• The Journal of Korean Physical Therapy
• /
• v.21 no.4
• /
• pp.97-102
• /
• 2009

Purpose: The purpose of this study was to investigate the effects of low intensity pulsed ultrasound on TGF-$\beta$1 expression and healing of rat femur penetrating fractures. Methods: Rats were anesthetized with ketamine and xylazine. Using aseptic technique, we exposed the lateral right femoral diaphysis with removal of the periosteum. We made one hole along its long axis with an electrically-driven 1.8 mm diameter drill bit. Postoperatively, rats were divided into two groups (a control group, n=15; an experimental group, n=15). The experimental group was treated with low intensity pulsed ultrasound (pulse rate: 1:4, 0.5 W/$cm^2$, 10 minutes, 1 time per day) for 3 weeks. The control group was treated with sham ultrasound (with the US unit turned off). Results: The experimental group achieved more callus formation and TGF-$\beta$1 expression than the control group at the $7^{th}$, $14^{th}$ and $21^{st}$ days after low intensity pulsed ultrasound treatment. Conclusion: This study suggests that low intensity pulsed ultrasound facilitates bone fracture repair, possibly via increased TGF-$\beta$1 expression.

• Journal of The Korean Society of Integrative Medicine
• /
• v.6 no.2
• /
• pp.69-76
• /
• 2018

Purpose : This study investigated the effects of low-intensity muscle training on neurotransmitters associated with depression and emotion regulation disorders in survivors with stroke who were diagnosed with depression or emotion regulation disorder. Methods : Survivors of chronic stroke diagnosed with depression or emotion regulation disorder (n = ) were included in the study. Concentrations of serotonin, norepinephrine, and epinephrine were measured before and after. Low-intensity muscle training was performed once a day for 50 minutes, 5 times a week for 10 weeks. Result : Levels of serotonin, norepinephrine, and epinephrine improved significantly after intervention (p < .05). Conclusion : These results confirm that low-intensity muscle training has a positive effect on neurotransmitter concentrations in survivors with stroke diagnosed with depression and emotion regulation disorders. Future studies should analyze the changes in neurotransmitters in more detail using various exercise methods and intensities to investigate their effects on depression and emotion regulation disorders.

• Journal of the Korean Society of Physical Medicine
• /
• v.19 no.1
• /
• pp.119-129
• /
• 2024

PURPOSE: The purpose of this study was to examine the effectiveness of a low-intensity combined exercise program on daily physical fitness parameters such as balance, flexibility, muscle strength, and fear of falling of elderly women in the community. METHODS: This study assigned 30 elderly women randomly into two groups: The control and experimental groups. The control group (n = 15) underwent routine gait. The experimental group (n = 15) underwent the low-intensity combined exercise. The exercise program in this study comprising combined exercise, including balance, flexibility, muscle strength training, and the exercise program using props was conducted twice a week for 8 weeks. RESULTS: The average age of the control and experimental groups was 77.27 years and 78.33 years, respectively. There were significant differences in static balance (t = -4.167, p < .001), dynamic balance (t = 2.463, p < .001), (t = -3.870, p < .001), (t = -2.262, p < .001), (t = -5.732, p < .001), (t = -6.573, p < .001), and fear of falling (t = -5.129, p < .001). CONCLUSION: The results show that low-intensity combined exercise is an effective intervention that improves physical health fear of falling in older women. The combined exercise program was found to be more effective in terms of physical function and fall-related psychological function compared to the control group that only walked.

