• International journal of thyroidology
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• v.11 no.2
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• pp.152-159
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• 2018

Background and Objectives: Sodium-iodine symporter (NIS) is a marker for the degree of differentiation in thyroid cancer. The genetic factors or microenvironment surrounding tumors can affect transcription of NIS. In this study, we investigated the NIS mRNA expression according to mutational status and coexistent lymphocytic thyroiditis in papillary thyroid cancer (PTC). Materials and Methods: The RNA expression levels of NIS in the samples from database of The Caner Genome Atlas (TCGA; n=494) and our institute (n=125) were analyzed. Results: The PTCs with the $BRAF^{V600E}$ mutation and the coexistence of $BRAF^{V600E}$ and TERT promoter mutations showed significantly lower expression of NIS (p<0.001, respectively), and those with BRAF-like molecular subtype also had reduced expression of NIS (p<0.001). NIS expression showed a positive correlation with thyroid differentiation score (r=0.593, p<0.001) and negative correlations with expressions of genes involved in ERK signaling (r=-0.164, p<0.001) and GLUT-1 gene (r=-0.204, p<0.001). The PTCs with lymphocytic thyroiditis showed significantly higher NIS expression (p=0.013), regardless of mutational status. Conclusion: The NIS expression was reduced by the $BRAF^{V600E}$ mutation and MAPK/ERK pathway activation, but restored by the presence of lymphocytic thyroiditis.

• Mass Spectrometry Letters
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• v.13 no.4
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• pp.152-157
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• 2022

Schisandra chinensis and its fruits have been used as a traditional herbal medicine to treat liver dysfunction, fatigue, and chronic coughs. Several in vitro and in vivo studies suggested that dibenzocyclooctadiene lignans present in Schisandra fruits strongly inhibit CYP3A4 activity. However, reports on the inhibitory potential of dietary Schisandra supplements against CYP3A activity are limited despite their increasing consumption as dietary supplements. In this study, we evaluated the CYP3A-inhibitory potential of four dietary Schisandra supplements in human liver microsomes. At a concentration of 0.05 mg/mL, Schisandra supplements from Nature's Way, Swanson, Planetary Herbals, and Only Natural inhibited CYP3A activity by 93.9, 70.8, 33.6, and 24.8%, respectively. Nature's Way, which exhibited the strongest inhibition against CYP3A, had the highest contents of gomisin B and gomisin C, which potently inhibit CYP3A activity. The in vivo pharmacokinetics of this product should be examined to determine whether the clinical relevance of inhibiting CYP3A activity by dietary Schisandra supplementation.

• Proceedings of the Korea Information Processing Society Conference
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• 2011.04a
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• pp.152-155
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• 2011

최근 사회생활의 다변화로 인한 개인의 질환을 예방하고 건강을 증진시키기 위한 개인 웰니스 관리는 현대 사회의 성인에게는 필수적인 자기 관리에 해당된다. 본 논문는 이러한 웰니스 관리에 적절한 상황 모델로써 상황 데이터를 추론할 수 있는 SWRL 상황규칙과 불확실성을 표현한 베이지안 네트워크를 포함한 통합 온톨로지 기반 상황모델을 제시하였다. 제안한 상황모델에 포함된 추론 규칙은 웰니스 관리에 필요한 상황 서비스를 수행하는 액션들을 정의한다. 즉 상황 온톨로지에 SWRL 규칙을 포함함으로써 주로 웹 시멘틱에 사용되고 있는 OWL 언어를 상황인식 분야의 지식 베이스 구축에도 적합하도록 하였다. 그리고 웰니스 관리를 위해 상황 온톨로지로 표현되는 원시 상황 데이터는 센서 부정확성, 또는 개인 판단기준 차이로 인해 불확실성을 포함하므로, 어떤 논리적 상황 데이터는 불확실성을 고려하여 추론되어야 하기 때문에 본 논문은 상황 온톨로지 및 SWRL 규칙과 함께 베이지안 네트워크를 함께 표현할 수 있게 하여 OWL 상황 온톨로지 기반 규칙 추론뿐만 아니라 확률 추론을 용이하게 하였다.

