• 동의생리병리학회지
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• 제26권5호
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• pp.577-587
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• 2012

Warm disease: Any of various heat disease characterizer by rapid onset and shifts, pronounced heat signs, and a tendency to form dryness and damage yin. Exterior heat sign: exterior heat patterns are characterizer by pronounced heat signs, such as a red sore pharynx and a relatively red tongue with dry fur, the pulse is floating and rapid, cough and the production of thick white or yellow phlegm. If wind-heat evil exist in weifen, it becomes exterior syndrome, and a remedy about that is dispelling wind-heat but when wind-heat evil invades in nasal and throat part so the disease occurs, you need to add relieving sore throat worsens invades in lung it makes disharmony of diffuse in lungs. So a remedy about it is diffuse the lung. disharmony of diffuse in lungs makes metabolic disorder of qi and liquid and humor malfunction therefore it occurs cough and heat-phlegm syndrome. heat from weifen invades the whole of lungs and form lung heat. So a remedy about lung heat is clearing away lung heat, this lung heat makes inevitably bleed in lungs, therefore a remedy in this case is clearing the lung to stop bleeding, or moistening the lung. Exterior heat sign means that exterior syndrome coexists with heat syndrome and it means that a remedy of this syndrome need to mix prescriptions for relieving exterior syndrome and heat-clearing prescriptions to treat this syndrome.

• 대한의생명과학회지
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• 제9권1호
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• pp.37-42
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• 2003

The present study was conducted to determine whether administration of heat extract of Lepidii Semen has an inhibitory effect on neutrophil-derived oxidative injury following dermal scald burn in rats. Acute lung injury was induced by scald burn (15% of TBSA) in rats. To identify acute edematous lung injury, protein concentrations and numbers of polymorphonuclear leukocytes were measured in bronchoalveolar lavage (BAL) at 5 h after skin burn. In addition, the level of lung KC (neutrophil chemoattractant cytokine) and activity of lung myeloperoxidase (MPO) were measured, and histopathological changes were observed as well. Lung weight and concentration of BAL protein, the index of lung injury, were clearly increased at 5 h postburn compared with those of sham-operated group. Administration of heat extract of Lepidii Semen after scald burn inhibited the production of KC in lung tissue and decreased the activity of lung MPO related to infiltration of neutrophils. In histopathological changes in lung tissue, infiltration of inflammatory cells and pulmonary edema induced by skin burn were decreased by administration of heat extract of Lepidii Semen after scald burn. These results suggest that Lepidii Semen may be an effective medical stuff for acute lung injury induced by skin burn.

• 혜화의학회지
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• 제14권1호
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• pp.113-128
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• 2005

1. Acute laryngitis is a hoarse voice or the complete loss of the voice because of irritation to the vocal folds. 2. Acute laryngitis belongs with the GeupHuEum, HuBi, HuPung in oriental medicine. 3. GeupHuEum is caused by wind and cold, weak of lung and kidney, evil energy of liver, sore throat, etc. It is treated with the methods of cooling lung and wetting, removing heat and changing phlegm, etc. 4. Hubi is caused by fire and wind, dampness, large lung. It is treated with the methods of removing heat and antidote, reinforcing and descending fire, bleeding by acupuncture, vomiting. 5. Hupung is caused by phlegm and heat of lung and stomach, wind and heat. It is treated with the methods of dispersing wind and removing heat and changing phlegm by medicine, acupuncture, moxibustion, vomiting, fumigation.

• 사상체질의학회지
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• 제30권2호
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• pp.1-7
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• 2018

