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Is the Diagnostic Trial with Proton Pump Inhibitors Reasonable for School Age Children with Gastroesophageal Reflux Symptoms?

  • Yang, Jaeeun;Lee, Jieon;Lee, Hyunju;Lee, Juyeon;Youn, Young Mee;Choi, Jae Hong;Kim, Yoon-Joo;Kang, Hyun Sik;Han, Kyoung Hee;Kim, Seung Hyo;Kang, Ki-Soo
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.22 no.6
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    • pp.511-517
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    • 2019
  • Purpose: On the basis of evidence, we aimed to reevaluate the necessity of the empirical proton pump inhibitor (PPI) trial for children with suspected gastroesophageal reflux disease (GERD). Methods: We analyzed the frequency of GERD in 85 school-age children with gastroesophageal reflux (GER) symptoms, who received 24-hour esophageal pH monitoring and/or upper endoscopy. According to the reflux index (RI), the children were classified into normal (RI <5%), intermediate (5%${\leq}$ RI <10%), or abnormal (RI ${\geq}$10%) groups. Results: Fifty six were female and 29 were male. Their mean age was $12.6{\pm}0.5$ (${\pm}$standard deviation) years (range: 6.8-18.6). The RI analysis showed that the normal group included 76 patients (89.4%), the intermediate group included 6 patients (7.1%), and the abnormal group included 3 patients (3.5%). The DeMeester score was $5.93{\pm}4.65$, $14.68{\pm}7.86$ and $40.37{\pm}12.96$ for the normal, intermediate and abnormal group, respectively (p=0.001). The longest reflux time was $5.56{\pm}6.00$ minutes, $9.53{\pm}7.84$ minutes, and $19.46{\pm}8.35$ minutes in the normal, intermediate, and abnormal group, respectively (p=0.031). Endoscopic findings showed reflux esophagitis in 7 patients. On the basis of the Los Angeles Classification of Esophagitis, 5 of these patients were included in group A, 1 patient, in group B and 1 patient, in group C. Conclusion: The incidence of GERD was very low in school-age children with GER symptoms. Therefore, injudicious diagnostic PPI trials would be postponed until the actual prevalence of GERD is verified in future prospective studies.

Oedipa's Quest and Two Americas (에디파의 탐구와 두 개의 미국)

  • Son, Dongchul
    • English & American cultural studies
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    • v.9 no.1
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    • pp.273-295
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    • 2009
  • As Oedipa Mass, the heroine of Thomas Pynchon's The Crying of Lot 49, is apparently associated with Oedipus, the hero in Sophocles' tragedy, this paper aims to show some of their similarities in quest theme and plot development as well as in the use of dramatic irony. Oedipus the King opens with a priest's pleas to relieve the Theban people from a plague and the king's promise to rid its cause by avenging the murder of the former king, as told by the oracle. Lot 49 begins as a Los Angeles law firm informs Oedipa that she is named as the executrix in her former lover Inverarity's will to sort out the mogul's estate. Ironically, however, Oedipus' investigation reveals himself to be the very cause of the national disaster, the murderer for whom he searched. Likewise, Oedipa starts her inquiry dedicating herself to make sense out of what Inverarity had left behind, only to find that the legacy was America. Sophocles and Pynchon both employ dramatic irony to provide a controlling principle for plot development in their works. In Oedipus the King, Sophocles creates mounting tension as well as distance between the reader's knowledge and the protagonist's ignorance, compressing the play's action into the moment that Oedipus discovers his real identity. For dramatic irony, however, Pynchon tends to work through authorial comments and utilize allegorical meanings of the characters' names, directing his novel at illuminating Oedipa's discovery of Inverarity's legacy as well as the meaning of Tristero, an underground postal service system. Unlike Oedipus the King that proceeds on a single line of action, Lot 49 develops in esoteric, multi-layered allusions and intricately-interrelated double strains involving Oedipa's roles as executrix and quester. At the end of Sophocles' tragedy, Oedipus stabs his eyes and decides to live in exile, realizing that, blinded, he begot his children through his mother; Oedipa comes to a painful realization that she allowed her former lover to create death-orienting America without her diversity and moral system in old times. As Oedipa now discovers herself through her search for Tristero, her tragic spirit lies in her determination to confront her binary choices between two Americas: transcendence or entropy, the Tristero possibility or Inverarity's America. Ultimately, Oedipa tries to find who will be the bidder for the Tristero forged stamps designated as lot 49, awaiting the auctioneer's cry and the "crying" of a new-born America.

