Ethyl Docosahexaenoate and Its Acidic Form Increase Bone Formation by Induction of Osteoblast Differentiation and Inhibition of Osteoclastogenesis |
Choi, Bo-Yun
(Department of Dental Pharmacology, School of Dentistry and Institute of Oral Bioscience, Brain Korea 21 Project, Chonbuk National University)
Eun, Jae-Soon (College of Pharmacy, Woosuk University) Nepal, Manoj (Department of Dental Pharmacology, School of Dentistry and Institute of Oral Bioscience, Brain Korea 21 Project, Chonbuk National University) Lee, Mi-Kyung (College of Pharmacy, Woosuk University) Bae, Tae-Sung (Department of Dental Biomaterials, School of Dentistry, Chonbuk National University) Kim, Byung-Il (Department of Materials Science and Metallurgical Engineering, Sunchon National University) Soh, Yun-Jo (Department of Dental Pharmacology, School of Dentistry and Institute of Oral Bioscience, Brain Korea 21 Project, Chonbuk National University) |
1 | Tachi, K., Takami, M., Zhao, B., Mochizuki, A., Miyamoto, Y., Inoue, T., Baba, K. and Kamijo, R. (2010b) Bone morphogenetic protein 2 enhances mouse osteoclast differentiation via increased levels of receptor activator of ligand expression in osteocblast. Cell Tissue Res. 342, 213-220. DOI |
2 | Takayanagi, H., Kim, S., Koga, T., Nishina, H., Isshiki, M., Yoshida, H., Saiura, A., Isobe, M., Yokochi, T., Inoue, J., Wagner, E. F., Mak, T. W., Kodama, T. and Taniguchi, T. (2002) Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev. Cell 3, 889-901. DOI |
3 | Luo, J. L., Kamata, H. and Karin, M. (2005) IKK/NF-kappaB signaling: balancing life and death--a new approach to cancer therapy. J. Clin. Invest. 115, 2625-2632. DOI |
4 | Meydani, S. N., Endres, S., Woods, M. M., Goldin, B. R., Soo, C., Morrill-Labrode, A., Dinarello, C. A. and Gorbach, S. L. (1991) Oral (n-3) fatty acid supplementation suppresses cytokine production and lymphocyte proliferation: comparison between young and older women. J. Nutr. 121, 547-555. |
5 | Mori, T. A. and Beilin, L. J. (2001) Long-chain omega 3 fatty acid blood lipids and cardiovascular risk reduction. Curr. Opin. Lipidol. 12, 11-17. DOI |
6 | Mukherjee, A., Wilson, E. M. and Rotwein, P. (2010) Selective signaling by Akt2 promotes bone morphogenetic protein2-mediated osteoblast differentiation. Mol. Cell. Biol. 30, 1018-1027. DOI |
7 | Otsuka, E., Notoya, M. and Hagiwara, H. (2003) Treatment of myoblastic C2C12 cells with BMP-2 stimulates vitamin D-induced formation of osteoclasts. Calcif. Tissue Int. 73, 72-77. DOI |
8 | Park, C. K., Lee, Y., Chang, E. J., Lee, M. H., Yoon, J. H., Ryu, J. H. and Kim, H. H. (2008) Bavachalcone inhibits osteoclast differentiation through suppression of NFATc1 induction by RANKL. Biochem. Pharmacol. 75, 2175-2182. DOI |
9 | Park, Y. R., Eun, J. S., Choi, H. J., Nepal, M., Kim, D. K., Seo, S. Y., Li, R., Moon, W. S., Cho, N. P., Cho, S. D., Bae, T. S., Kim, B. I. and Soh, Y. (2009) Hexane-soluble fraction of the common fig, ficus carica, inhibits osteoclast differentiation in murine bone marrowderived macrophages and RAW 264.7 cells. Korean J. Physiol. Pharmacol. 13, 417-424. DOI |
10 | Poulsen, R. C., Firth, E. C., Rigers, C. W., Moughan, P. J. and Kruger, M. C. (2007) Specific effects of gamma-linolenic, eicosapentaenoic, and docosahexaenoic ethyl esters on bone post-ovariectomy in rats. Calcif. Tissue Int. 81, 459-471. DOI |
11 | Calder, P. C. and Zurier, R. B. (2001) Poryunsaturated fatty acids and rheumatoid arthritis. Curr. Opin. Clin. Nutr. Metab. Care. 4, 115-121. DOI |
