This study was designed to evaluate the pharmacological effects of Vaccinium bracteatum Thunb. methanol extract (VBME) on microglial activation and to identify the underlying mechanisms of action of these effects. The anti-inflammatory properties of VBME were studied using lipopolysaccharide (LPS)-stimulated BV-2 microglial cells. We measured the production of nitric oxide (NO), inducible NO synthase (iNOS), cyclooxygenase (COX)-2, prostaglandin $E_2$ ($PGE_2$), tumor necrosis factor-alpha (TNF-${\alpha}$), interleukin-1 beta (IL-$1{\beta}$), and interleukin-6 (IL-6) as inflammatory parameters. We also examined the effect of VBME on intracellular reactive oxygen species (ROS) production and the activity of nuclear factor-kappa B p65 (NF-${\kappa}B$ p65). VBME significantly inhibited LPS-induced production of NO and $PGE_2$ and LPS-mediated upregulation of iNOS and COX-2 expression in a dose-dependent manner; importantly, VBME was not cytotoxic. VBME also significantly reduced the generation of the pro-inflammatory cytokines TNF-${\alpha}$, IL-$1{\beta}$, and IL-6. In addition, VBME significantly dampened intracellular ROS production and suppressed NF-${\kappa}B$ p65 translocation by blocking $I{\kappa}B-{\alpha}$ phosphorylation and degradation in LPS-stimulated BV2 cells. Our findings indicate that VBME inhibits the production of inflammatory mediators in BV-2 microglial cells by suppressing NF-${\kappa}B$ signaling. Thus, VBME may be useful in the treatment of neurodegenerative diseases due to its ability to inhibit inflammatory mediator production in activated BV-2 microglial cells.
Lee, Jung-Soo;Choi, JeeWon;Kim, Jin Se;Park, Me Hea;Choi, HyunJinn;Lee, YounSuk;Kim, Dong Eok;Hong, YuunPo;Kim, Ji-Gang
KOREAN JOURNAL OF PACKAGING SCIENCE & TECHNOLOGY
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v.23
no.3
/
pp.163-171
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2017
Effects of different packaging methods for maintaining the shelf life and postharvest quality of iceberg lettuce (Lactuca sativa L.) were studied after harvesting in summer season. Lettuce heads were packaged in plastic crate with or without different films such as (A) Individual lettuce head sealed packaging with linear low density polyethylene (LLDPE) film; (B) Packaging lettuce head in plastic crate and wrapped with LLDPE film; (C): Individual lettuce head sealed packaging with perforated high density polyethylene (HDPE) film; (D) Packaging lettuce head in plastic crate and wrapped with perforated HDPE; and (E) Packaging lettuce head in plastic crate without any film (control), and stored at $2^{\circ}C$ for 35 days. Several quality parameters such as fresh weight loss, SPAD (soil & plant analyzer development) meter value, respiration rate, moisture content and appearance of lettuce were investigated. The lettuce wrapped with individually-sealed LLDPE film showed the lowest weight loss and the highest SPAD value rendering the best appearance index among the treataments throughout the three-week storage period at $2^{\circ}C$. Extending the freshness of iceberg lettuce during low temperature storage will definitely increase the salability potential in the domestic market even during summer season.
Lim, Tae Kyoo;Yu, Byug Chul;Ma, Dae Sung;Lee, Gil Jae;Lee, Min A;Hyun, Sung Yeol;Jeon, Yang Bin;Choi, Kang Kook
Journal of Trauma and Injury
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v.30
no.4
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pp.140-144
/
2017
Purpose: The optic nerve sheath diameter (ONSD) measured by ultrasonography is among the indicators of intracranial pressure (ICP) elevation. However, whether ONSD measurement is useful for initial treatment remains controversial. Thus, this study aimed to investigate the relationship between ONSD measured by computed tomography (CT) and ICP in patients with traumatic brain injury (TBI). Methods: A total of 246 patients with severe trauma from January 1, 2015 until December 31, 2015 were included in the study. A total of 179 patients with brain damage with potential for ICP elevation were included in the TBI group. The remaining 67 patients comprised the non-TBI group. A comparison was made between the two groups. Receiver operating characteristic (ROC) curve analysis was performed to determine the accuracy of ONSD when used as a screening test for the TBI group including those with TBI with midline shift (with elevated ICP). Results: The mean injury severity score (ISS) and glasgow coma scale (GCS) of all patients were $24.2{\pm}6.1$ and $5.4{\pm}0.8$, respectively. The mean ONSD of the TBI group ($5.5{\pm}1.0mm$) was higher than that of the non-TBI group ($4.7{\pm}0.6mm$). Some significant differences in age ($55.3{\pm}18.1$ vs. $49.0{\pm}14.8$, p<0.001), GCS ($11.7{\pm}4.1$ versus $13.3{\pm}3.0$, p<0.001), and ONSD ($5.5{\pm}1.0$ vs. $4.7{\pm}0.6$, p<0.001) were observed between the TBI and the non-TBI group. An ROC analysis was used to assess the correlation between TBI and ONSD. Results showed an area under the ROC curve (AUC) value of 0.752. The same analysis was used in the TBI with midline shift group, which showed an AUC of 0.912. Conclusions: An ONSD of >5.5 mm, measured on CT, is a good indicator of ICP elevation. However, since an ONSD is not sensitive enough to detect an increased ICP, it should only be used as one of the parameters in detecting ICP along with other screening tests.
