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검색결과 901건 처리시간 0.024초

LAB Fermentation Improves Production of Bioactive Compounds and Antioxidant Activity of Withania somnifera Extract and Its Metabolic Signatures as Revealed by LC-MS/MS

  • Yu, Jinhui;Geng, Yun;Xia, Han;Ma, Deyuan;Liu, Chao;Wu, Rina;Wu, Junrui;You, Shengbo;Bi, Yuping
    • Journal of Microbiology and Biotechnology
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    • 제32권4호
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    • pp.473-483
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    • 2022
  • In this study we investigated the effect of lactic acid bacteria (LAB) fermentation on the ingredients and anti-oxidant activity of Withania somnifera extract. Four strains of LAB could proliferate normally in medium containing W. somnifera extract after the pH reached 3.1~3.5. LAB fermentation increased the content of alcohols and ketones, endowing the extract with the characteristic aroma of fermentation. Compared to the control, the DPPH and ABTS free radical scavenging rates in the fermented samples were significantly improved, ranging from 48.5% to 59.6% and 1.2% to 6.4%. The content of total phenols was significantly increased by 36.1% during the fermentation of mixed bacteria. Moreover, the original composition spectrum of the extract was significantly changed while the differentially accumulated metabolites (DAMs) were closely related to bile secretion, tryptophan metabolism and purine metabolism. Therefore, LAB fermentation can be used as a promising way to improve the flavor and bioactivity of the extracts of W. somnifera, making the ferments more attractive for use as functional food.

Investigating the acceptance of the reopening Bataan nuclear power plant: Integrating protection motivation theory and extended theory of planned behavior

  • Ong, Ardvin Kester S.;Prasetyo, Yogi Tri;Salazar, Jose Ma Luis D.;Erfe, Justine Jacob C.;Abella, Arving A.;Young, Michael Nayat;Chuenyindee, Thanatorn;Nadlifatin, Reny;Redi, Anak Agung Ngurah Perwira
    • Nuclear Engineering and Technology
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    • 제54권3호
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    • pp.1115-1125
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    • 2022
  • Nuclear power plant (NPP) is currently considered as one of the most reliable power sources. However, 182 of them are considered decommissioned and inactive including the one in Bataan, Philippines. The aim of this study was to investigate the acceptance of the reopening of Bataan Nuclear Power Plant (BNPP) by integrating the Theory of Planned Behavior and Protection Motivation Theory. A total of 815 Filipinos answered an online questionnaire which consisted of 37 questions. The Structural Equation Modeling (SEM) indicated that knowledge towards nuclear power plants was the key factor in determining people's acceptance towards NPP reopening. In addition, knowing the benefits would lead to positive perceived behavioral control (PBC) and attitude towards intention. Results showed that PBC and attitude are mediators towards the acceptance of people regarding the reopening of BNPP. If an individual's knowledge gravitates towards the perceived risk, then this can lead to the negative acceptance of the NPP reopening. On the other hand, if an individual's knowledge gravitates towards the perceived benefits, then this will lead to positive acceptance. This study is the first study that explored the acceptance of the reopening BNPP. Finally, the study's model construct would also be very beneficial for researchers, government, and even private sectors worldwide.

치매안심센터 간호사의 업무 중요도와 수행도에 대한 연구 (A Study on the Work Importance and Work Performance of Nurses in the Dementia Relief Center)

  • 장현정;마예원;박혜선;임선영
    • 대한통합의학회지
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    • 제10권2호
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    • pp.187-202
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    • 2022
  • Purpose : This study is a descriptive research study to establish basic data for stable operation of dementia relief center as a part of national responsibility system for dementia and to establish the role of the professional workforce. Methods : This study is a survey study involving 126 nurses working at 19 dementia relief centers. The collected data were analyzed using the SPSS/WIN 23.0. Results : The importance tasks that nurses think of were Dementia Diagnosis, Counseling, Register and Classification and Dementia Preventive Projects. In addition, tasks that showed high performance were in the order of Dementia Diagnosis, Counseling, Register and Classification, Management of Dementia subjects. As a result, the final items of work areas and contents included 45 subcategories of work content for eight work areas. Conclusion : Through this study, it was possible to investigate the overall work area and content of nurses at the Dementia relief Center. It is necessary to develop a work description suitable for nurses who are medical personnel specializing in dementia safety centers. It is necessary to develop a work description suitable for nurses who are medical personnel specializing in dementia safety centers. In connection with the purpose of establishing the centers for disease control and prevention, it is necessary to operate a systematic and continuous program to manage dementia patients and those with mild cognitive impairment in the community.

