• Journal of Korean Academy of Fundamentals of Nursing
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• v.6 no.3
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• pp.464-476
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• 1999

This study was conducted between October 1, 1998, and December 31, 1998, in order to provide basic data to develop better self-management educational programs for systemic lupus erythematosus (lupus) patients. In the study, the extent of each patients knowledge on the disease and their learning needs about it were examined for 100 lupus inpatients and outpatients at the Kangnam St. Marys Hospital. Data were collected by using questionnaires to those patients. Frequencies, percentage, average, standard deviation, t-test, ANOVA, and Duncans multiple range test were examined through the SAS program. The result of study follows : 1) The average score of patients knowledge on the disease was 15.7 (range, 7-20; standard deviation, 2.74). Subjects scored higher as far as the extent of their knowledge in the following categories : management of daily life, diet, characteristics of the disease, risk factors, and medication. Two categories shared the highest percentage of correct answers : 99% of subjects correctly identified that fatigue and stress aggravate symptoms of lupus and symptoms of lupus vary among individuals in range and type. However, when subjects were asked if patients should get a regular examination by an ophthalmologist every 4-6 months while they are on medication to treat rashes, lupus can be completely cured, and contraceptives that include a female hormone (estrogen) are good as contraceptive methods, the percentages of correct answers were low (32%, 31%, and 20%, respectively). In terms of subjects knowledge about the disease by their general characteristics, single subjects had more knowledge about the disease than married subjects did (t=2.14, p=0.0353). The extent of knowledge also varied by monthly income (F=4.96. p=0.0097). Those with more formal education had more knowledge about lupus than those who had less formation education did (t=2.95, 0.0039). Additionally, those who were satisfied with their education about the disease had better knowledge about it than those who were dissatisfied with their education did (t=2.71, p=0.0090). 2) The extent to which lupus patients wanted to be educated about the disease was, on average, 64.5 (range, 46-75; standard deviation, 7.91). Areas for which patients requested education are listed here in order : risk factors, sexual lives and patients associations. Patients who had been hospitalized demonstrated wanting more education than those who had not been did(t=3.73, p=0.0003). The extent to which they wanted the information was different by the number of educational sessions they had (F=3.98, p=0.0249). In conclusion, the results above would be considered when the education programme is planned for SLE patients.

• Journal of muscle and joint health
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• v.9 no.1
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• pp.40-52
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• 2002

This study was conducted to describe disease characteristics, psycho-social factors and treatment behavior of patients with lupus and to analyze relationships anions these variables. The subjects were consisted of 120 lupus patients at G university hospital in Seoul. Data were collected by means of structured interview with questionnaires, and analyzed by using frequencies, $x^2$test, t-test, ANOVA, and correlation. The results were as follows; 1. The average age of the subjects was 31.34 years and average duration of suffering lupus was about 7.3years. Severity of symptoms was moderate and the disturbance of living activities was at the very low level. 2. Self-efficacy score of lupus patients was high, and life satisfaction was at moderate level. 3. Dosage for most of the subjects was about twice a day. 16.7% of them took non-prescribed medicine and only 27.5% perform exercise. 4. Positive correlation was shown among symptom, discomfort of living activities, self-efficacy and life satisfaction, while there was negative correlation among symptom and self-efficacy, symptom and life satisfaction, discomfort of living activities and self-efficacy, and discomfort of living activities and life satisfaction. In addition, exercise showed significant relationship with discomfort of living activities, and non-prescribed medicine showed significant relationship with discomfort of living activities and self-efficacy. These results show that lupus is a chronic disease of long suffering duration among young people. Severity of the symptom was at modest level, while discomfort of living activities were relatively insignificant. However self-efficacy was relatively high. Furthermore self-efficacy has influences on symptom and discomfort of life activities, just as exercise affects discomfort of life activities. Therefore it is required to examine further measures for continuous exercise.

