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The Effect of Lidocaine Dose and Pretreated Diazepam on Cardiovascular System and Plasma Concentration of Lidocaine in Dogs Ansthetized with Halothane-Nitrous Oxide (Diazepam 전투여와 Lidocaine 투여용량이 혈중농도 및 심혈역학적 변화에 미치는 영향)

  • Lee, Kyeong-Sook;Kim, Sae-Yeon;Park, Dae-Pal;Kim, Jin-Mo;Chung, Chung-Gil
    • Journal of Yeungnam Medical Science
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    • v.10 no.2
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    • pp.451-474
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    • 1993
  • Lidocaline if frequently administered as a component of an anesthetic : for local or regional nerve blocks, to mitigate the autonomic response to laryngoscopy and tracheal intubation, to suppress the cough reflex, and for antiarrythmic therapy. Diazepam dectease the potential central nervous system (CNS) toxicity of local anesthetic agents but may modify the sitmulant action of lidocaine in addition to their own cardiovascular depressant. The potential cardiovascular toxicity of local anesthetics may be enhanced by the concomitant administration of diazepam. This study was designed to investigate the effects of lidocaine dose and pretreated diazepam to cardiovascular system and plasma concentration of lidocaine. Lidocaine in 100 mcg/kg/min, 200 mcg/kg/min, and 300 mcg/kg/min was given by sequential infusion to dogs anesthetized with halothane-nitrous oxide (Group I). And in group II, after diazepam pretreatment, lidocaine was infused by same way when lidocaine was administered in 100 mcg/kg/min, the low plasma levels ($3.97{\pm}0.22-4.48{\pm}0.36$ mcg/ml) caused a little reduction in cardiovascular hemodynamics. As administered in 200 mcg/kg/min, 300 mcg/kg/min, the higher plasma levels ($7.50{\pm}0.66-11.83{\pm}0.59$ mcg/ml) reduced mean arterial pressure (MAP), cardiac index (CI), stroke index (SI), left ventricular stroke work index (LVSWI), and right ventricular stroke work index (PVSWI) and increased pulmonary artery wedge pressure (PAWP), central venous pressure (CVP), systemic vascular resistance index (SVRI), but was associated with little changes of heart rate (HR), mean pulmonary artery pressure (MPAP), and pulmonary vascular resistance index (PVRI). When lidocaine with pretreated diazepam was administered in 100 mcg/kg/min, the low plasma level, the lower level than when only lidocaine administered, reduced MAP, but was not changed other cardiovascular hemodynamics. While lidocaine was infused in 200 mcg/kg/min, 300 mcg/kg/min in dogs pretreated diazepam, the higher plasma level ($7.64{\pm}0.79-13.79{\pm}0.82$ mcg/ml) was maintained and was associated with reduced CI, SI, LVSWI and incresed PAWP, CVP, SVRI but was a little changes of HR, MPAP, PVRI. After $CaCl_2$ administeration, CI, SI, SVRI, LVSWI was recovered but PAWP, CVP was rather increased than recovered. The foregoing results demonstrate that pretreated diazepam imposes no additional burden on cardiovascular system when a infusion of large dose of lidocaine is given to dogs anesthetized with halothanenitrous oxide. But caution may be advised if the addition of lidocaine is indicated in subjects who have impared autonomic nervous system and who are in hypercarbic, hypoxic, or acidotic states.

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Distribution of Major Plant Communities Based on the Climatic Conditions and Topographic Features in South Korea (남한의 기후와 지형적 특성에 근거한 주요 식물군락의 분포)

