• 대한치주과학회:학술대회논문집
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• 대한치주과학회 2001년도 제41회 종합학술대회 연제초록
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• pp.44-45
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• 2001

• Journal of Electrical Engineering and Technology
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• 제4권1호
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• pp.135-142
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• 2009

In this paper the Simplified Refined Instrumental Variable (SRIV) identification algorithm for SISO systems is extended to MIMO systems described by a Left Matrix Fraction Description (LMFD). The performance of the extended algorithm is compared to the well-known MIMO four-step instrumental variable (IV4) algorithm. Monte Carlo simulations for different signal to noise ratios are conducted to assess the performance of the algorithm. Moreover, the algorithm is applied to a simulated quadruple tank process.

• 소성∙가공
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• 제27권2호
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• pp.93-99
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• 2018

An analytical solution for the tensile ductility in porous ductile materials was derived based on an Irwin's approach of the elastic-plastic deformation in fracture mechanics. This was in good agreement with the experimental results of a tensile ductility in a sintered pure Al, and could solve the discrepancies in the Brown and Embury, or the McClintock models. This model was also offered as an advanced analytical solution considering the effect of stress triaxiality of pore tip in addition to pore interactions, material properties of matrix, and local deformation effect around pore. The evaluation of an analytical solution in the sintered pure Al powder compacts showed that the tensile ductility depends not only on the volume fraction of pores, but also on the pore size and on the mechanical properties of the matrix. The tensile ductility of the sintered pure Al compacts decreased rapidly with the increasing of a pore volume fraction, despite of the excellent tensile ductility of the matrix. This significant decrease in the tensile ductility was mainly attributed to the low yield strength of the matrix and small pore size. Particularly, the effects of the large radius and high volume fraction of the pore on the tensile ductility in Al-Form, were thus reasonably predicted by this analytical equation.

• 천문학회보
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• 제37권1호
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• pp.47.2-47.2
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• 2012

Using deep images taken at Maidanak 1.5m telescope, at McDonald 2.1m telescope and Canada-France-Hawaii Telescope, Dupont 2.5m telescope we investigated the fraction of merging galaxies in hosts of 39 AGN which are brighter than M = -22 mag and nearer than z = 0.3. We found that 16 to 17 of 39 AGN host galaxies show the evidence of mergers like tidal tail, shell via careful visual inspection. We also studied with the merging fraction of a control sample, SDSS Stripe82 early type galaxies of which surface brightness limit and bulge magnitude are similar to that of the AGN sample. We found that merging fraction of the AGN sample is higher than that of early type galaxy samples in the whole range of bulge magnitude. This result implies that AGN activity may be correlated with merging. We also investigated the detailed morphology of merging feature. At least - 1/4 of control samples classified as a tidal and tidal+dust are shell structures. On the other hand only one (5.9%) of AGN sample classified as merger shows shell structures, and almost all merging AGNs show tidal tail features. From point of view that tidal tail may be at the early stage of merging, and shell may be at the late stage of mergers, this result suggests that AGN might be evolved into early-type galaxies after merging.

• 천문학회보
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• 제36권2호
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• pp.79-79
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• 2011

Using deep images taken at Maidanak 1.5m telescope, at McDonald 2.1m telescope and Canada-France-Hawaii Telescope, we investigated the fraction of merging galaxies in hosts of 26 AGN which are brighter than M = -22.2 mag and nearer than z = 0.2. We found that 9 to 12 of 26 AGN host galaxies show the evidence of mergers like tidal tail, shell via visual inspection. We also studied with the merging fraction of a control sample, SDSS Stripe82 galaxies. Surface brightness limit and magnitude are similar to that of the AGN sample. We found that merging fraction of the AGN sample is higher than that of normal galaxy samples. This result implies that AGN activity may be correlated with merging. We also investigated the detailed morphology of merging feature. About ~1/4 of control sample classified as a tidal and tidal+dust are shell structures. On the other hand only one of the AGN sample shows shell structures. Almost all merging AGNs show tidal tail features. From point of view that tidal tail may be at the early stage of merging, and shell may be at the late stage of mergers, this result implies that AGN may be evolved into early-type galaxies after merging.

