• 한국임상약학회지
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• 제28권3호
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• pp.243-249
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• 2018

Background: The new type of diabetes treatment, SGLT2 inhibitors, has been approved for monotherapy and combination therapy, but medical insurance is only allowed in combination therapy with metformin, which is the first choice for type 2 diabetes treatment. Methods: The SGLT2 inhibitors prescribed in Korea are dapagliflozin, empagliflozin and ipragliflozin. A review was conducted using Pubmed to evaluate efficacy and safety for these medications with metformin combination therapy. 10 studies were selected by searching for keywords and related references and were reviewed in full. The mechanism of action, pharmacokinetics, and the economics of treatment with SGLT2 inhibitors were examined. Results: SGLT2 inhibitors had moderate glycemic control when added to the treatment of patients with type 2 diabetes who were not being regulated by metformin monotherapy. They also showed positive effects such as weight loss, as well as the lowering of blood pressure. Hypotension and serious side effects were relatively low. However, the risk of genital infection was increased. Conclusion: The SGLT2 inhibitors are a new class of drugs that promote glucose excretion in the urine. They are a good choice for combination therapy with metformin for the treatment of type 2 diabetes, with weight loss and very low risk of serious side effects.

• 대한전기학회논문지
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• 제39권11호
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• pp.1174-1182
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• 1990

A hgih efficiency and good dynamic performance drive system of an induction motor is presented in this paper using vector control technique. If the induction motor is driven under light loads with rated flux, the iron loss is excessively large compared with the copper loss, resulting in poor motor efficiency. High efficiency drive of an induction motor can be achieved by adjusting the flux level which leads the total motor loss to be a minimum value. Generally reducing the flux degrades the dynamic performance, but the dynamic performance of the proposed system is also maintained high. If the d-axis is coincident with rotor flux phasor in synchronous rotating reference frame, the stator current can be decoupled as flux component and torque component. At steady state, the developed motor torque is proportional to the product of the flux and torque component. The combination of the two components minimizing the motor loss could be found with numerical method. As the procedure to obtain the optimal combination is too hard, it is found experimentally. The system block diagram is suggested for maximum efficiency control. The proposed system is studied through digital simulation and verified with experiment. The experimental results show the possiblity of a high efficiency drive with good dynamic performance of maximum efficiency control.

• International Journal of Internet, Broadcasting and Communication
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• 제15권3호
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• pp.66-72
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• 2023

Little attention appears to have been paid to the relevance of learning a good representation function in solving long tail tasks. Therefore, we propose a new loss function to ensure a good representation is learnt while learning to classify. We call this loss function Triplet Class-Wise Difficulty-Based (TriCDB-CE) Loss. It is a combination of the Triplet Loss and Class-wise Difficulty-Based Cross-Entropy (CDB-CE) Loss. We prove its effectiveness empirically by performing experiments on three benchmark datasets. We find improvement in accuracy after comparing with some baseline methods. For instance, in the CIFAR-10-LT, 7 percentage points (pp) increase relative to the CDB-CE Loss was recorded. There is more room for improvement on Places-LT.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2004년도 추계학술대회 논문집 전력기술부문
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• pp.85-87
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• 2004

In the past, TR-cost was collected the combination of energy cost. When power market is restructured. TR-cost is collected the separated form of loss-cost, congestion-cost and maintenance-cost. One of thorn, loss-cost is computed by using TR loss-factor. We need correct and fair standards of loss factor to offer economical signal and to protect against confusions of investment and bidding. Therefore, we propose the method of minimizing system loss-cost that is based on fair and correct loss-factor.

• 대한기계학회논문집B
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• 제34권4호
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• pp.399-408
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• 2010

질소 희석된 프로판 층류 부상 화염에서 화염진동 불안정성과 화염 곡률 효과를 살펴보기 위하여 실험적 연구를 수행하였다. 화염 진동은 총 3가지 영역으로 열손실에 의한 진동, 열손실 및 부력이 혼재된 진동, 그리고 열손실 및 루이스 수에 의한 영향이 혼재된 진동으로 구분되었다. 순수 열손실에 의한 진동은 루이스 수에 의한 진동과 부력에 의한 수력학적 불안정성과 관련이 없으며 연료 루이스 수에 관계없이 모든 부상화염 조건에서 관찰되었다. 화염의 시간에 따른 부상높이 변화에 대한 FFT분석을 통해 화염진동 불안정성의 실험적 증거와 특성을 명확히 제시하였고, 부상 화염의 열손실에 의한 자기진동의 메커니즘에 대한 시나리오를 논의한다.