  • Yang, Keum-Chul;Shim, Jae-Kuk
    • Korean Journal of Environmental Biology
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    • v.25 no.2
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    • pp.168-177
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    • 2007
  • By using DEM and digital actual vegetation map with MGE GIS software program, topographic features (altitude, slope, latitude, etc.) quantitatively were analysed and their data integrated as the index of climatic conditions (WI, CI, air temperature, etc.) in South Korea. Warmth Index (WI) decreases $5.27^{\circ}C{\cdot}month$ with latitudinal $1^{\circ} degree, and $3.41^{\circ}C{\cdot}month$ with attitudinal 100 m increase. The relationship between CI and WI values is expressed as a linear regression, $WI=116.01+0.96{\times}CI,\;R^2=0.996$. The distributional peaks of different plant communities along Warmth Index gradient showed the sequence of Abies nephrolepis, Taxus cuspidata, Abies koreana, Quercus mongolica, Carpinus laxiflora, Q. dentata, C. tschonoskii, Q. serrate, Pinus densiflora, Q. aliena, Q. variabilis, Q. acutissima, P. thunbergii, Q. acute, Castanopsis cuspidata var. sieboldii, Camellia japonica, Machilus thunbergii community from lower to higher values. The Quercus mongolica forest occurred frequently on E-NW and SE slope aspect within WI $70{\sim}80^{\circ}C{\cdot}month$ optimal range at mesic sites, NW and SE slope than xeric sites S and SW slope. The Q. serrata forest showed the most distributional frequency in NW and W slope aspect within WI $90{\sim}100^{\circ}C{\cdot}month$ range, Q. variabilis and Q. acutissima forest showed the high frequency of distribution in SE slope in WI $95{\sim}100^{\circ}C{\cdot}month$ range. By the slope gradient analysis, five groups were found: 1. Abies nephrolepis, Machilus thunbergii, 2. Taxus cuspidata, Abies koreana, Quercus mongolica, Q. dentata, Q. serrata, Q. variabilis, Castanopsis cuspidata var. sieboldii 3. Pinus densiflora, Q. aliena, Q. acutissima, P. thunbergii, Q. acuta 4. Carpinus laxiflora, Camellia japonica 5. C. tschonoskii from steep slope to gentle slope sequence.

An integrated airborne gravity survey of an offshore area near the northern Noto Peninsula, Japan (일본 노토 반도 북쪽 연안의 복합 항공 중력탐사)

  • Komazawa, Masao;Okuma, Shigeo;Segawa, Jiro
    • Geophysics and Geophysical Exploration
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    • v.13 no.1
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    • pp.88-95
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    • 2010
  • An airborne gravity survey using a helicopter was carried out in October 2008, offshore along the northern Noto Peninsula, to understand the shallow and regional underground structure. Eleven flight lines, including three tie lines, were arranged at 2 km spacing within 20 km of the coast. The total length of the flight lines was ~700 km. The Bouguer anomalies computed from the airborne gravimetry are consistent with those computed from land and shipborne gravimetry, which gradually decrease in the offshore direction. So, the accuracy of the airborne system is considered to be adequate. A local gravity low in Wajima Bay, which was already known from seafloor gravimetry, was also observed. This suggests that the airborne system has a structural resolution of ~2 km. Reduction of gravity data to a common datum was conducted by compiling the three kinds of gravity data, from airborne, shipborne, and land surveys. In the present study, we have used a solid angle numerical integration method and an iteration method. We finally calculated the gravity anomalies at 300 m above sea level. We needed to add corrections of 2.5 mGals in order to compile the airborne and shipborne gravity data smoothly, so the accuracy of the Bouguer anomaly map is considered to be nearly 2 mGal on the whole, and 5 mGals at worst in limited or local areas.

Clinical Application of Acute Ischemic Stroke in Perfusion Computed Tomography (초급성 허혈성 뇌졸중에서 관류 전산화단층촬영의 임상적 적용에 대한 연구)

