• Journal of Mechanical Science and Technology
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• 제19권spc1호
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• pp.437-443
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• 2005

Controlling the friction between wheel and rail is direct and very effective measures to improve the curving performances of railway trucks, because the curving performances depend much on friction characteristics. Authors have proposed a method, 'friction control', which utilizes friction modifier ($KELTRACK^{TM}$ HPF) with onboard spraying system. With the method, not only friction coefficient, but also friction characteristics can be controlled as expected. In this study, MBD simulation is very valuable tool to foresee the effect of the control in advance of experiment with real car. And the creep characteristics of wheel/rail contact with the friction modifier takes very important role in the simulation. In this paper, authors propose a theoretical model of wheel/rail contact condition considering the creep characteristics of friction modifier, which is derived the application of principle tribological theories.

• Journal of Computing Science and Engineering
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• 제11권1호
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• pp.9-23
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• 2017

NuDE 2.0 (Nuclear Development Environment 2.0) is a formal-method-based software development, verification and safety analysis environment for safety-critical digital I&Cs implemented with programmable logic controller (PLC) and field-programmable gate array (FPGA). It simultaneously develops PLC/FPGA software implementations from one requirement/design specification and also helps most of the development, verification, and safety analysis to be performed mechanically and in sequence. The NuDE 2.0 now consists of 25 CASE tools and also includes an in-depth solution for indirect commercial off-the-shelf (COTS) software dedication of new FPGA-based digital I&Cs. We expect that the NuDE 2.0 will be widely used as a means of diversifying software design/implementation and model-based software development methodology.

• 대한의생명과학회지
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• 제9권2호
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• pp.105-110
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• 2003

Ankyrins are a ubiquitously expressed family of intracellular adaptor proteins involved in targeting diverse proteins to specialized membrane domains in both the plasma membrane and the endoplasmic reticulum. Canonical ankyrins are 190-220 kDa proteins expressed in most tissues and cell types and comprise a membrane-binding domain (MBD) of 24 ANK repeats, a spectrin-binding domain, a death domain and a C-terminal domain. Rescue studies with ankyrin-B/G chimeras have identified the C-terminal domain of ankyrin-B as the defining domain in specifying ankyrin-B activity, but the function of C-terminal domain of ankyrin-B is, however, not known. We report here that the C-terminal domain of ankyrin-B is capable of interacting with the C-terminal Region of Hsp40. The Hsps are induced not only by heat shock but also by various other environmental stresses. Hsps are also expressed constitutively at normal growth temperatures and have basic and indispensable functions in the life cycle of proteins as molecular chaperones, as well as playing a role in protecting cells from the deleterious stresses. The binding sites required in the interaction between C-terminal domain of ankyrin-B and C-terminal region of Hsp40 were characterized using the yeast two-hybrid system and GST-pull down assay. The interaction between ankyrin-B and Hsp40 represents the first direct evidence of ankyrin's role as chaperones.

• 한국산업융합학회 논문집
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• 제22권3호
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• pp.273-280
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• 2019

Carbon fiber composite laminate has been widely used in the area of sports applications such as race car, golf club, fishing rods, yacht. In this study, carbon fiber composite laminate was used in the rear upright of leisure purposed small size single-seat electric race car to reduce its unsprung mass of suspension system. The focus of this research is to investigate in finding optimal stacking lay-up of rear upright laminated with carbon fiber composite in the early design phase. Forces transferred from circuit road to rear upright were estimated through MBD(Multi-Body Dynamics)model of the rear suspension geometry. To evaluate the strength of the rear upright laminated with carbon fiber composite which generally behaves in an anisotropic or orthotropic manner, FEA(Finite Element Analysis) model suitable for composite materials was built followed by its strength was evaluated depending on different stacking lay-up. The result showed that Symmetric stacking lay-up [$45^{\circ}/-45^{\circ}/90^{\circ}/0^{\circ}$]s for frontal area and symmetric stacking lay-up with 1mm aluminum core [$45^{\circ}/-45^{\circ}/90^{\circ}/Core$]s for rear area were most suitable of 16 lay-up cases from the side of both strength based on Tasi-wu failure index and weight.

• Childhood Kidney Diseases
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• 제25권2호
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• pp.117-121
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• 2021

Chronic kidney disease (CKD)-mineral and bone disorder (CKD-MBD) is a common complication of CKD, often accompanied by extra-skeletal calcification in adult patients. As increased vascular calcification is predicted to increase cardiovascular mortality and morbidity, the revised Kidney Disease: Improving Global Outcomes guidelines recommend avoiding calcium-containing phosphate chelators. However, extra-skeletal calcification is less commonly noticed in pediatric patients. Here, we report our experience of such a complication in pediatric patients receiving maintenance peritoneal dialysis. Extra-skeletal calcification was noticed at the corneas, pelvic cavity, and soft tissues of the lower leg in 4 out of 32 patients on maintenance peritoneal dialysis. These patients experienced the aggravation of extra-skeletal calcifications during peritoneal dialysis, and 2 of them underwent excisional operations. It is required to monitor extra-skeletal calcifications in children on kidney replacement therapy.

