Food Science and Biotechnology

Korean Society of Food Science and Technology (한국식품과학회)
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Neuroprotective Effect of Scopoletin from Angelica dahurica on Oxygen and Glucose Deprivation-exposed Rat Organotypic Hippocampal Slice Culture

  • Son, Dong-Wook (KT&G Central Research Institute) ;
  • Lee, Pyeong-Jae (Department of Natural Medicine Resources, Semyung University) ;
  • Lee, Jong-Seok (Department of Anesthesiology and Critical Care Medicines, School of Medicine, Johns Hopkins University) ;
  • Lee, Sang-Hyun (Department of Applied Plant Science, College of Industrial Science, Chung-Ang University) ;
  • Choi, Sang-Yoon (Korea Food Research Institute) ;
  • Lee, Jong-Won (KT&G Central Research Institute) ;
  • Kim, Sun-Yeou (Department of Herbal Pharmacology, Graduate School of East-West Medical Science, Kyung Hee University)
  • Published : 2007.08.31
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Abstract

This study examined the neuroprotective effect of scopoletin from Angelica dahurica against oxygen and glucose deprivation-induced neurotoxicity in a rat organotypic hippocampal slice culture. Scopoletin reduced the propidium iodide (PI) uptake, which is an indication of impaired cell membrane integrity. In addition, it inhibited the loss of NeuN, which represents the viability of neuronal cells. The results suggests that scopoletin from A. dahurica protects neuronal cells from the damage caused by oxygen and glucose deprivation.

Keywords

References

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