  • Lee, Jong-Seok;Yoo, Beong-Gyu;Kweon, Dae-Cheol
    • Progress in Medical Physics
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    • v.18 no.3
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    • pp.149-160
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    • 2007
  • Recent advent of 64-multidetctor (MD) CT enables more coverage of Z-axis in the perfusion imaging. The purpose of this study was to evaluate the clinical usefulness of perfusion CT by using 64-MD CT in detecting the lesion in patients with acute stroke. The perfusion CT was performed by using 64-MD CT in 62 consecutive patients who were initially suspected to have subacute ischemic stroke symptoms during the period of recent 9 months. These patients had subacute stroke (n=62). CT scanning was conducted with Jog Mode which provided 16 imaging slices with 5 mm of slice thickness, and 8 cm of coverage in Z-axis. Scan interval was 1 seconds for each imaging slice and total 15 scans were repeated. After CT scanning, perfusion maps (CBV, CBF, MTT and TTP) were created at Extended Brilliance Workstation. The CBV and CBF maps showed that lesions were smaller images. While on the MTT and TTP map lesions were seen to be larger fifty-one were large than they appeared on these images. Two slices of perfusion maps obtained at the level of the basal ganglia were chosen to simulate conventional older perfusion CT with 8 cm of coverage in Z-axis. TTP and MTT maps may be clinically useful for evaluation of the penumbral zone in cases of aubacute cerebral ischemic stroke. The perfusion CT is useful in the assessment of acute stroke as an initial imaging modality.

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Assessing Red List categories to a Korean endangered species based on IUCN criteria - Hanabusaya asiatica (Nakai) Nakai- (멸종위기식물의 IUCN 적색목록 보전지위 평가 -금강초롱꽃에 대하여-)

  • Park, Soo-Kyung;Kim, Hui;Chang, Chin-Sung
    • Korean Journal of Plant Taxonomy
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    • v.43 no.2
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    • pp.128-138
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    • 2013
  • The conservation status of an endemic perennial herb, Hanabusaya asiatica (Nakai) Nakai (Campanulaceae) was determined by applying the IUCN risk assessment criteria from our field study and available specimen data. Also, the GIS technology was used to develop a species distribution map to calculate the extent of occurrence (EOO) and area of occupancy (AOO) for the taxon. After two years of continuous field studies, 269 mature individuals were found in four localities in 2011, while 216 mature individuals were confirmed in three localities in 2012. Based on the following data, such as EOO (2,742 $km^2$), AOO (76 $km^2$) and estimated population size of mature individuals, the taxon, which is known as 20 localities in Korean peninsula, is evaluated as the category of Endangered (EN). A major difficulty in application of IUCN criteria to Korean rare plants were the lack of essential biological information and understanding the correct knowledge of the IUCN criteria in previous Korean studies. Sound conclusions regarding the conservation status of individual species require more intensive population studies, observations, and applying IUCN assessment procedures correctly.

Numerical Simulation for Net-water Flux of the Cross-sectional area in the Nakdong River Estuary (낙동강 하구역내 사주간의 단면유량플럭스 수치모의)

  • Yoon, Han-Sam;Lee, In-Cheol;Ryu, Cheong-Ro
    • Journal of the Korean Society for Marine Environment & Energy
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    • v.8 no.4
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    • pp.186-192
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    • 2005
  • We investigated the deposition characteristics and mass transport flux estimation of the Nakdong estuary, Korea. To understand the effects of the tidal current circulation that influences estuary terrain changes, we used a 2D numerical model to map seawater circulation under three different situations, with the level of river flow being set as none or flood. The net-water flux of the cross-sectional area between sandbars (known as dung) was estimated. From our review of previous research, we know that the development of local sandbars shifted from the west to the east side of the estuary after the construction of the Nakdong River dike. Current development is occurring mostly at the Bakhap-dung near Tadea. The seawater circulation pattern over this large-scale area of tidal na is brings changes related to the quantity of the outflow from the Nakdong River. Based on the calculated results for the net-water flux of the cross-sectional area, we see very strong accumulation in local waters around Jangjiado, Bakhapdung, and Tadae under flood river flow conditions, but accumulation in local waters around Jinudo under the other states of flow. Consequently, in the Nakdong estuary, the main sensitive regions that are affected by changes in the flow of river discharge are the local waters around Jangiado, Bakhapdung, Tadae, and Jinudo.

