• Journal of Korean Neurosurgical Society
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• v.54 no.3
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• pp.220-224
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• 2013

Objective : This study aimed to determine the optimal time for tracheostomy by evaluating the benefits and safety of early versus late tracheostomy in spinal cord injury (SCI) patients. Methods : We retrospectively reviewed a total of 254 patients with spinal cord injury. Of them, we selected 21 spinal cord injury patients who required tracheostomy due to long-term mechanical ventilation and analyzed their medical records. The patients were categorized into two groups. Early tracheostomy was performed day 1-10 from intubation in 10 patients and the late tracheostomy was performed after day 10 in 11 cases. We also evaluated the duration of mechanical ventilation, stay in the ICU and complications related to tracheostomy, the injury level of and clinical severity. All data was analyzed using SPSS 18.0/WIN. Results : The early tracheostomy offered clear advantages for shortening the total ICU stay (20.8 day vs. 38.0 day, p=0.010). There was also statistically significant reduction in the total length of time on mechanical ventilation (5.2 day vs. 29.2 day, p=0.009). However, the reductions in the incidence of pneumonia (40% vs. 82%) and the length of ICU stay post to tracheostomy (6 day vs. 15 day) were found to be statistically not significant. There were also no statistically significant differences in the injury level and clinical severity between the groups. Conclusion : We concluded that the early tracheostomy (at least 10 days) is beneficial for SCI patients who are likely to require prolonged mechanical ventilation.

• Journal of Periodontal and Implant Science
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• v.26 no.1
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• pp.276-292
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• 1996

The purpose of this study was to evaluate whether removal of gingival epithelium with pulsed Nd :YAG laser could inhibit the downgrowth of junctional epithelium after alloplastic material grafting in periodontal bone defect. The periodontal bone defects were created surgically on the palatal aspect of the upper right and left molar teeth in 30 rats and filled with resorbable calcium carbonate($Biocoral\;450^{(R)}$: Inoteb, France). The control sites(right molar area) was sutured. The test side (left molar area) received controlled deepithelization of the oral and sulcular epithelium with pulsed Nd:YAG laser($Sunrise\;Maste^{(R)}$: Sunrise Technologies, U.S.A.) under the mode of 1.75W, 15Hz, 116mJ/pulse and was sutured. The control and test sites were evaluated clinically and histologically, at 1, 3, 7, 14, and 28 days postoperation. Clinically, the gingiva showed normal color and shape at the 5th day in the control site and at the 10th day in the test sites. Histologically, the junctional epithelium was formed at the 7th day in the control sites and at the 14th day in the test sites, and the long JE attachment were observed at the 28th day in both sites. The attachment of connective tissue to root surface was observed initially at the 7th day in the control sites and at the 14th day in the test sites, and completed at the 28th day in both sites. In summary, these results showed that the removal of oral epithelium using pulsed Nd:YAG Laser could not prevent epithelial downgrowth after alloplastic material implantation in rat periodontal bone defect.

• 대한핵의학회:학술대회논문집
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• 1991.05a
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• pp.164-164
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• 1991

• Journal of Korean Academy of Nursing
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• v.33 no.2
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• pp.275-283
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• 2003

Purpose: This study was to classify elderly in long-term care hospitals for using Resource Utilization Group(RUG-III) and to consider feasibility of payment method based on RUG-III classification system in Korea. Method: This study designed by measuring resident characteristics using the Resident Assessment Instrument-Minimum Data Set(RAI-MDS) and staff time. The data were collected from 382 elderly over sixty-year old, inpatient in the five long-term care hospitals. Staff time was converted into standard time based on the average wage of nurse and aids. Result: The subjects were classified into 4 groups. The group of Clinically Complex was the largest(46.3%), Reduced Physical Function(27.2%), Behavior Problem(17.0%), and Impaired Cognition(9.4%). The average resource use for one resident in terms of care time(nurses, aids) was 183.7 minutes a day. Relative resource use was expressed as a case mix index(CMI) calculated as a proportion of mean resource use. The CMI of Clinically Complex group was the largest(1.10), and then Reduced Physical Function(0.93), Behavior Problem(0.93), and Impaired Cognition(0.83) followed. The difference of the resource use showed statistical significance between major groups(p<0.0001). Conclusion: The results of this study showed that the RUG-III classification system differentiates resources provided to elderly in long-term care hospitals in Korea.

