the TERTC-DEQ (52.2%) than McMonnies & Ho DEQ (6.5%). Non-contact lens wearers also scored higher on the TERTC-DEQ (19.1%) than McMonnies & Ho DEQ (2.1%). Ocular symptoms worsened with progression of time of day in both groups of subjects. This study suggests that TERTC-DEQ provides a first-choice diagnosis tool to obtain a comprehensive assessment of patient's symptoms, especially in comparison with McMonnies & Ho DEQ. The TERTC-DEQ is an efficient screening survey and may be use in dry eye diagnosis of contact lens-related dry eye.

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An Improved Quine-McCluskey Algorithm for Circuit Minimization (회로 최소화를 위한 개선된 Quine-McCluskey 알고리즘)

  • Lee, Sang-Un
    • Journal of the Korea Society of Computer and Information
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    • v.19 no.3
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    • pp.109-117
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    • 2014
  • This paper revises the Quine-McCluskey Algorithm to circuit minimization problems. Quine-McCluskey method repeatedly finds the prime implicant and employs additional procedures such as trial-and-error, branch-and-bound, and Petrick's method as a means of circuit minimization. The proposed algorithm, on the contrary, produces an implicant chart beforehand to simplify the search for the prime implicant. In addition, it determines a set cover to streamline the search for $1^{st}$ and $2^{nd}$ essential prime implicants. When applied to 3-variable and 4-variable experimental data, the proposed algorithm has indeed proved to obtain the optimal solutions much more simply and accurately than the Quine-McCluskey method.

Effect of McKenzie Stretch Exercise and Sports Massage on the Forward Head Posture (멕켄지 운동과 스포츠 마사지가 머리전방자세에 미치는 영향)

  • Oh, Yeong-Taek
    • Archives of Orthopedic and Sports Physical Therapy
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    • v.14 no.2
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    • pp.91-97
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    • 2018
  • Purpose: The purpose of this study was to observe the effects of sport massage and McKenzie stretch exercise on forward head posture. To understand the effect, this study measured and analyzed body alignment of the neck. Methods: In this study, a total of 14 subjects with forward head posture were analyzed. Subjects were divided into two groups: group 1 (n=7) received a McKenzie stretch exercise and group 2 (n=7) received a McKenzie stretch exercise and a sport massage. The McKenzie stretch exercise was performed three times a week, for four weeks, while the sport massage was performed once a week. The body alignment of the neck (CVA, CRA) was measured using a goniometer. Results: The improvements in neck body alignments (CVA, CRA) after the McKenzie stretch exercise and sport massage were both significant (group 1: p<0.05; group 2: p<0.05), whereas the between-group comparison found no significant differences. Conclusions: In conclusion, our study confirmed that the McKenzie stretch exercise and sport massage had a significant positive effect on the body alignment of the neck. However, a study that included a greater number of subjects and a long-term treatment period is needed to generalize these results.

A Study of the McKenzie Exercise of the Cervical : Systematic Review (경추부위 멕켄지운동에 대한 연구)

  • Lee, Hyojeong;Woo, Sunghee
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2021.10a
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    • pp.652-654
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    • 2021
  • Objectives : The purpose of this study is to investigate the effectiveness of McKenzie Exercise of cervical part Method : A case-controlled clinical trial was searched for the effect of McKenzie Exercise on the cervical part. From 2015 to June 2021, 8 studies were selected from the RISS database published in Korea. The selected studies included an experimental group with McKenzie Exercise and a control group with general physical therapy and stretching Results : McKenzie Exercise, ROM, muscle activion, pain, posture were improved. Conclusion : This study summarizes the results of applying McKenzie Exercise of cervical part. This study suggests for cervical function who wants to intervene in McKenzie Exercise of cervical part.

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Comparsion of Dst forecast models during intense geomagnetic storms (Dst $\leq$ -100 nT)

  • Ji, Eun-Young;Moon, Yong-Jae;Lee, Dong-Hun
    • The Bulletin of The Korean Astronomical Society
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    • v.35 no.2
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    • pp.51.2-51.2
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    • 2010
  • We have investigated 63 intense geomagnetic storms (Dst $\leq$ -100 nT) that occurred from 1998 to 2006. Using these events, we compared Dst forecast models: Burton et al. (1975), Fenrich and Luhmann (1998), O'Brien and McPherron (2000a), Wang et al. (2003), and Temerin and Li (2002, 2006) models. For comparison, we examined a linear correlation coefficient, RMS error, the difference of Dst minimum value (${\Delta}$peak), and the difference of Dst minimum time (${\Delta}$peak_time) between the observed and the predicted during geomagnetic storm period. As a result, we found that Temerin and Li model is mostly much better than other models. The model produces a linear correlation coefficient of 0.94, a RMS (Root Mean Square) error of 14.89 nT, a MAD (Mean Absolute Deviation) of ${\Delta}$peak of 12.54 nT, and a MAD of ${\Delta}$peak_time of 1.44 hour. Also, we classified storm events as five groups according to their interplanetary origin structures: 17 sMC events (IP shock and MC), 18 SH events (sheath field), 10 SH+MC events (Sheath field and MC), 8 CIR events, and 10 nonMC events (non-MC type ICME). We found that Temerin and Li model is also best for all structures. The RMS error and MAD of ${\Delta}$peak of their model depend on their associated interplanetary structures like; 19.1 nT and 16.7 nT for sMC, 12.5 nT and 7.8 nT for SH, 17.6 nT and 15.8 nT for SH+MC, 11.8 nT and 8.6 nT for CIR, and 11.9 nT and 10.5 nT for nonMC. One interesting thing is that MC-associated storms produce larger errors than the other-associated ones. Especially, the values of RMS error and MAD of ${\Delta}$peak of SH structure of Temerin and Li model are very lower than those of other models.

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Effect of Insecticide Carbofuran and Phenobarbital Sodium and 3-Methylcholanthrene on Activity of Enzyme in Israeli Carp(Cyprinus israeli carpio L.) (살충제 Carbofuran과 Phenobarbital Sodium 및 3-Methylcholanthrene이 이스라엘 잉어의 효소활성에 미치는 영향)

  • Rim, Yo-Sup;Jeong, Jae-Hun;Han, Seong-Soo
    • Applied Biological Chemistry
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    • v.39 no.1
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    • pp.77-83
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    • 1996
  • Effects of insecticide carbofuran and Phenobarbital sodium(PB) or 3-methylcholanthrene(3-MC) on activities of several enzymes in israeli carps were investigated. Survival number of Israeli carp was the same as that of control when PB and 3-MC only was treated, individually and that was low compared to control when carbofuran only was treated. But survival rate of Israeli carp was high compared to individual treatment of carbofuran when combination treatment of carbofuran and PB or 3-MC was carried out. These results indicate that PB and 3-MC can intervene to detoxify carbofuran exposed to israeli carp. In in vivo test for the effect of this chemicals on activity of enzyme in israeli carp, activities of acetylcholinesterase(AChE) and glutathione S-transferase(GST) were inhibited in carbofuran treatment, but did not in combination treatment of carbofuran and P3 or 3-MC. Activities of UDP-glucuronosyltransfe-rase (UDPGT) and cytochrome P-450-dependent monooxygenase increased in individual or combined treatments of carbofuran and PB or 3-MC. These results suggest that a simultaneous application of carbofuran and PB or 3-MC is critical for the enhancement of activity of AChE, GST, UDPGT and monooxygenase and the protection of Israeli carp from carbofuran toxicity.

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