• Journal of muscle and joint health
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• v.7 no.2
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• pp.258-268
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• 2000

The purpose of this study is to describe anxiety, depression and disease activity index(SLEDAI) and correlations among these variables, to provide the basic information developing apporiate nursing interventions for the lupus patients. In this study, authors evaluated anxiety, depression and SLEDAI from 39 lupus patients at one university hospital in Seoul. Data were collected by using questionnaires and reviewing medical records. Frequencies, t-test, Duncan's multiple range test after ANOVA were evaluated with SAS program. The key results were as follows : 1. The average age of the subjects was 31.0 years and ranged from 20 to 51. Female comprised 70.9% and 79.5% were unemployed and housewife. Fifty one point nine percent of the sample had a spouse and above junior college graduates. 74.4% of the sample had a religion and average length of suffering from lupus was 66.59 months. Majority(94.9%) of the subjects had experience of hospitalization, and 55.3% had experience of learning about lupus and average number of learning was 3.9. 2. The average anxiety score of the subjects was 44.53, showing significant relationship with educational background(t=2.27, p< .05), monthly income(F=4.56. p< .05). 3. The depression score was 41.85, showing significant relationship with monthly income(F=3.81 p=0.0236) experience of learning about lupus(t=2.09, p< .05). 4. The SLEDAI score was 12.36, showing no significant relationship with demographical variables. 5. Anxiety showed positive correlations with depression(r=0.76, p< .001), SLEDAI(r=0.48, p< .01), and depression showed positive correlations with SLEDAI(r=0.42, p< .001).

• Annals of Clinical Neurophysiology
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• v.9 no.1
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• pp.29-32
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• 2007

Recurrent transverse myelitis is a rare manifestation of systemic lupus erythematosus. Recurrent transverse myelitis presents the biggest diagnostic problem, since it is common manifestation of multiple sclerosis. But it can also be the only feature or first manifestation in systemic lupus erythematosus. Neurological manifestations and magnetic resonance imaging can be indistinguishable, and there are no specific diagnostic tools. Here we describe a 59-year-old female having a systemic lupus erythematosus with recurrent transverse myeltitis. No uniform therapeutic protocol exists for systemic lupus erythematous with transverse myelitis, and the prognosis is usually poor. We suggest that aggressive treatment (usually with pulses of methylprednisolone and cyclophosphamide) might improve the prognosis of systemic lupus erythematosus with transverse myeltis.

• Journal of Preventive Medicine and Public Health
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• v.56 no.2
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• pp.154-163
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• 2023

Objectives: Systemic lupus erythematosus (SLE) or lupus patients usually experience various physical and psychological challenges. Since the coronavirus disease 2019 pandemic, these challenges have become even harsher. Using the participatory action research approach, this study evaluated how an e-wellness program (eWP) impacted SLE-related knowledge and health behaviors, mental health, and quality of life among lupus patients in Thailand. Methods: A 1-group, pretest-posttest design study was conducted among a purposive sample of lupus patients who were members of Thai SLE Foundation. The 2 main intervention components were: (1) online social support, and (2) lifestyle and stress management workshops. Sixty-eight participants completed all the study requirements, including the Physical and Psychosocial Health Assessment questionnaire. Results: After being in the eWP for 3 months, participants' mean score for SLE-related knowledge increased significantly (t=5.3, p<0.001). The increase in sleep hours was statistically significant (Z=-3.1, p<0.01), with the percentage of participants who slept less than 7 hours decreasing from 52.9% to 29.0%. The percentage of participants reporting sun exposure decreased from 17.7% to 8.8%. The participants also reported significantly lower stress (t(66)=-4.4, p<0.001) and anxiety (t(67)=-2.9, p=0.005). The post-eWP quality of life scores for the pain, planning, intimate relationship, burden to others, emotional health, and fatigue domains also improved significantly (p<0.05). Conclusions: The overall outcomes showed promising results of improved self-care knowledge, health behaviors, mental health status, and quality of life. It is recommended that the SLE Foundation continues to use the eWP model to help the lupus patient community.

• BMB Reports
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• v.39 no.3
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• pp.229-239
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• 2006

Sj$\"{o}$gren's syndrome (SS) is an autoimmune disorder that affects the salivary glands, leading to xerostomia, and the lacrimal glands, resulting in xerophthalmia. Secondary SS is associated with other autoimmune disorders such as systemic rheumatic diseases and systemic lupus erythematosis (SLE), which can affect multiple organs, including the epidermis. Recent studies have demonstrated that green tea polyphenols (GTPs) possess both anti-inflammatory and anti-apoptotic properties in normal human cells. Epidemiological evidence has indicated that, in comparison to the United States, the incidence of SS, clinical xerostomia and lupus is considerably lower in China and Japan, the two leading green tea-consuming countries. Thus, GTPs might be responsible, in part, for geographical differences in the incidence of xerostomia by reducing the initiation or severity of SS and lupus. Consistent with this, molecular, cellular and animal studies indicate that GTPs could provide protective effects against autoimmune reactions in salivary glands and skin. Therefore, salivary tissues and epidermal keratinocytes could be primary targets for novel therapies using GTPs. This review article evaluates the currently available research data on GTPs, focusing on their potential application in the treatment of the oral manifestations of SS and skin manifestations of SLE.

