• 아시안잔디학회지
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• 제10권2호
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• pp.105-115
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• 1996

To find out the mineral cycles of calcium, magnesium and sodium in dynamic grassland cosystems in a steady state condition, this investigation was conducted along the northwest side on Mt. Kwanak. The experimental results may he suromarized on the communities of a Zoysia japonica and a Miscanthus sinesis as follows. As compared with some properties of the surface soils among two semi-natural grasslands, cal- cium (Ca) was greater quantity in a Zoysia japonica, whereas, in a Miscanthus sicensis, sodium (Na)and magnesium (Mg) were greater in Mt. Kwanak. For the case of steady production and release, the ratio of annual mineral production to the amount accumulated on the top of mineral soil in a steady state provides the estimates of release constant k. The release constants of Ca, Mg and Na of the litter were 0.42, 0.25 and 0.29 in the Zoysia japonica grassland, and were 0.41, 0.54 arid 0.62 in the Miscanthus sinensis grassland, respect- ively. The half times of Ca, Mg and Na required for the release or accumulation of the litter on the grassland were 1.65, 2.77 and 2.39 in the Zoysia japonica, and were 1.69, 1.28 and 1.12 in the Miscauthus sinensis, respectively. The increasing order of the turnover parameters of the elements was Ca, Na and Mg in the Zoysia japonica grassland, and was Na, Mg and Ca in the Miscanthus Si nens is grassland. The amounts of annual cycles for Ca, Mg, Na in the grassland ecosystem under the steady-state conditions were 1.29, 0.20 and 0.12 g /m$^2$ in the Zoysia japonica grassland and 3.91, 1.04 and 0.61 g /m$^2$ in the Miscanthus sinensis grassland.

• Asian Pacific Journal of Cancer Prevention
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• 제15권1호
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• pp.291-297
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• 2014

The radioprotective effects of a single administration of kojic acid (KA) against ionizing radiation were evaluated via assessment of 30-day survival and alterations of peripheral blood parameters of adult C57BL/6 male mice. The 30-day survival rate of mice pretreated with KA (75 or 300 mg/kg body weight, KA75 or KA300) subcutaneously 27 h prior to a lethal dose (8 Gy, 153.52 cGy/min) of gamma irradiation was higher than that of mice irradiated alone (40% or 60% vs 0%). It was observed that the white blood cell (WBC) count/the red blood cell (RBC) count, haemoglobin content, haematocrit and platelet count of mice with or without KA pretreatment as exposed to a sub-lethal dose (4 Gy, 148.14 cGy/min) of gamma irradiation decreased maximally at day 4/day 8 post-irradiation. Although the initial WBC values were low in KA300 or WR-2721 (amifostine) groups, they significantly recovered to normal at day 19, whereas in the control group they did not. The results from the cytotoxicity and cell viability assays demonstrated that KA could highly protect Chinese hamster ovary (CHO) cells against ionizing radiation with low toxicity. In summary, KA provides marked radioprotective effects both in vivo and in vitro.

• Journal of Microbiology and Biotechnology
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• 제27권5호
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• pp.956-964
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• 2017

Compactin and pravastatin are competitive cholesterol biosynthesis inhibitors of 3-hydroxy-3-methylglutaryl-CoA reductase and belong to the statin drugs; however, the latter shows superior pharmacokinetic characteristics. Previously, we reported that the bacterial P450, CYP105D7, from Streptomyces avermitilis can catalyze the hydroxylation of 1-deoxypentalenic acid, diclofenac, and naringenin. Here, we demonstrate that CYP105D7 could also catalyze compactin hydroxylation in vitro. In the presence of both bacterial and cyanobacterial redox partner systems with an NADPH regeneration system, the reaction produced two hydroxylated products, including pravastatin (hydroxylated at the C6 position). The steady-state kinetic parameters were measured using the redox partners of putidaredoxin and its reductase. The $k_m$ and $k_{cat}$ values for compactin were $39.1{\pm}8.8{\mu}M$ and $1.12{\pm}0.09min^{-1}$, respectively. The $k_{cat}/K_m$ value for compactin ($0.029min^{-1}{\cdot}{\mu}M^{-1}$) was lower than that for diclofenac ($0.114min^{-1}{\cdot}{\mu}M^{-1}$). Spectroscopic analysis showed that CYP105D7 binds to compactin with a $K_d$ value of $17.5{\pm}3.6{\mu}M$. Molecular docking analysis was performed to build a possible binding model of compactin. Comparisons of different substrates with CYP105D7 were conclusively illustrated for the first time.