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Geometrical Interpretation on the Development Sequence and the Movement Sense of Fractures in the Cheongsong Granite, Gilan-myeon Area, Uiseong Block of Gyeongsang Basin, Korea (경상분지 의성지괴 길안면지역에서 청송화강암의 단열 발달사 및 운동성에 대한 기하학적 해석)

  • Kang, Ji-Hoon;Ryoo, Chung-Ryul
    • The Journal of the Petrological Society of Korea
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    • v.15 no.4 s.46
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    • pp.180-193
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    • 2006
  • The Gilan area in the central-northern part of Uiseong Block of Cretaceous Gyeongsang Basin is composed of Precambrian metamorphic rocks, Triassic Cheongsong granite, Early Cretaceous Hayans Group, and Late Cretaceous-Paleocene igneous rocks. In this area, the faults of various directions are developed: Oksan fault of $NS{\sim}NNW$ trend, Gilan fault of NW trend, Hwanghaksan fault of WNW trend, and Imbongsan fault of EW trend. Several fracture sets with various geometric indicators, which determine their relative timing (sequence and coexistence relationships) and shear sense, we well observed in the Cheongsong granite, the basement of Gyeongsang Basin. The aim of this study is to determine the development sequence of extension fractures and the movement sense of shear fractures in the Gitan area on the basis of detailed analysis of their geometric indicators (connection, termination, intersection patterns, and cross-cutting relations). This study suggests that the fracture system of the Gilan area was formed at least through seven different fracturing events, named as Pre-Dn to Dn +5 phases. The orientations of fracture sets show (W) NW, NNW, NNE, EW, NE in descending order of frequency. The orientation and frequency patterns are concordant with those of faults around and in the Gilan area on a geological map scale. The development sequence and movement sense of fracture sets are summarized as follows. (1) Pre-Dn phase: extension fracturing event of $NS{\sim}NNW$ and/or $WNW{\sim}ENE$ trend. The joint sets of $NS{\sim}NNW$ trend and of $WNW{\sim}ENE$ trend underwent the reactivation histories of sinistral ${\rightarrow}$dextral${\rightarrow}$sinistral shearing and of (dextral${\rightarrow}$) sinistral shearing with the change of stress field afterward, respectively. (2) Dn phase: that of NW trend. The joint set experienced the reactivations of sinistral${\rightarrow}$dextral shearing. (3) Dn + 1 phase: that of $NNE{\sim}NE$ trend. The joint set was reactivated as a sinistral shear fracture afterward. (4) Dn +2 phase: that of $ENE{\sim}EW$ trend. (5) Dn +3 phase: that of $WNW{\sim}NW$ trend. (6) Dn+4 phase: that of NNW trend. The joint set underwent a dextral shearing after this. (7) The last Dn +5 phase: that of NNE trend.

Prediction of Urban Flood Extent by LSTM Model and Logistic Regression (LSTM 모형과 로지스틱 회귀를 통한 도시 침수 범위의 예측)

  • Kim, Hyun Il;Han, Kun Yeun;Lee, Jae Yeong
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.40 no.3
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    • pp.273-283
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    • 2020
  • Because of climate change, the occurrence of localized and heavy rainfall is increasing. It is important to predict floods in urban areas that have suffered inundation in the past. For flood prediction, not only numerical analysis models but also machine learning-based models can be applied. The LSTM (Long Short-Term Memory) neural network used in this study is appropriate for sequence data, but it demands a lot of data. However, rainfall that causes flooding does not appear every year in a single urban basin, meaning it is difficult to collect enough data for deep learning. Therefore, in addition to the rainfall observed in the study area, the observed rainfall in another urban basin was applied in the predictive model. The LSTM neural network was used for predicting the total overflow, and the result of the SWMM (Storm Water Management Model) was applied as target data. The prediction of the inundation map was performed by using logistic regression; the independent variable was the total overflow and the dependent variable was the presence or absence of flooding in each grid. The dependent variable of logistic regression was collected through the simulation results of a two-dimensional flood model. The input data of the two-dimensional flood model were the overflow at each manhole calculated by the SWMM. According to the LSTM neural network parameters, the prediction results of total overflow were compared. Four predictive models were used in this study depending on the parameter of the LSTM. The average RMSE (Root Mean Square Error) for verification and testing was 1.4279 ㎥/s, 1.0079 ㎥/s for the four LSTM models. The minimum RMSE of the verification and testing was calculated as 1.1655 ㎥/s and 0.8797 ㎥/s. It was confirmed that the total overflow can be predicted similarly to the SWMM simulation results. The prediction of inundation extent was performed by linking the logistic regression with the results of the LSTM neural network, and the maximum area fitness was 97.33 % when more than 0.5 m depth was considered. The methodology presented in this study would be helpful in improving urban flood response based on deep learning methodology.