The Effect of COVID-19 on Academic Satisfaction with Online Lecture Types and Contents -Perspectives of the Domestic and Foreign University Students- (코로나19로 인한 온라인 강의 형태와 콘텐츠가 학업 만족도에 미치는 영향 -국내외 대학생의 관점에서-)

  • Jo, Ji-Soo;Bae, Jeong-In
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.22 no.3
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    • pp.643-650
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    • 2021
  • The purpose of this study was to evaluate the impact of lecture content on the overall academic satisfaction in non-contact online classes. The study was conducted using an online survey of 107 university students attending metropolitan, local and foreign universities for a week from August 25th, 2020 to September 2nd, 2020. The analysis methods used included descriptive statistics and chi-square distribution, Fisher's exact test, linear by linear association, and logistic regression. The result of the study showed a significant decrease in Junior by 0.025 times compared to Senior (p<.05). Furthermore, a significant decrease in the impact of recorded lectures by 0.036 times compared to a hybrid of face-to-face and online lectures (p<.05). Compared to the response 'No', the number of student's responses of 'Yes' increased significantly by 31.358 times (p<.05). Additionally, a significant increase was seen in teaching methods by 19.709 times, and academic satisfaction by 7.989 times(p<.05). In conclusion, the results imply that the quality of lecture content is also important to improve the student's satisfaction with school life, but overall management is required in the areas of appropriate teaching methods, appropriate tuition, and evaluation methods.

Eco-Friendly Interlocking Stabilized Soil Blocks for Urban Housing-Vulnerable Communities : A Community-Participatory Approach in Indonesia (도시 주거 취약층을 위한 친환경 조립형 흙블록 건축재 개발 - 인도네시아 주민 공동체의 참여적 접근 사례 -)

  • Park, Jaehyeon;Mulia, Jasri;Setiawan, Fajar
    • Journal of Appropriate Technology
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    • v.6 no.2
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    • pp.115-125
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    • 2020
  • Housing issues such as mushrooming slums remain as chronic in most developing countries. Due to the state's restrained capacity, the housing-vulnerable's self-help approaches have been increasingly inevitable and vital for addressing the housing issues. However, there are still two challenges: securing good quality with economic efficiency, and climate change mitigation and adaptation. This study aims at doing an architectural experiment by developing and educating the production of eco-friendly interlocking stabilized soil bricks (ISSB) by employing vernacular materials and technologies for housing-vulnerable communities in Indonesia. In collaboration with a local architectural NGO, the study features a co-creation workshop in which 40 evicted households participate in the whole process. Soil analysis, mixed design, compression tests, and economic analysis are carried out. This paper illustrates that ISSB also has a high potential as an alternative to a burned brick or a cement block. The application of ISSB to self-help housing is expected to have socioeconomic and environmental effects, thereby facilitating the housing-vulnerable's self-help approaches and contributing to addressing the housing challenges in Indonesia.

Racial Triangulation in Steph Cha's Your House Will Pay (스텝 차의 『너의 집이 대가를 치를 것이다』 에 나타난 인종 삼각구도)

  • Yim Jin-Hee
    • The Journal of the Convergence on Culture Technology
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    • v.9 no.2
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    • pp.19-27
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    • 2023
  • This paper is aimed at exploring a multi-racial, multi-ethnic, and multi-cultural trianglulation of Black, White, and Korean American race relations connected to a large-scale disturbance in the 1992 Los Angeles riots. The second generation Korean American Steph Cha's Your House Will Pay (2019) focuses on a social portrait of the racially marginalized beings as Korean immigrant merchants and African American native consumers. This family saga explores issues resulting from racial hierarchy, racialized stereotypes, and historical marginalization in the internalized sociometry of race and class inequality. This work grapples with issues involved in a sociocultural web of racial triangulation under the white dominant structure, and ensuing intergroup conflicts of social minorities in the economic geography of urban space. It opens up civil discussions for transracial, transethnic, and transcultural interactions and coexistence. It ultimately leads to extending young people's minds for a deep understanding of the socioecomonic landscape of racial matrix, and enhancing the cultural literacy for a better awareness of social empathy and the communal respect of life.