Journal of the Korea Academia-Industrial cooperation Society
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v.21
no.10
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pp.509-516
/
2020
Since the 1960s, many rivers have been polluted and destroyed due to river repair projects for economic development and the covering of small rivers due to urbanization. Many studies have analyzed rivers using measured river topographic factors, but surveying is not easy when the flow rate changes rapidly, such as during a flood. In addition, the previous research has been mainly about the cross section of a river, so information on the longitudinal profile is insufficient. This research used informational entropy theory to obtain an equation that can calculate the average river slope, river slope, and river longitudinal elevation for a river basin in real time. The applicability was analyzed through comparison with measured data of a river's characteristic factors obtained from a river plan. The parameters were calculated using informational entropy theory, nonlinear regression analysis, and actual data. The longitudinal elevation entropy equation for each stream was then calculated, and so was the average river slope. All of the values were over 0.96, so it seems that reliable results can be obtained when calculating river characteristic factors.
Cui Zhao-Hui;Li Yan-Ping;Liu Ai-Ling;Zhang Qian;Du Wei-Jing;Ma Guan-Sheng
Journal of Community Nutrition
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v.6
no.3
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pp.131-136
/
2004
The purpose of this study is to compare the relative risk of metabolic syndrome (MS) in middle aged adults with different body weights. 155 subjects living in urban Beijing were recruited from 24 neighborhood committees of urban Beijing. They were divided into normal weight, overweight and obese groups according to their BMIs. The general information of the subjects was collected using an interview-administered questionnaire. Standard procedure was followed to measure subject's weight, height and waist. Biochemical parameters (total cholesterol (TC), low- and highdensity lipoprotein cholesterol (LDL-C ; HDL-C), triglyceride (TG), and fasting glucose) and blood pressure were also determined. The results indicated that the systolic and diastolic blood pressure, HDL-C of obese group was lower than that of the normal weight group. Fasting glucose of obese males was significantly higher than that of normal weight males. No significant difference of fasting glucose was found among female groups. No significant difference of TG was found among male groups, while TG of overweight and obese females was both significantly higher than normal weight females. There was no significant difference of TC and LDL-C among normal weight, overweight and obese groups in both males and females. The MS rate of obese males was significantly higher than the normal weight and overweight males, as was the female. The relative risk of MS in obese group was about 11 times higher (OR=11.249, $95\%CI$ = 3.812 - 33.191) than the normal weight group after adjusting for age, gender, smoking, drinking, family economic level and education status. It is concluded that obesity contributed to lower HDL-C, hypertriglyceride, hypertension and MS after controlling the effects of age, gender, socioeconomic status, alcohol drinking and smoking. Obese individuals have a higher risk of having MS than their normal weight counterparts.
This study was carried out to understand the ecological variations of macrobenthos communities by construction dikes in the subtidal zone of Chonsu Bay. This study analyzed the distribution of benthos, the dominant species, spatial and temporal changes of benthos communities and benthic pollutions in the subtidal zone of Chonsu Bay. A total of 252 species of subtidal macrobenthos with a density of $681ind./m^2$ were studied. In all the seasons, the species diversity was found to be higher near the mouth of the bay. For all the seasons of the year, Lumbrineris japonica was found to be the most dominant species. These dominant species were found to have positive correlations with species diversity and sedimentary parameters such as organic content in sediments. Dominant species of benthos as well as species composition and diversity showed spatial and temporal distribution patterns.Benthic Pollution Index (BPI) values estimated for the stations near the embankment were in the 4~5 levels, which indicates that the organic matter has been polluted. And as for the stations near the mouth of the bay, the BPI values were in the 1~3 levels, which indicates that the organic matter has been relatively less polluted. According to the SAB-curve analysis, the number of transitional point stations became less in the mouth of the bay.
