• Journal of Korea Technology Innovation Society
• /
• v.21 no.4
• /
• pp.1606-1632
• /
• 2018

This study analyzes the technology billionaires with the combination of technology commercialization studies and billionaire research. However, we will not discuss individual billionaires, but discuss the general features of technology billionaires. This study assumes that the answers to the technology commercialization studies are in the technology billionaire researches. In other words, unlike the technology commercialization studies so far, it can be said that it is a retrospective approach of technology commercialization to see the process and the beginning from the result. The conclusion of this study is as follows. First, technology billionaires are in the middle rank among industries, but their wealth is the best. Second, in the technology sector, four 20s are self-made billionaires. It is a matter of securing technological opportunities, not a long training and preparation. Third, the determinants of technology billionaires are population size and venture capital investment. This means technological efforts and sufficient market conditions are the basis for the development of technology billionaires. Fourth, only high income is not the determinant of technology billionaires. There are many small countries that are very rich but can not utilize technology. Technology billionaires can appear in countries with a minimum of US $ 20,000, unless the country has a huge population such as China and India. Sixth, technology billionaires in the diversified business, classified as Chaebol in low-income countries become scarce in the countries over the US $ 40,000. Billionaires will increase rapidly from the mid-2000s. However, this is not explained by the income increase effect. The world's income increase has been slowing since the 1980s. The market economy effect of the socialist countries is not the reason, because it is limited to some socialist countries. Ultimately, the main reason is the new technology opportunity called the IT paradigm.

• Journal of Korean Society of Forest Science
• /
• v.110 no.1
• /
• pp.22-34
• /
• 2021

The implementation of the sunset provision of unexecuted urban parks in Seoul has been postponed; however, the mentioned parks still remain vulnerable since they can be subject to development under certain circumstances. Local governments may purchase the parks to prevent their loss but are constrained due to limited resources. The purpose of this study is to prioritize the purchase of unexecuted urban parks in Seoul based on landscape connectivity, which represents the important role of allowing the movement of wildlife and providing biodiversity in urban environments. In this study, we used four potential scenarios (PB100, PB1, PA100, PA1), which reflects the degree of land cover change resulting from the implementation of the sunset provision, and the role of Han River as a conduit or barrier for wildlife movement. Landscape connectivity was evaluated by calculating current flow betweenness centrality (CFBC). This was used to rank the importance of the unexecuted urban parks in Seoul. The results demonstrated that the implementation of the sunset provision will greatly decrease the connectivity of all parks in Seoul and particularly more so for parks in the southern part of the city. In addition, the results suggested that the low connectivity of Han river will diminish the connectivity around Bukhansan Mountain in the northern part of Seoul. Our study can be used for the prioritization of purchase, since it has the ability to evaluate the anticipated vulnerability of each park's connectivity after the sunset provision.

• Journal of the korean academy of Pediatric Dentistry
• /
• v.49 no.1
• /
• pp.65-75
• /
• 2022

The aim of this study was to evaluate QLF (quantitative light-induced fluorescence) technology for the caries detection in primary teeth and validate the relationships between the cavity volume of carious lesions and QLF analysis results. Total 125 tooth surfaces include 53 occlusal surfaces, and 72 proximal surfaces were investigated with the portable QLF device for detection of dental caries in primary molars. Micro-CT radiograph was also performed to classify carious lesions and calculate the cavity volume. QLF showed good accuracy and reliability (sensitivity 0.75 - 0.94, specificity 0.82 - 0.95, and AUROC 0.88 - 0.98) for the caries detection in primary teeth except 𝚫R average results of proximal caries which showed relatively low values. Statistically significant relationships were found between 𝚫F average, QS-Index and the cavity volume according to Spearman rank-order correlation coefficients (r = 0.805 - 0.832, p < 0.001). QLF detection method would be a harmless and reliable way for children to diagnose dental caries without the concern about radiation exposure.

