Journal of the korean academy of Pediatric Dentistry (대한소아치과학회지)

Korean Academy of Pediatric Dentistry (대한소아치과학회)
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Assessment of the Caries Detection Ability of Quantitative Light-induced Fluorescence (QLF) in Primary Teeth in vitro

유치의 치아우식증 확인을 위한 정량형광분석(QLF) 검사법의 우식탐지능력 평가

  • Cho, Kyung Hyun (Department of Pediatric Dentistry, College of Dentistry, Yonsei University) ;
  • Kang, Chung-Min (Department of Pediatric Dentistry, College of Dentistry, Yonsei University) ;
  • Jung, Hoi-In (Department of Preventive Dentistry & Public Oral Health, College of Dentistry, Yonsei University) ;
  • Lee, Tae Yang (Department of Pediatric Dentistry, College of Dentistry, Yonsei University) ;
  • Song, Je Seon (Department of Pediatric Dentistry, College of Dentistry, Yonsei University)
  • 조경현 (연세대학교 치과대학 소아치과학교실) ;
  • 강정민 (연세대학교 치과대학 소아치과학교실) ;
  • 정회인 (연세대학교 치과대학 예방치과학교실) ;
  • 이태양 (연세대학교 치과대학 소아치과학교실) ;
  • 송제선 (연세대학교 치과대학 소아치과학교실)
  • Received : 2021.09.08
  • Accepted : 2021.10.20
  • Published : 2022.02.28
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Abstract

The aim of this study was to evaluate QLF (quantitative light-induced fluorescence) technology for the caries detection in primary teeth and validate the relationships between the cavity volume of carious lesions and QLF analysis results. Total 125 tooth surfaces include 53 occlusal surfaces, and 72 proximal surfaces were investigated with the portable QLF device for detection of dental caries in primary molars. Micro-CT radiograph was also performed to classify carious lesions and calculate the cavity volume. QLF showed good accuracy and reliability (sensitivity 0.75 - 0.94, specificity 0.82 - 0.95, and AUROC 0.88 - 0.98) for the caries detection in primary teeth except 𝚫R average results of proximal caries which showed relatively low values. Statistically significant relationships were found between 𝚫F average, QS-Index and the cavity volume according to Spearman rank-order correlation coefficients (r = 0.805 - 0.832, p < 0.001). QLF detection method would be a harmless and reliable way for children to diagnose dental caries without the concern about radiation exposure.

본 연구의 목적은 유치의 치아우식증 검사를 위한 정량형광분석(quantitative light-induced fluorescence, QLF) 기술의 유효성을 평가하고, 우식병소의 부피와 QLF 분석결과 사이의 상관관계를 확인하는 것이다. 치아우식증 검사를 위해 53개의 교합면 및 72개의 인접면을 포함한 총 125개의 유구치 치면을 휴대용 QLF 장비를 이용해 조사하여 유구치의 치아우식증을 확인하였다. 또한 치아우식증을 분류하고 우식병소의 부피를 계산하기 위해 micro-CT 방사선 검사를 시행하였다. 상대적으로 낮은 수치를 보였던 인접면 우식에 대한 𝚫R average 결과를 제외하면, QLF 분석결과는 유치의 치아우식증 진단에 대해 충분한 수준의 정확성과 신뢰도를 보였다(민감도 0.75 - 0.94, 특이도 0.82 - 0.95, AUROC 0.88 - 0.98). Spearman 상관분석 결과에서는 𝚫F average 및 QS-Index와 우식병소 부피 사이에 통계적으로 유의한 높은 상관성을 확인할 수 있었다(r = 0.805 - 0.832, p < 0.001). QLF 기술을 이용한 치아우식증 검사는 어린이의 치아우식증 진단에 있어 방사선 노출에 대한 걱정 없이 안전하게 사용 가능하고, 신뢰할 만한 방법이 될 수 있을 것이다.

Keywords

Acknowledgement

This study was supported by AIOBIO, Seoul, Republic of Korea and Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2018R1D1A1B07041657).

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