• Proceedings of the Korea Information Processing Society Conference
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• 2021.11a
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• pp.152-155
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• 2021

최근 많은 이슈가 되고 있는 제 4 차 산업혁명 기술을 건설 분야에 적용하여 다양한 형태의 센서를 활용한 IoT 의 활용가치를 높이고 근로자의 위험사항을 사전에 예방함과 동시에 건설현장에서 IoT 기반 스마트 건설안전시스템 전호구축을 위한 아키텍처를 개발하는 것을 목적으로 하고 있다. 이를 위해 IoT 의 개념을 살펴보고, 현장 안전관리 프로세스를 근로자 편리성을 감안한 아키텍처로 전환연구를 하고자 한다. IoT 기반 스마트 건설안전시스템 구축을 위해서 활용 가능한 위험지역을 도식화하고, 적용 가능한 영역을 파악하였고, 다양한 사전예측분석 알고리즘을 활용하여 안전사고 예방에 관한 사전예측 유형을 분석하였다. 이를 바탕으로 위험지역에 대한 근로자의 동선을 파악한 후 위험지역에 사전정보 제공을 통한 건설현장의 IoT 기반 스마트 건설안전시스템을 전환해서 재해율 감소에 기여하고자 한다.

• Journal of Sensor Science and Technology
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• v.33 no.3
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• pp.152-157
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• 2024

In this study, we propose a novel 8T ternary SRAM that can process three logic values (0, 1, and 2) with only two additional transistors, compared with the conventional 6T binary SRAM. The circuit structure consists of positive and negative ternary inverters (PTI and NTI, respectively) with carbon-nanotube field-effect transistors, replacing conventional cross-coupled inverters. In logic '0' or '2,' the proposed SRAM cell operates the same way as conventional binary SRAM. For logic '1,' it works differently as storage nodes on each side retain voltages of V_DD/2 and V_DD, respectively, using the subthreshold current of two additional transistors. By applying the ternary system, the data capacity increases exponentially as the number of cells increases compared with the 6T binary SRAM, and the proposed design has an 18.87% data density improvement. In addition, the Synopsys HSPICE simulation validates the reduction in static power consumption by 71.4% in the array system. In addition, the static noise margins are above 222 mV, ensuring the stability of the cell operation when V_DD is set to 0.9 V.

• Parasites, Hosts and Diseases
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• v.54 no.1
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• pp.113-118
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• 2016

Hydatidosis has become a real concern for health care institutions and animal rearers in Tunisia. The Tunisian endemicity is aggravated by the growing number of dogs and the difficulty of getting rid of contaminated viscera because of the lack of equipment in most slaughterhouses. Therefore, microscopic and molecular tools were applied to evaluate the role of slaughterhouses in canine infection and Echinococcus granulosus sensu lato (s. l.) egg dissemination. Exposure risk to E. granulosus s. l. eggs in urban and rural areas was explored in order to implant preventive and adapted control strategies. Microscopic examinations detected taeniid eggs in 152 amongst 553 fecal samples. The copro-PCR demonstrated that 138 of 152 taeniid samples analyzed were positive for E. granulosus s. l. DNA. PCR-RFLP demonstrated that all isolated samples belonged to E. granulosus sensu stricto (s. s.). An important environmental contamination index (25.0%) by E. granulosus s. l. eggs was demonstrated. The average contamination index from the regions around slaughterhouses (23.3%; 95% CI: 17.7-28.9%) was in the same range as detected in areas located far from slaughterhouses (26.0%, 95% CI: 21.3-30.8%). Echinococcosis endemic areas were extended in both rural (29.9%, 95% CI: 24.8-34.9%) and urban locations (18.1%, 95% CI: 13.0-22.9%). The pathogen dissemination is related neither to the presence/absence of slaughterhouses nor to the location in urban or rural areas, but is probably influenced by human activities (home slaughtering) and behavior towards the infected viscera.

