• 한국수학교육학회지시리즈E:수학교육논문집
• /
• 제18권3호통권20호
• /
• pp.117-126
• /
• 2004

Breidenbach et al(1992)는 APOS(Actions, Processes, Objects, Schemas)를 소개하였고 Sfard(1991)는 수학적 개념에서의 Process 와 Object의 상호관련성에 대해서 발표하였다. 본 연구자는 이 이론들을 기반으로 초등학생(4$^{\sim}$6학년)과 중등 영재학생(1학년)을 대상으로 하여 조한혁의 JavaMAL Logo를 이용한 실험을 실행하였다. 이 실험에서는 Process와 Object의 의미와 이 개념들 간의 상호관계를 분석하였고 이러한 관계가 학생들의 창의성에 어떠한 영향을 끼치는지 비교분석하였다.

• 식품기술
• /
• 제16권1호
• /
• pp.3-15
• /
• 2003

• 호스피스
• /
• 통권21호
• /
• pp.2-6
• /
• 2001

• 좋은식품
• /
• 통권214호
• /
• pp.9-34
• /
• 2010

• 호스피스
• /
• 통권22호
• /
• pp.18-19
• /
• 2001

• International Journal of Oral Biology
• /
• 제37권3호
• /
• pp.121-129
• /
• 2012

Previous clinical studies have demonstrated that gabapentin, a drug that binds to the voltage-gated calcium channel ${\alpha}2{\delta}1$ subunit proteins, is effective in the management of neuropathic pain, but there is limited evidence that addresses the participation of glial cells in the antiallodynic effects of this drug. The present study investigated the participation of glial cells in the anti-nociceptive effects of gabapentin in rats with trigeminal neuropathic pain produced by mal-positioned dental implants. Under anesthesia, the left mandibular second molar was extracted and replaced by a miniature dental implant to induce injury to the inferior alveolar nerve. Mal-positioned dental implants significantly decreased the air-puff thresholds both ipsilateral and contralateral to the injury site. Gabapentin was administered intracisternally beginning on postoperative day (POD) 1 or on POD 7 for three days. Early or late treatment with 0.3, 3, or 30 ${\mu}g$ of gabapentin produced significant anti-allodynic effect in the rats with mal-positioned dental implants. On POD 9, in the mal-positioned dental implants group, OX-42, a microglia marker, and GFAP, an astrocyte marker, were found to be up-regulated in the medullary dorsal horn, compared with the naive group. However, the intracisternal administration of gabapentin (30 ${\mu}g$) failed to reduce the number of activated microglia or astrocytes in the medullary dorsal horn. These findings suggest that gabapentin produces significant antinociceptive effects, which are not mediated by the inhibition of glial cell function in the medullary dorsal horn, in a rat model of trigeminal neuropathic pain.

• 한국임상수의학회지
• /
• 제37권1호
• /
• pp.1-8
• /
• 2020

Canine otitis externa is a common disorder in small animal practice with prevalence up to 20%. In a large percentage of cases, canine otitis externa is a chronic and recurrent disease also associated with drug-resistant bacteria that is difficult to treat with traditional antibiotics. Photodynamic therapy (PDT) is a new strategy to exterminate pathogenic microorganisms such as bacteria and fungi. The purpose of this study was to investigate the effectiveness of photodynamic therapy against canine otitis externa using three photosensitizer (PS); 5-Aminolevulinic acid (5-ALA) and Methyl aminolevulinic acid (MAL) with semiconductor laser diode (SLD, 635nm of wave length), Chlorophyll-lipoid complex (CLC) with light-emitting diode (LED, 660nm of wave length). After PDT, dogs showed improved Otitis Index Score (OTIS) in swelling, exudate, odor, and pain. A result of the cytology test revealed decrease of bacteria and malassezia count in the oil immersion field and colony forming units count. PDT was effective as a bacteriocide of methicillin-resistant Staphylococcus pseudintermedius (MRSP) and a fungicide of Malassezia pachydermatis. MAL and 5-ALA were more effective PS against canine otitis externa than CLC. These results suggest that PDT is a new strategy to exterminate pathogenic microorganisms such as bacteria and fungi. PDT can be considered as a new therapeutic approach for canine recurrent otitis externa and a countermeasure to drug resistance that is a disadvantage of traditional antibiotic and antifungal therapy.

• 가족자원경영과 정책
• /
• 제16권2호
• /
• pp.41-57
• /
• 2012

This study uncovers the relationships between mental health, couple relationships and marital happiness. The sample included 180 inter-married Korean men. The data were analyzed by means of frequency, Pearson correlation and multiple regression analysis using the SPSS. Mental health is positively correlated with marital conflict, but is negatively correlated with efficient communication and marital happiness. Furthermore, marital conflict is negatively correlated with communication and marital happiness. Second, mental health has a positive influence on marital conflict and a negative influence on marital happiness. Depression and social mal-adaptation have a negative effect on communication and marital happiness. Marital conflict does not have a mediating effect on mental health and marital happiness. Third, depression and social mal-adaptation have a negative influence on communication and marital happiness. Communication has a mediating effect on mental health and marital happiness. In conclusion, to reduce marital conflict, it is important to intervene in inter-married Korean men's marital happiness through special education programs and counseling.

• 대한물리치료과학회지
• /
• 제9권2호
• /
• pp.7-16
• /
• 2002

This study was conducted to assess the changes in the functional levels of affected upper extremities after treating hemiplegic patients by applying constraint-induced movement therapy(CIMT). The subjects were selected from 20 hemiplegic patients with scores of 25 or more in Mini Mental State Examination(MMSE-k), transferred to the departments of physical therapy in two university hospitals in Busan from December, 2001 to march, 2002, and were divided into two groups. Eleven subjects with fixing unaffected arms by CIMT were assigned to the experimental patient group and the other 9 patients to control group without fixing unaffected arms. The function of upper arms for both groups were evaluated by using Actual Amount of Use Test(AAUT) and Motor Active Log(MAL) before and after physical therapy. The malts were as follows: The recovery rates of upper extremity by AOU(Activity of Use) and QOM(Quality of Movement) were 23.9% and 27.3% for CIMT treated group, and by 8.3% and 4.6% for the control group on the average, respectively, in AAUT after physical therapy, showing statistically significant differences between two groups. And in MAL, the average recovery rates were 27.3% by AOU and 22.6% by QOM for CIMT treated group while 3.1% by both AOU and QOM for the control group, and were significantly different between twogroups.

• 식물분류학회지
• /
• 제39권1호
• /
• pp.55-57
• /
• 2009

전라남도 여수시 안도리에 채집한 자라풀과(Hydrochariataceae)의 Halophila nipponica J. Kuo가 국내 연안에 분포하고 있음이 확인되었다. 일본에서 처음 발견되어 신종으로 기재된 H. nipponica는 Halophila에 속하는 종 가운데 유일하게 온대 수역에 생육하는 종으로 알려져 있다. 바다라는 서식환경을 고려하여 본 분류군의 국명을 해호말로 명명하였다.