• Biomolecules & Therapeutics
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• v.27 no.6
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• pp.553-561
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• 2019

Rab25, a member of the Rab11 small GTPase family, is central to achieving cellular polarity in epithelial tissues. Rab25 is highly expressed in epithelial cells of various tissues including breast, vagina, cervix, the gastrointestinal tract, and skin. Rab25 plays key roles in tumorigenesis, mainly by regulating epithelial differentiation and proliferation. However, its role in skin physiology is relatively unknown. In this study, we demonstrated that Rab25 knock-out (KO) mice show a skin barrier dysfunction with high trans-epidermal water loss and low cutaneous hydration. To examine this observation, we investigated the histology and epidermal differentiation markers of the skin in Rab25 KO mice. Rab25 KO increased cell proliferation at the basal layer of epidermis, whereas the supra-basal layer remained unaffected. Ceramide, which is a critical lipid component for skin barrier function, was not altered by Rab25 KO in its distribution or amount, as determined by immunohistochemistry. Notably, levels of epidermal differentiation markers, including loricrin, involucrin, and keratins (5, 14, 1, and 10) increased prominently in Rab25 KO mice. In line with this, depletion of Rab25 with single hairpin RNA increased the expression of differentiation markers in a human keratinocyte cell line, HaCaT. Transcriptomic analysis of the skin revealed increased expression of genes associated with skin development, epidermal development, and keratinocyte differentiation in Rab25 KO mice. Collectively, these results suggested that Rab25 is involved in the regulation of epidermal differentiation and proliferation.

• Journal of Korean Medicine for Obesity Research
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• v.3 no.1
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• pp.49-59
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• 2003

Objectives : The purpose of this study is to evaluate the effect the of treatment in obesity clinic in east-west collaboration center, furthermore to search for how to join and improve east medicine and west medicine more closely. Methods : 37 patients were classified into four groups by Body Mass Index(BMI); normal, overweight, 1st obesity and 2nd obesity groups. Weight, BMI, body fat rate and abdominal fat rate were compared in each group by paired t-test. Results & Conclusions : In distribution of sex, male were 10(27%), female were 27(73%). Mean age was $34{\pm}13$ and the patients in twenties un the most. Among four groups, the number of End obesity groups was the most. Most patients had a preference for western medication and ear acupuncture therapy. In general we could find the correlation between the effect of obesity treatment and the degree of obesity. The more the obesity degree was, the more weight loss was.

• Korean Journal of Soil Science and Fertilizer
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• v.48 no.4
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• pp.246-254
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• 2015

This study explored the effect of rainfall pattern and soil characteristics on water management in rice paddy fields, using a soil water balance model, BUDGET. In two sites with different soil textural group, coarse loamy soil (Gangseo series) and fine soil (Hwadong series), respectively, we have monitored daily decrease of water depth, percolation rate, and groundwater table. The observed evapotranspiration (ET) was obtained from differences between water depth decrease and percolation rate. The root mean square difference values between observed and BUDGET-estimated ET ranged between 10% and 20% of the average observed ET. This is comparable to the measurement uncertainty, suggesting that the BUDGET model can provide reliable ET estimation for rice fields. In BUDGET model of this study, irrigation requirement was determined as minimum water need for maintaining water-saturated soil surface, assuming 100 mm of bund height and no lateral loss of water. The model results showed different water balance and irrigation requirement with the different soil profile and indicated that minimum percolation rate by plow pan could determine the irrigation requirement of rice paddy field. For the condition of different rainfall distribution, the results presented different irrigation period and amounts, representing the importance of securing water for irrigation against different rainfall pattern.

