• Journal of Biomedical Engineering Research
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• v.43 no.4
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• pp.219-229
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• 2022

In this study, we propose a miniaturized micro-ceramic heater device. After screen-printing a silver paste between pre-sintered two aluminum oxide plates to integrate a heating circuit, the device was fabricated through a low-temperature sintering process. In order to configure the optimal heating circuit integration condition, the output current evaluation and heating test were performed according to the number of screen prints of the silver paste at various voltages. A silver paste-based heating circuit printed with a line width of 200 ㎛ and a thickness of 60 ㎛ was successfully integrated on a pre-sintered alumina substrate through a low-temperature sintering process. In the case of the 5 times printed device, the thermal response showed a response rate of 18.19 ℃/sec. To demonstrate feasibility of the proposed device in the medical field, such as bio-tissue suturing and hemostasis, a voltage was applied to pig tissue in the device to test tissue change due to heat generated from the device. These results show the possibility that the proposed small ceramic heater could be used in the medical field based on its excellent temperature response.

• Journal of Microbiology and Biotechnology
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• v.32 no.11
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• pp.1406-1415
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• 2022

The formation of macrophage foam cells stimulated by oxidized low-density lipoprotein (ox-LDL) is deemed an important cause of atherosclerosis. Transcription factor Yin Yang 1 (YY1), which is a universally expressed multifunctional protein, is closely related to cell metabolism disorders such as lipid metabolism, sugar metabolism, and bile acid metabolism. However, whether YY1 is involved in macrophage inflammation and lipid accumulation still remains unknown. After mouse macrophage cell line RAW264.7 cells were induced by ox-LDL, YY1 and proprotein convertase subtilisin/kexin type 9 (PCSK9) expressions were found to be increased while low-density lipoprotein receptor (LDLR) expression was lowly expressed. Subsequently, through reverse transcription-quantitative polymerase chain reaction (RT-qPCR), Western blot analysis, Oil Red O staining and cholesterol quantification, it turned out that silencing of YY1 attenuated the inflammatory response and lipid accumulation in RAW264.7 cells caused by ox-LDL. Moreover, results from the JASPAR database, chromatin immunoprecipitation (ChIP) assay, luciferase reporter assay and Western blot analysis suggested that YY1 activated PCSK9 by binding to PCSK9 promoter and modulated the expression of LDLR in the downstream of PCSK9. In addition, the results of functional experiments demonstrated that the inhibitory effects of YY1 interference on ox-LDL-mediated macrophage inflammation and lipid accumulation were reversed by PCSK9 overexpression. To sum up, YY1 depletion inhibited its activation of PCSK9, thereby reducing cellular inflammatory response, cholesterol homeostasis imbalance, and lipid accumulation caused by ox-LDL.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.9
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• pp.5237-5242
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• 2013

Background: Inflammation is a critical component of tumor progression. Many cancers arise from sites of infection, chronic irritation, and inflammation. It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an essential participant in the neoplastic process, promoting proliferation, survival and migration. Platelets can release some growth factors such as platelet-derived growth factor, platelet factor 4, and thrombospondin. Such factors have been shown to promote hematogenous tumour spread, tumor cell adhesion and invasion, and angiogenesis and to play an important role in tumor progression. In this study, we aimed to investigate effects of the pretreatment neutrophil to lymphocyte ratio (NLR) and the platelet to lymphocyte ratio (PLR) on survival and response to chemoradiotherapy in patients with non-small-cell lung cancer (NSCLC). Materials and Methods: Ninety-four patients with non-metastatic NSCLC were included and separated into two groups according to median valuse of NLR and PLR (low:<3.44 or high:${\geq}3.44$ and low:<194 or high${\geq}194$, respectively). Results: Pretreatment high NLR and PLR were associated with significantly shorter disease-free and overall survival rates. Multivariate analysis revealed that the overall survival rates were significantly linked with PLR (OR: 1.87, CI: 1.20-2.91, p: 0.006) and response to chemoradiotherapy (OR: 1.80, CI: 1.14-2.81, p: 0.012) and the disease-free survival rates were significantly associated with NLR (OR: 1.81, CI: 1.16-2.82, p: 0.009) and response to chemoradiotherapy (OR: 2.30, CI: 1.45-3.66, p: 0.001). There was no significant difference between patients with high and low NLR in terms of response to chemoradiotherapy. Similarly, there was no significant influence of the PLR. Conclusions: Pretreatment NLR and PLR measurements can provide important prognostic results in patients with NSCLC and assessment of the two parameters together appears to better predict the prognosis in patients with NSCLC. The effect of inflammation, indicators of NLR and PLR, on survival seems independent of the response to chemoradiotherapy.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.4
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• pp.37-41
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• 2021

This paper presents a study to implement a touch screen capable of real-time response processing in a low-end embedded system. This was done by introducing an algorithm using an interpolation method to represent real-time response characteristics when a touch input is performed. In this experiment, we applied a linear interpolation algorithm that estimates random data by deriving a first-order polynomial from 2-point data. We also applied a Lagrange interpolation algorithm that estimates random data by deriving a quadratic polynomial from 3-point data. As a result of the experiment, it was found that the Lagrange interpolation method was more complicated than the linear interpolation method, and the processing speed was slow, so the text was not smooth. When using the linear interpolation method, it was confirmed that the speed displayed on a screen is 2.4 times faster than when using the Lagrange interpolation method. For real-time response characteristics, it was confirmed that smaller size of the executable file of the algorithm is more advantageous than the superiority of the algorithm itself. In conclusion, in order to secure real-time response characteristics in a low-end embedded system, it was confirmed that a relatively simple linear interpolation algorithm performs touch operations with better real-time response characteristics than the Lagrange interpolation method.