• 대한기계학회논문집 C: 기술과 교육
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• 제3권2호
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• pp.155-164
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• 2015

기존의 자동차 생산라인의 경우 샤시를 중심으로 양측에 일렬로 배치된 로봇들이 작업을 진행하기 때문에 길고 넓은 공장 부지가 필요하다. 하지만 일렬이 아닌 이열 삼열로 로봇을 배치하여 작업을 진행할 수 있다면, 생산 공장 부지를 최대 절반이하로 줄일 수 있고, 생산 설비를 보다 적은 면적에 설치함으로 로봇 구동 에너지 또한 감소시킬 수 있다. 하지만, 이와 같이 좁은 공간에서 다양한 작업을 수행하려면 여러 작업 기구 장착이 가능한 모듈형 로봇과 원거리에서도 작업이 가능한 가늘고 긴 형태의 로봇 매니퓰레이터를 개발해야만 한다. 이때 로봇을 가상의 공간에서 사전에 모델링해서 가장 최적의 로봇 형태에 대한 성능 평가를 진행할 수 있다면 로봇 개발시 개발 시간의 단축과 개발 비용을 획기적으로 줄일 수 있는데 이러한 평가 작업에 CAE기법들이 활용된다. 특히 로봇의 동역학적 거동 특성을 분석하기 위해서는 다물체 동역학 기법이 활용되는데, 이때 기존 모델링 기술보다 더 효과적이고 좋은 결과를 얻을 수 있는 효율적인 로봇 동해석 모델링 기술에 대하여 연구 진행되었다.

• Journal of Plant Biotechnology
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• 제36권1호
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• pp.53-58
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• 2009

Calcium signals can be transduced by binding calmodulin (CaM), a $Ca^{2+}$ sensor in eukaryotes, is known to be involved in the regulation of diverse cellular functions. We isolated a CaM-binding protein 63 kD (AtCBP63) from the pathogen-treated Arabidopsis cDNA expression library. Recently, AtCBP63 was identified as a CaM bining protein. The CaM binding domain of AtCBP63 was reported to be located in its N-terminal region, In this study, however, we showed that ACaM2 could specifically bind to second CaM-binding domain (CaMBD) of AtCBP63 at the C-terminal region. The specific binding of CaM to CaM binding domain was confirmed by a gel mobility shift assay, a split ubiquitin assay, site-directed mutagenesis, and a competition assay using a $Ca^{2+}$/CaM-dependent enzyme. The gene expression of AtCBP63 was induced by pathogens and pathogens related second messengers. This result suggests that a CaM binding protein, AtCBP63, may play role in pathogen defense signaling pathway.

• 대한전자공학회논문지SP
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• 제44권1호
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• pp.85-93
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• 2007

다채널 암묵 디콘볼루션을 자기상관 값이 큰 신호에 적용할 경우 분리필터행렬의 주대각 성분에 의해서 분리신호의 시간백색화가 발생한다. 이러한 왜곡을 줄이기 위해 분리필터 행렬의 주대각 성분을 강제하거나 선형예측 잔여신호를 이용하여 분리필터 행렬을 구하는 방법들이 제안되었지만 신호자신의 반향성분이나 간섭신호 분리에 있어서 문제점이 발생된다. 본 논문에서는 이러한 문제들을 해결하기 위해서 간섭신호의 분리를 위한 단계와 신호자신의 반향을 감소시키기 위한 단계를 분리하여 처리하는 구조의 다채널 암묵 디콘볼루션 방법을 제안한다. 모의실험 결과 혼합신호에서 간섭신호를 분리해낼 수 있을 뿐만아니라 신호 자신의 반향 또한 감소됨을 확인하였다.

• 한국항공우주학회지
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• 제43권2호
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• pp.166-171
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• 2015

본 논문에서는 무인항공기 비행제어 소프트웨어 개발에 있어 개발위험 감소 및 개발기간 단축을 위해 최근 다양한 분야에서 사용중인 모델기반 개발기법을 이용하여 OFP를 설계하였다. 또한 Simulink 내부의 Model Advisor기능을 활용하여 DO-178C 지침항목에 대한 검사를 수행하였다. 설계된 Simulink 비행제어 로직을 자동코드생성 기법을 이용하여 32비트 DSP 기반의 비행제어 시스템에 적용하였으며, 비행시험에 앞서 X-Plane 시뮬레이터를 이용하여 HILS 환경을 구축하고 다양한 기상 환경속에서 모의 비행시험을 수행함으로써 그 성능을 검증하였다.

• 한국도로학회논문집
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• 제20권1호
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• pp.9-18
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• 2018

PURPOSES : In this research, the initiation and development of corrugation on a gravel road with certain wheel and boundary conditions were evaluated using a coupled discrete-element method (DEM) with multibody dynamics (MBD). METHODS : In this study, 665,534 particles with a 4-mm diameter were generated and compacted to build a circular roadbed track, with a depth and width of 42 mm and 50 mm, respectively. A single wheel with a 100-mm diameter, 40-mm width, and 0.157-kg mass was considered for the track. The single wheel was set to run slowly on the track with a speed of 2.5 rad/s so that the corrugation was gradually initiated and developed without losing contact between the wheel and the roadbed. Then, the shape of the track surface was monitored, and the movement of the particles in the roadbed was tracked at certain wheel-pass numbers to evaluate the overall corrugation initiation and development mechanism. RESULTS : Two types of corrugation, long wave-length and short wave-length, were observed in the circular track. It seems that the long wave-length corrugation was developed by the longitudinal movement of surface particles in the entire track, while the short wave-length corrugation was developed by shear deformation in a local section. Properties such as particle coefficients, track bulk density, and wheel mass, have significant effects on the initiation and development of long-wave corrugation. CONCLUSIONS : It was concluded that the coupled numerical method applied in this research could be effectively used to simulate the corrugation of a gravel road and to understand the mechanism that initiates and develops corrugation. To derive a comprehensive conclusion for the corrugation development under various conditions, the driver's acceleration and deceleration with various particle gradations and wheel-configuration models should be considered in the simulation.