• Journal of Wellbeing Management and Applied Psychology
• /
• v.4 no.4
• /
• pp.31-34
• /
• 2021

Purpose: The purpose of this study is to review health-care program using the recent robotic horse-riding technology and its clinical effects for chronic low back pain. Research design, data and methodology: Recent clinical articles were determined under three inclusion criteria for in-depth review: 1) article that is published within 1 year, 2) article that includes the detailed explanation of health-care program using robotic horse-riding, 3) the article that deals with chronic low back pain during more than 6 months. Results: As a result, the finally-determined two articles demonstrated the clinical effects of robotic horse-riding statistically on pain intensity, low back muscle strength, spinal alignment, and fear-avoidance belief. Conclusions: After in-depth review, I concluded that health-care program using robotic horse-riding for chronic low back pain needs to be provided at low-intensity (e.g. less than 6km/h horse walking program) in the beginning of health-care for improving their motor control ability, then, at the increased intensity for strengthening core muscles.

• Physical Therapy Rehabilitation Science
• /
• v.3 no.2
• /
• pp.107-111
• /
• 2014

Objective: In the present study, we investigated the protective effects of low-intensity treadmill training in doxorubicin-induced cardiotoxicity rat models. Design: Randomized controlled trial. Methods: In this study, we randomly divided them into four groups. The normal group included non-cardiotoxicity normal control (n=10), the control group included non-treadmill training after doxorubicin-induced cardiotoxicity (n=10), the experimental group I included low-intensity treadmill training (3 m/min) after doxorubicin-induced cardiotoxicity (n=10), and the experimental group II included low-intensity treadmill training (8 m/min) after doxorubicin-induced cardiotoxicity (n=10). Rats in the treadmill training group underwent treadmill training, which began at 2 weeks after first intraperitoneal injection. We determined the body weight change for each rat on days 1 and 21. Biochemical markers (lactate dehydrogenase [LDH], creatine kinase [CK], glutathion, aspartate transaminase [AST], and alanine transaminase [ALT]) concentration in the serum change of rats from all four groups was examined at the end of the experiment. Results: The results showed that the experimental group I and II showed a significant increase in body weight as compared with that of the control group (p<0.05). We observed that the biochemical markers (LDH, CK, glutathion, AST, and ALT) were improved in the experimental group I than the experimental group II (p<0.05). There was no difference between the experimental groups. Conclusions: In conclusion, our data suggest that low-intensity treadmill training applied after doxorubicin treatment protects against cardiotoxicity following treatment, possibly by enhancing antioxidant defenses and inhibiting cardiac muscle cell apoptosis.

• Journal of Lipid and Atherosclerosis
• /
• v.3 no.2
• /
• pp.97-104
• /
• 2014

Objective: The aim of this study is to compare the clinical benefits between high-intensity and low-to moderate-intensity statin therapy in patients with acute myocardial infarction (AMI). Methods: A total of 1,230 patients in the Korea AMI Registry (KAMIR) were enrolled. Patients were divided into two groups according to the dosage of statin for the secondary prevention after AMI. The primary endpoint was composite of major adverse cardiac events (MACEs) including cardiac death, non-fatal MI, repeat revascularization during the 12 months of clinical follow-up. Result: The primary endpoint occurred in 101 patients (11.3%) from the low-to moderate-intensity statin group and 45 patients (13.4%) from the high-intensity statin group. The cumulative incidence of MACEs during 12-month follow-up was not significantly different between the two groups (p=0.323). After multi-variate analysis, MACEs-free survival rate was not significantly different between the two groups. Conclusion: High-intensity statin therapy did not show additional clinical benefit over low-to moderate-intensity statin therapy after AMI.

• The Journal of the Korea Contents Association
• /
• v.12 no.6
• /
• pp.361-370
• /
• 2012

The Purpose of this study was to find out the effects of frequency and intensity of transcutaneous electrical nerve stimulation(TENS) on the patients with chronic low back pain. The subjects were 32 patients with chronic low back pain average age 39.19 (${\pm}12.96$)years. The duration of chronic low back pain was 8.57 (${\pm}3.07$)months. The treatments were given 15 minutes once a day five a week for two weeks. to low back. Lumbar range of motion(ROM) and Oswestry Disabilitv Index(ODI)) was evaluated before and after TENS application. Each group was compared using Wilcoxon Mann-Whitney test. The results were as followings: Each group showed significant effect. High intensity group showed more effect in low frequency group. High intensity group showed more effect in high frequency group. Therefore, the high intensity can be used more effectively with high frequency for treating chronic low back pain.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.12 no.2
• /
• pp.753-758
• /
• 2011

