Physical Therapy Rehabilitation Science

korean Academy of Physical Therapy Rehabilitation Science (물리치료재활과학회)
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Effects of cardiac biological activities on low-intensity physical training in doxorubicin-induced cardiotoxicity rat models

  • Ki, Yeong-Kye (Department of Physical Therapy, College of Health and Welfare, Dongshin University) ;
  • Kim, Gye-Yeop (Department of Physical Therapy, College of Health and Welfare, Dongshin University) ;
  • Kim, Eun-Jung (Department of Physical Therapy, College of Health and Welfare, Dongshin University)
  • Received : 2014.08.11
  • Accepted : 2014.10.15
  • Published : 2014.10.26
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Abstract

Objective: In the present study, we investigated the protective effects of low-intensity treadmill training in doxorubicin-induced cardiotoxicity rat models. Design: Randomized controlled trial. Methods: In this study, we randomly divided them into four groups. The normal group included non-cardiotoxicity normal control (n=10), the control group included non-treadmill training after doxorubicin-induced cardiotoxicity (n=10), the experimental group I included low-intensity treadmill training (3 m/min) after doxorubicin-induced cardiotoxicity (n=10), and the experimental group II included low-intensity treadmill training (8 m/min) after doxorubicin-induced cardiotoxicity (n=10). Rats in the treadmill training group underwent treadmill training, which began at 2 weeks after first intraperitoneal injection. We determined the body weight change for each rat on days 1 and 21. Biochemical markers (lactate dehydrogenase [LDH], creatine kinase [CK], glutathion, aspartate transaminase [AST], and alanine transaminase [ALT]) concentration in the serum change of rats from all four groups was examined at the end of the experiment. Results: The results showed that the experimental group I and II showed a significant increase in body weight as compared with that of the control group (p<0.05). We observed that the biochemical markers (LDH, CK, glutathion, AST, and ALT) were improved in the experimental group I than the experimental group II (p<0.05). There was no difference between the experimental groups. Conclusions: In conclusion, our data suggest that low-intensity treadmill training applied after doxorubicin treatment protects against cardiotoxicity following treatment, possibly by enhancing antioxidant defenses and inhibiting cardiac muscle cell apoptosis.

