• Journal of Pharmaceutical Investigation
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• v.33 no.3
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• pp.245-253
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• 2003

Dissolution profile comparsions can be done by virtue of the similarity factor $(f_2)$. It is a logarithmic reciprocal square root transformation of the sum of squared error of % dissolution differences between two profiles at several time points. It gives information on the degree of similarity between the two profiles: An $f_2$ value between 50 and 100 suggests the similarity/equivalence of the two dissolution curves being compared. The objective of this report was to provide a careful examination on the $f_2$ metrics in detail. It was shown that $f_2$ values exceeded 50, when relative differences in % dissolved between two products were less than 15% at all time points. The similarity factor value was also found to be greater than 50, in cases when absolute % dissolution differences were below 10% at all time points. Interestingly, the $f_2$ value was changed by the number of the time points selected for calculation. In particular, $f_2$ tended to have higher values, when the $f_2$ metrics used a large number of time points in which % dissolved reached plateau. Finally, since the similarity factor was a sample statistics, it was impossible to infer type I/II errors and sampling error. Despite certain limitations inherited in the $f_2$ metrics, it was easy and convenient to evaluate how similar the two dissolution profiles were.

• Bulletin of the Korean Space Science Society
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• 2003.10a
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• pp.82-82
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• 2003

It is well known that electromagnetic (EM) waves are mode converted to electrostatic (ES) waves in inhomogeneous plasmas. We examine this issue in a three-dimensional multi-fluid numerical model. First, we derive a set of coupled linear wave equations when a one-dimensional inhomogeneous density profile is assumed in a cold and collisionless plasma. The massive ions are considered as fixed because we are interested in high frequency waves in plasmas. It is shown that the EM mode satisfies the 0th order modified Bessel equation near the resonant region where the frequency matches the local electron plasma frequency. It is expected that the EM waves are coupled and damped to the ES waves owing to the logarithmic singular behavior at such resonances. Second, we numerically test the same case in a 3-D multi-fluid model. An impulsive input is assumed to excite EM waves in the inhomogeneous 3-D box model. The wave spectra of electric and magnetic fields are presented and compared with the analytical results. Our results suggest that the EM energy is irreversibly converted into the ES energy wherever the resonant condition is satisfied. Finally we discuss how the mode conversion appears in both electric and magnetic fields by analyzing time histories of each component. We also compare our results with MHD wave coupling. It is numerically confirmed in this study that the coupling of EM and ES waves is similar to that of compressional and transverse MHD waves.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.26 no.11
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• pp.1531-1541
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• 2002

The NOx emission characteristics of C$H_4$-Air coflow jet flames were numerically and experimentally investigated. NOx was measured using a chemiluminescent detection and calculated by the parabolic -type equation solver with a detatiled NOx chemistry. The fuel flow rate( $Q_{F}$), the diameter of mixture nozzle and the equivalence rate(Ф) were varied to discuss the EINOx of each flames at the various combustion conditions. The NOx emission index(EINOx) was introduced to quantify the NOx emission from the parametrically varied flames. The results show that Prompt EINOx increases on a logarithmic profile with increasing ${\Phi}$ and keeps nearly constant for the variation of $Q_{F}$. Thermal EINOx reaches the maximum value at around ${\Phi}$ =1.5 and then slowly decrease for ${\Phi}$ >1.5. In addition, Thermal EINOx increases with increasing $Q_{F}$, but nearly indifferent to the variation of the mixture nozzle diameter. Total EINOx also shows a peak at around ${\Phi}$ =1.5, followed by a relatively sharp decrease for 1.5< ${\Phi}$ <2.5 and increase slowly for 2.5 < ${\Phi}$ < $\infty$ The present Total EINOx trend is well explained by a combination of above Thermal and Prompt EINOx trend with the variation of ${\Phi}$ n of ${\Phi}$.

• International Journal of Fluid Machinery and Systems
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• v.2 no.4
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• pp.353-362
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• 2009

In the process of turbine modernizations, the investigation of the influences of water passage roughness on radial flow machine performance is crucial and validates the efficiency step up between reduced scale model and prototype. This study presents the specific losses per component of a Francis turbine, which are estimated by CFD simulation. Simulations are performed for different water passage surface roughness heights, which represents the equivalent sand grain roughness height. As a result, the boundary layer logarithmic velocity profile still exists for rough walls, but moves closer to the wall. Consequently, the wall friction depends not only on roughness height but also on its shape and distribution. The specific losses are determined by CFD numerical simulations for each component of the prototype, taking into account its own specific sand grain roughness height. The model efficiency step up between reduced scale model and prototype value is finally computed by the assessment of specific losses on prototype and by evaluating specific losses for a reduced scale model with smooth walls. Furthermore, surveys of rough walls of each component were performed during the geometry recovery on the prototype and comparisons are made with experimental data from the EPFL Laboratory for Hydraulic Machines reduced scale model measurements. This study underlines that if rough walls are considered, the CFD approach estimates well the local friction loss coefficient. It is clear that by considering sand grain roughness heights in CFD simulations, its forms a significant part of the global performance estimation. The availability of the efficiency field measurements provides an unique opportunity to assess the CFD method in view of a systematic approach for turbine modernization step up evaluation. Moreover, this paper states that CFD is a very promising tool for future evaluation of turbine performance transposition from the scale model to the prototype.