Effects of maternal dietary energy restriction on laying performance, embryonic development, and lipid metabolism in broilers

  • Sun, Hao;Chen, Zhihui;Ma, Chengzhan;Lian, Lina;Zhao, Zeyu;Niu, Shupeng;Xu, Liangmei;Sun, Jinhua
    • Animal Bioscience
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    • 제35권5호
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    • pp.698-710
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    • 2022
  • Objective: The objective of this study was to investigate the effects of different degrees of maternal dietary energy restriction on lipid deposition in embryonic tissues during the medium laying period (37 to 39 weeks) in Arbor Acres (AA) broiler breeders. Methods: A single factor design was adopted, and 400 AA broiler breeders (20 weeks of age) with a similar weight were randomly allocated into four groups. The birds in the control group were fed a corn-soybean meal based diet, and those in trial groups were fed diets with 80%, 70%, and 50% energy levels of the basal diet. Incubated eggs from the medium laying period were collected. Samples of developing embryos at various stages were prepared for composition analysis. Results: The embryo weight in the 80% energy group was higher than those of the other groups on embryonic day (E) 13, but at 21 E, they were significantly decreased with decreasing energy intake of the broiler breeders (p<0.05). Additionally, the levels of crude fat in tissues in the restriction groups were significantly decreased (p<0.05). The long axis and area of adipocytes in breast muscle, thigh muscle and the liver were significantly decreased (p<0.05) at 21 E in the 80%, 70%, and 50% energy groups. Conclusion: The effects of the 80% maternal dietary energy restriction energy affects egg production performance, egg quality, and nutrient deposition in egg weights, which then directly impacts on the developmental process of embryos, especially on fat utilization and deposition.

ICR 마우스를 이용한 발효삼출건비탕의 단회투여 독성에 대한 연구 (Single Oral Dose Toxicity Test of Fermented Samchulgeonbi-tang Extract in ICR mice)

  • 정영필;임남희;김애영;황윤환;박화용;마진열
    • 대한본초학회지
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    • 제28권2호
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    • pp.61-65
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    • 2013
  • Objectives : Samchulgeonbi-tang (shenzhujianpi-tang) has been prescribed as one of traditional herbal medicine for treatment of stomach diseases since ancient time in Korea. Samchulgeonbi-tang extract was fermented by Lactobacillus spp. for improving the effect. However, the toxicity and safety of fermented Samchulgeonbi-tang (FS) extract were not confirmed. Therefore, this study was performed to evaluate the acute toxicity and safety of FS extract. Methods : To evaluate the acute toxicity and safety of FS extract, several doses of FS extract, 0, 500, 1000 and 2000 mg/kg, were orally administered to 20 male and 20 female ICR mice, respectively. After treatment with FS extract, we observed mortality, general toxicity, behavior and change of body weight for the 14 days. After 14 days of oral administration, all mice were sacrificed and hematological parameters were analyzed from blood serum. Results : In present study, the toxic signs such as mortality or abnormal behaviors by FS extract were not observed. There are no significant differences between FS-treated group and control group in body weight, organ weights, and hematological parameters. Conclusions : The remarkable adverse effects by FS extract were not observed in ICR mice. Also, any death was not occurred at all treated FS doses, 500, 1000 and 2000 mg/kg. Therefore, the approximate lethal dose (ALD) of FS extract may be more than 2000 mg/kg.