• Biomolecules & Therapeutics
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• 제1권1호
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• pp.44-49
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• 1993

cis-Dichlorodiammineplatinum(cisplatin) is one of the most effective antitumor agents currently available for cancer therapy. However, its clinical use has been limited by its severe side effects, especially nephrotoxicity. So, to evaluate the effects of 2(3)-tert-butyl-4-hydroxyanisole(BHA) on cisplatin nephrotoxicity in rats, both compounds were given intraperitoneally. Remarkable protective effects of BHA against nephrotoxicity of cisplatin were observed when BHA was administered to rats 1hr after cisplatin injection. On the other hand pretreatment with BHA 1hr prior to cisplatin did not reduce weight loss, blood urea nitrogen and creatinine levels. Hepatotoxicity induced by combination treatment of cisplatin and BHA was evaluated by measuring serum glutamic pyruvate transaminase and serum glutamic oxalate transaminase. Combination treatment did not affect the levels of SGPT and sGOT except 1hr pretreatment. The present results indicate that BHA may provide protection against cisplatin nephrotoxicity, when it is given 1hr after cisplatin.

• Asian-Australasian Journal of Animal Sciences
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• 제14권12호
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• pp.1763-1768
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• 2001

The combined effects of low voltage electrical stimulation (ES) and early short-term temperature conditioning on meat quality of Hanwoo beef (Korean native cattle) during storage were investigated. Shear force was influenced by ES and aging. Combination of ES and the $30^{\circ}C$ conditioning resulted in higher myofibril fragmentation index and improved lightness. There was no substantial difference in drip loss among treatments but ES samples showed higher cooking loss than control. Negative effect on shelf-life was not found by early short-term high temperature conditioning. Therefore, the meat quality of Korean native cattle was effectively improved by the combination of ES and the $30^{\circ}C$ conditioning.

• Biomolecules & Therapeutics
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• 제16권2호
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• pp.141-146
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• 2008

Imbalance in calcium and phosphorous metabolism due to aging or menopause leads to osteoporosis. In contrast to patients with normal blood pressure, hypertensive patients have a higher loss of calcium in the urine with its attendant risk of osteoporosis. The high blood pressure is associated with the risk of bone loss and abnormalities in calcium metabolism leading to calcium loss. So we retrospectively investigated the changes of bone mineral density (BMD) which drugs can have clinical influences over osteoporosis treatments of patients with calcium-antagonists as common antihypertensive drugs and with bisphosphonates which causes a most effective inhibition of osteoclasts resorption. As a result over 70 years of age group and within bisphosphonates group, alendronate 70 mg once-weekly group showed significant increase of BMD in lumbar area. Combination group of cilnidipine and $maxmarvil^{(R)}$ showed very significant decrease of BMD. In conclusion, it is desirable that combination therapy with calcium-antagonists is used carefully in the treatment of osteoporosis with high blood pressure.

• 한국초전도ㆍ저온공학회논문지
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• 제13권1호
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• pp.17-21
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• 2011

A hybrid superconducting fault current limiter (SFCL) with fast switch had been previously suggested by our research group. To make a hybrid SFCL, different superconducting wires were wound two pancake coils so that two pancake coils had asymmetric configuration. The impedance of the asymmetric non-inductive coils are zero with applied normal current. However during the fault. currents were distributed unequally into the two pancake coils because each superconducting wires have different electrical characteristics. This unequal distribution of current causes effective magnetic flux which generate repulsive force. Fast switch was thus opened by the force applied to the aluminum plate which consists of SFCL. In this paper, the AC loss characteristics of the asymmetric non-inductive coils with combinations of superconducting wires were studied and calculated by related experiments and finite element method (FEM) simulation. From these results, we suggested the appropriate combination of two superconducting wires to be used for the asymmetric non-inductive coils.

• 한국세라믹학회지
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• 제52권1호
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• pp.28-32
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• 2015

In this article, the influence of a hydrolyzed wheat protein retarder on the hydration process, ion concentration in liquid phase, degree of supersaturation, and crystal morphology of plaster was investigated. Furthermore, the retarding mechanism and the strength loss of gypsum were also studied by scanning electron microscopy (SEM). The results indicate that the use of the hydrolyzed wheat protein retarder for plaster achieved a better retarding effect and lower strength loss. The combination of gypsum plaster with the retarder not only decreased the plaster's early hydration rate and prolonged its setting time efficiently, but also militated against the crystal morphology of dihydrate gypsum. For example, the crystal dimensions changed little, but the proportion of needle-shaped crystals decreased. Combination with calcium ions on the surface of dihydrate gypsum crystal nuclei may form a chemisorbed layer, reduce the surface energy of the crystal nuclei, and inhibit the growth of the crystal nuclei of dihydrate gypsum. Consequently, the hydration process of building gypsum becomes greatly extended and is slowed down significantly.