• Journal of Oral Medicine and Pain
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• 제32권4호
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• pp.383-396
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• 2007

노화가 미각기능에 미치는 영향에 관해서는 아직도 많은 논란이 계속되고 있다. 노인에게서 보이는 미각기능의 감퇴를 정상적인 노화현상으로 보는 시각과 약물사용이나 타액분비의 감소에 의한 결과로 보는 시각이 교차하고 있으며, 또한 미각 기능을 평가하는 방법에 따라 서로 다른 주장이 제기되기도 하였다. 저자들은 노화가 초역치 미각강도에 미치는 영향을 구명하기 위해서 본 연구를 시행하였으며, 약물사용에 의한 영향을 배제하기 위해서 장기적인 약물사용의 병력이 없는 20대의 여성 30명과 40-50대의 여성 31명을 피검자로 선택하여 염화나트륨, 설탕, 구연산, 염산키니네 수용액에 대한 초역치 미각강도를 소리자극을 이용한 규모짝짓기 방법으로 측정한 다음 그 결과를 서로 비교하였으며, 40-50대 여성에 대해서는 또한 폐경의 여부와 타액분비량의 다과에 따른 차이를 비교하여 다음과 같은 결론을 얻었다. 1. 한국인 40-50대 여성은 20대 여성에 비해 저 농도의 염화나트륨 수용액과 저 농도의 설탕 수용액에 대한 초역치 미각강도가 감소되었으며, 고농도의 염화나트륨 수용액과 고농도의 설탕 수용액, 그리고 모든 농도의 구연산 수용액과 염산키니네 수용액에서는 차이가 없었다. 2. 한국인 40-50대 여성에서 폐경으로 인한 초역치 미각강도의 변화는 나타나지 않았다. 3. 한국인 40-50대 여성에서 타액분비량의 다과에 따른 초역치 미각강도의 변화가 염화나트륨 수용액, 설탕 수용액, 염산키니네 수용액에 대해서는 나타나지 않았다. 4. 한국인 40-50대 여성에서 타액분비량이 적은 군이 많은 군에 비해 저 농도의 구연산 수용액에 대한 초역치 미각강도가 높게 나타났다.

• Archives of Pharmacal Research
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• 제24권6호
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• pp.546-551
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• 2001

We have previously shown that, in circular muscle cells of the lower esophageal sphincter (LES) isolated by enzymatic digestion, contraction in response to maximally effective doses of acetylcholine (ACh) or Inositol Triphosphate ($IP_3$) depends on the release of $Ca^{2+}$ from intracellular stores and activation of a $Ca6{2+}$-calmodulin (CaM)-dependent pathway. On the contrary, maintenance of LES tone, and response to low doses of ACh or $IP_3$ depend on a protein kinase C (PKC) mediated pathway. In the present investigation, we have examined requirements for $Ca6{2+}$ regulation of the interaction between CaM- and PKC-dependent pathways in LES contraction. Thapsigargin (TG) treatment for 30 min dose dependently reduced ACh-induced contraction of permeable LES cells in free $Ca6{2+}$ medium. ACh-induced contraction following the low level of reduction of $Ca6{2+}$ stores by a low dose of TG ($10^{-9}{\;}M$) was blocked by the CaM antagonist, CCS9343B but not by the PKC antagonists chelerythrine or H7, indicating that the contraction is CaM-dependent. After maximal reduction in intracellular $Ca{2+}$ from $Ca6{2+}$stores by TG ($10^{-6}{\;}M$), ACh-induced contraction was blocked by chelerythrine or H7, but not by CCS9343B, indicating that it is PKC-dependent. In normal $Ca^{2+}$medium, the contraction by ACh after TG ($10^{-9}{\;}M$) treatment was also CaM-dependent, whereas the contraction by ACh after TG ($10^{-9}{\;}M$) treatment was PKC-dependent. We examined whether PKC activation was inhibited by activated CaM. CCS 7343B Inhibited the CaM-induced contraction, but did not inhibit the DAC-induced contraction. CaM inhibited the DAC-induced contraction in the presence of CCS 9343B. This inhibition by CaM was $Ca{2+}$dependent. These data are consistent with the view that the switch from a PKC-dependent pathway to a CaM dependent pathway can occur and can be regulated by cytosolic $Ca{2+}$ in the LES.