Efficient Visual Place Recognition by Adaptive CNN Landmark Matching

  • Chen, Yutian;Gan, Wenyan;Zhu, Yi;Tian, Hui;Wang, Cong;Ma, Wenfeng;Li, Yunbo;Wang, Dong;He, Jixian
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • 제15권11호
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    • pp.4084-4104
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    • 2021
  • Visual place recognition (VPR) is a fundamental yet challenging task of mobile robot navigation and localization. The existing VPR methods are usually based on some pairwise similarity of image descriptors, so they are sensitive to visual appearance change and also computationally expensive. This paper proposes a simple yet effective four-step method that achieves adaptive convolutional neural network (CNN) landmark matching for VPR. First, based on the features extracted from existing CNN models, the regions with higher significance scores are selected as landmarks. Then, according to the coordinate positions of potential landmarks, landmark matching is improved by removing mismatched landmark pairs. Finally, considering the significance scores obtained in the first step, robust image retrieval is performed based on adaptive landmark matching, and it gives more weight to the landmark matching pairs with higher significance scores. To verify the efficiency and robustness of the proposed method, evaluations are conducted on standard benchmark datasets. The experimental results indicate that the proposed method reduces the feature representation space of place images by more than 75% with negligible loss in recognition precision. Also, it achieves a fast matching speed in similarity calculation, satisfying the real-time requirement.

Assessment of dietary quality and nutrient intake of obese children in Changwon area

  • Ji-Sook Park;Ha-Neul Choi;Jae-Young Kim;Sang-Hyuk Ma;Jung-Eun Yim
    • Journal of Nutrition and Health
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    • 제55권6호
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    • pp.630-641
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    • 2022
  • Purpose: In this study, we assessed the intake of nutrients and food groups and analyzed the nutrition quotient of obese children in South Korea. The hypothesis was that dietary quality and nutrient intake are related to the body mass index (BMI) of obese children. Methods: The participants included 48 children (20 boys and 28 girls). Based on the guidelines for the age-for-body mass index provided by the Korean National Growth Charts for children and adolescents, the participants were divided into 3 groups: overweight, BMI ≥ 85th percentile; obese, BMI ≥ 95th percentile; severely obese, BMI ≥ 99th percentile. Results: The energy distribution showed that the carbohydrate ratio was significantly higher in the overweight group (p < 0.01), whereas the fat ratio was significantly higher in the obese and severely obese groups (p < 0.05). Thus, in the overweight and obese groups, the percent body fat was negatively associated with the carbohydrate ratio (p < 0.05) but was positively associated with the fat ratio (p < 0.05). The Dietary Reference Intakes (DRI) data revealed that the intake levels of protein, vitamin B1, vitamin B12, and sodium were higher in all groups. Intakes of fiber, calcium, potassium, and magnesium were insufficient in all groups, and the DRI percent for protein was significantly higher in the obese and severely obese groups than in the overweight group. No significant differences were obtained in food group patterns or Nutrition Quotient (NQ) scores among the 3 groups. According to the evaluation results by food record and NQ, a significant difference was obtained in the dietary quality of obese children. Conclusion: We conclude that a higher intake of fat enhances weight gain. Based on the study results, we propose that the guidelines should consider the energy distribution of carbohydrate and fat intake to prevent and control obesity among Korean children.

Healthy eating-out options are related to healthy eating intention in adults residing in Daqing (China)