• Journal of Powder Materials
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• v.15 no.5
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• pp.399-404
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• 2008

Spray pyrolysis was applied to prepare $M_{3}MgSi_{2}O_{8}:Eu^{2+}$ (M=Ca, Sr, Ba) blue phosphor powder. The library of a Ca-Sr-Ba ternary system was obtained by a combinatorial method combined with the spray pyrolysis in order to optimize the luminescent property under vacuum ultraviolet (VUV) excitation. 10 potential compositions were chosen from the first screening. The emission shifted to longer wavelength as Ca became a dominant element and the emission intensity was greatly reduced in the composition region at which Ba is dominant element. On the base of the first screening result, the second fine tuning was carried out in order to optimize the luminescence intensity under VUV excitation. The optimal composition for the highest luminescence intensity was $(Ca_{1.7},\;Sr_{0.3},\;Ba_{1.0})Si_{2}O_{8}:Eu^{2+}$ which had the color coordinate of (0.152, 0.072) and about 64% emission intensity of $BaMgAl_{10}O_{17}$ (BAM) phosphor.

• Bulletin of the Korean Chemical Society
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• v.32 no.5
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• pp.1593-1598
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• 2011

Blue fluorescent materials based on 9,9'-diethyl-2-diphenylaminofluorene derivatives were synthesized and characterized. These materials were used as the blue dopant materials for the emitting layer of organic light-emitting diode devices with the following device structure: ITO/DNTPD (40 nm)/NPB (20 nm)/MADN: dopants (2%, 20 nm)/$Alq_3$ (40 nm)/Liq (1.0 nm)/Al. All devices exhibited highly efficient blue emission. One of these devices exhibited a maximum luminance, luminous efficiency, power efficiency and CIE x, y coordinates of 8400 $cd/m^2$, 8.10 cd/A at 20 $mA/cm^2$, 3.36 lm/W at 20 $mA/cm^2$ and (0.151, 0.159), respectively. A deep blue device with CIE coordinates of (0.152, 0.139) showed the maximum luminance, luminous efficiency and power efficiency of 8630 $cd/m^2$, 6.31 cd/A at 20$mA/cm^2$ and 2.62 lm/W at 20 $mA/cm^2$, respectively.

• Korean Journal of Microbiology
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• v.42 no.2
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• pp.149-152
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• 2006

The sp%pl null mutant was constructed to study the function of fission yeast Schizosaccharomyces pombe spThp1, which is homologous to budding yeast Saccharomyces cerevisiae THP1. Tetrad analysis showed that the spThp1 is not essential for vegetative growth. The spThp1 null mutant also showed no massive poly(A)+ RNA export defect. However, spThp1 null is genetically associated with spMex67 null. These results suggest that spThp1 is involved in mRNA export out of the nucleus.

• Journal of the Korean Crystal Growth and Crystal Technology
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• v.14 no.6
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• pp.267-271
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• 2004

Lithium cobalt oxide $(LiCoO_2)$ cathode powders for rechargeable battery have been successfully prepared using urea hydrolysis method. The obtained hydrolysis-derived precursors with different Li/Co molar ratio were calcined at various temperatures. Low temperature phase $(LT-LiCoO_2)$ and high temperature phase $(HT-LiCoO_2)$ were obtained after calcination at $500^{\circ}C$ for 2 hr, and phase transformation from $LT-LiCoO_2{\;}to{\;}HT-LiCoO_2$ was completely occurred over $700^{\circ}C$. The layered structure of $LiCoO_2$ was well developed with a rise in the calcination temperature. Charge-discharge test show that the lithium cobalt oxide with 1.2 molar ratio prepared at $800^{\circ}C$ has an initial discharge capacity as high as 152 mAh/g, and the relatively stable cycling characteristic with 9.2 % of capacity fading was obtained after 40th charge-discharge test.