Objective This study was designed to define the efficacy of medicinal herbs of Taeeumin in Sasang constitutional medicine. Method We searched and analyzed original text such as Donguisusebowon Sinchuk edition written in 1901, Donguisusebowon Gabo edition written in 1894, Donguisusebowon Sansang Chobongwon, and posthumous manuscripts left by Je-ma Lee published by the Ministry of Health of North Korea. Results Seven herbs such as Ephedrae Herba, Coicis Semen, Castaneae Semen, Fel Ursi, Mori Cortex Radicis, Ginkgonis Semen, and Farfarae Flos regulate the mechanism of Esophagus-Cold (Wiwanhan). Three herbs such as Melonis Pedicellus, Ailanthi Radicis Cortex, and Quisqualis Fructus regulate the mechanism of Cold Lung-Dry (HanpaeJo). Sixteen herbs such as Rhei Rhizoma, Angelicae Tenuissimae Radix, Puerariae Radix, Cimicifugae Rhizoma, Angelicae Dahuricae Radix, Moschus, Gleditsiae Spina, Mume Fructus, Aurum, Glycine Semen Germinatum, Ampelopsis Radix, Cornu rhinocerotis, Antelopis Cornu, Bomeolum, Bezoar Bovis, and Typhae Pollen regulate the mechanism of Liver-Heat (Ganyeol). Three herbs such as Chrysanthemi Indici Flos, Nelumbinis Semen, and Spirodelae Herba regulate the mechanism of Heat Lung-Dry (YeolpaeJo). Conclusion Forty four herbs of Taeeumin regulate the mechanisms of Esophagus-Cold (Wiwanhan), Cold Lung-Dry (HanpaeJo), Liver-Heat (Ganyeol), Heat Lung-Dry (YeolpaeJo) and correct the energy-fluid pathology of Taeeumin.

• 대한한방내과학회지
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• 제12권1호
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• pp.45-55
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• 1991

It has been known that the nosebleeding is a king hemorrhage occured to be damaged yang-rak (陽略) & lung. the results obtained were as follows; 1. The cause of nosebleeding were divided internal external, these were lung-heat(肺實熱), wind-heat(風熱), dry-heat(煥熱), wind-cold(風寒), summer-heat(暑熱), and those were transporting of Liver-fire(肝火犯肺), Liver-kidney-fire(肝腎陰虛熱傷肺), Stomach-fire(胃火熾盛), Heart-fire(心火千肺). 2. The treatment of external ; Chungpaesulyul(淸肺泄熱), Yanghyuljihyul(凉血止血), Sanpungchungyul(散風淸熱), Jaeumchungjo(滋陰淸煥). 3. The treatment of internal ; Chungkansahwa(淸肝瀉火), Yanghuljihyul(凉血止血), Jayumganghwa(滋陰降火), Chunguysahwa(淸胃瀉火). The cause of nosebleeding was almost heat (fire), and the treatment were Sanpyo(散表) & Chungri(淸裏).

• Tuberculosis and Respiratory Diseases
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• 제44권6호
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• pp.1343-1352
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• 1997

연구배경 : 패혈증이나 이에 합병된 급성호흡곤란증후군 환자들은 고열을 동반하는 경우가 많다. 발열은 조직의 대사를 항진시키므로 조직내 산소공급에 제한이 초래되는 패혈증 환자들에서 발열이 동반되는 경우 열을 동반하지 않는 경우보다 중요기관의 산소공급이 상대적으로 저하될 가능성이 있다. 반면, 발열상태는 조직내 열충격단백질 (heat shock protein, HSP)의 생성을 유도하여 패혈증에 의한 비가역적인 손상으로부터 세포들을 보호함으로써 생체의 방어기전에 유려하게 작용할 수도 있어 패혈중 이에 합병된 급성 폐손상 환자들의 발열에 대한 임상적 의미는 아직 규명되어 있지않았다. 본 연구는 열을 전처치 하였거나 하지 않은 Sprague-Dawley rat의 기도에 TNF를 주입한 후 TNF에 의해 유도되는 급성 폐손상의 정도를 비교함으로써 열이 급성 폐손상에 미치는 효과를 관찰하고자 하였다. 대상 및 방법 : 급성 폐손상의 지표로는 백서의 우측폐내 $I^{125}$의 분당 측정량 대비 1mL의 혈중내 $I^{125}$의 분당 측정량의 비율로 정의한 단백누출지표와 백혈구의 조직내 침윤정도를 반영하는 myeloperoxidase(MPO)의 활성도를 측정하였다. 결과는 평균(${\pm}$ 표준오차)로 표기하였다. 결 과 : 백서의 기도에 생리식염수를 주입한 백서들은 열을 전처치 하였거나 하지 않은 경우 두 군사이의 단백 누출 지표는 각각 0.099(${\pm}0.024$) 및 0.123(${\pm}0.005$)로서 차이가 없었으며 MPO도 4.58(${\pm}0.79\;U/gm$) 및 7.32(${\pm}0.97\;U/gm$)로서 열을 전처치 할 경우 다소 감소되는 경향(P=0.064)를 보였으나 차이가 없었다. 백서의 기도에 TNF-$\alpha$을 주입한 치료군에서 열 전처치한 백서군은 단백누출지표 0.137(${\pm}0.012$) 및 MPO 7.01(${\pm}0.89\;U/gm$)로서 열 전처치 않은 백서군 단백누출지표 0.186(${\pm}0.015$) 및 MPO 14.11(${\pm}1.08\;U/gm$)에 비해 낮았으며(각 P<0.05) 정상군과는 차이가 없었다. MPO 활성도가 단백 증가되었다(r=0.564, P<0.005). 열 전처치 하지 않은 백서에 비해 열 전처치한 백서의 폐 조직내 HSP 72 단백질의 발현은 열 충격 후 18시간 및 23시간 뒤에도 증가되어 나타났다. 결 론 : 백서에 열을 전처치 할 경우 TNF-$\alpha$로 유도되는 급성 폐손상이 경감되므로 발열이 백서의 방어기전에 유리하게 작용한 것으로 사료되었다.