• The Journal of Korean Academy of Sensory Integration
• /
• v.20 no.2
• /
• pp.1-10
• /
• 2022

Objective : This study aimed to investigate the importance, performance, and educational needs of sensory integration intervention competency for newly employed therapists who use sensory integration intervention. Methods : The general characteristics, importance, performance, and educational needs of sensory integration intervention competency were investigated for therapists with less than three years of experience in sensory integration intervention. Educational needs and rankings were identified through Borich needs analysis. Results : The competency cluster that newly employed therapists perceived as the most important but with the lowest performance level was "Expertise," and the demand of the "Expertise" competency cluster was also the highest in the analysis of educational needs. The difference in importance and performance in all sub-competencies was statistically significant. In the Borich needs analysis, the rank of educational needs was derived as follows: "Evaluation skill" (5.56), "Analysis skill" (5.50), and "Overall knowledge of occupational therapy" (5.47). Conclusion : It was found that the newly employed therapist using sensory integration intervention recognized professional competency as the most important, while also recognizing that their professional competency was low. Accordingly, education to enhance professional competency was most needed. This study presented basic data for the direction of education to strengthen competency in consideration of the educational needs of newly employed therapists.

• Journal of Microbiology and Biotechnology
• /
• v.32 no.8
• /
• pp.1017-1025
• /
• 2022

Bone homeostasis is regulated by constant remodeling through osteogenesis by osteoblasts and osteolysis by osteoclasts and osteoporosis can be provoked when this balance is broken. Present pharmaceutical treatments for osteoporosis have harmful side effects and thus, our goal was to develop therapeutics from intrisincally safe natural products. Fucoidan is a polysaccharide extracted from many species of brown seaweed, with valuable pharmaceutical activities. To intensify the effect of fucoidan on bone homeostasis, we hydrolyzed fucoidan using AMG, Pectinex and Viscozyme. Of these, fucoidan biotransformed by Pectinex (Fu/Pec) powerfully inhibited the induction of tartrate-resistant acid phosphatase (TRAP) activity in osteoclasts differentiated from bone marrow macrophages (BMMs) by the receptor for activation of nuclear factor-κB ligand (RANKL). To investigate potential of lower molecular weight fucoidan it was separated into >300 kDa, 50-300 kDa, and <50 kDa Fu/Pec fractions by ultrafiltration system. The effects of these fractions on TRAP and alkaline phosphatase (ALP) activities were then examined in differentiated osteoclasts and MC3T3-E1 osteoblasts, respectively. Interestingly, 50-300 kDa Fu/Pec suppressed RANKL-induced osteoclasts differentiation from BMMs but did not synergistically enhance osteoblasts differentiation induced by osteogenic agents. In addition, this fraction inhibited the expressions of NFATc1, TRAP, OSCAR, and RANK, which are all key transcriptional factors involved in osteoclast differentiation, and those of Src, c-Fos and Mitf, as determined by RT-PCR. In conclusion, enzymatically low-molecularized 50-300 kDa Fu/Pec suppressed TRAP by downregulating RANKL-related signaling, contributing to the inhibition of osteoclasts differentiation, and represented a potential means of inducing bone remodeling in the background of osteoporosis.

• KSCE Journal of Civil and Environmental Engineering Research
• /
• v.43 no.3
• /
• pp.381-395
• /
• 2023

This paper presents a GIS-based site suitability analysis for a smart hydrogen energy plant in the Gangwon-Do region, South Korea. A GIS-based multi-criteria decision analysis (MCDA) was implemented in this study to identify the most suitable sites for the development of smart hydrogen energy plants. The study utilizes various spatial data layers, including hydrogen generation potential and climatic conditions, environmental and topographic conditions, and natural catastrophic conditions, to evaluate the suitability of potential sites for the hydrogen energy plant. The spatial data layers were then used to rank and prioritize the sites based on suitability. The findings revealed that 4.26% of the study area, or 712.14 km², was suitable for constructing smart hydrogen energy plants. Some regions of Cheorwon-gun, Chuncheon-si, Wonju-si, Yanggu-gun, Gangneung-si, Hoengseong-gun, and near the coastal region along the east coast were found to be suitable for solar and wind energy utilization. The proposed MCDA provides a valuable tool for decision-makers and stakeholders to make informed decisions on the location of smart hydrogen energy plants and supports the transition to a sustainable and low-carbon energy system. Decision-makers can use the results of this study to select suitable sites for constructing smart hydrogen energy plants.

