• Journal of Pharmaceutical Investigation
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• 제34권4호
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• pp.311-317
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• 2004

A bioequivalence study of $Gomcillin^{TM}$ capsules (DAEWOONG Pharmaceutical Co., Korea) to $Famoxin^{TM}$ capsules (Dong Wha Pharm. Ind. Co., Korea) was conducted according to the guideline of Korea Food and Drug Administration (KFDA). Twenty four healthy male Korean volunteers received each medicine at the amoxicillin dose of 500 mg in a $2{\times}2$ crossover study. There was a one-week wash out period between the doses. Plasma concentrations of amoxicillin were monitored by a high-performance liquid chromatography for over a period of 8 hours after the administration. $AUC_t$ (the area under the plasma concentration-time curve from time zero to 8 hr) was calculated by the linear trapezoidal rule method. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t$ and $C_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for $Gomcillin^{TM}/Famoxin^{TM}$ were $log0.91\;{\sim}\;log1.03$ and $;log0.93\;{\sim}\;log1.10$, respectively. These values were within the acceptable bioequivalence intervals of $log0.80\;{\sim}\;log1.25$. Thus, our study demonstrated the bioequivalence of $Gomcillin^{TM}$ and $Famoxin^{TM}$ with respect to the rate and extent of absorption.

• 대한기계학회논문집
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• 제4권2호
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• pp.47-53
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• 1980

Kikukawa-Compliance method using a conventional clip-on gauge was employed to investigate fatigue crack growth and crack closure in 2017-T3 aluminum alloy. The crack growth rate plot against stress intensity range .DELTA.K on a log-log diagram exhibits a bilinear form with a transition at the growth rate of 10$\^$-4/ mm/cycle. The bilinear form appears still in the plot of growth rate versus effective stress intensity range .DELTA.K$\_$eff/. Fatigue crack growth rate could be well represented by .DELTA.K$\_$eff. The experimental results indicate that the effective stress intensity range ratio U depends on the maximum stress intensity factor K$\_$max/, but the stress ratio R does not affect U. The crack opening stress intensity factor K$\_$op/ tends to increase with increasing K$\_$max/ and decrease with increasing .DELTA.K.

• 한국통신학회논문지
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• 제34권12C호
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• pp.1197-1207
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• 2009

Orthogonal Frequency Multiple Access (OFDMA) 방식은 차세대 이동통신을 위한 다중접속 방식으로 널리 고려되고 있으나 Peak-to-Average Power Ratio (PAPR)이 높다는 단점이 있다. 따라서, 송신전력에 민감한 상향링크에서는 PAPR이 낮은 Single Carrier Frequency Division Multiple Access (SC-FDMA) 방식이 OFDMA 방식보다 더 적합한 것으로 여겨지고 있다. 본 논문에서는 주파수 영역 MMSE 등화방식을 기반으로 한 SC-FDMA 시스템의 성능향상 기법을 제안한다. 제안된 기법은 채널의 다이버시티 특성과 수신신호로부터 얻는 쌍방향성 특성을 활용하여 채널복호기의 입력이 되는 Log-likelihood Ratio (LLR) 의 신뢰도를 향상시키는 방식이다. 본 논문에서는 제안된 방식에 의해 추가적으로 증가하는 복잡도를 분석하고, 이에 따른 성능이득을 모의실험을 통해 검증한다.

• 음성과학
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• 제9권2호
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• pp.135-146
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• 2002

Generally a speaker verification system improves its system recognition ratio by regularizing log likelihood ratio, using a speaker model and its background speaker model that are required to be verified. The speaker-based cohort method is one of the methods that are widely used for selecting background speaker model. Recently, Gaussian-based cohort model has been suggested as a virtually synthesized cohort model, and unlike a speaker-based model, this is the method that chooses only the probability distributions close to basic speaker's probability distribution among the several neighboring speakers' probability distributions and thereby synthesizes a new virtual speaker model. It shows more excellent results than the existing speaker-based method. This study compared the existing speaker-based background speaker models and virtual speaker models and then constructed new virtual background speaker model groups which combined them in a certain ratio. For this, this study constructed a speaker verification system that uses GMM (Gaussin Mixture Model), and found that the suggested method of selecting virtual background speaker model shows more improved performance.