• 한국음향학회지
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• 제16권4호
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• pp.11-20
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• 1997

지금까지 널리 사용된 수동 소음 제어 방법은 소리에 대한 재질 상의 특성을 이용하여 소음을 제거하는 방법으로서 무게와 부피를 증가시키고 소음의 고주파 성분에 대해서만 효율적인 성능을 발휘하는 단점을 가지고 있다. 이에 반해 최근에 발전된 능동 소음 제어 방법은 무게와 부피를 감소시키고 저주파 소음에 대한 성능이 우수하다는 장점을 가지고 있다. 본 논문에서는 능동 소음 제어의 원리를 디지털 신호 처리 기술을 이용하여 자동차 실내에서의 엔진 부밍 소음(Engine Booming Noise)을 감쇠시키는 실시간 능동 소음 제어 시스템을 구현하였다. 능동 제어를 위한 적응 알고리듬으로는 다채널 Filtered-x LMS 알고리듬을 사용하였으며 이를 위해 Motorola사의 디지털 신호처리 프로세서인 DSP560001을 제어기로 사용하여 적응 알고리듬을 실시간으로 구현하였다. 능동 소음 제어 시스템을 실제로 자동차에 장착하여 RPM에 따른 엔진 소음의 감쇠 성능을 평가한 결과 자동차 실내의 모든 위치에서 소음 감쇠 효과를 얻었으며 특정 주파수에서 20 dB 이상의 소음 감쇠 성능과 전체적으로 15 dB 이상의 소음 감쇠 성능을 확인할 수 있었다.

• 패션비즈니스
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• 제8권4호
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• pp.141-155
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• 2004

The purpose of this study was to arrange the korean women's hair styles of the beginning of 21st century and make hair style image making chart to use personal image making consulting data through analyze actress hair styles of broadcasting TV drama. To accomplish this purposes, picked up the two most popular dramas per each broadcasting stations, KBS1, KBS2, MBC, SBS, in february 2004. and analyzed and arranged hair styles of actress and at the last made the hair style image making chart. The results of the research are as belows. 1. Hair trends of february 2004. were Modern Sophisticated, Active and Romantic. 2. The results of three classifications of hair style trends, form, color, accessory, were as belows. 1) Form : Layer, left part, straight, low wave, long hair, no volme, bang were in vogue. Generally, Modern Sophisticated, Active, Romantic feeling were in vogue. 2) Color : Black, brown, two tone color were in vogue. Generally Modern Sophisticated, Romantic, Active feeling were in vogue. 3) Accessory : Hair bands & pins were in vogue. Generally these gave the Modern, Active feeling. 3. Hair style image making chart manufacturing depends on fashion feeling. 1) Classification of feeling, 2) Analysis of form, 3) Analysis of color, 4) Hair style image making chart manufacturing depends on fashion feeling This research will be a historical data of korean women's hair styles of the beginning of 21st century & can be used the basic data of personal hair style image making consulting.

• The Korean Journal of Physiology and Pharmacology
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• 제2권6호
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• pp.715-724
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• 1998