  • Xiaoyu Ma;Seungwoo Lee;Ji-Yun Hwang
    • Journal of Nutrition and Health
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    • 제56권1호
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    • pp.112-121
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    • 2023
  • Purpose: Eating behaviors are influenced by food environments, such as availability and/or accessibility of healthy food options. In this study, we examined the relationship between healthy eating-out options and the intention to eat healthily in adults residing in Daqing, China, using an extended theory of planned behavior (TPB). Methods: Data were collected via an online survey conducted from April to May 2021 using a previously validated questionnaire in Daqing. A total number of 308 subjects aged 18-64, either Daqing oilfield workers or their family members were eligible and finally included in the analysis. The relationships among the attributes and the quality of healthy eating-out options, the three major constructs of TPB, and the intentions of healthy eating were examined using multiple linear regression analyses. Results: Subjective norms (p = 0.049) and perceived behavioral control (PBC) (p = 0.000) were significantly related to the healthy eating intention. The quality and attributes of the food served statistically significantly explained the intention to eat healthily. After controlling for age, sex, and body mass index, not the quality but the attributes of food served (p = 0.037), subjective norms (p = 0.016), and PBC (p = 0.000) had a significant relationship with the intention to eat healthily. The model explained 83.7% of the variance. Conclusion: The healthy eating-out choices, along with subjective norms and PBC of TPB, may be a potential determinant of healthy eating intention among Chinese adults living in Daqing, China. Policy implications have highlighted that not only the personal intention to eat healthy foods, but also the available healthy food environment may be important for the choice of healthy options by the population of interest. Therefore, building an environment for healthy eating choices and campaigns aimed at increasing consumer awareness of healthy eating are equally important for a smart eating choice.

Effects of a Modified Six-Sigma-Methodology-Based Training Program on Core Competencies in Rehabilitation Nurse Specialists

  • Gu, Jiayi;Luo, Lan;Li, Chengjuan;Ma, Sumin;Gong, Fanghua
    • 대한간호학회지
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    • 제53권4호
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    • pp.412-425
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    • 2023
  • Purpose: Nurses play an important role in ensuring patient rehabilitation and are involved in all aspects of multidimensional rehabilitation. Therefore, strengthening rehabilitation nursing education is vital to ascertain high-quality rehabilitation and optimum outcomes. This study examined the effectiveness of a new teaching reform-a modified Six-Sigma-based training program-against a conventional educational program on rehabilitation specialist nurses' core competencies, post-training performance, and satisfaction. Methods: A quasi-randomized controlled trial was conducted to assess the effectiveness of the modified training program. We recruited 56 learners from the 2020 training course at the Hunan Rehabilitation Specialist Nurse Training Base as the control group. Sixty learners from the base's 2021 training course were recruited as the intervention group. Data were collected in a consistent manner from both groups after the training program was implemented. Results: Those who underwent the modified training program showed better improvement in all core competencies than those who underwent the conventional training program (p < .05); the scores for theoretical knowledge, clinical nursing lectures, reviews, and nursing case management improved significantly following the teaching reform (p < 0.05). Further, overall satisfaction as well as base management and theoretical teaching satisfaction improved significantly (p < .05). Conclusion: The modified training program strengthens rehabilitation nurses' base management abilities; enhances their core competencies; expands their interest in and breadth, depth, and practicability of theoretical courses; and updates the teaching methods.

Study of oxidation behavior and tensile properties of candidate superalloys in the air ingress simulation scenario

  • Bin Du;Haoxiang Li;Wei Zheng;Xuedong He;Tao Ma;Huaqiang Yin
    • Nuclear Engineering and Technology
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    • 제55권1호
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    • pp.71-79
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    • 2023
  • Air ingress incidents are major safety accidents in very-high-temperature reactors (VHTRs). Air containing a high volume fraction of oxygen may cause severe oxidation of core components at the VHTR, especially for the significantly thin alloy tube wall in the intermediate heat exchanger (IHE). The research objects of this study are Inconel 617 and Incoloy 800H, two candidate alloys for IHE in VHTR. The air ingress accident scenario is simulated with high-temperature air flow at 950 ℃. A continuous oxide scale was formed on the surfaces of both the alloys after the experiment. Because the oxide scale of Inconel 617 has a loose structure, whereas that of Incoloy 800H is denser, Inconel 617 exhibited significantly more severe internal oxidation than Incoloy 800H. Further, Inconel 617 showed a significant decrease in ultimate tensile strength and plasticity after aging for 200 h, whereas Incoloy 800H maintained its tensile properties satisfactorily. Through control experiment under vacuum, we preliminarily concluded that serious internal oxidation is the primary reason for the decline in the tensile properties of Inconel 617.