• Journal of Pharmaceutical Investigation
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• 제38권2호
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• pp.135-142
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• 2008

The present study describes the evaluation of the bioequivalence of two atorvastatin tablets, Lipitor $Tablet^{(R)}$ (Pfizer, reference drug) and Atorva $Tablet^{(R)}$ (Yuhan, test drug), according to the guidelines of Korea Food and Drug Administration (KFDA). Forty-nine healthy male Korean volunteers received each medicine at the atorvastatin dose of 40 mg in a $2{\times}2$ crossover study with a two weeks washout interval. After drug administration, serial blood samples were collected at a specific time interval from 0-48 hours. The plasma atorvastatin concentrations were monitored by an high performance liquid chromatography -tandem mass spectrometer (LC-MS/MS) employing electrospray ionization technique and operating in multiple reaction monitoring (MRM) and positive ion mode. The total chromatographic run time was 4.5 min and calibration curves were linear over the concentration range of 0.1-100 ng/mL for atorvastatin. The method was validated for selectivity, sensitivity, linearity, accuracy and precision. $AUC_t$ (the area under the plasma concentration-time curve from time zero to 48hr) was calculated by the linear log trapezoidal rule method. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were complied trom the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t$ and $C_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for Atorva $Tablet^{(R)}$ / Lipitor $Tablet^{(R)}$ were ${\log}\;0.9413{\sim}{\log}\;1.0179$ and ${\log}\;0.831{\sim}{\log}\;1.0569$, respectively. These values were within the acceptable bioequivalence intervals of ${\log}\;0.8{\sim}{\log}\;1.25$. Based on these statistical considerations, it was concluded that the test drug, Atorva $Tablet^{(R)}$ was bioequivalent to the reference drug, Lipitor $Tablet^{(R)}$.

• Communications for Statistical Applications and Methods
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• 제5권3호
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• pp.847-853
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• 1998

Suppose we want to compare following non-hierarchical log-linear models, $H_0:f(x, heta inTheta_a)$ vs H_1:g(x, heta inTheta_eta); for; Theta_a,;Theta_etasubsetTheta;such;that;Theta_$\alpha$/ Theta_eta$. The goodness of fit test using the likelihood ratio test statistic for comparing these models could not be acceptable. By using the polyhedrons plots of Choi and Hong (1995), we propose a method to decide a better model between two non-hierarchical log-linear models $f(x: heta inTheta_a) and g(x: heta inTheta_eta)$.

• 정보처리학회논문지A
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• 제8A권4호
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• pp.499-502
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• 2001

프랙탈 코딩은 높은 압축률을 포함한 여러 가지 장점을 가지고 있으나 유사블록 탐색에 긴 시간이 소요되는 문제점을 가지고 있다. 본 논문은 각 블록의 정규화 된 분산 값은 명도(contrast)와 밝기(brightness)에 독립적임을 발견하고, 이를 이용하여 d(key의 수)차원 공간에서 최근접부근탐색(nearest neighbor search)을 하여 효율적인 유사블록을 탐색하는 방법을 제안한다. 본 방법은 각 치역 블록 당 Ο(log N), (N : 정의역블록 수) 시간에 유사 정의역 블록 찾을 수 있음을 보였다. 압축처리 된 이미지는 각 치역 블록 당 Ο(N) 시간이 요구되는 전체탐색의 PSNR (Peak Signal Noise Ratio)과 거의 같은 값을 얻게 되었다. 또한, 본 방법은 에지가 많은 이미지에도 전체탐색과 거의 유사한 PSNR로 압축되는 장점을 가진다.

• 한국지리정보학회지
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• 제13권1호
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• pp.101-113
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• 2010