Frequency-force relationships (FFR) were studied in electrically field stimulated rat left atria (LA) by reducing the stimulation frequency from resting 3 Hz to test frequencies (0.1-1 Hz) for 5 minutes. The twitch amplitudes of LA elicited the typical negative staircases with 3-phased changes: the initial rapid increase, the second decrease and the following plateau at test frequencies. Verapamil $(3{\times}10^{-5}\;M)$ pretreatment elicited frequency-dependent suppression of the twitch amplitudes, exaggerating the negative staircase. Monensin pretreatment enhanced not the peak but the plateau amplitudes in a concentration-dependent manner. When the $Na^+-Ca^{2+}$ exchange was blocked by $Na^+\;and\;Ca^{2+}$ depletion in the Krebs Hensleit buffer (0 $Na^+-0\;Ca^{2+}$ KHB), the twitch amplitudes increased in a frequency-dependent manner, changing the negtive staircase into the positve one. Meanwhile, the 0 $Na^+-0\;Ca^{2+}$ KHB applicationinduced enhancement was strongly suppressed by caffeine (5 mM) pretreatment. Only dibucaine among the local anesthetics increased the basal tone during frequency reduciton. There were no differences in $^{45}Ca$ uptakes between 0.3 Hz and 3 Hz stimulation except at 1 min when it was significantly low at 0.3 Hz than 3 Hz, illustrating net $Ca^{2+}$ losses. Monensin pretreatment enhanced the rate of this $Ca^{2+}$ loss. Taken together, it is concluded that $Na^+-Ca^{2+}$ exchange extrudes more SR released $Ca^{2+}$ out of the cell in proportion to the frequency, resulting in the negative rate staircase in the rat LA.

• 한국HCI학회:학술대회논문집
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• 한국HCI학회 2008년도 학술대회 1부
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• pp.697-702
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• 2008

2007년 현재 전 세계적으로 모바일 기기 사용 인구수는 약 30억 명으로 전 세계 PC사용자 수의 두 배에 달한다. 모바일 디스플레이는 작은 크기로 인해 휴대성이 높은 등 많은 장점을 갖고 있지만, 소형화와 전력 절감을 위해 얇은 디스플레이 패널과 저성능 이미지 센서를 채택하는 등 대형 디스플레이에 비해 색상표현력이 떨어질 수 밖에 없다. 따라서 본 연구에서는 모바일 디스플레이 자체의 성능이 떨어지더라도 사람의 눈에 인식되기 용이하게 색채이론에 입각해 이미지 환경을 변경하는 방법을 제안한다. 사람의 눈은 망막상의 색신경이 어떤 색의 자극을 받게 되면 그 색의 보색에 대한 감수성이 높아지고, 명암차이가 분명한 색상들을 나열하면 반대 밝기에 대한 민감도가 높아진다. 사람의 시각신경에서 느끼는 색채에 대한 감성적인 색상처리(RGB의 채도를 증가 시키거나 다이나믹 레인지의 확장과 보색대비의 강조에 따른 변화)를 통하여 얻은 데이터를 비교 분석 한다. 그 결과 적용 전의 이미지보다 적용 후의 이미지의 인식률이 높아지고 화질이 향상됨을 알 수 있다.

• 한국전자파학회논문지
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• 제14권1호
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• pp.68-74
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• 2003

본 논문에서는 Ka-band 위성중계기에 사용되어지는 수신하향변환기(Receiver-Downconverter) 모듈의 설계 및 제작 그리고 시험 결과에 대하여 기술하였다. 개발된 수신하향변환기는 30.6 GHz∼31 GHz대역의 신호를 입력으로 받아들여 20.8 GHz∼21.2 GHz 대역의 신호를 출력하는 일종의 Downconverter 이지만, 모듈의 입력단에 저잡음 증폭부가 포함된 수신기의 역할도 하고 있다 개발된 모듈은 제작과정 및 시험과정에 있어 위성중계기 부품 제작 규정을 준수하였으며, 그 개발된 성능은 현재까지 알려진 국내외 유사 부품중의 최고의 성능을 보여주고 있다. 측정된 모듈의 성능은 상온에서 1.9 dB의 잡음지수, 55 dB 이득, 58 dBc의 C/I3 값을 보여주고 있다. 제작된 모듈의 크기는 93 mm${\times}$84 mm${\times}$26 mm이며 무게는 240 g으로서 국내외 유사 제품에 비해 소형이다.