• Transactions of the Korean Society of Mechanical Engineers
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• v.16 no.3
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• pp.540-546
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• 1992

Turbulent Couette flow between coaxial cylinders with inner one rotating has been investigated experimentally and numerically. The radius ratio of the coaxial cylinders is 0.43. Mean velocity and turbulent stresses have been measured by hot-wire anemometer in the range of Reynolds number based on the velocity at rotating wall and the radial distance between walls, 60,900-187,000. For the numerical computation, the Reynolds stress model has been used as a turbulence closure model. Measurements of mean velocity show that the velocity profile of wall layer largely deviates from universal logarithmic law due to the effect of streamline curvature, especially in the region near the stationary outer cylinder. The results computed with the Reynolds stress model agree well with the experimental data in the prediction of circumferential intensity of turbulent fluctuations. However, the computed level of radial intensity is much higher than the measurement. Curvature-corrected versions of the Reynolds stress model improves the prediction of turbulent intensities, but the results are not fully satisfactory.

• Wind and Structures
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• v.11 no.4
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• pp.275-289
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• 2008

Large eddy simulations have been performed within and over different types of urban building arrays. This paper adopted three dimensionless parameters, building frontal area density (${\lambda}_f$) the variation degree of building height (${\sigma}_h$), and the staggered degree of building range ($r_s$), to study the systematic influence of building spacing, height and layout on wind and turbulent characteristics. The following results have been achieved: (1) As ${\lambda}_f$ decrease from 0.25 to 0.18, the mean flow patterns transfer from "skimming" flow to "wake interference" flow, and as ${\lambda}_f$ decrease from 0.06 to 0.04, the mean flow patterns transfer from "wake interference" flow to "isolated roughness" flow. With increasing ${\lambda}_f$, wind velocity within arrays increases, and the vortexes in front of low buildings would break, even disappear, whereas the vortexes in front of tall buildings would strengthen and expand. Tall buildings have greater disturbance on wind than low buildings do. (2) All the wind velocity profiles and the upstream profile converge at the height of 2.5H approximately. The decay of wind velocity within the building canopy was in positive correlation with ${\lambda}_f$ and $r_s$. If the height of building arrays is variable, Macdonald's wind velocity model should be modified through introducing ${\sigma}_h$, because wind velocity decreases at the upper layers of the canopy and increases at the lower layers of the canopy. (3) The maximum of turbulence kinetic energy (TKE) always locates at 1.2 times as high as the buildings. TKE within the canopy decreases with increasing ${\lambda}_f$ and $r_s$ but the maximum of TKE are very close though ${\sigma}_h$ varies. (4) Wind velocity profile follows the logarithmic law approximately above the building canopy. The Zero-plane displacement $z_d$ heighten with increasing ${\lambda}_f$, whereas the maximum of and Roughness length $z_0$ occurs when ${\lambda}_f$ is about 0.14. $z_d$ and $z_0$ heighten linearly with ${\sigma}_h$ and $r_s$, If ${\sigma}_h$ is large enough, $z_d$ may become higher than the average height of buildings.

• Korean Journal of Agricultural and Forest Meteorology
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• v.12 no.1
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• pp.45-62
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• 2010

Zero plane displacement (d) is the elevated height of the apparent momentum sink exerted by the vegetation on the air. For a vegetative canopy, d depends on the roughness structure of a plant canopy such as leaf area index, canopy height and canopy density, and thus is critical for the analysis of canopy turbulence and the calculation of surface scalar fluxes. In this research note, we estimated d at the Gwangneung coniferous forest by employing two independent methods of Rotach (1994) and Martano (2000), which require only a single-level eddy-covariance measurement. In general, these two methods provided comparable estimates of $d/h_c$ (where $h_c$ is the canopy height, i.e., ~23m), which ranged from 0.51 to 0.97 depending on wind directions. These estimates of $d/h_c$ were within the ranges (i.e., 0.64~0.94) reported from other forests in the literature but were sensitive to the forms of the nondimensional functions for atmospheric stability. Our finding indicates that one should be careful in interepreation of zero plane displacement estimated from a single-level eddy covariance measurement that is conductaed within the roughness sublayer.

• Journal of Life Science
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• v.31 no.10
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• pp.922-928
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• 2021

To profile the microbial compositions of Korean traditional fermented paste made from whole soybeans, Doenjang and Cheonggukjang, and compare their taxonomic differences, we analyzed the V3-V4 region of 16S rRNA of naturally fermented foods by using next generation sequencing. α-Diversity results showed that values indicating bacterial community abundances (OTUs) and richness (ACE, Chao1) were statistically significant (p=0.0001) in Doenjang and Cheonggukjang. Firmicutes was the most common phylum in both groups, representing 97.02% and 99.67% in the Doenjang and Cheonggukjang groups, respectively. Bacillus was the most dominant genus, accounting for 71.70% and 59.87% in both groups. Linear discriminant (LDA) effect size (LEfSe) analysis was performed to reveal the significant ranking of abundant taxa in different fermented foods. A size-effect threshold of 2.0 on the logarithmic LDA score was used for discriminative functional biomarkers. On the species level, Bacillus subtilis, Tetragenococcus halophilus, and Clostridium arbusti were significantly more abundant in Doenjang than in Cheonggukjang, whereas Bacillus thermoamylovorans, Enterococcus faecium, and Lactobacillus sakei were significantly more abundant in Cheonggukjang than in Doenjang. Permutational multivariate analysis of variance (PERMANOVA) showed that the statistical difference in microbial clusters between the two groups was significant at the confidence level of p=0.001. This research could be used as basic research to identify the correlation between the biochemical characteristics of Korean fermented foods and the distribution of microbial communities.