• YAKHAK HOEJI
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• v.50 no.5
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• pp.301-307
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• 2006

A simple and sensitive high-performance liquid chromatographic method for quantitation of hydrochlorothiazide in human plasma was developed and bioavailability parameters of hydrochlorothiazide were assessed in Korean healthy male volunteers. Caffeine was used as an internal standard. Hydrochlorothiazide and internal standard in plasma sample were extracted using tert-butylmethylether (TBME). A centrifuged upper layer was then evaporated and reconstituted with mobile phase of acetonitrile-25 mM phosphate buffer (20/80, pH 2.5). The reconstituted samples were injected into a Luna C18 column $(250{\times}4.6\;mm,\;5{\mu}m)$ at a flow-rate of 1.0 ml/min. The wavelength was set at 230 nm and no endogenous substances were found to interfere, A linear relationship for hydrochlorothiazide was found in the range of $10{\sim}300\;ng/ml$. The lower limit of quantitation (LLOQ) was 10 ng/ml with acceptable precision and accuracy. Assayed in plasma, the intra- and inter-day validation for all coefficients of variation (R.S.D.%) were found less than 15%. Main pharmacokinetic parameters of 50mg of hydrochlorothiazide were revealed as follows: $AUC_t\;1761{\pm}509.0\;ng{\cdot} hr\;ml,\;C_{max}\;296.5{\pm}95.5\;ng/ml,\;T_{max}\;1.94{\pm}0.85hr,\;K_{el}\;0.12{\pm}0.04\;hr^{-1}\;and T_{12}\;6.81{\pm}2.92\;hr.\;C_{max}\;and\;T_{max}$ were in accordance with the values $(270{\sim}350\;ng/ml\;and\;1.9{\sim}2.7\;hr)$ of Caucasian.

• Journal of the Korean Society of Propulsion Engineers
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• v.12 no.1
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• pp.29-36
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• 2008

Spray characteristics for APU gas turbine engine are investigated. In the test, four flight conditions such as sea level idle, sea level max power, 20,000 feet idle, 20,000 feet max power are used as spray experimental conditions. Spray visualization was performed by using ND-YAG laser bean PDPA(Phase Doppler Particle Analyzer) was used for measuring the particle diameter and velocity from 20 mm to 100 mm from discharge orifice. From the test result, SMD is $90{\sim}95\;{\mu}m$ 맛 20,000 ft idle condition and SMD is $60{\sim}75\;{\mu}m$ at sea level idle condition. Also SMD is $55{\sim}65\;{\mu}m$ at 20,000 ft max power condition and SMD is $30{\sim}70\;{\mu}m$ at sea level max power condition. In the case of 20,000 ft idle condition, combustion instability could be occurred due to the higher drop diameter. Therefore it is necessary to decrease the droplet diameter in the high altitude condition.

• The Journal of Advanced Prosthodontics
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• v.8 no.6
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• pp.479-488
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• 2016

PURPOSE. The aim of this study was to test the modulus of elasticity (E) across the interfaces of yttria stabilized zirconia (YTZP) / veneer multilayers using nanoindentation. MATERIALS AND METHODS. YTZP core material (KaVo-Everest, Germany) specimens were either coated with a liner (IPS e.max ZirLiner, Ivoclar-Vivadent) (Type-1) or left as-sintered (Type-2) and subsequently veneered with a pressable glass-ceramic (IPS e.max ZirPress, Ivoclar-Vivadent). A $5{\mu}m$ (nominal tip diameter) spherical indenter was used with a UMIS CSIRO 2000 (ASI, Canberra, Australia) nanoindenter system to test E across the exposed and polished interfaces of both specimen types. The multiple point load - partial unload method was used for E determination. All materials used were characterized using Scanning Electron Microscopy (SEM) and X - ray powder diffraction (XRD). E mappings of the areas tested were produced from the nanoindentation data. RESULTS. A significantly (P<.05) lower E value between Type-1 and Type-2 specimens at a distance of $40{\mu}m$ in the veneer material was associated with the liner. XRD and SEM characterization of the zirconia sample showed a fine grained bulk tetragonal phase. IPS e-max ZirPress and IPS e-max ZirLiner materials were characterized as amorphous. CONCLUSION. The liner between the YTZP core and the heat pressed veneer may act as a weak link in this dental multilayer due to its significantly (P<.05) lower E. The present study has shown nanoindentation using spherical indentation and the multiple point load - partial unload method to be reliable predictors of E and useful evaluation tools for layered dental ceramic interfaces.

• Publications of The Korean Astronomical Society
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• v.30 no.2
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• pp.79-82
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• 2015

The physical and chemical properties of prestellar cores, especially massive ones, are still far from being well understood due to the lack of a large sample. The low dust temperature (< 14 K) of Planck cold clumps makes them promising candidates for prestellar objects or for sources at the very initial stages of protostellar collapse. We have been conducting a series of observations toward Planck cold clumps (PCCs) with ground-based radio telescopes. In general, when compared with other star forming samples (e.g. infrared dark clouds), PCCs are more quiescent, suggesting that most of them may be in the earliest phase of star formation. However, some PCCs are associated with protostars and molecular outflows, indicating that not all PCCs are in a prestellar phase. We have identified hundreds of starless dense clumps from a mapping survey with the Purple Mountain Observatory (PMO) 13.7-m telescope. Follow-up observations suggest that these dense clumps are ideal targets to search for prestellar objects.

