• 대한치과교정학회지
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• 제48권2호
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• pp.90-97
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• 2018

Objective: The aim of this study was to assess the analgesic effect of a single application of low-level laser therapy (LLLT) on spontaneous pain and pain on chewing after placement of initial archwires. Methods: Forty-two patients (26 women, 16 men) were randomly recruited for this split-mouth randomized clinical trial. Each patient received super-elastic nickel-titanium (NiTi) initial archwires (0.012, 0.014, 0.016, and 0.018-inch [in]) in the maxilla for leveling and alignment for an interval of 4 weeks between archwires. One side of the mouth was randomly designated as experimental, while the other side served as placebo. After insertion of each archwire, the experimental side was irradiated with a diode laser for 3 seconds each on 5 points facially and palatally per tooth, from the central incisor to first molar. On the placebo side, the laser device was held the same way but without laser application. A numerical rating scale was used to assess the intensity of spontaneous and masticatory pain for the following 7 days. The Mann-Whitney U test was used to compare pain scores between sides. Results: Patients in the LLLT group exhibited significantly lower mean scores for spontaneous pain after insertion of the initial two archwires (0.012-in and 0.014-in NiTi; p < 0.05), while there was no significant difference for 0.016-in and 0.018-in wires between the LLLT and placebo groups. LLLT significantly reduced chewing pain scores (p < 0.05) for all archwires. Conclusions: A single dose of LLLT considerably lessened postoperative pain accompanying the placement of super-elastic NiTi wires for initial alignment and leveling.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제35권2호
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• pp.120-124
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• 2009

The concept of biostimulation of wounds by low-level laser therapy(LLLT) is attracting considerable attention. Although its effect on whole tissues has been studied quite extensively, the biological and cellular mechanisms underlying LLLT have not been clarified. In an experimental radius fracture in rabbits, Tang and Chai reported that LLLT enhanced the activity of red blood cells, macrophages, fibroblasts, chondrocytes, and osteoclasts within the fracture area. The purpose of the present study was to evaluate the effect of LLLT with a GaAlAs diode laser device on bone healing in rabbit mandibular fractures. We use 12 rabbits for this study. All rabbits were fractured mandible angle area using saw in anesthetic condition. In control group(n=6), none treatment was performed at fracture site. In experimental group(n=6), LLLT with a GaAlAs diode laser was radiated at fracture site daily for 7 days. All rabbits were sacrificed at 6 weeks later from performed fracture day. We studied the immunohistochemical staining of CD34 and Vimentin and the histochemical analysis for calcium and phosphorus content. The results were as follows. 1. In the histological and immunohistological staining, after 6week, fibroblasts, osteogenic cells and collgen fibers were observed more in experimental group than in control group. 2. In the histochemical analysis, the amount of calcium and phosphorus contents of the experimental group were more than the control group. From the results obtained, we suggest that the bone healing is stimulated by low-level laser irradiation in bone fractures.

• 대한화장품학회지
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• 제48권3호
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• pp.245-254
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• 2022

본 연구에서는 655 nm에서 저출력 레이저와 625 ± 5 nm와 850 ± 10 nm에서 파장을 방출하는 LED를 이용한 복합 광선 요법이 탈모 및 두피에 나타나는 효능을 조사하고자 하였다. 이번 연구에는 총 33 명의 시험대상자가 등록되었다. 각 시험대상자는 Low-level laser therapy (LLLT)와 light-emitting diode (LED) 기기를 매일 10 min 씩 12 주간 두피와 모발에 사용했다. LLLT와 LED 기기를 사용한 지 12 주 후, 두피의 붉은기, 탄력, 수분 함량에서 상당한 개선이 있었으며, 모발의 윤기와 인장 강도, 탈락 모발 수가 개선되었다. 시험대상자가 시험 기기를 사용하는 기간 동안 특별한 피부 이상반응에 대한 보고는 없었다. LLLT와 LED를 이용한 복합 광선 요법은 탈모와 두피 상태 개선에 효과적인 요법임이 입증되었다.