A Study of the shade of between maxillary and mandibular anterior teeth in the Korean (한국인의 상하악 전치부 색조에 관한 연구)

  • Kim, Tae-Jin; Kwon, Kung-Rock;Kim, Hyeong-Seob;Woo, Yi-Hyung
    • The Journal of Korean Academy of Prosthodontics
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    • v.46 no.4
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    • pp.343-350
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    • 2008
  • Purpose: The purpose of this study was to spectrophotometrically evaluate the shade difference between of maxillary and mandibular anterior teeth in the Korean by the standard of vita classical shade guide using $SpectroShade^{TM}$. Material and methods: In this study, the shades of healthy anterior teeth were examined and analyzed using the digital shade analysis of $SpectroShade^{TM}$. This study examined 80 individuals in their twenties, thirties, fourties, fifities ages and 40 males and 40 females, presenting 12 healthy, unrestored maxillary and mandibular anterior teeth. Tooth brushing and oral prophylaxis were performed prior to evaluation. The $SpectroShade^{TM}$ was used to acquire images of the 12 maxillary and mandibular anterior teeth. These images were analyzed using $SpectroShade^{TM}$ Software, and shade maps of each tooth were acquired. The shade difference of upper and lower, and gender differences and ages difference were investigated and analyzed with CIE $L^{*}a^{*}b^{*}$ color order system. One-Way ANOVA test was used to find out if there were significant differences between groups tested and Sheffe multiple comparison was used to identify where the differences were. Results: 1. Shade differences were significant (P < .05) between maxillary and mandibular central incisor, lateral incisor, canine. 2. No significant differences in shade distribution were seen between lateral incisors and central incisors. 3. Canine's shade difference were more significant than central incisor's and lateral incisors's. 4. No significant differences in shade distribution were seen between genders in maxillary and mandibulr central incisor, lateral incisor, canine. 5. No significant differences in shade distribution were seen in order of years in maxillary and mandibulr central incisor, lateral incisor, canine. Conclusions: The results of this study show that 1. Shade difference was founded in maxillary and mandibular anterior teeth and ${\Delta}E^{*}$ value was more than 2.0. 2. Canine's shade difference were more significant than central incisor's and lateral incisors's and between central incisors and lateral incisors shade differences were no significant. 3. No significant differences in shade distribution were seen between genders in maxillary and mandibular anterior teeth. 4. No significant differences in shade distribution were seen in order of years grade in maxillary and mandibular anterior teeth.

Improvement in the Future of the Dental Internet Homepage (치과 인터넷 홈페이지의 개선 방안)

  • Kim, Bit-Na
    • Journal of dental hygiene science
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    • v.3 no.2
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    • pp.77-82
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    • 2003
  • The purpose of this study was to examine the characteristics of dental homepages in korea to discuss how they could be improved better. The findings of this study could be described as below : First, dental homepage should include differentiated, specialized content and features. Second, the use of three-dimensional image or multimedia would contribute to increasing people's understanding of dental treatment or general dental information and elevating the effectiveness of dental publicity activities. Third, the want ad and order system used by the business sector or hospital would serve to multiply the management efficiency of dental institutions. Fourth, dental hospitals and clinics that belong to the same network or franchise need to make publicity banner for feasible mutual link, and the use of the same homepage design or common logo would be effective for better image and publicity activities. Fifth, it would be convenient to add the map search function or inquiry system. Seventh, if multiple types of services, such as entertainment or game, are prepared, it would be possible for dental institutions to project a better image and to induce visitors to hit the sites again.

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