• Journal of the Earthquake Engineering Society of Korea
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• v.24 no.6
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• pp.267-275
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• 2020

In the event of an earthquake, non-structural components require seismic performance to ensure evacuation routes and to protect lives from falling non-structural components. Accordingly, the seismic design code proposes horizontal force for the design and evaluation of non-structural components. Ground motion observed on each floor is affected by a building's eigen vibration mode. Therefore, the earthquake damage of non-structural components is determined by the characteristics of the non-structural component system and the vibration characteristics of the building. Floor response spectra in the seismic design code are estimated through time history analysis using seismic waves. However, it is difficult to use floor response spectra as a design criterion because of user-specific uncertainties of time history analysis. In addition, considering the response characteristics of high-rise buildings to long-period ground motions, the safety factor of the proposed horizontal force may be low. Therefore, this study carried out the horizontal force review proposed in the seismic design code through dynamic analysis and evaluated the floor response of seismic waves considering buildings and predominant periods of seismic waves.

• Proceedings of the IEEK Conference
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• 2004.08c
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• pp.872-875
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• 2004

In this paper, thermal response analysis of a temperature controlled three-axis accelerometer for high temperature environments with integrated micro-heaters and temperature sensors is investigated with finite element method (FEM) program, ANSYS and infrared thermal measurement systems. And availability to application fields from a viewpoint about short thermal response time is discussed. In this paper, the time of three-axis accelerometer for high temperatures becoming $300^{\circ}C$ by integrated micro-heaters and temperature sensors to reduce thermal drift characteristics was analyzed as a thermal response time of this device. The simulated thermal response time (time until SOI piezoresistors actually becomes $300^{\circ}C$) of three-axis accelerometer for high temperatures with ANSYS is about 0.6s, and measured result with infrared temperature measurement systems is about 0.64s. Experimental results using infrared thermal measurement systems agreed well with these theoretical results.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.sup3
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• pp.87-91
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• 2016

To investigate whether excision repair cross complementing-group1 (ERCC1) expression status could serve as a bio-predictor of response to platinum-based induction chemotherapy for head and neck cancers (HNCs) patients with a diagnosis of epithelial HNC were studied retrospectively. Paraffin embedded tumor samples of the patients were analyzed by reverse transcription-polymerase chain reaction (RT-PCR) to determine ERCC1 expression status and its correlation with response to platinum-based induction chemotherapy was investigated. Of 44 included patients, 33 were male (75%) and 11 were female (25%) with a mean age of 53 years. Some 36% of patients whose tumor samples had high ERCC1 expression showed no response to induction chemotherapy. The value for patients with low ERCC1 expression was 9% and the difference was statistically significant (p=0.03). The ERCC1 expression state did not significantly vary between patient groups according to sex, age, primary tumor site, and tumor and node stage. Our study indicates that ERCC1 expression status detected by RT-PCR might serve as a bio-predictor of response to platinum-based induction chemotherapy for epithelial HNCs.

• Journal of the Korea Fashion and Costume Design Association
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• v.18 no.4
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• pp.87-99
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• 2016

The purpose of this study was to investigate the appearance orientation and clothing and cosmetics purchasing behaviors according to media contact responses. The subjects were 445 female university students in Daejeon and Chungnam province. The measuring instruments was a questionnaire with media contact responses, appearance orientation, clothing and cosmetics purchasing behavior, and subjects' demographic characteristics. The data were analyzed by Cronbach's ${\alpha}$, frequency analysis, ${\chi}^2$ test, ANOVA, Duncan's multiple range test, and regression analysis using SPSS program. The results were as follows. First, female university students had very positive response and attitude on entertainers' appearance, style and products showed by media. Second, media contact response had a significant effect on appearance orientation. The group with a high level of media contact response showed higher appearance orientation than the groups with mediate and low level of media contact response. Third, media contact response had meaningful effects on clothing and cosmetics purchasing behaviors. The group with a high level of media contact response showed higher shopping frequency, purchasing frequency, and more spending on clothing and cosmetics than other groups.

• The Korean Journal of Ecology
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• v.28 no.2
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• pp.105-112
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• 2005

Environmental factors such as light and low $CO_2$ concentrations trigger events which may result in stomatal opening. Stomatal aperature is largely controlled by the solute contents of guard cells, but not exclusively, by through changes in their content of potassium salts, with $K^+$ balanced either by $Cl^-$ or malate, depending on the species and conditions. However, how these signals are sensed and how they are transduced into driving the ion fluxes that control stomatal movements is not still fully understood. The basic role of stomata is regulating transpiration and photosynthesis. Photosynthesis plays a central role in the physiology of plants and an understanding of its response to light is, therefore, critical to any discussion of how plants sense and respond to light. It had been proposed that the evidences pointed three possible mechanisms for the light response. Firstly, there is a direct response of stomata to light. Secondly. there is an indirect response of stomata to light through the effect of $CO_2$. Lastly, there are some evidences for a third effect of light on stomata. However, attempts to investigate how these three possible mechanisms explained in detail in response to light have not been made. Therefore, this study is examined the differences among these three possible mechanisms.