The Effects of cultural values on the physical health of Korean American caregivers through caregiver burden and social support, applying to the socio-cultural stress and coping model (문화적 가치가 수발부담 및 사회적 지지를 통해 남가주 한인 가족수발자의 신체적 건강에 미치는 영향 - 사회문화적 스트레스 대처모델을 적용하여)

  • Kim, Jung-Hyun;Knight, B.G.
    • 한국노년학
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    • v.29 no.2
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    • pp.377-394
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    • 2009
  • Using the Socio-cultural Stress and Coping model, this study proposed a path model to explore how cultural values affect the physical health of Korean American caregivers through caregiver burden, receipt of informal social support and utilization of formal care services. For physical health outcomes, three physical health indicators were employed: self-reported global physical health, self-reported blood pressure, and salivary cortisol. The path model was analyzed by using a sample of 87 Korean caregivers living in Los Angeles County and Orange County, California, USA. The major findings of this study included the following: 1) Stronger belief in cultural values was associated with more frequent utilization of formal care services, leading to lower levels of systolic boold pressure; 2) Cultural values did not affect the physical health of Korean American caregivers through caregiver burden. The demonstration of positive effects of cultural values on the physical health of Korean America caregivers through social support utilization call attention to the need of further research on the understudied group providing family care to frail older family members.

Prevalence of and Factors Associated with Depression in Korean American Men (재미 한인 남성의 우울증 실태 및 영향요인)

  • In Ju Cho
    • Korean Journal of Culture and Social Issue
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    • v.16 no.3
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    • pp.221-240
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    • 2010
  • The purpose of this study is to examine the prevalence of depression in Korean American men and factors associated with the Korean American men's depression by examining how depression is affected by socio-demographic characteristics, immigration-related characteristics, and psychological and social characteristics. Socio-demographic characteristics include age, education, occupation, and monthly income. Immigration-related characteristics include years in the U. S., being U. S. citizens, and acculturation level. Psychological and social characteristics include anger, marital satisfaction, and social support. Using an availability sampling method, data were collected from 201 Korean American married men who were between the ages of 20 and 64 and resided in Los Angeles County. This study used a structured self-administered questionnaire. Due to the unreliable responses, five questionnaires were excluded from the study. Therefore 196 completed questionnaires were used for the data analyses. In order to measure the respondents' depression, the CES-D(Center for Epidemiological Studies of Depression) was used in this study. In the hierarchical multiple regression analyses, monthly income, anger, marital satisfaction, and social support were significantly associated with the respondents' depression. However, there were no significant associations between depression and age, education, occupation, being a U. S. citizen, and acculturation. Implications of the findings for mental health practitioners and social works are discussed.

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Polarus Intramedullary Nail for Nonunion of Humerus neck (Polarus 골수정을 이용한 상완골 경부 불유합의 수술적 치료)

  • Kang, Ho-Jung;Kim, Sul-Gee;Yoon, Hong-Kee;Hahn, Soo-Bong;Kim, Sung-Jae
    • Clinics in Shoulder and Elbow
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    • v.10 no.1
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    • pp.112-123
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    • 2007
  • Purpose: Evaluate the clinical results of humerus neck nonunion treated with Polarus intramedullary nail. Materials and Methods: 8 patients who underwent surgery for nonunion of humerus surgical neck fracture were included. All patients were female, the average age was 65 years. 5 out the total 8 cases initially received surgery, open reduction and internal fixation with metal plate in 1 case, Ender nail insertion in 2 cases, external fixator in 1 case and closed reduction and percutaneous pinning in 1 case. The other 3 non union cases initial received conservative managemnent. The average period of nonunion was 9 months in the operated group and 6.2 months in the conservative group. All 8 cases received closed reduction with intrameedullary Polarus nail and auto iliac bone graft. Union was confirmed radiologically, and functional evaluation was done with the UCLA functional criteria. Results: All 8 cases showed union on radiologic evaluation. Average time to union was 3.5 months, average follow up period was 27 months. Average UCLA shoulder evaluation score was 7.6 points preoperatively which improved to 26.3 points after surgery. Active shoulder flexion was 40.7 degrees preoperatiely which increased to 104 degrees after surgery. Shoulder abduction improved from 32.9 degrees preoperatively to 96.3 degrees after surgery. UCLA functional criteria was good in 5 cases and fair in 3 cases, which no poor cases. Conclusion: Polarus IM nailing and AIBG is a useful method for treating nonunion of humerus neck fracture with improvement in union and function.

