Korean Journal of Veterinary Service (한국동물위생학회지)

The Korean Society of Veterinary Service (한국동물위생학회)
권호 표지
DOI QR코드

DOI QR Code

Clinical efficacy of L. plantarum, L. reuteri, and Ped. acidilactici probiotic combination in canine atopic dermatitis

개 아토피 피부염에서 3종 프로바이오틱스 복합제의 임상 효능 평가

  • Hye-Kang Jung (College of Veterinary Medicine, Jeonbuk National University) ;
  • Jae-Hun Kim (College of Veterinary Medicine, Jeonbuk National University) ;
  • Jeseong Park (Microbiome R&D Center, Lactomason Co., Ltd.) ;
  • Yeonhee Kim (Microbiome R&D Center, Lactomason Co., Ltd.) ;
  • Minn Sohn (Microbiome R&D Center, Lactomason Co., Ltd.) ;
  • Chul Park (College of Veterinary Medicine, Jeonbuk National University)
  • 정혜강 (전북대학교 수의과대학) ;
  • 김재훈 (전북대학교 수의과대학) ;
  • 박제성 ((주)락토메이슨 마이크로바이옴연구소) ;
  • 김연희 ((주)락토메이슨 마이크로바이옴연구소) ;
  • 손민 ((주)락토메이슨 마이크로바이옴연구소) ;
  • 박철 (전북대학교 수의과대학)
  • Received : 2024.01.02
  • Accepted : 2024.03.14
  • Published : 2024.03.30
Download PDF
⟨ Previous Next ⟩

Abstract

Canine atopic dermatitis (CAD) is an inflammatory and pruritic skin disease with a genetic predisposition, characterized by allergic sensitivity. It is known for its distinctive clinical features, including a high recurrence rate and chronic progression. To manage CAD, medications such as steroids and immunosuppressants are commonly used, but consideration should be given to the potential resistance and side effects associated with long-term use. In order to reduce these risks, various adjunctive factors are currently under consideration. One of these adjunctive agents, probiotics have shown effectiveness in regulating atopic dermatitis by modulating immune responses, as demonstrated in several recent studies. In this study, a substance combining three probiotics-L. plantarum, L. reuteri, and Ped. Acidilactici-was used in patients diagnosed with CAD, and its clinical effects and safety were evaluated. The trial involved four groups: a group receiving conventional treatment for atopic dermatitis (A), a group prescribed low-dose probiotics (B), a group prescribed high-dose probiotics (C), and a group prescribed topical probiotics (D). For assessment, the Canine Atopic Dermatitis Extent and Severity Index (CADESI), Trans-Epidermal Water Loss (TEWL) test, gut microbiome, and serum IgE test were conducted. As a result, the CAD severity index (CADESI-4) significantly decreased in the probiotics groups (B & C). In the serum total IgE test, the groups consuming probiotics showed a significant difference, while the group using topical probiotics (D) did not exhibit a significant change. Also, the TEWL test showed improved scores in the probiotics groups (B & C). Therefore, L. plantarum, L. reuteri, and Ped. Acidilactici probiotic combination could be considered as an effective adjunctive treatment, especially for atopic patients with moderate to severe skin lesions.