12 | Choi, H. J., Park, Y. R., Nepal, M., Choi, B. Y., Cho, N. P., Choi, S. H., Heo, S. R., Kim, H. S., Yang, M. S. and Soh, Y. (2010) Inhibition of osteoclastogenic differentiation by Ikarisoside A in RAW 264.7 cells via JNK and NF-kappaB signaling pathways. Eur. J. Pharmacol. 636, 28-35. DOI ScienceOn |
13 | Hudert, C. A., Weylandt, K. H., Lu, Y., Wang, J., Hong, S., Dignass, A., Serhan, C. N. and Kang J. X. (2006) Transgenic mice rich in endogenous omega-3 fatty acids are protected from colitis. Proc. Natl. Acad. Sci. USA. 103, 11276-11281. DOI |
14 | Kobayashi, N., Kadono, Y., Naito, A., Matsumoto, K., Yamamoto, T., Tanaka, S. and Inoue, J. (2001) Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis. EMBO J. 20, 1271-1280. DOI |
15 | Yoshida, H., Hayashi, S., Kunisada, T., Ogawa, M., Nishikawa, S., Okamura, H., Sudo, T., Shultz, L. D. and Nishikawa, S. (1990) The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene. Nature. 345, 442-444. DOI |
16 | Lee, S. E., Woo, K. M., Kim, S. Y., Kim, H. M., Kwack, K., Lee, Z. H. and Kim, H. H. (2002) The phosphatidylinositol 3-kinase, p38, and extracellular signal-regulated kinase pathways are involved in osteoclast differentiation. Bone 30, 71-77. |
17 | Lee, W. T. (1996) Coloured standard illustrations of Korean plants. pp. 642. Academy Press, Seoul. |
18 | Liu, C., Walter, T. S., Huang, P., Zhang, S., Zhu, X., Wu, Y., Wedderburn, L. R., Tang, P., Owens, R. J., Stuart, D. I., Ren, J. and Gao, B. (2010) Structural and functional insights of RANKL-RANK interaction and signaling. J. Immunol. 184, 6910-6919. DOI |
19 | Theill, L. E., Boyle, W. J. and Penninger, J. M. (2002) RANK-L and RANK: T cells, bone loss, and mammalian evolution. Annu. Rev. Immunol. 20, 795-823. DOI |
20 | Yaqoob, P. and Calder, P. (1995) Effects of dietary lipid manipulation upon inflammatory mediator production by murine macrophages. Cell Immunol. 163, 120-128. DOI |
21 | Zhao, Q., Shao, J., Chen, W. and Li, Y. P. (2007) Osteoclast differentiation and gene regulation. Front Biosci. 12, 2519-2529 DOI |
22 | Simopoulos, A. P., Kifer, R. R. and Wykes, A. A. (1991) Omega 3 fatty acid: Research advance and support in the fi eld since June 1985(worldwide). World Rev Nutr Diet. 66, 51-71. |
23 | Raggatt, L. J. and Partridge, N. C. (2010) Cellular and molecular mechanisms of bone remodeling. J. Biol. Chem. 285(33), 25103-25108. DOI |
24 | Rahman, M. M., Bhattacharya, A. and Fernandes, G. (2008) Docosahexaenoic acid is more potent inhibitor of osteoclast differentiation in RAW 264.7 cells than eicosapentaenoic acid. J. Cell. Physiol. 214, 201-209 DOI |
25 | Reddy, S. V., Hundley, J. E., Windle, J. J., Alcantara, O., Linn, R., Leach, R. J., Boldt, D. H. and Roodman, G. D. (1995) Characterization of the mouse tartrate-resistant acid phosphatase (TRAP) gene promoter. J. Bone Miner. Res. 10, 601-606. |
26 | Sun, D., Krishnan, A., Zaman K., Lawrence, R., Bhattacharya, A. and Fernandes, G. (2003) Dietary n-3 fatty acids decrease osteoclastogenesis and loss of bone mass in ovariectomizes mice. J. Bone Miner Res. 18, 1206-1216. DOI |
27 | Tachi, K., Takami, M., Sato, H., Mochizuki, A., Zhao, B., Miyamoto, Y., Tsukasaki, H., Inoue, T., Shintani, S., Koike, T., Honda, Y., Suzuki, O., Baba, K. and Kamijo, R. (2010a) Enhancement of bone morphogenetic protein-2-inhanced ectopic bone formation by transforming growth . Tissue Eng. Part A. Epub ahead of print. |