• Journal of the Korean Geosynthetics Society
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• v.20 no.4
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• pp.151-163
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• 2021

This paper is dealt with railway slope stability for slope reinforcement using a geosynthetic concrete composite mat(GCCM). Recently, according to a change in weather caused by global warming, train operation has been restricted by the loss of backfill slope at the roadbed, which is consists of gravel, due to typhoons and heavy rainfall. In addition, the amount of damage is getting more significant than the cost of restoration, and the safety of workers is worried. In order to improve this limitation, a slope stability analysis was applied with a rapid hardening composite mat so that it can quickly secure a construction surface with increased workability and work stability and reduce maintenance costs by preventing re-loss in case of heavy rain and fundamentally blocking vegetation. As a result of the analysis, it was confirmed that the increase in safety factor was confirmed when the rapid harding composite mat was applied.

• Journal of the Earthquake Engineering Society of Korea
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• v.12 no.6
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• pp.25-33
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• 2008

Fires that result from the excessive leakage of gas due to earthquakes cause enormous loss of property as well as numerous human casualties. To prevent such disasters, an emergency gas shut-off system is considered to be one of the effective and rational methods. Considering the seismicity, the earthquake frequency and the gas-supply system of Korea, mass gas shut-off by a gas company is determined to be more cost-effective than individual gas shut-off by customers. In this study, an emergency response system was proposed that would shut off the gas supply immediately. Two different reference seismicities were proposed, to specify rapid response according to the measured seismicity. The gas supply area was divided into several gas shut-off blocks in order to facilitate the shut-off of gas supply in damaged blocks. This proposed system was implemented in the actual gas supply area with reference seismicities on the basis of seismic damage analysis.

• Bulletin of the Korean Chemical Society
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• v.31 no.10
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• pp.2873-2876
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• 2010

Excess free iron generates oxidative stress that may contribute to the pathogenesis of various causes of neurodegenerative diseases. Previous studies have shown that one of the primary causes of increased brain iron may be the release of excess iron from intracellular iron storage molecules. In this study, we attempted to characterize the oxidative damage of DNA induced by the reaction of ferritin with $H_2O_2$. When DNA was incubated with ferritin and $H_2O_2$, DNA strand breakage increased in a time-dependent manner. Hydroxyl radical scavengers strongly inhibited the ferritin/$H_2O_2$ system-induced DNA cleavage. We investigated the generation of hydroxyl radical in the reaction of ferritin with $H_2O_2$ using a chromogen, 2,2'-azinobis-(2-ethylbenzthiazoline-6-sulfonate) (ABTS), which reacted with ${\cdot}OH$ to form $ABTS^{+\cdot}$. The initial rate of $ABTS^{+\cdot}$ formation increased as a function of incubation time. These results suggest that DNA strand breakage is mediated in the reaction of ferritin with $H_2O_2$ via the generation of hydroxyl radicals. The iron-specific chelator, deferoxamine, also inhibited DNA cleavage. Spectrophotometric study using a color reagent showed that the release of iron from $H_2O_2$-treated ferritin increased in a time-dependent manner. Ferritin enhanced mutation of the lacZ' gene in the presence of $H_2O_2$ when measured as a loss of $\alpha$-complementation. These results indicate that ferritin/$H_2O_2$ system-mediated DNA cleavage and mutation may be attributable to hydroxyl radical generation via a Fenton-like reaction of free iron ions released from oxidatively damaged ferritin.

• Journal of the Earthquake Engineering Society of Korea
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• v.8 no.3
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• pp.43-52
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• 2004

This paper describes a method of evaluating seismic system performance of highway transportation network in California. The basic element that plays a crucial role in this study is the fragility information of highway bridges in Caltrans' (California Department of Transportation) freeway network. The bridge fragility information is expressed as a function of the ground motion intensity, such as peak ground acceleration (PGA) or peak ground velocity (PGV). Network damage was evaluated under the 1994 Northridge earthquake and scenario earthquakes. A probabilistic model was developed to determine the effect of repair of bridge damage on the improvement of the network performance as days passed after the event. As an example, the system performance degradation measured in terms of an index, “Drivers Delay”, is calculated for the Los Angeles area transportation system, and losses due to Drivers Delay with and without retrofit were estimated.

