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Clinical efficacy of L. plantarum, L. reuteri, and Ped. acidilactici probiotic combination in canine atopic dermatitis (개 아토피 피부염에서 3종 프로바이오틱스 복합제의 임상 효능 평가)

  • Hye-Kang Jung;Jae-Hun Kim;Jeseong Park;Yeonhee Kim;Minn Sohn;Chul Park
    • Korean Journal of Veterinary Service
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    • v.47 no.1
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    • pp.19-26
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    • 2024
  • Canine atopic dermatitis (CAD) is an inflammatory and pruritic skin disease with a genetic predisposition, characterized by allergic sensitivity. It is known for its distinctive clinical features, including a high recurrence rate and chronic progression. To manage CAD, medications such as steroids and immunosuppressants are commonly used, but consideration should be given to the potential resistance and side effects associated with long-term use. In order to reduce these risks, various adjunctive factors are currently under consideration. One of these adjunctive agents, probiotics have shown effectiveness in regulating atopic dermatitis by modulating immune responses, as demonstrated in several recent studies. In this study, a substance combining three probiotics-L. plantarum, L. reuteri, and Ped. Acidilactici-was used in patients diagnosed with CAD, and its clinical effects and safety were evaluated. The trial involved four groups: a group receiving conventional treatment for atopic dermatitis (A), a group prescribed low-dose probiotics (B), a group prescribed high-dose probiotics (C), and a group prescribed topical probiotics (D). For assessment, the Canine Atopic Dermatitis Extent and Severity Index (CADESI), Trans-Epidermal Water Loss (TEWL) test, gut microbiome, and serum IgE test were conducted. As a result, the CAD severity index (CADESI-4) significantly decreased in the probiotics groups (B & C). In the serum total IgE test, the groups consuming probiotics showed a significant difference, while the group using topical probiotics (D) did not exhibit a significant change. Also, the TEWL test showed improved scores in the probiotics groups (B & C). Therefore, L. plantarum, L. reuteri, and Ped. Acidilactici probiotic combination could be considered as an effective adjunctive treatment, especially for atopic patients with moderate to severe skin lesions.

Analysis of Thermal Environment Modification Effects of Street Trees Depending on Planting Types and Street Directions in Summertime Using ENVI-Met Simulation (ENVI-Met 시뮬레이션을 통한 도로 방향별 가로수 식재 형태에 따른 여름철 열환경 개선 효과 분석)

  • Lim, Hyeonwoo;Jo, Sangman;Park, Sookuk
    • Journal of the Korean Institute of Landscape Architecture
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    • v.50 no.2
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    • pp.1-22
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    • 2022
  • The modification effects of street trees on outdoor thermal comfort in summertime according to tree planting types and road direction were analyzed using a computer simulation program, ENVI-met. With trees, the air temperature and wind speed decreased, and the relative humidity increased. In the case of mean radiant temperature (Tmrt) and human thermal sensation, physiological equivalent temperature (PET) and universal thermal climate index (UTCI), there was a decrease during the daytime. The greatest change among the meteorological factors by trees happened in Tmrt, and PET and UTCI showed similar patterns with Tmrt·The most effective tree planting type on thermal comfort modification was low tree height, wide tree crown, high leaf area index, and narrow planting interval (LWDN). Tmrt, PET and UTCI showed a large difference depending on shadow patterns of buildings and trees according to solar altitude and azimuth angles, and building locations. When the building shade areas increased, the thermal modification effect by trees decreased. In particular, results on the east and west sidewalks showed a large deviation over time. When applying the LWDN, the northwest, west and southwest sidewalks showed a significant reduction of 8.6-12.3℃ PET and 4.2-4.5℃ UTCI at 10:00, and the northeast, east and southeast sidewalks showed 8.1-11.8℃ PET and 4.4-5.0℃ UTCI at 16:00. On the other hand, when the least effective type (high tree height, narrow tree crown, low leaf area index, and wide planting interval) was applied, the maximum reduction was up to 1.8℃ PET and 0.9℃ UTCI on the eastern sidewalks, and up to 3.0℃ PET and 0.9℃ UTCI on the western ones. In addition, the difference in modification effects on Tmrt, PET and UTCI between the tree planting types was not significant when the tree effects were reduced by the effects of buildings. These results can be used as basic data to make the most appropriate street tree planting model for thermal comfort improvement in urban areas in summer.