• Journal of the Korean Society of Marine Environment & Safety
• /
• v.29 no.7
• /
• pp.819-827
• /
• 2023

If respiratory arrest occurs or cardiopulmonary resuscitation (CPR) is performed for a long period on board ships, CPR with rescue breathing (not compression-only CPR) is required. Accordingly, ships must have resuscitation equipment for oxygen supply, and seafarers must have the maritime competence to use it. This study aimed to analyze the placement status of resuscitation equipment on ships and seafarers' intention to use them in order to increase the usability of resuscitation equipment on board ships and propose improvement measures. The study was conducted from February 2, 2023, to April 21, 2023, and a total of 340 seafarers were surveyed. The data were analyzed by frequency, percentage, and chi-square test using SPSS WIN 23.0. The results showed that the checking of resuscitation equipment was high among seafarers in the positions of officer, captain, deck department personnel, and ocean-going personnel. The intention of seafarers to use resuscitation equipment was low, and the main barrier was the lack of knowledge on how to use. Among the general characteristics of the study participants, those whose rank was that of officer or captain, whose working department was the deck, voyage who were ocean-going, and who managed a gross tonnage of 20,000 tons or more had a high intention to use resuscitation equipment. Participants who knew the necessity of rescue breathing and had received practice and equipment-based training were active in using resuscitation equipment. Therefore, a system should be developed so that all ships can be equipped with resuscitation equipment, and an environment must be created to increase accessibility to resuscitation equipment on board ships. In addition, an education system based on practical and resuscitation equipment training must be established to ensure that seafarers have maritime competence.

• Korean Journal of Radiology
• /
• v.22 no.9
• /
• pp.1514-1524
• /
• 2021

Objective: To develop a radiomics risk score based on dynamic contrast-enhanced (DCE) MRI for prognosis prediction in patients with glioblastoma. Materials and Methods: One hundred and fifty patients (92 male [61.3%]; mean age ± standard deviation, 60.5 ± 13.5 years) with glioblastoma who underwent preoperative MRI were enrolled in the study. Six hundred and forty-two radiomic features were extracted from volume transfer constant (K^trans), fractional volume of vascular plasma space (V_p), and fractional volume of extravascular extracellular space (V_e) maps of DCE MRI, wherein the regions of interest were based on both T1-weighted contrast-enhancing areas and non-enhancing T2 hyperintense areas. Using feature selection algorithms, salient radiomic features were selected from the 642 features. Next, a radiomics risk score was developed using a weighted combination of the selected features in the discovery set (n = 105); the risk score was validated in the validation set (n = 45) by investigating the difference in prognosis between the "radiomics risk score" groups. Finally, multivariable Cox regression analysis for progression-free survival was performed using the radiomics risk score and clinical variables as covariates. Results: 16 radiomic features obtained from non-enhancing T2 hyperintense areas were selected among the 642 features identified. The radiomics risk score was used to stratify high- and low-risk groups in both the discovery and validation sets (both p < 0.001 by the log-rank test). The radiomics risk score and presence of isocitrate dehydrogenase (IDH) mutation showed independent associations with progression-free survival in opposite directions (hazard ratio, 3.56; p = 0.004 and hazard ratio, 0.34; p = 0.022, respectively). Conclusion: We developed and validated the "radiomics risk score" from the features of DCE MRI based on non-enhancing T2 hyperintense areas for risk stratification of patients with glioblastoma. It was associated with progression-free survival independently of IDH mutation status.