• Journal of Photoscience
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• v.9 no.2
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• pp.186-189
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• 2002

Many of the adverse effects of solar UV exposure appear to be directly attributable to damage to epidermal DNA. In particular, cyclobutane pyrimidine dimers (CPD) may initiate mutagenic changes as well as induce signal transduction responses that lead to a loss of skin immune surveillance and micro-destruction of skin structure. Our approach is to reverse the DNA damage using prokaryotic DNA repair enzymes delivered into skin using specially engineered liposomes. T4 endonuclease V encapsulated in liposomes (T4N5 liposome lotion) enhanced DNA repair by shifting repair of CPD from the nucleotide excision to the base excision repair pathway. Following topical application to humans, increased repair limited UV-induction of cytokines, many of which are immunosuppressive. In a recent clinical study, topical treatment of UV-irradiated human skin with T4N5 liposome lotion reduced the suppression of the nickel sulfate contact hypersensitivity response. Similarly, the photoreactivating enzyme enhances repair by directly reversing CPDs after absorbing activating light. Here also treatment of UV-irradiated human skin with photoreactivating enzyme in liposomes and photoreactivating light restored the response to the contact allergen nickel sulfate. These findings confirm in humans the observation in mice that UV induced suppression of contact hypersensitivity is caused in part by CPDs. We have tested the ability of T4N5 liposome lotion to prevent UV-induced skin cancer in patients with xeroderma pigmentosum (XP), who have an elevated incidence of skin cancer resulting from a genetic defect in DNA repair. Daily use of the lotion for one year in a group of 20 XP patients reduced the average number of actinic keratoses by 68% and basal cell cancers by 30% compared to 9 patients in the placebo control group. Delivery of DNA repair enzymes to skin is a promising new approach to photoprotection.

• Korean journal of applied entomology
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• v.48 no.2
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• pp.229-236
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• 2009

Cage experiments by artificial infestations with different initial densities of Frankliniella occidentalis were conducted to analyze damages and develop control thresholds of F. occidentalis on greenhouse eggplant in 2005 and on greenhouse sweet pepper in 2007. In the eggplant experiment, the infestations of F. occidentalis resulted in direct damage on fruit surface and non-marketable fruits which had several thin or thick lines or bleaching patches on the surface. F. occidentalis adults were frequently found on the flowers of eggplants, while nymphs were mainly observed on leaves. The fruit yield of eggplants was not significantly different among experimental plots with different initial density of F. occidentalis. Relationship between % non-marketable fruits among harvested fruits of eggplant and sticky trap catches of F. occidentalis (no. thrips/trap/week) at two weeks before the harvest showed a positive correlation. Using the estimated relationship, the control threshold of F. occidentalis on greenhouse eggplant was estimated at 10 adults per week at two weeks before the harvest when 5% of non-marketable fruit was applied for the gain threshold. In the experiment of sweet pepper, the direct damage by F. occidentalis was observed on the fruit surface and calyx, and the marketable grade of the damaged fruits decreased. The significant yield loss of marketable fruits was found in plots with high initial introduced-densities. There was a high relationship between thrips density and percentage of damaged fruits. Assuming 5% yield loss (non-marketable fruit) for the gain threshold, the control threshold of F. occidentalis on greenhouse sweet pepper was 4.8 adults per trap and 0.9 individuals per flower at two weeks before harvest.