• Journal of Environmental Science International
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• v.2 no.3
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• pp.207-216
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• 1993

The concentrations of $SO_2$ and $SO_3$ were measured to estimate a new developed long time exposure $SO_2$ sampler at Onsan industrial area considering the meteorological factors from June to October, 1992. The mean concentration of $SO_3$ by $PbO_2$ method was 0.924 mg $SO_3 / 10cm^2$ $PbO_2$/day and their high values were shown in the center of the industrial area, which show potential pollution due to the increase of industrial activities and micrometeorological factors in and around the sites. As a result of statistical correlation between $SO_2$ concentration by new sampling method and $SO_3$ concentration by $PbO_2$ method in July and August, 1992, correlation coefficients were high (r=0.87, 0.91) and shown more than 0.83 value in the high concentration data set, which was arbitrarily divided into 7~10${\mu}l$$SO_2$ concentration in an attempt to further investigate these relationships. Therefore, use of new developed long time exposure TEX>$SO_2$ sampler is good for TEX>$SO_2$ measurement and valuable for estimation of air quality in the urban and industrial area. Key Words : a new developed long time exposure TEX>$SO_2$ sampler, correlation coefficients, high, $SO_2$ measurement, estimation of air Quality.

• Biomolecules & Therapeutics
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• v.28 no.6
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• pp.512-518
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• 2020

Stroke is a leading cause of long-term disability in ischemic survivors who are suffering from motor, cognitive, and memory impairment. Previously, we have reported suppressing LPA₅ activity with its specific antagonist can attenuate acute brain injuries after ischemic stroke. However, it is unclear whether suppressing LPA₅ activity can also attenuate chronic brain injuries after ischemic stroke. Here, we explored whether effects of LPA₅ antagonist, TCLPA5, could persist a longer time after brain ischemic stroke using a mouse model challenged with tMCAO. TCLPA5 was administered to mice every day for 3 days, starting from the time immediately after reperfusion. TCLPA5 administration improved neurological function up to 21 days after tMCAO challenge. It also reduced brain tissue loss and cell apoptosis in mice at 21 days after tMCAO challenge. Such long-term neuroprotection of TCLPA5 was associated with enhanced neurogenesis and angiogenesis in post-ischemic brain, along with upregulated expression levels of vascular endothelial growth factor. Collectively, results of the current study indicates that suppressing LPA₅ activity can provide long-term neuroprotection to mice with brain ischemic stroke.

• Journal of Korean Society for Atmospheric Environment
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• v.20 no.4
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• pp.503-514
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• 2004

In Seoul metropolitan area, nocturnal variation of surface ozone concentrations observed at 27 monitoring sites from 1998 to 2002 showed that high ozone levels occurred frequently during the spring. Frequency distributions for nighttime ozone indicated that elevated concentrations in spring were influenced by advection of different air mass compared to other seasons. Surface wind analysis during the spring revealed that relatively strong southwesterly winds were associated with nocturnal ozone enhancement, which can be attributed to the regional transport of ozone. In order to identify the origin of nocturnal ozone enhancement in spring, 3-day backward trajectories were calculated by HYSPLIT 4 for the episode days and then classified. The results showed that NW, W, and SW flows, indicating influence of polluted air masses from the China continent, have 51% in a]1 the episode days, which suggest that the nocturnal ozone enhancement can occur under the effect of long-range transport of ozone-laden air mass on a regional scale. Case study of nocturnal ozone maxima associated with long-range transport was discussed in more detail in the light of meteorological conditions. Southwesterly synoptic flow along the outer edge of moving high-pressure system was found to be the important cause of nocturnal ozone maxima in Seoul. This flow could lead to be long-range transport of ozone that had effectively accumulated in the stagnating portion of the system located eastern coast of China. Low atmosphere soundings, backward trajectories, and elevated ozone and CO levels at the back-ground tiles gave evidence for regional effects on nocturnal ozone enhancement In Seoul.

