• 생명과학회지
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• 제17권11호
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• pp.1587-1592
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• 2007

Locus control region (LCR) is a cia-acting element which regulates the transcription of genes in developmental stage and/or tissue-specific pattern. Typically, LCR consists of several DNase I hypersensitive sites (HSs), where the binding motifs for transcriptional activators are present. The binding of activators to the HSs recruits chromatin modifying complexes to the LCR, opening chromatin structure and modifying histones covalently through the locus. LCR forms close physical contact with target gene located at a distance by looping away intervening region. In addition, non-coding RNA is transcribed from LCR toward target genes in continuously acetylated active domain. These structural and functional features of LCR suggest that the LCR plays many roles in chromatin activation and transcriptional regulation.

• 농촌지도와개발
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• 제3권2호
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• pp.265-271
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• 1996

Locals of Control is considered one of the main imporment factors on responsible environmental behaviors(REB). It is defined as an individual's perception of his or ha ability to bring about change through his a her behavior. This psychological construct is divided in two, external and internal. Internal locus of control(ILOC) is imporment as predictor for responsible environmental behaviors. This study was conducted to investigate the Locus of Control and relations with REB in Undergraduate Students. The data were collected mainly through questionnaires and a total of 157 responded questionnaires was analyzed for the study. The statistical methods used in this study were frequency, percentile and correlation. The major findings of this study were (1) Most of undergraduate students had internal locus of control(75.2%). (2) According to region, rural students showed high levels in ILOC and REB.

• 생명과학회지
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• 제22권11호
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• pp.1587-1594
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• 2012

3C는 진핵세포의 핵에서 크로마틴의 입체 구조/구성을 알아보는 연구 기법이다. 이 기법은 살아있는 세포를 포름알데히드로 처리하여 단백질들 사이의 결합 및 단백질과 DNA 사이의 결합을 고정시킨 후, 제한효소로 DNA를 절단하고, 그 절편들의 연결 빈도를 측정함으로써 DNA 절편 사이의 물리적 근접성을 보여준다. 이 기법을 이용하여 복합 유전자 좌위인 ${\beta}$-글로빈 좌위에서 locus control region이 전사가 활발한 유전자와 가까이 위치하고 있음이 밝혀졌으며, 이러한 결과는 크로마틴 입체 구조가 유전자 전사 조절에 관여함을 나타낸다. 또한 3C 기법은 ChIP 및 genome-wide sequencing과 결합되어 다양한 기술로 진화되었다. 본 총설은 3C의 원리 및 과정을 짚어보고, 3C 기법으로 밝혀진 ${\beta}$-글로빈 좌위의 크로마틴 입체 구조를 설명하고자 하며, 나아가 3C를 기본으로 한 다양한 응용 연구 기법도 살펴보고자 한다.

• 가정과삶의질연구
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• 제15권4호
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• pp.253-268
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• 1997

the purpose of this study was to analyze the relationship between elderly's leissure participation and the type of leisure attitude and leisure constraints. The sample of this study consisted of 485 elderly over 55 years old living in Seoul Daejeon Jeonju and Daegu. Statistics employed for the analysis were frequencies means cross-tabs and multiple regression analysis. The results could be summarized as follows The types of leisure attitude and leisure constraints of elderly was affected by the age educational attaintment health status region total asset income pocket money family relationship locus of control and self-esteem. And educational attaintment health status region family relationship locus of control and self-esteem had effects on leisure participation level of elderly. These findings pointed that psychological factors such as family relation self-esteen and type of leisure attitude and leisure constraints were the variables explaining leisure activities of elderly.

• 한국학교보건학회지
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• 제6권1호
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• pp.9-44
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• 1993