Chang, Eun Ha;Lee, Ji Hyun;Choi, Ji Weon;Shin, Il Sheob;Hong, Yoon Pyo
Korean Journal of Medicinal Crop Science
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v.28
no.2
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pp.152-166
/
2020
Background: Ginsenosides, which have various physiological activities, are known to be abundant in the leaves and roots of ginseng. Ginseng sprouts can be used as a fresh vegetable and roots, stems, and leaves of ginseng can be consumed. This study aimed to investigate the effect of carbon dioxide treatment and the modified atmosphere (MA) packaging method in suppressing quality deterioration during the distribution of ginseng sprouts. Methods and Results: Ginseng sprouts were packed using Styrofoam, barrier film + non gas treatment, barrier film + gas treatment, 15 ㎛ polyamide (PA) double film + non gas treatment, 15 ㎛ PA double film + gas treatment, 25 ㎛ PA film + non gas treatment, or 25 ㎛ PA film + gas treatment. Quality parameters including gas composition, relative humidity, chlorophyll SPAD (Soil Plant Analysis Development) value, firmness, and rate of quality loss in ginseng sprouts were monitored at the following temperatures: 20℃, and 10℃. Ginseng sprouts packaged with 25 ㎛ PA film showed loss in quality because of wilting owing to low relative humidity within the film. Chlorophyll and firmness did not differ between film and gas treatments. The time point at which the combined loss from softening and decay owing to fungal, and bacterial infection and wilt reached 20% was considered the limit of distribution. At 20℃, the packaging not included in the 20% distribution loss rate limit or up to 7 days was 15 ㎛ PA double film + gas treatment. At 10℃, the packaging not included in the 20% distribution loss rate limit for up to 18 days were barrier film + gas treatment and 15 ㎛ PA double film + gas treatment. Conclusions: The film packaging suitable for the distribution of ginseng sprouts was found to be the barrier film and PA film with low gas permeability and maintaining hygroscopicity at 95% relative humidity. To prevent the loss in quality of ginseng sprouts, gas treatment (8% of O2 and 18% of CO2) in the film was found to be more suitable than no gas treatment for inhibition of decay.
Ma, Jong Won;Nguyen, Cong Hieu;Lee, Kyungdo;Heo, Joon
Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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v.34
no.5
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pp.525-534
/
2016
In South Korea, paddy rice has been consumed over the entire region and it is the main source of income for farmers, thus mathematical model for the estimation of rice yield is required for such decision-making processes in agriculture. The objectives of our study are to: (1) develop rice yield estimation model using Convolutional Neural Networks(CNN), (2) choose hyper-parameters for the model which show the best performance and (3) investigate whether CNN model can effectively predict the rice yield by the comparison with the model using Artificial Neural Networks(ANN). Weather and MODIS(The MOderate Resolution Imaging Spectroradiometer) products from April to September in year 2000~2013 were used for the rice yield estimation models and cross-validation was implemented for the accuracy assessment. The CNN and ANN models showed Root Mean Square Error(RMSE) of 36.10kg/10a, 48.61kg/10a based on rice points, respectively and 31.30kg/10a, 39.31kg/10a based on 'Si-Gun-Gu' districts, respectively. The CNN models outperformed ANN models and its possibility of application for the field of rice yield estimation in South Korea was proved.
Journal of the Korean Institute of Intelligent Systems
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v.21
no.6
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pp.749-754
/
2011
In this study, we propose the design of optimized pRBFNNs-based face recognition system using two-dimensional Image and ASM algorithm. usually the existing 2 dimensional face recognition methods have the effects of the scale change of the image, position variation or the backgrounds of an image. In this paper, the face region information obtained from the detected face region is used for the compensation of these defects. In this paper, we use a CCD camera to obtain a picture frame directly. By using histogram equalization method, we can partially enhance the distorted image influenced by natural as well as artificial illumination. AdaBoost algorithm is used for the detection of face image between face and non-face image area. We can butt up personal profile by extracting the both face contour and shape using ASM(Active Shape Model) and then reduce dimension of image data using PCA. The proposed pRBFNNs consists of three functional modules such as the condition part, the conclusion part, and the inference part. In the condition part of fuzzy rules, input space is partitioned with Fuzzy C-Means clustering. In the conclusion part of rules, the connection weight of RBFNNs is represented as three kinds of polynomials such as constant, linear, and quadratic. The essential design parameters (including learning rate, momentum coefficient and fuzzification coefficient) of the networks are optimized by means of Differential Evolution. The proposed pRBFNNs are applied to real-time face image database and then demonstrated from viewpoint of the output performance and recognition rate.
Journal of the Korea Academia-Industrial cooperation Society
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v.12
no.7
/
pp.3109-3116
/
2011
We studied the effects of vibration stimulation method on upper limbs spasticity in patients with brain lesion. 21 patients with spasticity of the upper limbs selected and divided randomly 3 groups. And then vibratory stimulation was applied to the triceps brachii muscle in group I(n=7), to biceps brachii muscle in group II (n=7), and to both muscles in group III (n=7). Using Neuro-EMG_Micro to investigate the changes in spinal neuronal excitability, F-waves were measured at before and directly after stimulation, and 10 minutes later and 20 minutes later after stimulation especially. MAS(Modified Ashworth Scale) test for muscle tone and MFT(Manual Function Test) for the upper extremity motor function were performed before stimulation and 20 minutes later after stimulation for the purpose of clinical evaluation. In our study, MAS was significant decreased in all groups, F wave and F/M ratio parameters were decreased in all groups and more decreased specially in group III. MFT was increased in group II and III, and more increased specially in group III. Vibration stimulation reduced the neuronal excitability of spinal cord and also muscle tone, and improved the motor function of the upper extremity. These results suggested that vibration stimulation giving to both muscles(triceps and biceps brachii muscle) at the same time was more efficiency in reducing the neuronal excitability of spinal cord and improving the motor function of the upper limbs.
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