• Biomolecules & Therapeutics
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• 제19권1호
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• pp.70-76
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• 2011

Bone remodeling is a dynamic process involving a constant balance between osteoclast-induced bone resorption and osteoblast-induced bone formation. Osteoclasts play a crucial homeostatic role in skeletal modeling and remodeling, and destroy bone in many pathological conditions. Previously, we reported that the hexane soluble fraction of Ficus carica inhibited osteoclast differentiation. Poly unsaturated fatty acids, such as ethyl docosahexaenoate (E-DHA), docosahexaenoic acid (DHA), cis-11,14-eicosadienoic acid (EDA) and eicosapentaenoic acid (EPA), were identified from the hexane soluble fraction of Ficus carica. Among them, E-DHA most potently inhibited osteoclastogenesis in RAW264.7 cells. E-DHA reduced the activities of JNK and NF-$\kappa}B$. E-DHA suppressed the expression of c-Fos and nuclear factor of activated T cells c1 (NFATc1). Interestingly, DHA increased the activity of alkaline phosphatase and expression of bone morphogenetic protein 2 (BMP2) more than E-DHA in MC3T3-E1 cells, suggesting that DHA may induce osteoblast differentiation. The data suggests that a combination of E-DHA and DHA has potential use in the treatment of diseases involving abnormal bone lysis, such as osteoporosis, rheumatoid arthritis and periodontal bone erosion.

• 대한한방소아과학회지
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• 제30권3호
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• pp.1-30
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• 2016

Objectives Previous studies have found out that Forsythiae Fructus (FF) extracts have anti-atopic activities by in vitro experiment. In order to understand more about FF extracts' benefit, we subdivided FF extracts depending on systematic fractionation method by using Methylene chloride (MC), Ethyl acetate (EtOAc), n-BuOH and n-hexane (n-Hx). This study is designed to examine the effect of FF fractions on the PMA- ionomycin-induced activation of RBL-2H3 mast cell lines in vitro and on the DNCB-induced activation of NC/Nga mice in vivo. Methods For this study, we examined IL-4, IL-13 production by ELISA analysis, IL-4, IL-13, IL-31, IL-31RA and TNF-${\alpha}$ mRNA expression by real-time PCR and manifestations of AP-1 and MAPKs transcription factors by western blotting in vitro. Through in vitro experiment, we selected FF n-BuOH fraction that seems the best effective in atopic dermatitis then induced it on NC/Nga mice by DNCB. We measured mice's WBC, eosinophil and neutrophil in heart blood, IL-4, IL-5, IFN-${\gamma}$ in the spleenocyte culture supernatant, the absolute cell numbers of CD4+, CD8+, B220+CD23+, CD3+CD69+ and Gr-1+CD11b+ in the PBMCs, ALN and dorsal skin, IL-5, IL-13, IL-31, IL-31RA in the dorsal skin by real-time PCR and the distribution of immune cells by H&E on dorsal skin and ANL and toluidine blue staining on dorsal skin. Results FF n-BuOH fraction suppressed IL-4, IL-13 production and mRNA expression of IL-4, IL-13, IL-31, IL-31RA and TNF-${\alpha}$. Results from the western blot analysis showed that FF n-BuOH fraction reduced the activation of the mast cell specific transduction factors involved in AP-1 by suppressing JNK and ERK phosphorylation. In the gross, atopic dermatitis induced by DNCB in NC/Nga mice were improved by oral administration of FF n-BuOH fraction. Oral FF n-BuOH fraction also decreased the level of IgE in mice's serum and the level of IL-4 and IL-5 in the spleenocyte culture supernatant, cell numbers of CD8+, B220+CD23+ in the PBMCs, CD4+ in the ALN and CD4+, Gr-1+CD11b+ in the dorsal skin and suppressed mRNA expression of IL-5, IL-13, IL-31, IL-31RA in the dorsal skin. Histological examination showed that infiltration levels of immune cells in atopic dermatitis induced NC/Nga mice were improved by FF n-BuOH fraction. Conclusions FF n-BuOH fraction can reduce pruritus by suppressing IL-31, IL-31RA secretion and modulate molecular mediators and immune cells associated with atopic dermatitis induced in NC/Nga mice which may have played a significant role in recovering atopic dermatitis symptoms.