• 사상체질의학회지
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• 제27권1호
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• pp.57-70
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• 2015

Objectives This research was performed to present Clinical Practice Guideline(CPG) for Taeeumin Disease of Sasang Constitutional Medicine(SCM): Liver Heat-based Interior Heat (Gansuyeol-liyeol) disease. This CPG was developed by the national-wide experts committee consisting of SCM professors. Methods First, it was performed that search and collection of literature related to SCM such as "Dongeuisusebowon", Textbook of SCM, Clinical Guidebook of SCM and fundamental researches to standardize the diagnosis of Sasang Constitutional Medicine. And journal search related to clinical trials and case studies concerning SCM was performed domestic and overseas. Finally, 12 articles were selected and included in CPG for Liver Heat-based Interior Heat (Gansuyeol-liyeol) disease in Taeeumin Disease. Experts consensus was drawn through several meetings. Results & Conclusions CPG of Liver Heat-based Interior Heat (Gansuyeol-liyeol) disease in Taeeumin Disease include classification, definition and standard symptoms of each pattern. Liver Heat-based Interior Heat (Gansuyeol-liyeol) disease is classified into Liver-Heat (Ganyeol) symptomatology and Liver-Heat Lung-Dry (Ganyeol-paeJo) symptomatology. Depending on the severity of Liver Heat, Liver-Heat (Ganyeol) symptomatology is classified into mild pattern and moderate pattern. Mild pattern contains 1 disease, namely, Liver-Heat (Ganyeol) initial pattern. Moderate pattern classified into advanced pattern and intense pattern. Depending on the severity of the Lung-Dry, Liver-Heat Lung-Dry (Ganyeol-paeJo) symptomatology is classified into severe pattern and critical pattern. Severe pattern is classified into Dry-Heat (Joyeol) pattern and Dry-Heat (Joyeol) advanced pattern. Critical pattern contains 1 disease, namely, Dry-Heat (Joyeol) intense pattern (Eumhyeol-mogal yeolda pattern).

• 동의생리병리학회지
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• 제30권1호
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• pp.14-19
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• 2016

This study was designed to define the efficacy of prescriptions of Taeeumin in Sasang constitutional medicine. The twenty four prescriptions registered in Donguisusebowon Sinchuk edition written by Je-ma Lee in 1901 are the targets of this paper. We searched and analyzed original text such as Donguisusebowon Sinchuk edition written in 1901, Donguisusebowon Gabo edition written in 1894, Donguisusebowon Sansang Chobongwon, and posthumous manuscripts left by Je-ma Lee published by the Ministry of Health of North Korea. The pathology of the Taeeumin is classified into four mechanisms those are Esophagus-Cold (Wiwanhan), Cold Lung-Dry (HanpaeJo), Liver-Heat (Ganyeol), and Heat Lung-Dry (YeolpaeJo). The prescriptions of Taeeumin regulate four mechanisms. Twenty four prescriptions of Taeeumin regulate the mechanisms of Wiwanhan, HanpaeJo, Ganyeol, YeolpaeJo and correct the energy-fluid pathology of Taeeumin.