• 한국의류학회지
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• 제34권11호
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• pp.1844-1858
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• 2010

Ethnical tendency follows the current political, economical, and cultural influence eastwards, highlighting films, architecture and interiors as well as fashion. With this tendency, the ethnic outfits are expressed by various styles. This study analyzes the features of current ethnic styles with 1,535 ethnic image pieces from 2005 S/S to 2010 F/W of Pr${\^{e}}$t-${\'{a}}$-Porte in Paris and Milan. First, 'ethnic' is to refer to the distinct features of an ethnic group or a country. 'Ethnic look' refers to the adaptation or re-arrangement of various ethnic group's traditional costumes, dying, textile, patterns, color, silhouettes, and accessories. Second, the most popular ethnics in the modern fashion is the African style, followed by India, Japan, China, and Latin America in both collections. Third, the proportion of ethnics decreased, 2005 (14.9%), 2006 (12.8%) and 2007 (8.2%). In 2008 the proportion increased again. 2010 (27.3%) and compared 2010 to 2007, it increased by 20%. By season, S/S had 1.4 times more ethnic styles than F/W with the prevalence of African and Indian styles. Fourth, as of 2005, the ethnic style became colorful and went through changes to combine various images. This is from the polycentric tendency of co-existing various styles with a prevalence of low tone and various colors. It also shows warm colors in front to show a sense of nature.

• 생물정신의학
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• 제12권1호
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• pp.13-19
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• 2005

Objective:The purposes of this study were to investigate heart rate variability(HRV) in patients with generalized anxiety disorder(GAD) compared with major depressive disorder in Korea. Methods:Fifty-six GAD patients(20 male and 36 female) was classified into their comorbid psychiatric illness. Among them, Twenty-five patients(10 male and 15 female) who do not have any psychiatric comorbidity were compared with 30 major depressive disorder patients(12 male and 18 female). Clinical symptoms, HRV and MMPI were analysed between two group. Results:Comorbid psychiatric illnesses of GAD were ranked into no diagnosis(44.6%), MDD(32.1%), panic disorder(10.7%), social phobia(5.3%), PTSD(1.7%), OCD(1.7%), MDD+panic disorder(1.7%) and MDD+specific phobia(1.7%). GAD patients showed low functioning in HRV, but degree of decreasing HRV is not so severe compared with MDD patient. Balance of sympathetic and parasympathetic nerve tone is more severely impaired in GAD patients compared with MDD patient. The score of MMPI did not reveal any differences between two groups. Conclusions:The result showed that HRV can differenciate GAD and MDD patients. GAD patients could show decreased HRV functioning, less than MDD patients. But autonomic imbalance could be more severe in GAD than MDD patients.

• Journal of Korean Neurosurgical Society
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• 제50권2호
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• pp.95-98
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• 2011

Objective : This study aimed to evaluate the surgical outcomes of selective median neurotomy (SMN) for spastic wrist and fingers. Methods : We studied 22 patients with wrist and finger spasticity refractory to optimal oral medication and physical therapy. The authors evaluated spasticity of the wrist and finger muscles by comparing preoperative states with postoperative states using the modified Ashworth scale (MAS). We checked patients for changes in pain according to the visual analog scale (VAS) and degree of satisfaction based on the VAS. Results : The preoperative mean MAS score was $3.27{\pm}0.46$ ($mean{\pm}SD$), and mean MAS scores at 3, 6, and 12 months after surgery were $1.82{\pm}0.5$, $1.73{\pm}0.7$, and $1.77{\pm}0.81$ ($mean{\pm}SD$), respectively. On the last follow-up visit, the mean MAS score measured $1.64{\pm}0.9$ ($mean{\pm}SD$). Wrist and finger spasticity was significantly decreased at 3, 6, and 12 months after the operation (p<0.01). The preoperative mean pain VAS score was $5.85{\pm}1.07$ ($mean{\pm}SD$), and the mean pain VAS score on the last follow-up visit after surgery was $2.28{\pm}1.8$ ($mean{\pm}SD$). Compared with the preoperative mean pain VAS score, postoperative mean pain VAS score was decreased significantly (p<0.01). On the basis of a VAS ranging from 0 to 100, the mean degree of patient satisfaction was $64.09{\pm}15.93$ ($mean{\pm}SD$, range 30-90). Conclusion : The authors propose SMN as a possible effective procedure in achieving useful, long-lasting tone and in gaining voluntary movements in spastic wrists and fingers with low morbidity rates.