Modified Septal Extension Graft for the Correction of Nasal Tip and Columella (코끝과 코기둥의 교정을 위한 변형된 코중격 연장 이식술)

  • Kim, Jun Sik;Choi, Jae Hoon;Choi, Tae Hyun;Kim, Nam Gyun;Lee, Kyung Suk;Han, Ki Hwan;Son, Dae Gu
    • Archives of Plastic Surgery
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    • v.33 no.6
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    • pp.681-687
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    • 2006
  • Purpose: The nose of most Koreans is characterized as a low nasal dorsum, retracted columella, and an acute columella-labial angle. For the surgical correction of the tip and columella, a modified septal extension graft, along with augmentation rhinoplasty has been developed. Methods: With this technique, a septal extension graft is fixed on the entire caudal margin of the septum (the cephalic-caudal axis) and at the same time, it is placed above the anterior nasal spine, in the membranous portion of the septum and at the base of the columella(the anterior-posterior axis). The present report describes the results obtained in 13 patients and offers an analysis of the results as judged by the columella-labial angle and 4 proportional indices(nose height index, nasal bridge length index, nasal tip projection index, columella length index), measured by photogrammetry. Results: The postoperative values obtained in these 5 categories increased significantly compared to the preoperative ones, thus confirming that the projection of tip was augmented, the nose was lengthened, and the columella was advanced caudally and lengthened. Moreover, these positive outcomes were still maintained during the follow-up period, and no side effects, such as saddle nose deformity, were reported. Conclusion: A modified septal extension graft can be considered as an effective method for the surgical correction of the nasal tip and columella in Koreans.

A Study on Development of Safety Management Evaluation Index for Shipping Company (해운선사 안전관리 평가지표 개발에 관한 연구)

  • Kim, Hwa-Young
    • Journal of the Korean Society of Marine Environment & Safety
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    • v.19 no.6
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    • pp.629-636
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    • 2013
  • There is no safety evaluation index with marine accidents and information of ship's safety management result for good grasp of safety management level of shipping company and effective monitoring. In this paper, we proposed a SMEI(Safety Management Evaluation Index) for evaluation of shipping companies. The SMEI is consist of MAR(marine accidents ratio), SSMR(ship safety management ratio) and SAP(safety advantage point) through brainstorming of the expert group and AHP(analysis hierarchy process)in previous study. And weights of SMEI are calculated using experts's opinions through the Delphi method. We also verified the validity of proposed SMEI to 119 Korean shipping companies with 916 ocean-going ships of Korean flag, which grouped three part (small, mid and big) by number of ship and gross tonnage. And we found out 19 shipping companies, 8 companies in group1 & group2 respectively and 3 companies in group 3, with score below 1.0 by SMEI. In these companies, there are no marine accidents in recent 3 years and appeared low frequency remarkably in the detention and mojor non-conformity by data analysis.

The ultrasonographic estimate of renal arteries in the dog (개에 있어서 신장혈관의 초음파적 평가에 관한 연구)