• 대한한의학원전학회지
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• 제21권4호
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• pp.179-191
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• 2008

Yuchang(喩昌), prominent doctor in the early days of Cheong Dynasty, argued in favor of Daegiron(大氣論) and Chujoron(秋燥論). He referred the concept of Daegi(大氣) to the initiatory force that maintains and perpetuates the vital activities of human body. The historical background of his argument can be related to the abuses of the doctrine of warming and tonifying. At that time, the practice of misusing warming and tonifying herbal medicines without deteriorations of a case was widespread among doctors. Dryness and heat disease mechanism was triggered from this malpractice. Subsequently Yuchang(喩昌) witnessed many cases of lung diseases resulting from dryness and heat. That's why he suggested relieving dryness of the lung as a treatment, further establishing Daegi(大氣) - which correlates with the lung - as the vital fundamentals. Yuchang(喩昌)'s argues that the autumn energy emanates after the Autumn Equinox and that is what Chujo(秋燥) signifies in Chujoron(秋燥論). He articulates that most of the autumn diseases can be attributed to fire and heat. This argument is distinguished from the one that attributes lung diseases to coldness, thus providing an important factor in deteriorating a lung disease.

• 사상체질의학회지
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• 제23권1호
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• pp.63-78
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• 2011

1. Objectives: We aimed to propose a sub-classification system for the Taeeumin symptomatology by examining the Taeeumin pathology and symptomatology descriptions appearing in "Donguisusebowon". 2. Methods: The Gabo Edition and the Sinchuk Edition (the upgraded and revised edition) of "Donguisusebowon" were reviewed and examined for relevant information on the Taeeum pathology and symptomatology. 3. Results and Conclusions: 1) In the Taeeumin symptomatology, the Exterior disease develops from the basic pathology of Esophagus-Cold and the Interior disease from that of Liver-Heat, eventually progressing to damage of the expirational and dispersive energy of the Lung Sector, the Prime Core Organ or the excessively small organ of the Taeeum constitutional type. The resulting pathology can be broadly defined as the "Lung-Dryness symptomatology". 2) The case reports introduced in the Exterior disease section, including the Zhang Zhongjing Mahuang-tang treatment, Prolonged-affliction disease treatment, and Exterior disease Pestilential disease treatment, share several points in common. They all arise from the pathology of "weakness in the Lung sector and deficiency in the Exterior sector", and they can all be assigned to the same symptomatological division that presents with systemic heat and cold intolerance; this symptomatology can be defined as the "Esophagus-Cold symptomatology", the milder subdivision of the exterior symptomatology. 3) The body of text appearing in the last part of the Interior disease section commonly referred to as the "Taeeumin Conspectus" is in fact not a conspectus when its contents are actually examined. Instead, it can be understood from its pathological and symptomatological descriptions that the passage is explaining the more severe subdivision of the exterior symptomatology that has progressed from Esophagus-Cold to a pathology characterized by damaged expirational and dipersive energy of the Lung Sector. 4) The relocation of the "dry-related pathology" indicates a change in perspective regarding the "Dry-related symptomatology", which caused the rearrangement of the Interior disease into divisions of Liver-Heat symptomatology that is characterized by fulminant heat pathology and Dry-Heat symptomatology that is also accompanied by Lung-Dryness. 5) The Interior disease Yin-Blood Consumptive symptomatology should be included in the Dry-Heat symptomatology in the pathological scheme. 6) Based on the above, the subdivisions of the Taeeumin symptomatology should be arranged as "Esophagus-Cold symptomatology" and "Lung-Dry-Cold symptomatology" in the Exterior disease and "Liver-Heat symptomatology" and "Dry-Heat symptomatology" in the Interior disease.