An explorative and descriptive study in order to determine the effect of family structure and other socio-demographic variables on health behavior, belief, locus, and value and utilization of public health service was carried out. Data were collected from 1,653 subjects randomly sampled in three areas, Seoul, Kyunggi province, and Cheju province. From Seoul 849 subjects were selected, 397 subjects Kyunggi, and 407 subjects from Cheju, respectively. Self-reporting questionaires were administered during the period from March to June, 1992. The major findings were as follows: 1) The subjects visited herb-doctor's at irregular intervals mainly to have tonic medicine prepared. They preferred herb-doctor's rather than with doctors at clinics and hospitals. Statistically significant difference was found among the regions studied (p<0.05). 2) The reason for visiting hospitals was primarily for treatment of diseases. They preferred hospital because they felt that the hospitals offer much highly reliable treatment services as well as medical accessibility. For the purpose of hospital utilization, statistically significant differences existed among sex, educational level, family type and region. However, no significance was found among sex, educational level, and region (p<0.05). 3) The subjects utilized general hospitals mainly for diagnosis and treatment of diseases. They preferred general hospitals because of their much better facilities and reliability. Statistical significance was found among sex, educational level, and region (p<0.05). 4) The subjects visited dentist at irregular intervals basis. They visited once half a year or three to four months. their purpose of visit was mainly for diagnosis and treatment of diseases. Statistical significance differences were found among educational level, region and economic standard (p<0.05). 5) Whenever their illnesses were mild and the pharmacies was located in nearby they visited to pharmacies. They visited once a month and patient medicines. Statistically significant differences were found among sex, educational level and region (p<0.05). 6) The subjects believed that herb medicine was quite efficacious for treatment of some diseases, particularly by information handed down through time-honored tradition and experience. However, they recognized that the efficacy of folk medicine can vary with type and severity of diseases. Statistical significance was among sex, educational level, region and economic standard (p<0.05). 7) The reason why subjects believed that pray and superstition are effective for treatment of certain type of diseases, particularly in neuropathy, was the belief in God's almighty. Statistically significant differences were found among sex, educational level, regions and economic standard (p<0.05). 8) Most of subjects under same condition preferred western medicine because they believed that it is more scientific and prompts in showing therapeutic effect. Statistical significance was not found in the choice of type of public health service among, regions. But significant differences were found among sex, educational level and region (p<0.05). 9) The subjects looked for pharmacy if they thought the symptom was mild. However, they visited hospitals for chronic disease and general hospitals for emergency treatment. Statistical significances were found among educational level, region and economic standard (p<0.05). 10) Although most of students wanted to have a healthy life as for the component of health standard and value, they think that they are not healthy (p<0.05). As for the health behavior, significant difference was found in the proportion of smoking and drinking between educational level and region (p<0.05). The health locus was affected by educational level, and health behavior was influenced by region, sex and educational level. The utilization of type of public health service was influenced by family type and region, and health belief by region and educational level, and the health values by region and economic standard respectively, most of correlation showed statistical significance. Among them, the highest correlation was seen between locus of control and external/internal locus of control, which is quite obvious. The correlation between health belief and behavior was the next highest, but still low (0.343). All the other variables are low but significant except only a few of those. These findings indicate that health education should be incorporated into the curriculum so as to develop desirable health habit, and ability of self-control in accordance with their growth stages. A systematic and scientific understanding on the herb/folk medicine is needed, and greater reliability of the utilization of public health services are is still required. Health policy for equal distribution of health service throughout the country along the hierarchical health service system and complementary mutual assistance and cooperation among various health organizations are also required.

• 대한본초학회지
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• 제22권2호
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• pp.127-135
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• 2007

Objective : Investigation of the anti-stress effects of Sihosogansan Methods : Passive avoidance test(PAT) was performed after applying immobilization stress in water to rats. Also, forced swimming test(FST) was performed to another rats and after FST, the degree of Tyrosine Hydroxylase(TH) expression was measured with immunohistochemical method in the regions of locus coeruleus(LC) and ventral tegmental area (VTA). Results : In the PAT after immobilization stress in water, response latency was significantly increased in the Sihosogansan(400mg/kg) group in comparison with the control group. In the FST, immobility was significantly decreased in the Sihosogansan groups (100mg/kg, 400mg/kg), comparing with the control group. Stress-induced TH increases were suppressed in the Sihosogansan groups (100mg/kg, 400mg/kg) at the LC and the VTA region respectively. Conclusion : Sihosogansan can improve memory ability of rats, reduce behavior of depression in rats, decrease TH-immunoreactive cells at the LC and VTA region in rat, and it may be concluded that Sihosogansan has significant effect in reducing stress.

• Journal of Korean Neurosurgical Society
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• 제64권2호
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• pp.309-315
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• 2021

Objective : To explore the correlation between the polymorphism of histone deacetylase 9 gene (rs1060499865, rs723296, rs957960) and ischemic stroke (IS) in Chinese Han population in Dali region. Methods : This study included 155 IS patients and 128 healthy physical examinees. TaqMan-polymerase chain reaction technology and multivariate logistic regression were performed. Results : In the case group, there was no polymorphism of rs1060499865 observed in the two groups; whereas on the rs723296 locus the frequencies of C allele and TC genotype were significantly higher than that in the control group, alleles C and T were associated with a 2.158-fold increase in IS risk, and genotypes TC and TT were associated with a 2.269-fold increase in IS risk. The locus rs957960 exhibited no significant difference between the two groups. Conclusion : An association between rs723296 and the risk of IS was found in the Chinese Han population in Dali region. No significant association was found between rs1060499865, rs957960 and IS in the Chinese Han population in Dali region.