• Korean Journal of Clinical Pharmacy
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• v.31 no.3
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• pp.231-236
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• 2021

Background: Sarcopenia is a skeletal muscle disorder that involves the loss of muscle mass and function. Handgrip strength (HGS) is the most commonly used tool to assess muscle strength to diagnose sarcopenia. HGS is also associated with various diseases and health outcomes. Thus, we aimed this study to examine the HGS status in Korean adults and relevant factors of HGS. Methods: Data was obtained from the 7th Korea National Health and Nutrition Examination Survey (KNHANES), a population-based nationwide survey. The estimated mean value of HGS was calculated in each age group. The mean HGS in men and women aged over 40 was compared according to the household income level, lifestyle factors, and comorbidities. Results: A total of 16,708 participants were included in this study. The mean HGS showed a maximum value in the 30s for both men and women, and then tended to decrease with increasing age. When analyzed for people aged 40 or older, the mean HGS was significantly higher in the current or past smoker, drinker, and aerobic exercise groups in both men and women. The mean HGS was lower in the group with comorbidities such as hypertension, dyslipidemia, type 2 diabetes, and bone diseases. Conclusion: Our study found that the mean HGS was significantly different between those with and without underlying chronic diseases. In groups with relevant comorbidities, close monitoring for the development of sarcopenia and taking preventive measures such as exercise and nutritional support may be recommended.

• Steel and Composite Structures
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• v.30 no.6
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• pp.535-550
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• 2019

Prestressed concrete (PC) bridges using corrugated steel webbing have emerged as one of the most promising forms of steel-concrete composite bridge. However, their long-term behavior is not well understood, especially in the case of large-span bridges. In order to study the time-dependent performance, a large three-span PC bridge with corrugated steel webbing was compared to a similar conventional PC bridge to examine their respective time-dependent characteristics. In addition, a three-dimensional finite element method with step-by-step time integration that takes into account cantilever construction procedures was used to predict long-term behaviors such as deflection, stress distribution and prestressing loss. These predictions were based upon four well-established empirical creep prediction models. PC bridges with a corrugated steel web were observed to have a better long-term performance relative to conventional PC bridges. In particular, it is noted that the pre-cambering for PC bridges with a corrugated steel web could be smaller than that of conventional PC bridges. The ratio of side-to-mid span has great influence on the long-term deformation of PC bridges with a corrugated steel web, and it is suggested that the design value should be between 0.4 and 0.6. However, the different creep prediction models still showed a weak homogeneity, thus, the further experimental research and the development of health monitoring systems are required to further progress our understanding of the long-term behavior of PC bridges with corrugated steel webbing.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.13 no.6
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• pp.2964-2985
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• 2019

Global data center IP traffic is expected to reach 20.6 zettabytes (ZB) by the end of 2021. Intra-data center networks (Intra-DCN) will account for 71.5% of the data center traffic flow and will be the largest portion of the traffic. The understanding of traffic distribution in IntraDCN is still sketchy. It causes significant amount of bandwidth to go unutilized, and creates avoidable choke points. Conventional transport protocols such as Optical Packet Switching (OPS) and Optical Burst Switching (OBS) allow a one-sided view of the traffic flow in the network. This therefore causes disjointed and uncoordinated decision-making at each node. For effective resource planning, there is the need to consider joining the distributed with centralized management which anticipates the system's needs and regulates the entire network. Methods derived from Kalman filters have proved effective in planning road networks. Considering the network available bandwidth as data transport highways, we propose an intelligent enhanced SDN concept applied to OBS architecture. A management plane (MP) is added to conventional control (CP) and data planes (DP). The MP assembles the traffic spatio-temporal parameters from ingress nodes, uses Kalman filtering prediction-based algorithm to estimate traffic demand. Prior to packets arrival at edges nodes, it regularly forwards updates of resources allocation to CPs. Simulations were done on a hybrid scheme (1+1) and on the centralized OBS. The results demonstrated that the proposition decreases the packet loss ratio. It also improves network latency and throughput-up to 84 and 51%, respectively, versus the traditional scheme.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.64 no.2
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• pp.159-164
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• 2019

Weed control is a crucial practice not only in organic farming, but also in modern agriculture because it can lead to loss in crop yield. In general, weed is distributed in patches heterogeneously in the field. These patches vary in size, shape, and density. Thus, it would be efficient if chemicals are sprayed on these patches rather than spraying uniformly in the field, which can pollute the environment and be cost prohibitive. In this sense, weed detection could be beneficial for sustainable agriculture. Studies have been conducted to detect weed patches in the field using remote sensing technologies, which can be classified into a method using image segmentation based on morphology and a method with vegetative indices based on the wavelength of light. In this study, the latter methodology has been used to detect the weed patches. As a result, it was found that the vegetative indices were easier to operate as it did not need any sophisticated algorithm for differentiating weeds from crop and soil as compared to the former method. Consequently, we demonstrated that the current method of using vegetative index is accurate enough to detect weed patches, and will be useful for farmers to control weeds with minimal use of chemicals and in a more precise manner.