• Archives of Pharmacal Research
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• 제20권1호
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• pp.39-45
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• 1997

Changes in glutamatergic nervous activities following intracerebroventricular (icv) administration of ethylcholine aziridinium (AF64A) were studied in rats. The levels of total glutamate, those of glutamate in cerebrospinal fluid (CSF) and in extracellular fluid (ECF) of striatum, the activities of glutamine synthetase (GS), glutaminase and glutamate dehydrogenase (GDH) and the specific binding sites of $[^3H]$MK801 in striatum, hippocampus and frontal cortex were assessed a week after the infusion of AF64A (3 nmol) into lateral ventricle. The levels of total glutamate were significantly decreased in striatum, hippocampus and frontal cortex after AF64A treatment. Although the levels of glutamate in CSF weren't changed after AF64A treatment, the levels of glutamate in ECF of striatum were significantly decreased (62.6%). GS activities in striatum were significantly decreased. But, glutaminase activities in striatum were significantly increased. However, the activities of GS and glutaminase in frontal cortex and hippocampus weren't changed. Although GDH activities in frontal cortex were significantly decreased, those in striatum and hippocampus weren't altered. The striatal densities of $[^3H]$MK 801 binding sites were increased without changes in its affinity. Also, the specific binding sites of $[^3H]$MK801 were increased in frontal cortex but not in hippocampus. These results indicate that the glutamatergic nervous activities were altered with the infusion of AF64A into lateral ventricle. Furthermore, it suggest that the decreased levels of glutamate after AF64A treatment may affect the change in the other parameters of glutamatergic neuronal activities.

• Journal of the Korean Wood Science and Technology
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• 제46권4호
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• pp.355-361
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• 2018

In this study, the dimensional stability and mechanical properties of bamboo fiber-based composites (BFBCs) were studied at two pressing manufacturing processes, i.e., hot- and cold- pressing, and were compared with three density parameters (1.0, 1.1, and $1.2kg/m^3$). Width swelling ratio (WSR), thickness swelling ratio (TSR), and water absorption ratio (WAR) were calculated for water immersions of 4 and 28 h. WSR, TSR, and WAR for specimens immersed for 28 h were higher than those for 4 h treatment, which shows that the immersion time has a significant influence on the dimensional stabilities of BFBCs. Moreover, the positive linear relations between density and dimensional were observed at both the pressing ways, indicating that the WSR, TSR, and WAR decreased with an increase in the density of BFBCs. The compressive strength, shear strength, modulus of rupture (MOR), and modulus of elasticity (MOE) were determined. The compressive strength, MOR, and MOE of hot-pressed specimens were significantly higher than those for the cold-pressed specimens, which are also directly proportional to density. Moreover, the samples with the highest density of $1.2kg/m^3$ performed high values on mechanical properties in both the manufacturing methods.

• Current Optics and Photonics
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• 제2권1호
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• pp.15-22
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• 2018

To measure atmospheric temperature, water vapor, and aerosol simultaneously, an efficient multi-function Raman lidar using an ultraviolet-wavelength laser has been developed. A high-performance spectroscopic box that utilizes multicavity interference filters, mounted sequentially at small angles of incidence, is used to separate the lidar return signals at different wavelengths, and to extract the signals with high efficiency. The external experiments are carried out for simultaneous detection of atmospheric temperature, water vapor, and aerosol extinction coefficient in Beijing, under clear and hazy weather conditions. The vertical profiles of temperature, water vapor, and aerosol extinction coefficient are analyzed. The results show that for an integration time of 5 min and laser energy of 200 mJ, the mean deviation between measurements obtained by lidar and radiosonde is small, and the overall trend is similar. The statistical temperature error for nighttime is below 1 K up to a height of 6.2 km under clear weather conditions, and up to a height of 2.5 km under slightly hazy weather conditions, with 5 min of observation time. An effective range for simultaneous detection of temperature and water vapor of up to 10 km is achieved. The temperature-inversion layer is found in the low troposphere. Continuous observations verify the reliability of Raman lidar to achieve real-time measurement of atmospheric parameters in the troposphere.

