• Bulletin of the Korean Chemical Society
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• v.27 no.10
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• pp.1531-1536
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• 2006

Microsomal prostaglandin $E_2$ synthase (mPGES-1) is an enzyme that is associated with inflammation, pain, fever and cancer. Hologram quantitative structure activity relationship (HQSAR) was conducted on the series of MK-886 compounds acting as mPGES-1 inhibitors. A training set with 24 compounds was used to establish the HQSAR model. The best model was chosen based on the cross-validated correlation coefficient ($q^2$=0.884) and the correlation coefficient($r^2$=0.976). The model was utilized to predict the activity of the eight-test set of compounds giving the predictive $r^2$ value of 0.845. The descriptors of the model are based on fragment distinction (atoms, bond and connectivity) and fragment size (2-5 atoms). The atomic contribution maps generated from HQSAR were useful in identifying the important structural features responsible for the inhibitory activity of MK-886 inhibitors. Based on the generated model, the presence of hydrophobic biphenyl group seems to enhance inhibition of mPGES-1 that is in agreement with the previous experiments. In addition, it seems important for a halogen to be substituted to the biphenyl ring and for an acyl group to be attached to the indole moiety for enhanced activity.

• Korean Journal of Environmental Agriculture
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• v.10 no.1
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• pp.67-75
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• 1991

The QUAL-II E Model was applied to predict the water quality of the Mankyong drainage System, and lead to following conclusion. 1. The difference between computed and measured BOD at the M-3 (Bakgugeong) station was within 10%, indicating that the application of the QUAL-IIE Model for the prediction of water quality was satisfactory thus far. 2. The application of the model states that the discharge of concentrated pollutants at the M-1 station on the Jeonju stream, located 41Km upstream from the estuary, causes the worst problems. The sluice which extends residence time and enlarges watery surface improves water quality by a Self-purification process at the M-3 station, 28km upstream from the estuary. 3. The accuracy of the model diminished when this model was applied on the estuary downstream of the sluice. Hence, the application of the model on the estuary needs to be used with caution. 4. Among the conputed water quality parameters, BOD is the worst problem. At the M-3 station, BOD is computed to be 26.6 mg/1 in 1996, 30.7 mg/1 in 2,001, 33.0 mg/l in 2006, and 37.5 mg/1 in 2011. When preventive measures against water pollution are not properly exercised, severe problems in irrigation and water resources are expected. This study will be of used in the selection of irrigation water intake points, the criteria of effluent treatment, the management of water resources, and the establishment of water quality managemont policy.

• Journal of Plant Biology
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• v.21 no.1_4
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• pp.33-38
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• 1978

Phosphate absorption from a Na2H32PO4 solution by Oryza sativa L. was studied in order to elucidate kinetic mechanisms of ion transport. The rates of phosphate absorption from different concentraitons indicated the presence of dual mechanisms in root tips, one in the low (1$\times$10-6 to 8$\times$10-5M) and the other in the high (1$\times$10-4 to 8$\times$10-3M). A phosphate compensation point of phosphate transport was revealed with a 1$\times$10-6M solution of Na2H32PO4. The kinetic model that ion transport involves an exchange reaction of absorption and desorptin is prosposed as follows: where C represents an ionic-specific organic carrier in the membrane; M, Mo and Mi are the mineral ions, M-outside and M-inside; MC is a carrier-ion complex; and the K's represent rate constants. In this model, the Mi velocity, v, is given by: {{{{v= {dMi} over {dt}= {(K1K3Mo-K2K4Mi) Ct} over {(K2＋K3)＋K1Mo＋K4Mi} }} where Ct is equal to C＋MC, and t is time.

• Korean Journal of Optics and Photonics
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• v.11 no.3
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• pp.171-178
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• 2000

We present a numerical model which enables to analyze $1.47mu$m amplification band characteristics for thulium doped fluoride fiber amplifiers. We focused on upconversion pumping scheme, thus many transitions affecting $1.47mu$m band amplification was considered simultaneously. Backward propagating waves and transverse mode were also considered in the model. The parameters for modeling were then acquired using published experimental data and related theories such as Judd-Ofelt theory for radiative transition, empirical energy gap law for non-radiative transition, and McCumber relations for cross-sections. The simulation showed well-matched results with experiment and internal dynamics. amics.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.18 no.1
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• pp.8-14
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• 1985

A circulation water channel with observational section of $4m{\times}2.4m{\times}1m(length{\times}breadth{\times}depth)$ and the maximum channel flow speed of 2 m/sec was designed for model tests of fishing gears. It consists of 6 sections evenly divided for easy connection. Two observational acryl windows of $1.2m{\times}1.5m$ and 2cm thick are provided. Steel deflection plates, equally spaced in 20-40cm, are fixed at corners of the channel to reduce the loss of water pressure head through the channel. The flow in the channel is controlled by D.C. motor control system with 50 H.P. driving propeller system. A series of model testing capabilities for fishing gear have been examined and the results are as follows. 1) The speed of water flow was in the range from zero to 2.3 m/sec. 2) The difference between the velocity of channel flow along the center line and that along both sides in the channel was less than 0.2 m/sec.