• Journal of dental hygiene science
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• v.19 no.1
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• pp.23-30
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• 2019

Background: The health of the economically active population contributes to increased corporate productivity by reducing the productivity loss caused by disease and increasing job efficiency, which in turn is a national benefit. Since the economically active population is a concept encompassing workers and a source of economic development for a country, that population's health should be treated with importance not only from a personal standpoint but also at a national level. Methods: In this study, data of 11,007 adults aged 20 years and older who participate in economic activities were analyzed in the five-year Korea Health Panel Study from 2010 to 2014 including the number of dental visits and dental medical expenses. Results: Factors related to "gender," "education level," "age," "duty category," "income level," "employment type," "national health insurance," and "chronic disease status" of the economically active population are affected in relation to the number of visits and dental medical expenses. The number of dental visits increased with higher education levels (p<0.001), and the number of visits to the dentist increased with older age (p <0.001). Dental medical expenses were 91,806 Korean won (KRW) more for "white-collar workers" than for "blue-collar workers" (p<0.03), and 127,674 KRW more for "regular workers" than for "atypical workers" (p<0.02). Conclusion: When it is necessary to improve policies to enhance the efficiency of the distribution of health and medical resources in the overall balance of the dental health sector, we should try to identify various factors of oral health disorder due to income inequality among the classes according to the country's employment type in order to find ways to reduce the health gap among the social classes.

• Journal of Ecology and Environment
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• v.42 no.4
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• pp.298-307
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• 2018

Background: Subalpine ecosystems at high altitudes and latitudes are particularly sensitive to climate change. In South Korea, the prediction of the species richness of subalpine plant species under future climate change is not well studied. Thus, this study aims to assess the potential impact of climate change on species richness of subalpine plant species (14 species) in the 17 mountain national parks (MNPs) of South Korea under climate change scenarios' representative concentration pathways (RCP) 4.5 and RCP 8.5 using maximum entropy (MaxEnt) and Migclim for the years 2050 and 2070. Results: Altogether, 723 species occurrence points of 14 species and six selected variables were used in modeling. The models developed for all species showed excellent performance (AUC > 0.89 and TSS > 0.70). The results predicted a significant loss of species richness in all MNPs. Under RCP 4.5, the range of reduction was predicted to be 15.38-94.02% by 2050 and 21.42-96.64% by 2070. Similarly, under RCP 8.5, it will decline 15.38-97.9% by 2050 and 23.07-100% by 2070. The reduction was relatively high in the MNPs located in the central regions (Songnisan and Gyeryongsan), eastern region (Juwangsan), and southern regions (Mudeungsan, Wolchulsan, Hallasan, and Jirisan) compared to the northern and northeastern regions (Odaesan, Seoraksan, Chiaksan, and Taebaeksan). Conclusions: This result indicates that the MNPs at low altitudes and latitudes have a large effect on the climate change in subalpine plant species. This study suggested that subalpine species are highly threatened due to climate change and that immediate actions are required to conserve subalpine species and to minimize the effect of climate change.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.18 no.6
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• pp.181-186
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• 2018

With progress in industrialization, facilities for generating, delivering, and receiving high levels of electric power are in great demand. The scale of electric power equipment is increasing in both size and complexity. This has contributed to the development of our modern, high-tech and information-based society. However, if the generation of electric power is suspended due to unexpected accidents at power facilities or power stations, a range of equipment the operations of which are dependent on electric power can be damaged, causing substantial socioeconomic losses in an industrial society. A great deal of time and money would be expended to repair damaged facilities at a power station, causing enormous economic loss. In order to detect the deterioration processes of power cables, and to prevent the destruction of power cables, the operation status of power cables should be monitored on a regular basis. We studied the method in order to improve accuracy and reliability for diagnosising the junction where accident occurs frequently. We present the method of data acquisition and statistical processing.