Keywords

References

  1. Boothe DW, Tarbox JA, Tarbox MB. 2017. Atopic dermatitis: pathophysiology. Adv Exp Med Biol 1027: 21-37.
  2. Butler E, Lundqvist C, Axelsson J. 2020. Lactobacillus reuteri DSM 17938 as a novel topical cosmetic ingredient: a proof of concept clinical study in adults with atopic dermatitis. Microorganisms, 8: 1026.
  3. Cornegliani L, Vercelli A, Sala E, Marsella R. 2012. Transepidermal water loss in healthy and atopic dogs, treated and untreated: a comparative preliminary study. Vet Dermatol 23: 41-44, e9-10.
  4. Doron S, SnydmanDR. 2015. Risk and safety of probiotics. Clin Infect Dis 60(suppl_2): S129-S134.
  5. Grzeskowiak L, Endo A, Beasley S, Salminen S. 2015. Microbiota and probiotics in canine and feline welfare. Anaerobe 34: 14-23.
  6. Hensel P, Santoro D, Favrot C, Hill P, Griffin C. 2015. Canine atopic dermatitis: detailed guidelines for diagnosis and allergen identification. BMC veterinary research 11: 1-13.
  7. Hill PB, DeBoerDJ. 1994. Quantification of serum total IgE concentration in dogs by use of an enzyme-linked immunosorbent assay containing monoclonal murine anti-canine IgE. Am J Vet Res 55: 944-948.
  8. Hill PB, Lau P, RybnicekJ. 2007. Development of an owner-assessed scale to measure the severity of pruritus in dogs. Vet Dermatol 18: 301-308.
  9. Hong SJ, Chong MS, Ahn SH. 2020. A review on effects of probiotics in atopic dermatitis. J Korean Med Ophthalmol Otolaryngol Dermatol 33: 25-44.
  10. Jeong DY, Ryu MS, Yang HJ, Jeong SY, Zhang T, Yang HJ, Kim MJ, Park S. 2020. Pediococcus acidilactici intake decreases the clinical severity of atopic dermatitis along with increasing mucin production and improving the gut microbiome in Nc/Nga mice. Biomed Pharmacother 129: 110488.
  11. Kim H, Rather IA, Kim H, Kim S, Kim T, Jang J, Seo J, Lim J, Park YH. 2015. A double-blind, placebo controlled-trial of a probiotic strain Lactobacillus sakei probio-65 for the prevention of canine atopic dermatitis. J Microbiol Biotechnol 25: 1966-1969.
  12. Kim SO, Ah YM, Yu YM, Choi KH, Shin WG, Lee JY. 2014. Effects of probiotics for the treatment of atopic dermatitis: a meta-analysis of randomized controlled trials. Ann Allergy Asthma Immunol 113: 217-226.
  13. Lee KI, Yun T, Ham J, Lee WK, Kang JH, Yang MP, Kang BT. 2020. Clinical trial of oral administration of Bifidobacterium longum in dogs with atopic dermatitis. Korean J Vet Res 60: 19-24.
  14. Marsella R, Santoro D, Ahrens K. 2012. Early exposure to probiotics in a canine model of atopic dermatitis has long-term clinical and immunological effects. Vet immunol immunopathol 146: 185-189.
  15. Matsumoto M, Ebata T, Hirooka J, Hosoya R, Inoue N, Itami S, Tsuji K, Yaginuma T, Muramatsu K, Nakamura A, Fujita A, Nagakura T. 2014. Antipruritic effects of the probiotic strain LKM512 in adults with atopic dermatitis. Ann Allergy Asthma Immunol 113: 209-216. e7.
  16. Noli C. 2019. Assessing quality of life for pets with dermatologic disease and their owners. Vet Clin North AmSmall Anim Pract 49: 83-93.
  17. Ohshima-Terada Y, Higuchi Y, Kumagai T, Hagihara A, Nagata M. 2015. Complementary effect of oral administration of L actobacillus paracasei K 71 on canine atopic dermatitis. Vet Dermatol 26: 350-353, e74-e75.
  18. Olivry T, DeBoer DJ, Favrot C, Jackson HA, Mueller RS, Nuttall T, Prelaud P. 2015. Treatment of canine atopic dermatitis: 2015 updated guidelines from the International Committee on Allergic Diseases of Animals (ICADA). BMC Veterinary Research 11: 1-15.
  19. Olivry T, Saridomichelakis M, Nuttall T, Bensignor E, Griffin C, Hill PB. 2014. Validation of the Canine Atopic Dermatitis Extent and Severity Index (CADESI)-4, a simplified severity scale for assessing skin lesions of atopic dermatitis in dogs. Vet Dermatol 25: 77-e25.
  20. Prakoeswa CRS, Herwanto N, Prameswari R, Astari L, Sawitri S, Hidayati AN, Indramaya DM, Kusumowidagdo ER, Surono IS. 2017. Lactobacillus plantarum IS-10506 supplementation reduced SCORAD in children with atopic dermatitis. Benef Microbes 8: 833-840.
  21. RatherI A, Bajpai V, Kumar S, Lim J, Paek WK, Park YH. 2016. Probiotics and atopic dermatitis: an overview. Front Microbiol 7: 1-7.
  22. Santoro D. 2019. Therapies in canine atopic dermatitis: an update. Vet Clin North Am Small Anim Pract 49: 9-26.
  23. Weston S, Halbert A, Richmond P, Prescott SL. 2005. Effects of probiotics on atopic dermatitis: a randomised controlled trial. Arch Dis Child 90: 892-897.