최근에 발생하는 강우양상은 강우일수는 감소하고, 강우강도는 증가해 홍수발생 빈도 역시 증가하는 추세이다. 이를 반영하기 위한 기존의 방법은 수공구조물의 설계홍수량을 산정할 때 가능최대강우량을 도입하거나, 설계빈도를 높이는 등의 확정론적 방법에 의존한다. 그러나 이렇게 설계기준을 상향 조정한 경우, 설계빈도의 강우가 발생하지 않으면 수공구조물의 경제성 측면에서 문제가 될 소지가 있다. 또한 수공구조물의 규모가 클수록 인근 주민과의 마찰이 커지고, 환경 문제의 발생 역시 고려하지 않을 수 없다. 이에 따라 설계빈도의 무조건적인 상향조정에 의존하기보다 추계학적 방법을 도입한 수문량의 확충 및 매개변수의 불확실성을 수공구조물 설계 시에 고려하기 위한 연구가 활발히 진행되고 있다. 본 연구에서는 강우발생의 불확실성을 반영하여 제내지에서의 침수범위를 GIS상에서 검토하였다. 이를 위해 log-ratio 방법, Johnson 시스템, 직교변환을 활용한 다변량 Monte Carlo 기법으로 추계학적 시간에 따른 강우변동을 생성하였다. 생성된 강우변동 결과를 토대로 수문분석, 홍수위 분석 등을 실시하고 FLUMEN 모형을 적용하여 해당유역에 대한 홍수범람시 침수범위를 산정하였다. 본 연구결과는 실제 강우의 불확실성을 반영하고 있어 시 공간적 강우특성이 반영된 유역별 주민대피지도, 홍수위험지도 등을 제작하는데 활용될 수 있을 것으로 판단된다.

• 방송공학회논문지
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• 제1권2호
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• pp.165-175
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• 1996

본 논문에서는 영상분할에 이용되는 대부분의 기존방법들에서의 문제점을 해결하기 위해 입력 영상으로부터 형성된 계층적 피라밋 영상구조를 이용하여 영상을 분할하는 방법을 제안하였다. 제안된 방법은 통계적 방식에 의한 물체검출 및 묘사과정으로 이루어져 있다. 물체검출 방법에서는 계층적 영상구조에서 발생하는 클러스터링의 유효성 문제를 해결하기 위해 통계적 IFSVR 알고리듬과 FSVR 알고리듬을 제안하였고, 이를 이용하여 관심대상 화소를 검출하였다. 물체묘사 방법은 고해상도 레벨로 검출된 최적 물체화소를 투사하고 처리하기 위해 톱다운 추적방식인 반복 알고리듬을 제안하였다. 시뮬레이션을 통하여 2진 영상과 실영상 모두에서 제안된 분할방법을 분석하였고, 그 결과 계층적 피라밋구조에 기초를 둔 접근방법이 영상분할에 대한 유용한 특성을 가지고 있음을 입증하였으며, 병렬처리기에서 처리된다면 각 알고리듬이 n${\times}$n 영상에 대해 0(log n)의 계산량이 요구된다.

• Journal of Pharmaceutical Investigation
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• 제37권5호
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• pp.315-321
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• 2007

The purpose of the present study was to evaluate the bioequivalence of two lercanidipine hydrochloride tablets, Zanidip tablet (LG Life Sciences Ltd., Korea, reference drug) and Samchundang Lercanidipine tablet 10 mg (Sam Chun Dang Pharm. Co. Ltd., Korea, test drug), according to the guidelines of Korea Food and Drug Administration (KFDA). After adding an internal standard (amlodipine maleate) to human serum, serum samples were extracted using hexan-isoamyl alcohol (100:1, v/v). Compounds were analyzed by liquid chromatography/tandem mass spectrometry. This method showed linear response over the concentration range of 0.05-20 ng/mL with correlation coefficient of 0.9999. The lower limit of quantitation using 0.5 mL of serum was 0.05 ng/mL which was sensitive enough for pharmacokinetic studies. Thirty healthy male Korean volunteers received each medicine at the lercanidipine hydrochloride dose of 20 mg in a $2\;{\times}\;2$ crossover study. There was a one-week washout period between the doses. Serum concentrations of lercanidipine were monitored by an LC/MS/MS fer over a period of 24 hr after the administration. $AUC_t$ (the area under the serum concentration-time curve from time 0 to 24 hr) was calculated by the linear trapezoidal rule method. $C_{max}$ (the maximum serum drug concentration) and $T_{max}$ (the time to reach $C_{max}$) were compiled from the serum concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t$ and $C_{max}$. No significant sequence effect was found for all of the bioavailability parameters, indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for Samchundang Lercanidipine/Zanidip were log 0.9505-log 1.2258 and log 0.9987-log 1.2013, respectively. These values were within the acceptable bioequivalence intervals of log 0.80-log 1.25. Thus, the criteria of the KFDA guidelines for the bioequivalence was satisfied, indicating Samchundang Lercanidipine tablet 10 mg and Zanidip tablet are bioequivalent.