• BMB Reports
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• v.32 no.5
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• pp.440-444
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• 1999

Membrane lipid peroxidation processes yield reactive aldehydes that may react with copper,zinc superoxide dismutase (Cu,Zn SOD), one of the key antioxidant enzymes against oxidative stress. We investigated this possibility and found that exposing Cu,Zn SOD to malondialdehyde (MDA) or 4-hydroxynonenal (HNE) caused the loss of dismutase activity, cross-linking of peptides, and an increase in protein oxidation, reflected by the increased level of carbonyl groups. When Cu,Zn SOD that had been exposed to MDA or HNE was subsequently analyzed by amino acid analysis, histidine content was found to be significantly lost. Both MDA-and HNE-treated Cu,Zn SOD were resistant to proteolysis, which may imply that damaged proteins exist in vivo for a longer period of time than the native enzyme. The lipid peroxidation-mediated damage to Cu,Zn SOD may result in the perturbation of cellular antioxidant defense mechanisms, and subsequently lead to a pro-oxidant condition.

• Toxicological Research
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• v.23 no.2
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• pp.107-114
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• 2007

Although there are some questions about the venues of adult neurogenesis, it is undoubtedly accepted that new neurons are born in adult brains. Adult neurogenesis is regulated by a wide array of factors. Insults harmful to brain, such as neurodegenerative diseases, seizure, ischemia and exposure to drugs of abuse, are intricately related to adult neurogenesis. Whereas neurodegenerative diseases are characterized by death or functional loss of specific neurons, recent studies report that they can be accompanied by neurogenesis. In addition, alcohol and drugs of abuse which have been reputed to cause irreversible damage to brain can also generate newly born cells in adult brain. As yet, however, we have little knowledge of the functional significance and roles of adult neurogenesis under pathological settings, not to mention under physiological settings. Accordingly, in this review we briefly summarize the results of studies which focus on adult neurogenesis in insulted brain, instead of trying to draw hurried conclusion regarding the relationship between adult neurogenesis and brain insults.

• Journal of the Korean Professional Engineers Association
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• v.44 no.2
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• pp.46-50
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• 2011

Wind energy, as an alternative to fossil fuels, is plentiful, renewable, widely distributed, clean, and produces no greenhouse gas emissions during operation. However, the construction of wind farms is not universally welcomed because of their visual impact, competing land use, comprising human health impacts, building and crop damage, loss of amenities and ecological impact, impact on wildlife, danger to birds, safety hazard, aesthetics and noise. Offshore wind power, in particular, offers a huge potential to generate clean energy. However, the envisaged massive expansion of wind farms in oceans is already causing severe environmental conflicts. Wind farms cause further harm to already threatened oceans. Wind power has negligible fuel costs, but a high capital cost. The expansion of climate-friendly wind energy use both onshore and offshore can only be successful it the legal and organizational conditions undergo some clear improvements.

• The Journal of Engineering Geology
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• v.28 no.3
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• pp.341-348
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• 2018

Landslides can be caused by localized intense rainfall. The loss of human lives and damage to property from landslides is increasing. However, little information exists on the movement and flow of sediment material at the time of rapid landslides. In this study, a field survey was conducted of landslides that occurred in 2013 in the Hadari area of Yeoju city in Korea. This was followed by numerical analysis. The purpose is to analyze the characteristics of a consequent debris flow and its movement at the time of failure. The results of the field survey and numerical analysis are consistent with each other. The maximum velocity of the debris flow was ~9.335 m/s and the maximum sediment thickness ~4.674 m. The latter is similar to the traces of debris flow observed in the field.