• 한국태양에너지학회:학술대회논문집
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• 2012.03a
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• pp.134-139
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• 2012

This study observed downward long and short-wave radiant environment with selecting 4 areas which have different height in downtown and 1 suburban area to figure out the characteristic of radiant environment in each altitude. The purpose of this study is to collect the preliminary data for interpreting urban thermal environment in summer season by analyzing thermal characteristic of atmosphere in the upper of downtown. The results of this study are as follows. 1) The higher altitude has the lower temperature, and temperature difference was more huge in day time than night time. 2) The short wave radiation according to altitude was higher as altitude was high. 3) Generally, the higher altitude has the lower air temperature, and also the higher altitude has the lower downward long wave radiation by the atmospheric radiation. 4) The ratio short wave radiation of long wave radiation was lower as altitude was high. And the urbanization effect was higher as the ratio was low.

• Clinical and Experimental Pediatrics
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• v.61 no.5
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• pp.150-155
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• 2018

Purpose: Infantile spasms, also known as West syndrome, is an age-specific epileptic seizure. Most patients with this condition also exhibit delayed development. This study aimed to determine the effect of long-term prenatal stress on susceptibility to infantile spasms. Methods: We subjected pregnant rats to acute or chronic immobilization stress. Resulting offspring received N-methyl-D-aspartic acid (15 mg/kg, intraperitoneally) on postnatal day 15, and their behaviors were observed 75 minutes after injection. The expression of KCC2 and GAD67 was also determined using immunohistochemistry. Results: Exposure to long-term prenatal stress increased the frequency of spasms and decreased the latency to onset of spasms compared with offspring exposed to short-term prenatal stress. Expression of KCC2 and GAD67 also decreased in the group exposed to long-term prenatal stress compared with the group exposed to short-term prenatal stress. Conclusion: Our study suggests that exposure to long-term prenatal stress results in increased susceptibility to seizures.

• Journal of Photoscience
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• v.9 no.2
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• pp.13-16
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• 2002

A comparison of the functional components underlying photoperiodism and circadian rhythmicity in the same species is an interesting issue in the context of unravelling clock mechanisms. In the present study, covering or surgical removal of the compound eyes was performed to localize photoreceptors for photoperiodism to control reproductive diapause and for entrainment of circadian locomotor rhythms in the blow fly Protophormia terraenovae. Intact flies showed a long-day photoperiodic response. When the compound eyes were covered by silver paint, diapause incidence increased under diapause-averting conditions of a long-day photoperiod and constant light, as if flies were kept under constant darkness. Covering of a medial region of the head capsule or solvent painting of the compound eyes gave no significant effects. When the compound eyes were removed, flies did not distinguish the photoperiod, whereas removal of antennal lobes or ocelli did not affect the photoperiodism. Intact flies showed a freerunning rhythm under constant darkness. The rhythm entrained to light-dark (LD) cycles with light of high and low intensity. When the compound eyes and ocelli were surgically removed, the rhythm entrained to LD cycles with light of high intensity but freeran under LD cycles with light of low intensity. The results suggest the retinal pathways are involved in photoperiodism and that flies use both retinal and extraretinal pathways for rhythm entrainment. Under dim light-LD cycles, the retinal pathways mainly mediate rhythm entrainment. Retinal photoreceptors seem to be used both for photoperiodism and entrainment of the rhythm.