• Korean Journal of Acupuncture
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• 제21권4호
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• pp.53-68
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• 2004

Objectives : Laser therapy started in 1958 when Schawlow and Townes suggested medical value of Laser therapy. He-Ne laser has been utilized as a clinical treatment for various diseases by Plog since 1975. Low Level Laser Therapy (LLLT) has been used as medication for controlling obesity in the Korean Medicine. So this study is planned to investigate the effects of LLLT on the level of serum lipid and weight gain Methods : Experimental groups were divided into normal group(Normal), high fat diet group(Control), high fat diet and LLLT by helium-neon (He-Ne) on the tail is carried out once a 2 day during 5 weeks. The animals were divided into six groups: no ischemia-induced and no LLLT-treated group (Normal), the ischemia-induced and no LLLT-treated group (Control), the ischemia-induced and 5 mW 5 min LLLT-treated group (LLLT5-5), the ischemia-induced and 30 mW 5 min LLLT-treated group (LLLT30-5), the ischemia-induced and 5 mW 10 min LLLT-treated group (LLLT5-10), 30 mW 10 min LLLT-treated group (LLLT30-10). The effect of LLLT is observed by weight gain, food intake, food efficiency, serum of lipid concentrations, liver function and HDL to total cholesterol ratio of rats fed high fat diet for 5weeks. Results : Body weight and food intake were decreased in LLL5-5, LLLT30-5, LLLT30-10. Food efficiency was decreased in LLLT30-10. The level of serum Triglyceride, Free fatty acid, AST, ALT, ALP were decreased in LLLT30-10. Serum HDL-cholesterol was increase in LLLT5-10, LLLT30-10. Also serum ALT was decrease in LLLT5-5 Conclusions : LLLT(30 mW-10 min) is effective on Body weight, food efficiency ratio, the level of serum lipid and protection of liver function by obesity induced by high fat diet, and LLLT(5 mW-5 min) act on decrease of Body weight, food intake and ALT.

• The Journal of Korean Physical Therapy
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• 제12권2호
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• pp.1-6
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• 2000

This studies were to investigate the effects of low power wavelengths Helium-Neon Infra-Red(He-Ne 1R) laser on the changes of the serum mineral components in burn rats. The thirty Spraque-Dawley adult male rats were assigned to the 5 groups: the experimental groups(3), the bum control group (1) and the control group(1). There was made three degree bum by the 250mW IR on the back of each rats. from 3 days after being burned. the experimental laser groups were irradiated low power wavelengths(292 Hz. 1168Hz, 4672Hz) He-He IR laser far 5 minutes every day during the 7 days. The results were as tallows: 1. There were significantly not changes of the levels of serum sodium between all experimental groups. 2. The concentration of potassium in serum on the treated with 292Hz wavelengths group during 5 minutes were significantly increased ,but with 1168Hz wavelenghths group were decreased to the those of burn group. 3. The concentrations of serum calcium in serum 1168Hz wavelengths laser group on the treated with 5 minutes laser were significantly higher to normal level than those of bum groups. As above results. the changes of the 2 essentials mineral(calcium and potassium) in serum levels on the healing process have meaningful effected with the low power wavelengths role on the treated with He-Ne IR laser.

• Korean Journal of Acupuncture
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• 제24권3호
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• pp.91-103
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• 2007

Objectives : The purpose of this study was to investigate the usability of live blood analysis on interior and exterior vascular laser irradiation therapy. Methods : We had analyzed the changing forms of the live blood sample with microscope before and after vascular laser irradiation therapy of blood. The live blood analysis was operated on Rouleau of red cell, erythrocyte aggregation, thrombocyte aggregation, uric acid crystals, red crystals, protoplasts. First, we analyzed all patients on each item, then did same thing classified two groups, Interior and exterior. Results : Rouleau of red cell, erythrocyte aggregation, thrombocyte aggregation, uric acid crystals, red crystals, protoplasts were decreased significantly, after interior and exterior aggregation, uric acid crystals. Interior vascular laser irradiation therapy was more effective than interior on Rouleau of red cell, erythrocyte aggregation, thrombocyte aggregation, uric acid crystals. Interior vascular laser irradiation therapy was more effective than exterior on red crystals, protoplasts. Conclusions : This study suggests that live blood analysis has the usability on vascular laser irradiation therapy. Then according to interior and exterior vascular laser irradiation therapy, the result has some different on each item. So it is better that choose the method, interior or exterior, for more effective therapy.