• Journal of Environmental Impact Assessment
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• v.9 no.3
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• pp.249-255
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• 2000

The comparison of three different kind of simulation by screen3 model, Tem-8 model and EPA formula were undertaken to get a potential concentration and hourly maximum concentration of fugitive dust produced from each construction site in the downtown area of puchon city. The amount of dust estimate U.S EPA formula and fugitive dust formula 22.6078g/sec, 27.9572g/sec respectively. Hourly maximum concenstration at the distance from each construction site by screen3 model are average of $78.89{\sim}728.40{\mu}g/m^3$ and Tem-8 model are $97{\mu}g/m^3$ in site-1, $241{\mu}g/m^3$ in site-2, $268{\mu}g/m^3$ in site-3, $232{\mu}g/m^3$ in site-4, $69{\mu}g/m^3$ in site-5, $36{\mu}g/m^3$ in site-6. Through our experiment, Screen3 model is more encouragingly used than any other model.

• Korean Journal of Food Science and Technology
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• v.20 no.3
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• pp.310-316
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• 1988

The gelatinized model food system were prepared by combining moisture, starch and protein, and the textural properties of their gels of different temperatures and times of heating were investigated by the use of Instron Universal Testing Machine. The hardness, springiness, cohesiveness, gumminess and chewiness of model foods had a high correlation with solid content and the regression equations between the hardness of model foods and moisture content heated for 20min. at $80{\circ}C$ were as follows; $H(PS_4)=18.6405-3.8201M+0.1959M^2,\;H(P_1S_1)=244.7933-5.692M+0.0332M^2,\;H(P_4S)=693.0292-16.6884M+0.1005M^2$, The correlation coefficients were $0.996^{**},\;0.998^{**}\;and\;0.998^{**}$, respectively. Total correlations between textural parameters and temperature and heating times were different according to model foods. The correlation between textural parameters was proportional to protein foods, but the hardness and cohesiveness of starch foods showed the relationship of inverse proportion. Under low solid content, the parameters of model foods appeared to decrease as protein content increased. Under high solid content, the parameters of protein foods were higher than those of starch foods above some level of protein content. The regression equation between the hardness and protein content heated for 20min. at $80^{\circ}C$ was as follows; Hardness(20%)=5.6858-13.5670P+$9.7758P^2$ and the correlation coefficient was $0.95^{**}$.

• Toxicological Research
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• v.12 no.2
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• pp.271-275
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• 1996

Carcinogenic potential of HPV-16 DNA and NNK in a human keratinocyte cell line was assessed to study effects of viral-chemical interaction. Human cells were transfected with HPV-16 DNA and 6 clonal cell lines were subsequently obtained. Clonal line-3 and 6 at passage 7 showed characteristics of tumor cells such as increases of saturation density, soft-agar colony formation, cell aggregation and foci appearance. Among cells treated with 1$\mu M$, 10$\mu M$, 100$\mu M$ or 1 mM of NNK for 4 weeks, 100$\mu M$ treatment showed most tumorigenic characteristics at passage 7. These results indicate that either HPV-16 or NNK alone is tumorigenic in this in human in vitro model. When cells transfected with HPV-16 were subsequently exposed by 100 uM NNK for 4 weeks, all the clonal cells except clone-1 showed higher levels of tumor cell characteristics than HPV-16 DNA or NNK exposure alone. Clonal line-6, the most tumorigenic cells, showed higher transcriptional level of fibronectin and lower level of TGF-$\beta_1$, as compared to control cells, suggesting that alteration of growth factor or extracellular matrix may play a role in carcinogenesis process induced by HPV-16 and NNK. Taken together, the present study indicates that viral-chemical interactions between HPV-16 DNA and NNK enhance carcinogenic potentials of human cells and implies that smoking among people infected with human papillomavirus may pose an additional risk of causing cancer.

• Journal of the Korean Magnetics Society
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• v.21 no.1
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• pp.15-22
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• 2011

It is necessary to describe the hysteresis characteristics of magnetic material precisely for the analysis or design of system with ferromagnetic materials. Although Preisach model is regarded as the most accurate method to describe the hysteresis characteristics, it is not widely applied to the real systems because of some difficulties. The conventional Preisach model shows the numerical instabilities during the iterative computations because the density distribution obtained from the sets of M-H curves are strongly localized. To remove such numerical instabilities, M-B instead of M-H is adopted as an implementation variable in normal Preisach modeling. The two dimensional computations with hysteresis characteristics by using normal Preisach modeling are tested and the result showed that the modeling by using M-B variables showed better stabilities than M-H variables.

• KEPCO Journal on Electric Power and Energy
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• v.6 no.1
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• pp.29-33
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• 2020

Despite the same system architecture and operation principle, Advanced Metering Infrastructure (AMI) and Internet of Things (IoT) are recognized as a heterogeneous system. This is due to the different object modeling and communication protocols used in smart meters and sensors. However, data interworking between AMI and IoT is expected to be inevitable in the future. In this paper, we propose Device Language Message Specification (DLMS) to Lightweight Machine to Machine (LwM2M) conversion model. The proposed interworking model can reduce the packet size by 46.5% compared to that of the encapsulation method.