• Journal of Ship and Ocean Technology
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• v.1 no.1
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• pp.57-72
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• 1997

The larger trends related to cracking in ocean going vessels (primarily tankers and bulk carriers) are reviewed on the basis of available data. The typical interrelated causes of such cracking are: high local stresses, extensive use of higher strength steels, inadequate treatment of dynamic loads, adverse operational factors (harsh weather, improper vessel handling), and controllable structural degradation (corrosion, wear, stevedore damage). Three consequences of cracking are then discussed: structural failure, pollution, and increased maintenance. The first two, while rare, are potentially of high consequence including loss of life. The types of solutions that can be employed to improve the durability of ships in the face of fatigue cracking are then presented. For existing vessels, these solutions range from repairs based on structural analysis or service experience, control of corrosion, and enhanced surveys. For new vessels, the use of advanced design procedures that specifically address dynamic loads and fatigue cracking is necessary. As the preferred solution to the problem of cracking in ships, this paper advocates prevention by explicit design by first principles.

• Journal of the Korean Society of Safety
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• v.21 no.1 s.73
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• pp.1-5
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• 2006

The damage of important equipments for the nuclear power plant by the earthquake brings the loss of human lives and economic losses. Therefore safety-related equipment of nuclear power plant must be proved that function must be designed and structural integrity so that it can be maintained also from accident condition of various kinds. In this study, the computer room air conditioner to be delivered at the nuclear power plant applied to this qualification, try to develop an optimum model. This model ended up with good results which were under suitably allowable conditions about structurally safe earthquake.

• Food Science and Biotechnology
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• v.16 no.4
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• pp.632-635
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• 2007

This study examined the neuroprotective effect of scopoletin from Angelica dahurica against oxygen and glucose deprivation-induced neurotoxicity in a rat organotypic hippocampal slice culture. Scopoletin reduced the propidium iodide (PI) uptake, which is an indication of impaired cell membrane integrity. In addition, it inhibited the loss of NeuN, which represents the viability of neuronal cells. The results suggests that scopoletin from A. dahurica protects neuronal cells from the damage caused by oxygen and glucose deprivation.

• 기술발표회
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• s.2006
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• pp.220-231
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• 2006

Debris flows are a natural hazard which looks like a combination of flood, land and rock slide. Large rainfall in July 2006 produced several large scale debris flows and many small debris flows that resulted in loss of life and considerable property and highway damage, as was widely reported in the national media. The hazard "debris flow" is still insufficiently researched Furthermore debris flows are very hard to predict. In this paper, a general over view of the debris flow problems along the highway, a generic way for the design and dimensioning of flexible barrier systems will be presented. A brief description of the various unique barrier types will be provided, too. The future for these barrier concepts looks promising because these barriers represent the state of art for such applications and are superior to many other available options.

• The Korean Journal of Ceramics
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• v.3 no.3
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• pp.195-198
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• 1997

Post-firing process of electronic ceramic, such as electroding and encapsultion with resin, often causes damage by thermal shock. The thermal shock behavior of $BaTiO_3$ ceramics was investigated by the down-quench test, where the relative strength retained is determined after the sample is quenched from an elevated temperature into a fixed temperature bath. The critical temperature drop, $\DeltaTc$, was evaluated for three kinds of sintered $BaTiO_3$ ceramics, which were formed by extrustioin, uniaxial pressing using granules, and uniaxial pressing using powders. A drastic loss in strength caused by microcracking was observed for the specimens quenched with $\DeltaT\geq150^{\circ}C$. This concentp can be adopted as a method of the quality control by monitoring the sudden drop of the strength of capacitor products after each exposure to heat.

• Korean Journal of Computational Design and Engineering
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• v.20 no.1
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• pp.55-64
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• 2015

The earthquake is a natural disaster causing loss of life or property damage and happens more often in Korea recently. Moreover, considering the increase of massive buildings, it is required to predict and visualize the information of the vibration in a building. In this paper, we developed a prototype framework to visualize the displacement information in the AR environments. In order to avoid the irregular halts of the scene and the unnatural distortion of the object, this framework uses the synchronization method at the scene update time and the interpolation of the sensor data for the displacement of vertices. In addition, we studied displacement estimation methods with the acceleration data to extend this framework to the system with accelerators.