• The Transactions of the Korean Institute of Electrical Engineers C
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• v.49 no.1
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• pp.19-23
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• 2000

Partial discharges(PD)in air insulated electric power apparatus often lead to deterioration of solid insulation by electron bombardments and electrochemical reaction. The PD caused to reduce the life time of power apparatus and to increase power losses. Thus understanding and classification of PD patterns in air are very important to discern sources of PD. In this paper, PD in air by using statistical methods was investigated. We classified air discharges, corona, surface discharges and cavity discharges by Kohonen network. For classification of PD patterns, we used statistical operators and parameters such as skewness$(S^+,\; S^-),\; kurtosis(K^+, K^-),\; mean phase(AP^+, AP^-)$, cross-correlation factor(CC) and asymmetry derived from the mean pulse-height phase distribution$(H_{avg}(\phi))$, the max pulse-height phase distribution $(H_{qmax}(\phi))$, the pulse count phase distribution $(H_n(\phi))$ and the pulse height vs. Repetition rate $(H_q(n))$.

• Membrane and Water Treatment
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• v.10 no.2
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• pp.127-137
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• 2019

The D2EHPA/TBP co-extractants immobilized PolyHIPE membrane can be used for the selective separation of Mn (II) from Co (II). By solvent-nonsolvent method, D2EHPA/TBP co-extractants can be effectively immobilized into PolyHIPE membrane. The pore structure of PolyHIPE membrane and the presence of TBP enhance the stability of immobilized co-extractants. The optimal operating conditions for the separation of Mn (II) and Co (II) are feeding phase at pH 5.5, sulfuric acid concentration in the stripping phase of about 50 g/L and stirring speed at 400 rpm. The D2EHPA/TBP co-extractants ratio of 5:1 shows synergetic effect on Mn/Co separation factor about 22.74. The removal rate and recovery rate of Mn (II) is about 98.4 and 97.1%, respectively, while for Co (II) the transport efficiency is insignificant. The kinetic study of Mn (II) transport shows that high initial flux, $J_f^o=80.1({\mu}mol/m^2s)$, and maxima stripping flux, $J_s^{max}=20.8({\mu}mol/m^2s)$, can be achieved with D2EHPA/TBP co-extractants immobilized PolyHIPE membrane. The stability and reusability study shows that the membrane can maintain a long term performance with high efficiency. High purity of Co (II) and Mn (II) can be recovered from the feeding phase and stripping phase, respectively.

• Bulletin of the Korean Chemical Society
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• v.34 no.2
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• pp.609-614
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• 2013

Extended H$\ddot{u}$ckel tight-binding band structure calculations are used to address the chemical bonding and elastic properties of $Zr_2AC$ (A=Al, Si, P, and S). Elastic properties are interpreted by analyzing the density of states and the crystal orbital overlap population for the respective phases. Our results show that the bulk modulus of these ternary compounds is determined by the strength of Zr-A bonds.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.20 no.10
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• pp.1050-1060
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• 2009

In this paper, a X-Band T/R-module for SAR(Synthetic Aperture Radar) systems based on active phased array antennas is designed and fabricated. The T/R modules have a and width of more than 800 MHz centered at X-Band and support dual, switched polarizations. The output power of the module is 7 watts over a wide bandwidth. The noise figure is as low as 3.9 dB. Phase and amplitude are controlled by a 6-bit phase shifter and a 6-bit digital attenuator, respectively. Further the fabricated T/R module has est and calibration port with directional coupler and power divider. Highly integrated T/R module is achieved by using LTCC(Low Temperature Co-fired Ceramic) multiple layer substrate. RMS gain error is less than 0.8 dB max. in Rx mode, and RMS phase error is less than $4^{\circ}$ max. in Rx/Tx phase under all operating frequency band, or the T/R module meet the required electrical performance m test. This structure an be applied to active phase array SAR Antennas.

• Journal of the Korean Ceramic Society
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• v.33 no.4
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• pp.391-398
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• 1996

In order to understand the electrostrictive behavior of Pb(Mg1/3Nb2/3)O3-PbTiO3(PMN-PT) solid solutions the dielectric constants and the electric-field-induced strains in (1-x)PMN-xPT (x=0.0-0.4) were investigated in the temperature range -5$0^{\circ}C$-20$0^{\circ}C$. Powder of (1-x)Pb(Mg2/3Nb2/3)O3-xPbTiO3 (x=0.0, 0.1, 0.2, 0.3, 0.35, and 0.4) were prepared from the oxide forms of Pb, Mg, Nb and Ti via a columbite precursor method As the amount of PbTiO3 increases the temperature of maximum dielectric constant(T$\varepsilon$max) increases and the phase transition become less diffusive. The strain maximum occurs only when the diffuse phase transition occurs from rhombohedral to cubic or rhombohedral to tetragonal as in x=0.1-0.35 The strains monotonically decrease with temperature in the materials in which phase transition occurs from tetragonal to cubic as in x=0.4.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.9 no.2
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• pp.111-116
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• 2009

In this paper, we propose a phase offset estimation algorithm which is based on turbo coded digital broadcasting system. The phase estimator is an estimator outside turbo code decoder using LMS (Least Mean Square) algorithm to estimate the phase of next state. While the conventional LMS algorithm with a fixed step size is easy implemented, it has weak points that are difficult the channel estimation and tracking in the multipath environment. To resolve this problem, we propose new phase offset estimation method with a variable step size LMS (VS-LMS). Additionally, we propose a scheme which consists of a conventional LMS. The performance is verified by computer simulation according to a fixed phase offset and a increased phase offset, the proposed algorithm improve the bit error rate performance than the conventional algorithm.