• 한국통신학회논문지
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• 제28권9B호
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• pp.823-833
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• 2003

인터넷에서 실시간 서비스를 지원하기 위해서는 큐 관리 및 스케줄링 기법이 고도화되어야 한다. 기존의 큐 관리 기법은 TCP 플로우의 혼잡을 제어하는 기능은 제공하고 있으나 실시간 서비스 지원에는 문제점을 가지고 있다. 즉, 큐가 어느 정도 점유된 이후 계속적인 버스트 성의 트래픽이 발생할 경우 성능이 급격히 떨어지고, 특히 큰 지터 값으로 인해 실시간 전송에 부적절하다. 본 논문에서는 최대 임계값과 큐 가중치 등의 RED 파라미터를 큐 상태에 따라 적응적으로 조정하여 실시간 서비스에 대한 지연 및 지터 성능을 향상시킬 수 있는 상태 의존 RED (SDRED; State Dependent Random Early Detection) 큐 관리 및 동적 스케줄링 기법을 제안한다. 제안한 기법은 큐 상태에 따라 RED의 최대 임계값과 큐 가중치를 네 개의 서로 다른 레벨로 변경하여 트래픽 상황에 적응하도록 설계하였으며, 시뮬레이션을 통하여 SDRED가 평균 큐 크기를 가지는 RED나 평균 큐 크기를 가지지 않고 현재의 큐 크기를 사용하여 흔잡을 제어하는 BLUE, 그리고 RED 게이트웨이의 수율이나 지연 특성을 향상하기 위해 제안된 ARED 및 DSRED에 비해 낮은 지연 값과 안정적인 지터 값을 나타냄을 검증하였다.

• Journal of the Korean Data and Information Science Society
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• 제21권4호
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• pp.641-650
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• 2010

본 연구는 퇴행성 슬관절염 여성 30명을 대상으로 물리치료와 멀리건 도수치료를 병용하여 4주간 실시한 후 운동전, 2주 후, 그리고 4주 후에 통증과 근 기능평가 측정에 미치는 효과에 대해 알아보기 위해 실시하였다. 본 연구의 측정은 시각적 상사 척도 검사, 근력 검사, 근 기능 검사, 그리고 협응력/균형감을 검사하였다. 반복측정자료 분산분석 결과, 물리치료와 멀리건 도수치료를 병용한 실험군에서 중재기간에 따라 효과적 이었으며, 시간과 그룹 간 상호작용도 있었다. 퇴행성 슬관절염의 통증과 근 기능평가를 개선시키기 위해 물리치료와 멀리건 도수치료 병용 시 효과적이란 것을 검증하였다.

• 대한예방한의학회지
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• 제15권3호
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• pp.141-152
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• 2011

Objective : This study was carried out to investigate the acute toxicity and safety of Insampaedok-san and Fermented Insampaedok-san. Methods : SPF ICR male and female mice were administered orally with Insampaedok-san and Fermented Insampaedok-san. of 0(control group), 1,250, 2,500 and 5,000 mg/kg. After single administration, we daily examined number of deaths, clinical signs, gross findings and changes of body weight for 14 days. Hematological parameters and isolated organ weights were determined after 14 days of administration. Results : No dead animal and no significant changes of body weights were found during experimental period. In addition, no differences were found between control and all of treated groups in clinical signs, organ weights, hematology, and other findings. Conclusions : Insampaedok-san and Fermented Insampaedok-san. did not show any toxic effects and oral $LD_{50}$ values of the extracts was over 5,000 mg/kg in ICR mice.

• 대한기계학회논문집B
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• 제41권1호
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• pp.9-19
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• 2017

본 연구에서는 단단 천음속 축류압축기 정익부 슈라우드에 공기분사기를 설치하는 방안을 제시하고 이 것이 공력성능에 미치는 영향을 분석하기 위해 매개변수 연구를 수행하였다. 분사기의 곡률, 폭, 정익 앞전으로부터의 거리, 원주방향 각도 및 공기분사 비율을 변수로 선정하였고, 각 변수의 변화에 따른 공력성능 영향을 분석하기 위해 삼차원 레이놀즈평균 나비어-스톡스 방정식을 사용한 공력해석을 수행하였다. 매개변수 연구 결과, 정익 분사가 적용된 단단 축류압축기의 공력성능이 향상되었고, 공력성능이 공기분사 비율에 민감한 영향을 받는 것이 확인되었다. 원주방향 각도의 비율이 10%일 때 전압력비와 단열 효율이 가장 크게 향상되었다.