• The Korean Journal of Air & Space Law and Policy
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• v.31 no.1
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• pp.37-62
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• 2016

Two controversial issues exist in interpretation of "Force Majeure" set forth in the Article 931 (4) of the Korean Commercial Code. Firstly, its scope of application is ambiguous. Secondly, there is a concern that the "immunity" under paragraph 1 and "Force Majeure" may overlap each other. "Force Majeure" refers an event resulted from either natural disaster or 3rd-party. Meanwhile, the latter implies relatively extensive and comprehensive meaning and its interpretation may vary depends on law enforcement. In general, the aircraft accident hardly results in damage or loss to the 3rd-party. Additionally, it is worth to review newly enacted clause and to define its applicability. When the 3rd party is suffered from damage or loss incurred by any external act, it is necessary to explicit the concept of the non-contractual liabilities with respect to 3rd party. From the perspective of protecting aviation industries, the commercial aviation operator may be entitled to immunity in respect of claim for damage incurred by the event of Force Majeure. However, this approach is directly opposite to the victim's benefit and protection by the law. Therefore, the priority of the legal protection should be considered. Although the interest of the commercial aviation operator is not negligible, the protection of the law should be favorable to the 3rd party. Otherwise, the innocent party has no right to claim for damage incurred by aviation accident. Another issue is about the possibility of overlapping of the provision set forth in the paragraph 1 and 4. The former states that the liabilities shall be exempted on account of either the unsettled political or economic situation but this clause is inconsistent with the interpretation on Force Majeure under the latter. As argued above, this may include any event resulted from either political or economic account by the external influence of the 3rd party, thus these two provisions are overlapped. Consequently, in order to develop ordinances and guidelines and to ensure an equal protection to both parties, above two issues must remain open for further discussions.

• Journal of Animal Environmental Science
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• v.8 no.2
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• pp.119-124
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• 2002

To evaluate composting process of piggery slurry, we made $1m^3$ bench scale composting reactor, and investigated the input and output of mass, moisture evaporation, volatile solid degradation, and running cost. For 15 days experimentation the results was as followed, The quantity of sawdust used was 0.47ton(18,000won) per 1ton slurry. The amount of moisture evaporated was 16.8kg/kg VS degradated. Total evaporation and VS degradation were 24.8%, 5.7% respectably. To analysis the running cost of that, we included only two factors, sawdust cost and compost income. The compost price to sell was 63won/kg(50% of market price) it made 8,694won income to 756 won loss, but 25won/kg, it was $13,650{\sim}23,100won$ loss per 1 ton slurry in the current pig farmer's condition. This cost was $8.5{\sim}14.4%$ of pig production cost and damage strongly to pig farmers to treat it.

• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.2
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• pp.438-445
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• 2008

Dodam formula (Dodam) has been used for neurodegenerative disease in Oriental medicine. Dodam is capable of protecting diverse kinds of cells from damage caused by a variety of toxic stimuli. In the present study, we investigated the underlying protective mechanism of Dodam on rotenone-induced cytotoxicity in rat neuroblastoma Neuro-2A cells. Treatment with Neuro-2A cells with rotenone caused the loss of cell viability, and condensation and fragmentation of nuclei, which was associated with the elevation of ROS level, and lipid peroxidation, the increase in Bax/Bcl-2 ratio. Rotenone induced mitochondrial dysfunction characterized by mitochondrial membrane potential loss and cytochrome-c release. These phenotypes induced by rotenone were reversed by pretreatment with Dodam. Our results suggested that major features of rotenone-induced neurotoxicity are partially mediated by mitochondrial dysfunction and oxidative stress, and that Dodam markedly protects Neuro-2A cells from oxidative injury. These data indicated that Dodam might provide a useful therapeutic strategy in treatment of the neurodegenerative diseases caused by oxidative injuries.

• Nuclear Engineering and Technology
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• v.21 no.1
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• pp.1-11
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• 1989

Numerous losses of decay heat removal capability have occurred at U during stutodwn while its significance to safety is needless to say. A study is carried out as an attempt to assess what could be done to lower the frequency of these events and to mitigate their consequences in the unlikely event that one occurs. The shutdown risk model is developed and analyzed using Event/Fault Tree for the typical pressurized water reactor. The human cognitive reliability (HCR) model, two-stage bayesian approach and staircase function model are used to estimate human reliability, initiating event frequency and offsite power non-recovery probability given loss of offsite power, respectively. The results of this study indicate that the risk of a Pm at shutdown is not much lower than the risk when the plant is operating. By examining the dominant accident sequences obtained, several design deficiencies are identified and it is found that some proposed changes lead to significant reduction in core damage frequency due to loss of cooling events.