• Journal of muscle and joint health
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• v.11 no.1
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• pp.42-49
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• 2004

Purpose: To establish more effective health counselling system by internet and to provide basic data for developing on-line education program for lupus patients. Method: This survey analyzed the contents of health counselling cases from September, 2002 to March, 2004. Among 108 questioners visited questioning/answering(Q/A) site in one lupus center home page. Contents of Q/A were classified and analyzed using SAS program. Results: Most frequent questioners were female and twenties, they needed to know diagnosing process, treatment principles and information regarding the clinic visits. During the study period, the average number of user's questioning were 166.2 cases and answering was 171.1 cases. Conclusions: These findings suggest that computer mediated health counselling may be useful supplement of health education for lupus patients. More research is needed to develop better health counselling service and education program on the web.

• Journal of muscle and joint health
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• v.24 no.3
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• pp.196-204
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• 2017

Purpose: This study was conducted to explore the mediating effect of resilience in the relationship between stress and therapeutic compliance in patients with systemic lupus erythematosus. Methods: The subject (N=145) was a systemic lupus erythematosus patient who visited the D Hospital in B city. Data collection was conducted from January 2016 to August 2016. Twenty-five resilience measurement tools, 20 stress measurement tools, 39 therapeutic compliance measurement tools used to measure resilience, stress and therapeutic compliance levels. The collected data were analyzed using descriptive analysis, Pearson correlation, 3-step regression analysis of Baron and Kenny, and Sobel test in SPSS/WIN 21.0. Results: There was a significant negative correlation between stress and therapeutic compliance, a significant negative correlation between stress and resilience, and significant positive correlation between resilience and therapeutic compliance. Resilience showed a direct effect on therapeutic compliance through stress as a mediating variable. Conclusion: It is necessary to develop appropriate resilience enhancement program to improve therapeutic compliance with systemic lupus erythematosus.

• Journal of Digital Convergence
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• v.19 no.11
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• pp.615-623
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• 2021

The purpose of this study was to identify the factors influencing resilience of patients with systemic lupus erythematosus. The subject(N=118) was a systemic lupus erythematosus patient who visited the E hospital in D city. The collected data were analyzed by descriptive statistics, t-tset, ANOVA, pearson correlation, and multiple regression. As a result of the study, impact domain of uncertainty, fatigue, self-management domain of uncertainty, trust in doctors domain of uncertainty significant effects on resilience. Based on this study, in order to improve the resilience of patients with systemic lupus erythematosus, a multifaceted approach is needed to reduce the uncertainty perceived by the patient and control fatigue. In addition, it is required to develop an effective nursing intervention program to enhance resilience reflecting influencing factors.

• IMMUNE NETWORK
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• v.19 no.1
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• pp.1.1-1.13
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• 2019

Systemic lupus erythematosus (SLE) is the prototypic systemic autoimmune disease characterized by production of autoantibodies to various nuclear antigens and overexpression of genes regulated by IFN-I called IFN signature. Genetic studies on SLE patients and mutational analyses of mouse models demonstrate crucial roles of nucleic acid (NA) sensors in development of SLE. Although NA sensors are involved in induction of antimicrobial immune responses by recognizing microbial NAs, recognition of self NAs by NA sensors induces production of autoantibodies to NAs in B cells and production of IFN-I in plasmacytoid dendritic cells. Among various NA sensors, the endosomal RNA sensor TLR7 plays an essential role in development of SLE at least in mouse models. CD72 is an inhibitory B cell co-receptor containing an immunoreceptor tyrosine-based inhibition motif (ITIM) in the cytoplasmic region and a C-type lectin like-domain (CTLD) in the extracellular region. CD72 is known to regulate development of SLE because CD72 polymorphisms associate with SLE in both human and mice and CD72^-/- mice develop relatively severe lupus-like disease. CD72 specifically recognizes the RNA-containing endogenous TLR7 ligand Sm/RNP by its extracellular CTLD, and inhibits B cell responses to Sm/RNP by ITIM-mediated signal inhibition. These findings indicate that CD72 inhibits development of SLE by suppressing TLR7-dependent B cell response to self NAs. CD72 is thus involved in discrimination of self-NAs from microbial NAs by specifically suppressing autoimmune responses to self-NAs.