  • Kang, Suk-jae;Bae, Chun-sik;Kim, Hwi-yool;Chang, Kyung-jin
    • Korean Journal of Veterinary Research
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    • v.39 no.1
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    • pp.230-239
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    • 1999
  • Digital color doppler ultrasonographic system(DCDUS) has a lot of diagnostic functions. One of these is a detection of low velocity vessels in the organs of abdominal cavity. The purpose of study was to determine the clinical usefulness of DCDUS. Interlobar artery resistive index(RI), pulsatility index(PI) and systolic diastolic ratio(SDr) were measured for diagnosis of obstructed urinary tract. RI, PI and SDr were a measure of intrarenal blood flow impedance. This study was consisted of 2 groups. The normal group was studied in 16 normal adult dogs and the study group was studied 7 dogs with surgically induced, unilateral ureteral obstruction. In the study group, parameters were checked in normal condition and on 1, 2, 3, 5, 7 and 10th day after ligation. The result were summarized as follows. In the normal group, RI, PI and SDr of the left kidney was $0.65{\pm}0.04$, $1.25{\pm}0.12$ and $292.45{\pm}29.40$, respectively. RI, PI and SDr of the right kidney were $0.64{\pm}0.05$, $1.28{\pm}0.20$ and $282.25{\pm}37.26$, respectively. In the study group, RI of the left kidney induced ligation was increased significantly on 1, 2, 3, 5, 7 and 10th day. RI of the left kidney on 1, 2, 3, 5, 7 and 10th day were $0.75{\pm}0.05$, $0.71{\pm}0.03$, $0.74{\pm}0.04$, $0.74{\pm}0.02$, $0.73{\pm}0.02$ and $0.73{\pm}0.04$, respectively. PI of the left kidney was increased significantly on 1, 3, 5 and 7th day. PI of the left kidney on 1, 3, 5 and 7th day were $1.57{\pm}0.21$, $1.54{\pm}0.24$, $1.60{\pm}0.15$ and $1.60{\pm}0.26$, respectively. SDr of the left kidney increased significantly on 1, 2, 3, 5 and 7th day. SDr of the left kidney on 1, 2, 3, 5 and 7th day were $412.18{\pm}86.69$, $352.14{\pm}47.05$, $399.77{\pm}65.54$, $369.43{\pm}48.34$ and $365.57{\pm}22.46$, respectively(p<0.05). In the study group, RI of the left kidney was more increased than that of the right kidney on 1, 2, 3, 5, 7 and 10th day. PI of the left kidney was more increased than that of the right kidney on 1, 3, 5, and 7th day. SDr of the left kidney was more increased than that of the right kidney on 1, 2, 3, 5 and 7th day(p<0.05). RI was effective in the diagnosis of an acute unilateral ureteral obstruction. PI and SDr were insufficient in the diagnosis of an acute unilateral ureteral obstruction.

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The Review of Exposure Index in Digital Radiography and Image Quality (디지털 영상에서 화질관리에 관한 노출지수(EI)의 유용성 연구)

  • Yang, Sook;Han, Jae Bok;Choi, Nam Gil;Lee, Seong Gil
    • Journal of Radiation Protection and Research
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    • v.38 no.1
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    • pp.29-36
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    • 2013
  • The aim of this study was to determine the correlation between exposure index (EI) and dose factors related to radiation dose optimization in digital radiography (DR) system. Two phantoms with built-in regional test object for quantitative assessment of images were used to produce image signals that acquired in chest radiography background. EI and entrane surface dose (ESD) increased proportionally with rise of radiation dose (kVp, mAs) in both DR and CR systems. Especially, DR detector was effective to form good contrast and hence, reached easily to improvement of image quality with minimal dose changes. It made operators possible to expect the accuracy of EI values deeply related to absorbed dose of the detector. The evaluation of images was obtained specially employed calculation of noise to signal ratio (NSR) and contrast to noise ratio (CNR). These measurements were performed for how exposure factors affect image quality. NSR was inversely proportional to kVp and mAs and low NSR represented high signal detection efficiency. Consequently, EI values was the measure of the amount of exposure received by the image receptor and it was proportional to exposure factors. Therefore the EI in a recommended range from manufacturer can offer optimal image quality. Also, continuous monitoring of EI values in the digital radiography can reduce the unnecessary patient dose and help the quality control of the system.

Application of an Interferometric Biosensor Chip to Biomonitoring an Endocrine Disruptor

  • Kim, Byung-Woo;Lim, Sung-Hyuk
    • Biotechnology and Bioprocess Engineering:BBE
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    • v.9 no.2
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    • pp.118-126
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    • 2004
  • Recombinant E.coli ACV 1003 (recA::lacZ) releasing ${\beta}$-galactosidase by a SOS regulon system, when exposed to DNA-damaging compounds, have been used to effectively monitor endocrine disruptors. Low enzyme activity of less than 10 units/mL, corresponding to a $\mu\textrm{g}$/L(ppb) range of an endocrine disruptor (tributyl tin, bisphenol A. etc.), can be rapidly determined, not by a conventional time-consuming and tedious enzyme assay, but by an alternative interferometric biosensor. Heavily boron-doped porous silicon for application as an interferometer, was fabricated by etching to form a Fabry-Perot fringe pattern, which caused a change in the refractive index of the medium including ${\beta}$-galactosidase. In order to enhance the immobilization of the porous silicon surface, a calyx crown derivative (ProLinker A) was applied, instead of a conventional biomolecular affinity method using biotin. This resulted in a denser linked formation. The change in the effective optical thickness versus ${\beta}$-galactosidase activity, showed a linear increase up to a concentration of 150 unit ${\beta}$-galactosidase/mL, unlike the sigmoidal increase pattern observed with the biotin.