Promoter Polymorphisms of ST3GAL4 and ST6GAL1 Genes and Associations with Risk of Premalignant and Malignant Lesions of the Cervix

  • de los Angeles Rivera-Juarez, Maria;Rosas-Murrieta, Nora Hilda;Mendieta-Carmona, Victoriano;Hernandez-Pacheco, Raquel Esneidy;Zamora-Ginez, Irma;Rodea-Avila, Carlos;Apresa-Garcia, Teresa;Garay-Villar, Onix;Aguilar-Lemarroy, Adriana;Jave-Suarez, Luis Felipe;Diaz-Orea, Maria Alicia;Milflores-Flores, Lorena;Reyes-Salinas, Juan Salvador;Ceja-Utrera, Francisco Javier;Vazquez-Zamora, Victor Javier;Vargas-Maldonado, Tomas;Reyes-Carmona, Sandra;Sosa-Jurado, Francisca;Santos-Lopez, Gerardo;Reyes-Leyva, Julio;Vallejo-Ruiz, Veronica
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.3
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    • pp.1181-1186
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    • 2014
  • Sialyltransferase gene expression is altered in several cancers, including examples in the cervix. Transcriptional regulation of the responsible genes depends on different promoters. We aimed to determine the association of single-nucleotide polymorphisms in the B3 promoter of the ST3GAL4 gene and the P1 promoter of the ST6GAL1 gene with cervical premalignant lesions or cervical cancer. A blood sample and/or cervical scrapes were obtained from 104 women with normal cytology, 154 with premalignant lesions and 100 with cervical cancer. We also included 119 blood samples of random donors. The polymorphisms were identified by sequencing from PCR products. For the B3 promoter, a fragment of 506 bp (from nucleotide -408 to +98) was analyzed, and for the P1 promoter a 490 bp (-326 to +164) fragment. The polymorphism analysis showed that at SNP rs10893506, genotypes CC and CT of the ST3GAL4 B3 promoter were associated with the presence of premalignant lesions (OR=2.89; 95%CI 1.72-4.85) and cervical cancer (OR=2.23; 95%CI 1.27-3.91). We detected only one allele of each polymorphism in the ST6GAL1 P1 promoter. We did not detect any genetic variability in the P1 promoter region in our study population. Our results suggest that the rs10893506 polymorphism -22C/T may increase susceptibility to premalignant and malignant lesions of the cervix.

Arthroscopic Treatment of Greater Tuberosity fracture - Preliminary Report - (상완골 대결절 골절 손상에 대한 관절경적 치료 -예비 보고-)

  • Ji, Jong-Hoon;Kim, Young-Yul;Park, Sang-Eun;Ra, Ki-Hang;Do, Jeong-Hun;Kim, Weon-Yoo
    • Journal of Korean Orthopaedic Sports Medicine
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    • v.6 no.1
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    • pp.57-65
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    • 2007
  • Purpose: The purpose of this study was to evaluate the clinical result of arthroscopic treatments by using suture anchors or suture anchors combined with cannulated screw in the greater tuberosity fracture of the proximal humerus fracture. Materials and Methods: From March 2004 to March 2006 we have used suture anchor or suture anchors combined with cannulated screw for 6 cases of the greater tuberosity fracture which include displaced fractures, comminuted fractures and minimally displaced fractures with comcomittent lesions such as rotator cuff tears, stiffness and labral lesion. In this retrospective study, we analyzed the clinical outcomes by using the range of motion, University of California at Los Angeles shoulder rating scale (UCLA) and the ASES shoulder index score (ASES) in the average 6 months follow up. Results: At the last follow up, average range of motion was improved to 154.3 degree, 145.8 degree, 32.6 degree and L1 vertebrae in each forward flexion, abduction, external rotation and internal rotation. Clinically the UCLA rating scales improved to 31.5 and the ASES shoulder index score (ASES) improved to 93.6 in the last follow up. Conclusion: Arthroscopic treatments by using suture anchor or suture anchors combined with cannulated screw in the greater tuberosity fracture of the proximal humerus fracture is an alternative treatment of the greater tuberosity fracture of the proximal humerus fracture.

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