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References

  1. Glozier N, Tofler GH, Colquhoun DM, Bunker SJ, Clarke DM, Hare DL, et al. Psychosocial risk factors for coronary heart disease. Med J Aust 2013;199:179-80. https://doi.org/10.5694/mja13.10440
  2. Swift DL, Lavie CJ, Johannsen NM, Arena R, Earnest CP, O'Keefe JH, et al. Physical activity, cardiorespiratory fitness, and exercise training in primary and secondary coronary prevention. Circ J 2013;77:281-92. https://doi.org/10.1253/circj.CJ-13-0007
  3. Hansen D, Dendale P, Berger J, Meeusen R. Rehabilitation in cardiac patients:what do we know about training modalities? Sports Med 2005;35:1063-84. https://doi.org/10.2165/00007256-200535120-00005
  4. Heran BS, Chen JM, Ebrahim S, Moxham T, Oldridge N, Rees K, et al. Exercise-based cardiac rehabilitation for coronary heart disease. Cochrane Database Syst Rev 2011;(7):CD001800.
  5. Lawler PR, Filion KB, Eisenberg MJ. Efficacy of exercise-based cardiac rehabilitation post-myocardial infarction: a systematic review and meta-analysis of randomized controlled trials. Am Heart J 2011;162:571-584. https://doi.org/10.1016/j.ahj.2011.07.017
  6. Soares D, Viamonte S, Magalhaes S, Ribeiro MM, Barreira A, Fernandes P, et al. What factors determine the levels of physical activity after cardiac rehabilitation program? Acta Med Port 2013;26:689-98.
  7. Cipriano G Jr, Cipriano VT, da Silva VZ, Cipriano GF, Chiappa GR, de Lima AC, et al. Aerobic exercise effect on prognostic markers for systolic heart failure patients: a systematic review and meta-analysis. Heart Fail Rev 2014;19:655-67.
  8. Santaularia N, Jaarsma T. Motivational factors for exercise in cardiac patients? A literature review. Eur J Prev Med 2013;1:1-19. https://doi.org/10.11648/j.ejpm.20130101.11
  9. Heger Z, Cernei N, Kudr J, Gumulec J, Blazkova I, Zitka O, et al. A novel insight into the cardiotoxicity of antineoplastic drug doxorubicin. Int J Mol Sci 2013;14:21629-46. https://doi.org/10.3390/ijms141121629
  10. Zhang YW, Shi J, Li YJ, Wei L. Cardiomyocyte death in doxorubicin-induced cardiotoxicity. Arch Immunol Ther Exp (Warsz) 2009;57:435-45. https://doi.org/10.1007/s00005-009-0051-8
  11. Lebrecht D, Walker UA. Role of mtDNA lesions in anthracycline cardiotoxicity. Cardiovasc Toxicol 2007;7:108-13. https://doi.org/10.1007/s12012-007-0009-1
  12. Fouad AA, Albuali WH, Al-Mulhim AS, Jresat I. Cardioprotective effect of cannabidiol in rats exposed to doxorubicin toxicity. Environ Toxicol Pharmacol 2013;36:347-57. https://doi.org/10.1016/j.etap.2013.04.018
  13. Albeck DS, Sano K, Prewitt GE, Dalton L. Mild forced treadmill exercise enhances spatial learning in the aged rat. Behav Brain Res 2006;168:345-8. https://doi.org/10.1016/j.bbr.2005.11.008
  14. Singal PK, Gupta M, Prasad K. Effects of increase in extracellular calcium on frequency-dependent inotropism in cardiac muscle. Can J Cardiol 1985;1:294-7.
  15. Dhalla NS, Singal PK, Panagia V, Harrow JA, Anand-Srivastava MB, Beamish RE. Progress and problems in understanding the involvement of calcium in heart function. Can J Physiol Pharmacol 1984;62:867-73. https://doi.org/10.1139/y84-146
  16. Vedam K, Nishijima Y, Druhan LJ, Khan M, Moldovan NI, Zweier JL, et al. Role of heat shock factor-1 activation in the doxorubicin-induced heart failure in mice. Am J Physiol Heart Circ Physiol 2010;298:H1832-41. https://doi.org/10.1152/ajpheart.01047.2009
  17. Dudka J, Gieroba R, Korga A, Burdan F, Matysiak W, Jodlowska-Jedrych B, et al. Different effects of resveratrol on dose-related Doxorubicin-induced heart and liver toxicity. Evid Based Complement Alternat Med 2012;2012:606183.
  18. Ohno H, Yamashita H, Ookawara T, Saitoh D, Mimura K, Taniguchi N. Effects of brief physical exercise on the concentrations of immunoreactive superoxide dismutase isoenzymes in human plasma. Tohoku J Exp Med 1992;167:301-3. https://doi.org/10.1620/tjem.167.301
  19. Berthiaume JM, Wallace KB. Persistent alterations to the gene expression profile of the heart subsequent to chronic Doxorubicin treatment. Cardiovasc Toxicol 2007;7:178-91. https://doi.org/10.1007/s12012-007-0026-0
  20. Al-Shabanah OA, Aleisa AM, Hafez MM, Al-Rejaie SS, Al-Yahya AA, Bakheet SA, et al. Desferrioxamine attenuates doxorubicin-induced acute cardiotoxicity through TFG-${\beta}$/Smad p53 pathway in rat model. Oxid Med Cell Longev 2012;2012:619185.
  21. Pointon AV, Walker TM, Phillips KM, Luo J, Riley J, Zhang SD, et al. Doxorubicin in vivo rapidly alters expression and translation of myocardial electron transport chain genes, leads to ATP loss and caspase 3 activation. PLoS One 2010;5:e12733. https://doi.org/10.1371/journal.pone.0012733
  22. Thompson KL, Rosenzweig BA, Zhang J, Knapton AD, Honchel R, Lipshultz SE, et al. Early alterations in heart gene expression profiles associated with doxorubicin cardiotoxicity in rats. Cancer Chemother Pharmacol 2010;66:303-14. https://doi.org/10.1007/s00280-009-1164-9
  23. Sen CK, Atalay M, Hanninen O. Exercise-induced oxidative stress: glutathione supplementation and deficiency. J Appl Physiol (1985) 1994;77:2177-87. https://doi.org/10.1152/jappl.1994.77.5.2177
  24. Gleeson M. Immune function in sport and exercise. J Appl Physiol (1985) 2007;103:693-9. https://doi.org/10.1152/japplphysiol.00008.2007
  25. Ronsen O, Haug E, Pedersen BK, Bahr R. Increased neuroendocrine response to a repeated bout of endurance exercise. Med Sci Sports Exerc 2001;33:568-75.
  26. Pedersen BK, Bruunsgaard H. How physical exercise influences the establishment of infections. Sports Med 1995;19:393-400. https://doi.org/10.2165/00007256-199519060-00003
  27. Sureda A, Ferrer MD, Tauler P, Romaguera D, Drobnic F, Pujol P, et al. Effects of exercise intensity on lymphocyte $H_2O_2$ production and antioxidant defences in soccer players. Br J Sports Med 2009;43:186-90. https://doi.org/10.1136/bjsm.2007.043943
  28. Evans WJ. Vitamin E, vitamin C, and exercise. Am J Clin Nutr 2000;72(2 Suppl):647S-52S. https://doi.org/10.1093/ajcn/72.2.647S