• 한국전기전자재료학회논문지
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• 제24권1호
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• pp.42-46
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• 2011

Light can be divided into ultraviolet rays, visible rays, and infrared rays depending on the wavelengths. Visible rays with specific wavelength are those predominantly used for would treatment. Especially low level laser irradiates into cells, effectively stimulating cellular tissues and activating cellular function. This study was intended to verify the effect of white LED irradiation therapy on wound recovery in animal tests by applying white LED irradiator, which was independently designed and developed to emit beams of similar wavelength to that of a laser. The designed LED Irradiator was used to find out how white LED light source affected the skin wound of SD-Rat(Sprague-Dawley Rat). We divided the participants into two groups; white LED irradiation group which was irradiated 1 hour a day for 9 consecutive days, and none irradiation group. The results showed that the study group had lower incidence of inflammation and faster recovery, compared with the control group.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제38권
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• pp.48.1-48.8
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• 2016

Background: This study investigates the effect of alendronate-treated osteoblasts, as well as the effect of low-level laser therapy (LLLT) on the alendronate-treated osteoblasts. Bisphosphonate decreases the osteoblastic activity. Various treatment modalities are used to enhance the bisphosphonate-treated osteoblasts; however, there were no cell culture studies conducted using a low-level laser. Methods: Human fetal osteoblastic (hFOB 1.19) cells were treated with $50{\mu}M$ alendronate. Then, they were irradiated with a $1.2J/cm^2$ low-level Ga-Al-As laser (${\lambda}=808{\pm}3nm$, 80 mW, and 80 mA; spot size, $1 cm^2$; NDLux, Seoul, Korea). The cell survivability was measured with the MTT assay. The three cytokines of osteoblasts, receptor activator of nuclear factor ${\kappa}B$ ligand (RANKL), osteoprotegerin (OPG), and macrophage colony-stimulating factor (M-CSF) were analyzed. Results: In the cells treated with alendronate at concentrations of $50{\mu}M$ and higher, cell survivability significantly decreased after 48 h (p < 0.05). After the applications of low-level laser on alendronate-treated cells, cell survivability significantly increased at 72 h (p < 0.05). The expressions of OPG, RANKL, and M-CSF have decreased via the alendronate. The RANKL and M-CSF expressions have increased, but the OPG was not significantly affected by the LLLT. Conclusions: The LLLT does not affect the OPG expression in the hFOB cell line, but it may increase the RANKL and M-CSF expressions, thereby resulting in positive effects on osteoclastogenesis and bone remodeling.

• Journal of Acupuncture Research
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• 제18권3호
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• pp.23-34
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• 2001

Objective : The purpose of this study was to investigate the effect of Intravascular Laser Irradiation of Blood(ILIB) by the live blood analysis. Methods : We had analysed the changing forms of the live blood samples with Ultra Darkfield Microscope before and after Intravascular Laser Irradiation of Blood. Results and Conclusion : 1. Nomal Erythrocytes were increased significantly after ILIB by the live blood analysis. 2. Poikilocytes were decreased significantly after ILIB by the live blood analysis. 3. Target Cells were decreased significantly after ILIB by the live blood analysis. 4. Somatid was improved significantly after ILIB by the live blood analysis. 5. Erythrocyte Aggregtion was improved significantly after ILIB by the live blood analysis.

• The Korean Journal of Pain
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• 제32권1호
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• pp.51-52
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• 2019