• Animal Systematics, Evolution and Diversity
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• 제24권1호
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• pp.25-32
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• 2008

The Gold-spotted pond frog, Rana plancyi chosenica, designated as a vulnerable species by IUCN Red list. This species is a typical example facing local population threats and extinction due to human activities in South Korea. A strategic conservation plan for this endangered species is urgently needed. In order to provide information for future conservation planning, accurate information on the genetic diversity and taxonomic status is needed for the establishment of conservation units for this species. In this study, we used a molecular genetic approach using the mitochondrial cytochrome b gene and control region sequences to find the genetic diversity of gold-spotted pond frogs within South Korea. We sequenced the mitochondrial DNA cytochrome b gene and control region of 77 individuals from 11 populations in South Korea, and one from Chongqing, China. A total of 15 cytochrome b gene haplotypes and 34 control region haplotypes were identified from Korean gold-spotted pond frogs. Mean sequence diversity among Korean gold-spotted pond frogs was 0.31% (0.0-0.8%) and 0.51% (0.0-1.0%), respectively. Most Korean populations had at least one unique haplotype for each locus. The Taean, Ansan and Cheongwon populations had no haplotypes shared with other populations. There was a sequence divergence between Korean and Chinese gold-spotted pond frogs (1.3% for cyt b; 2.9% for control region). Analysis of genetic distances and phylogenetic trees based on both cytochrome b and control region sequences indicate that the Korean gold-spotted pond frog are genetically differentiated from those in China.

• 유통과학연구
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• 제17권11호
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• pp.5-15
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• 2019

Purpose: This study aimed to empirically demonstrate how self-esteem, self-efficacy, locus of control, and neuroticism, which is core self-evaluation factors of door-to-door salespersons within food and cosmetic retail industry, affected the sales performance of female salespersons via job satisfaction and organizational commitment. Research design, data and methodology: Using a 23-item questionnaire constructed based on previous studies, this study selected six domestic door-to-door sales companies and conducted a 1:1 face-to-face survey with female door-to-door salespersons belonging to branches and agencies in Seoul and the capital region. The data of 208 respondents were analyzed. The results of path analysis based on structural equation modeling and mediation analysis through the Sobel test were presented. Results: Self-efficacy and locus of control had the largest effect on job satisfaction and organizational commitment, respectively. Neuroticism, however, did not significantly influence job satisfaction and organizational commitment. Overall, core self-evaluation factors positively affected sales performance via job satisfaction but not via organizational commitment. Conclusions: This study found that factors which were oriented to female salespersons' ability and sales goals, such as self-efficacy and job satisfaction, were considered important in managing them in the door-to-door sales-distribution channels. In the future, policies should be developed for managing female door-to-door salespersons to help them achieve job satisfaction.

• 동아시아식생활학회지
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• 제17권6호
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• pp.798-807
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• 2007

본 연구는 건강식품 섭취자와 비섭취자의 인구 통계학적 특성 및 사회 심리적인 변수에 따른 차이를 살펴보고 향후 건강식품의 섭취 의도에 영향을 미치는 요인들을 분석하기 위하여 부산 및 경남지역에 거주하고 있는 성인 453명으로부터 자료를 수집하였으며, SPSS Windows를 통해 분석하였다. 본 연구에서 얻어진 결과를 요약하면 다음과 같다. 첫째, 전체 응답자의 48.%가 건강식품을 섭취하고 있는 것으로 나타났으며, 건강식품 섭취자의 주된 섭취 이유는 일반적인 건강 유지 및 증진을 위해서이었으며, 비섭취자의 비섭취 이유는 건강해서 필요성을 느끼지 못하기 때문으로 나타났다. 둘째, 건강식품 섭취자와 비섭취자의 인구 통계학적 특성을 비교한 결과, 여성인 경우, 연령이 $30{\sim}39$세이며, 전문대졸 이상의 학력을 가진 경우, 기혼자이며 월가계 소득이 $2,000,001{\sim}3,000,000$원인 경우 건강식품을 섭취한다고 응답한 비율이 높았다. 그리고 사회 심리적 요인을 비교해보면 건강식품 섭취자는 비섭취자에 비해 건강에 대한 관심도가 높고 자가 건강 상태 평가 및 동년배 비교시 자가 건강 상태 평가에서 건강 상태가 좋지 않고, 건강식품에 대한 관심도가 높고 건강식품에 대해 긍정적으로 인식하고 있으며, 내적 통제위 성향을 많이 가지고 있는 것으로 나타났다. 셋째, 향후 건강식품 섭취 의도에 영향을 미치는 변수를 살펴보기 위하여 다항로지스틱 회귀분석을 실시한 결과, 향후 건강식품을 섭취할지 잘 모르겠다고 응답한 집단에 비해 건강식품을 섭취하지 않겠다라고 응답한 집단의 경우, 학력, 월가계 소득, 결혼여부, 건강식품에 대한 관심도, 현재 건강식품의 섭취 여부가 유의하였다. 한편 향후 건강식품을 섭취할지 잘 모르겠다라고 응답한 집단에 비해 건강식품을 섭취하겠다라고 응답한 집단의 경우, 성별, 건강에 대한 관심도, 건강식품에 대한 관심도, 건강식품에 대한 인식도, 타인 의존 통제위, 내적 통제위, 현재 전강식품의 섭취 여부가 유의한 것으로 나타났다.