• Korean Journal of Radiology
• /
• v.25 no.2
• /
• pp.189-198
• /
• 2024

Objective: To investigate the prognostic utility of radiomics features extracted from ¹⁸F-fluorodeoxyglucose (FDG) PET/CT combined with clinical factors and metabolic parameters in predicting progression-free survival (PFS) and overall survival (OS) in individuals diagnosed with extranodal nasal-type NK/T cell lymphoma (ENKTCL). Materials and Methods: A total of 126 adults with ENKTCL who underwent ¹⁸F-FDG PET/CT examination before treatment were retrospectively included and randomly divided into training (n = 88) and validation cohorts (n = 38) at a ratio of 7:3. Least absolute shrinkage and selection operation Cox regression analysis was used to select the best radiomics features and calculate each patient's radiomics scores (RadPFS and RadOS). Kaplan-Meier curve and Log-rank test were used to compare survival between patient groups risk-stratified by the radiomics scores. Various models to predict PFS and OS were constructed, including clinical, metabolic, clinical + metabolic, and clinical + metabolic + radiomics models. The discriminative ability of each model was evaluated using Harrell's C index. The performance of each model in predicting PFS and OS for 1-, 3-, and 5-years was evaluated using the time-dependent receiver operating characteristic (ROC) curve. Results: Kaplan-Meier curve analysis demonstrated that the radiomics scores effectively identified high- and low-risk patients (all P < 0.05). Multivariable Cox analysis showed that the Ann Arbor stage, maximum standardized uptake value (SUVmax), and RadPFS were independent risk factors associated with PFS. Further, β2-microglobulin, Eastern Cooperative Oncology Group performance status score, SUVmax, and RadOS were independent risk factors for OS. The clinical + metabolic + radiomics model exhibited the greatest discriminative ability for both PFS (Harrell's C-index: 0.805 in the validation cohort) and OS (Harrell's C-index: 0.833 in the validation cohort). The time-dependent ROC analysis indicated that the clinical + metabolic + radiomics model had the best predictive performance. Conclusion: The PET/CT-based clinical + metabolic + radiomics model can enhance prognostication among patients with ENKTCL and may be a non-invasive and efficient risk stratification tool for clinical practice.

• Korean Journal of Radiology
• /
• v.23 no.5
• /
• pp.539-547
• /
• 2022

Objective: To investigate the association between functional tumor burden of peritoneal carcinomatosis (PC) derived from diffusion-weighted imaging (DWI) and overall survival in patients with advanced ovarian carcinoma (OC). Materials and Methods: This prospective study was approved by the local research ethics committee, and informed consent was obtained. Fifty patients (mean age ± standard deviation, 57 ± 12 years) with stage III-IV OC scheduled for primary or interval debulking surgery (IDS) were recruited between June 2016 and December 2021. DWI (b values: 0, 400, and 800 s/mm²) was acquired with a 16-channel phased-array torso coil. The functional PC burden on DWI was derived based on K-means clustering to discard fat, air, and normal tissue. A score similar to the surgical peritoneal cancer index was assigned to each abdominopelvic region, with additional scores assigned to the involvement of critical sites, denoted as the functional peritoneal cancer index (fPCI). The apparent diffusion coefficient (ADC) of the largest lesion was calculated. Patients were dichotomized by immediate surgical outcome into high- and low-risk groups (with and without residual disease, respectively) with subsequent survival analysis using the Kaplan-Meier curve and log-rank test. Multivariable Cox proportional hazards regression was used to evaluate the association between DWI-derived results and overall survival. Results: Fifteen (30.0%) patients underwent primary debulking surgery, and 35 (70.0%) patients received neoadjuvant chemotherapy followed by IDS. Complete tumor debulking was achieved in 32 patients. Patients with residual disease after debulking surgery had reduced overall survival (p = 0.043). The fPCI/ADC was negatively associated with overall survival when accounted for clinicopathological information with a hazard ratio of 1.254 for high fPCI/ADC (95% confidence interval, 1.007-1.560; p = 0.043). Conclusion: A high DWI-derived functional tumor burden was associated with decreased overall survival in patients with advanced OC.