• 천문학회보
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• 제39권1호
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• pp.75.2-75.2
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• 2014

We have developed a set of daily solar flare peak flux forecast models using the multiple linear regression (MLR), the auto regression (AR), and artificial neural network (ANN) methods. We consider input parameters as solar activity data from January 1996 to December 2013 such as sunspot area, X-ray flare peak flux, weighted total flux $T_F=1{\times}F_C+10{\times}F_M+100{\times}F_X$ of previous day, mean flare rates of a given McIntosh sunspot group (Zpc), and a Mount Wilson magnetic classification. We compute the hitting rate that is defined as the fraction of the events whose absolute differences between the observed and predicted flare fluxes in a logarithm scale are ${\leq}$ 0.5. The best three parameters related to the observed flare peak flux are as follows: weighted total flare flux of previous day (r=0.5), Mount Wilson magnetic classification (r=0.33), and McIntosh sunspot group (r=0.3). The hitting rates of flares stronger than the M5 class, which is regarded to be significant for space weather forecast, are as follows: 30% for the auto regression method and 69% for the neural network method.

• Advances in materials Research
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• 제4권4호
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• pp.227-233
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• 2015

We present a method, supported by theoretical analysis, for optimizing the usage of the critical rare earth element dysprosium in $Nd_2Fe_{14}B$ (NdFeB)-based permanent magnets. In this method, we use Dy selectively in locations such as magnet edges and faces, where demagnetization factors are largest, rather than uniformly throughout the bulk sample. A200 nm thick Dy film was sputtered onto a commercial N-38, NdFeB magnets with a thickness of 3 mm and post-annealed at temperatures from $600-700^{\circ}C$. Magnets displayed enhanced coercivities after post-annealing and as much as a 5 % increase in the energy product, while requiring a total Dy content of 0.06 wt. % - a small fraction of that used in the commercial grade Dy-NdFeB magnets. By assuming all Dy diffused into NdFeB magnets, the improvement in energy product corresponds to a saving of over 1% Dy (critical element). Magnets manufactured using this technique will therefore be higher performing which would potentially broaden the application space of these magnets in the traction motors of hybrid and pure electric vehicles, and wind generators.

• 한국식품저장유통학회지
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• 제18권4호
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• pp.590-596
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• 2011

참나물은 광범위하게 이용되는 식용산채임에도 불구하고 그 연구는 전 세계적으로 미미한 상태이다. 본 연구에서는 최근 고급 식용 산채로서 각광받고 있는 참나물의 메탄올 추출물을 조제하고, 이로부터 n-hexane, methylene chloride, ethylacetate 및 butanol을 이용하여 순차적 유기 용매 분획물과 물 잔류물을 조제하여 각각의 항산화, 항균 및 대장암세포 생육억제 활성을 평가하였다. 참나물 메탄올 추출물의 71.51%는 물 잔류물로 이행되어 추출물 대부분이 수용성 물질이었으며, n-hexane, methylene chloride, ethylacetate 및 butanol 분획 효율은 각각 18.71, 0.7, 0.56, 및 4.57%로 나타났다. 총 플라보노이드 및 총 폴리페놀 함량은, 분획수율이 가장 낮은 ethylacetate 분획에서 가장 높았으며 물 잔류물에서 가장 낮았다. 항균 활성 평가결과, ethylacetate 분획에서 그람양성 및 그람음성세균에 대해 광범위한 항균 활성을 나타내었으며, 특히 그람양성세균에는 n-hexane 분획이, 그람음성세균에는 ethylacetate 분획이 효과적이었다. 항산화 활성의 경우 ethylacetate 및 butanol 분획에서 양호한 DPPH 및 ABTS 소거능, 환원력을 나타내었으며, n-hexane및 methylene chloride 분획에서 우수한 nitrite 소거능을 나타내었다. 한편 butanol 분획에서는 다른 분획과는 달리 우수한 인간 대장암세포 생육억제 활성을 나타내었다. 본 연구 결과는 참나물을 이용한 기능성 식품개발 및 ethylacetate 분획을 대상으로 한 유용 소재개발의 기본 자료로 활용될 것이다.