A Study on Fuzzy Rule Functional Verification for Threshold Value Prediction of Buffer in ATM Networks (ATM 망에서 버퍼의 임계값 예측을 위한 퍼지 규칙 기능 검증에 관한 연구)

  • 정동성;이용학
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.29 no.8C
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    • pp.1149-1158
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    • 2004
  • In this thesis, we created a Fuzzy rule in a Fuzzy logic that are Fuzzy logic which is composed of linguistic rules and Fuzzy inference engine for effective traffic control in ATM networks. The parameters of the Fuzzy rules are adapted to minimize the given performance index in both cases. In other words, the difuzzification value controls the threshold in the buffer to arrival ratio to traffic priority (low or high) using fuzzy set theory for traffic connected after reasoning. Also, show experiment result about rule by MATLAB6.5 and on-line bulid-up to verify validity of created Fuzzy rule. As a result, we can verify that threshold value in buffer is efficiently controlled by the traffic arrival ratio.

Effects of Walking Program based on Social Cognitive Theory for Office Workers (사무직 근로자를 위한 사회인지이론 기반 걷기 프로그램의 효과)

  • Choi, Hye-Young;Yang, Sook-Ja
    • Korean Journal of Adult Nursing
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    • v.25 no.6
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    • pp.712-724
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    • 2013
  • Purpose: The purpose of this study was to examine the effects of a walking program for office workers in terms of social cognitive theory, walking activities and physiological indexes. Methods: A nonequivalent control group pretest-posttest design was used. The sample consisted of 50 office workers who were identified as having low levels of physical activity according to the International Physical Activity Questionnaire (IPAQ Research Committee, 2005). The participants were recruited from two companies in Seoul. Of the 50 participants, 26 were assigned to the non-equivalent experimental group and 24 to the control group. The walking program consisted of six didactic sessions via e-mail, two individual telecoaching sessions and three support group meetings over ten weeks. Data were analyzed using SPSS 17.0 program. Results: The non-equivalent experimental group reported significantly higher posttest scores in walking activities and adhering to the walking protocol than the control group. There were no differences in reported self-efficacy, outcome expectations, body mass index and blood pressure between the two groups. Conclusion: These findings indicate that a walking program based on social cognitive theory is effective in increasing physical activities for office workers.

Effect of fineness of high lime fly ash on pozzolanic reactivity and ASR mitigation

  • Afshinnia, Kaveh;Rangaraju, Prasada R.
    • Computers and Concrete
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    • v.20 no.2
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    • pp.197-204
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    • 2017
  • Typically, high lime fly ash (Class C) has been characterized as a fly ash, which at lower replacement levels is not as effective as the low lime (Class F) fly ash, in mitigating alkali-silica reaction (ASR) in portland cement concrete. The influence of fineness of Class C, obtained by grinding virgin fly ash into finer particles, on its pozzolanic reactivity and ASR mitigation performance was investigated in this study. In order to assess the pozzolanic reactivity of mortar mixtures containing virgin or ground fly ashes, the strength activity index (SAI) test and thermo-gravimetric analysis (TGA) were conducted on the mortar cubes and paste samples, respectively, containing virgin fly ash or two ground fly ashes. In addition, to evaluate any improvement in the ASR mitigation of ground fly ashes compared to that of the virgin fly ash, the accelerated mortar bar test (AMBT) was conducted on the mortar mixtures containing different dosages of either virgin or ground fly ashes. In all tests crushed glass aggregate was used as a highly reactive aggregate. Results from this study showed that the finest fly ash (i.e., with an average particle size of 3.1 microns) could increase the flow ability along with the pozzolanic reactivity of the mortar mixture. However, results from this study suggested that the fineness of high lime fly ash does not seem to have any significant effect on ASR mitigation.