The purpose of this study was to investigate effect of low intensity resistance exercise and aerobic exercise on serum lipid level in chronic stroke patients. A total of 37 chronic stroke patients were enrolled in this study. The participants were allocated randomly to 2 groups: the low intensity resistance exercise group(n=19) and aerobic exercise group(n=18). Low intensity resistance exercise group took exercise with low intensity resistance for 50minutes, 5 times per week over a 8 week period. Aerobic exercise group received only aerobic exercise. We measured serum lipid level to compare of effectiveness both exercises. Paired t test was executed to determine differences between pre and post exercise. For all analyses, a significant level set at p<.05. The low intensity resistance exercise group showed significant increase in TG, TC HDL-C and LDL-C(p<.05). The aerobic exercise group had significantly higher TC and LDL-C (p<.05). Theses results suggest that low intensity resistance exercise and aerobic exercise are feasible for stroke patients by improving motivation and interest. Further studies is necessary to clinical implication classified by onset time and disability level.

• The Korean Journal of Physiology and Pharmacology
• /
• v.26 no.5
• /
• pp.313-323
• /
• 2022

Atrial fibrillation (AF) is the most common supraventricular arrhythmia, and it corresponds highly with exercise intensity. Here, we induced AF in mice using acetylcholine (ACh)-CaCl₂ for 7 days and aimed to determine the appropriate exercise intensity (no, low, moderate, high) to protect against AF by running the mice at different intensities for 4 weeks before the AF induction by ACh-CaCl₂. We examined the AF-induced atrial remodeling using electrocardiogram, patch-clamp, and immunohistochemistry. After the AF induction, heart rate, % increase of heart rate, and heart weight/body weight ratio were significantly higher in all the four AF groups than in the normal control; highest in the high-ex AF and lowest in the low-ex (lower than the no-ex AF), which indicates that low-ex treated the AF. Consistent with these changes, G protein-gated inwardly rectifying K⁺ currents, which were induced by ACh, increased in an exercise intensity-dependent manner and were lower in the low-ex AF than the no-ex AF. The peak level of Ca²⁺ current (at 0 mV) increased also in an exercise intensity-dependent manner and the inactivation time constants were shorter in all AF groups except for the low-ex AF group, in which the time constant was similar to that of the control. Finally, action potential duration was shorter in all the four AF groups than in the normal control; shortest in the high-ex AF and longest in the low-ex AF. Taken together, we conclude that low-intensity exercise protects the heart from AF, whereas high-intensity exercise might exacerbate AF.

• Journal of Digital Convergence
• /
• v.14 no.10
• /
• pp.483-497
• /
• 2016

Purpose of this study is to compare and analyze effect of exercise intensity in complex training for 8 weeks on leptin, growth hormone, IGF-1, and body composition in middle school with intellectual disability. Subjects of this study were 26 middle school students, 9 in high-intensity group, 9 in middle-intensity group, and 8 in low-intensity group. To compare the difference from different exercise intensity, pre-value before training has been set as covariate and different exercise intensity has been set as independent variable, with changes in leptin, growth hormone, IGF-1, and body composition. Analysis of covariance (ANOVA) has been performed for data analysis and effect size ${\eta}^2$(eta) has been deduced. Result acquired from analyzed data is as following. First, when equal exercise has been imposed on middle school students with intellectual disability, in regard of exercise intensity, it was shown that leptin most decreased in middle-intensity, growth hormone most increased in middle-intensity, and IGF-1 increased in low-intensity. Second, in regard of body composition, low-intensity was most effective in increase of total body weight without fat. Decrease of body fat was most prominent in middle-intensity and increase of bone density, in low-intensity. Also, in further studies, study that differentiates subjects in gender and individual exercise performance is deemed mandatory.