Browse > Article
http://dx.doi.org/10.3340/jkns.2020.0040

Association between Histone Deacetylase 9 Gene Polymorphism and Stroke in Chinese Han Population  

Yang, Xitong (Genetic Testing Center, The First Affiliated hospital of Dali University)
Xu, Hongyang (Deparment of Encephalopathy, Hospital of Traditional Chinese Medicine)
Liu, Dan (Genetic Testing Center, The First Affiliated hospital of Dali University)
Ma, Rong (Genetic Testing Center, The First Affiliated hospital of Dali University)
Zhang, Yuanyuan (Genetic Testing Center, The First Affiliated hospital of Dali University)
Wang, Guangming (Genetic Testing Center, The First Affiliated hospital of Dali University)
Publication Information
Journal of Korean Neurosurgical Society / v.64, no.2, 2021 , pp. 309-315 More about this Journal
Abstract
Objective : To explore the correlation between the polymorphism of histone deacetylase 9 gene (rs1060499865, rs723296, rs957960) and ischemic stroke (IS) in Chinese Han population in Dali region. Methods : This study included 155 IS patients and 128 healthy physical examinees. TaqMan-polymerase chain reaction technology and multivariate logistic regression were performed. Results : In the case group, there was no polymorphism of rs1060499865 observed in the two groups; whereas on the rs723296 locus the frequencies of C allele and TC genotype were significantly higher than that in the control group, alleles C and T were associated with a 2.158-fold increase in IS risk, and genotypes TC and TT were associated with a 2.269-fold increase in IS risk. The locus rs957960 exhibited no significant difference between the two groups. Conclusion : An association between rs723296 and the risk of IS was found in the Chinese Han population in Dali region. No significant association was found between rs1060499865, rs957960 and IS in the Chinese Han population in Dali region.
Keywords
Stroke; HDAC9 protein; Polymorphism;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Musunuru K, Hickey KT, Al-Khatib SM, Delles C, Fornage M, Fox CS, et al. : Basic concepts and potential applications of genetics and genomics for cardiovascular and stroke clinicians: a scientific statement from the American Heart Association. Circ Cardiovasc Genet 8 : 216-242, 2015   DOI
2 Petrie K, Guidez F, Howell L, Healy L, Waxman S, Greaves M, et al. : The histone deacetylase 9 gene encodes multiple protein isoforms. J Biol Chem 278 : 16059-16072, 2003   DOI
3 Prestel M, Prell-Schicker C, Webb T, Malik R, Lindner B, Ziesch N, et al. : The atherosclerosis risk variant rs2107595 mediates allele-specific transcriptional regulation of HDAC9 via E2F3 and Rb1. Stroke 50 : 2651-2660, 2019   DOI
4 Qingxu G, Yan Z, Jiannan X, Yunlong L : Association between the gene polymorphisms of HDAC9 and the risk of atherosclerosis and ischemic stroke. Pathol Oncol Res 22 : 103-107, 2016   DOI
5 Qingxu G, Yan Z, Jiannan X, Yunlong L : Association between the gene polymorphisms of HDAC9 and the risk of atherosclerosis and ischemic stroke. Pathol Oncol Res 22 : 103-107, 2016   DOI
6 Smith JD : New role for histone deacetylase 9 in atherosclerosis and inflammation. Arterioscler Thromb Vasc Biol 34 : 1798-1799, 2014   DOI
7 Traylor M, Farrall M, Holliday EG, Sudlow C, Hopewell JC, Cheng YC, et al. : Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE Collaboration): a meta-analysis of genome-wide association studies. Lancet Neurol 11 : 951-962, 2012   DOI
8 Venketasubramanian N, Yoon BW, Pandian J, Navarro JC : Stroke epidemiology in South, East, and South-East Asia: a review. J Stroke 19 : 286-294, 2017   DOI
9 Wang M, Gu M, Li Z, Sun B, Cheng X, Dai Z, et al. : HDAC9 polymorphisms predict susceptibility, severity, and short-term outcome of large artery atherosclerotic stroke in Chinese population. J Mol Neurosci 67 : 165-171, 2019   DOI
10 Wang X, Sun Z, Zhang Y, Tian X, Li Q, Luo J : Impact of the PDE4D gene polymorphism and additional SNP-SNP and gene-smoking interaction on ischemic stroke risk in Chinese Han population. Neurol Res 39 : 351-356, 2017   DOI
11 Zhou M, Wang H, Zhu J, Chen W, Wang L, Liu S, et al. : Cause-specific mortality for 240 causes in China during 1990-2013: a systematic sub-national analysis for the Global Burden of Disease Study 2013. Lancet 387 : 251-272, 2016   DOI
12 Wang XB, Han YD, Sabina S, Cui NH, Zhang S, Liu ZJ, et al. : HDAC9 variant Rs2107595 modifies susceptibility to coronary artery disease and the severity of coronary atherosclerosis in a Chinese Han population. PLoS One 11 : e0160449, 2016   DOI
13 Xu YL, Hu YY, Li JW, Zhou L, Li L, Niu YM : Aldehyde dehydrogenase 2 rs671G>A polymorphism and ischemic stroke risk in Chinese population: a meta-analysis. Neuropsychiatr Dis Treat 15 : 1015-1029, 2019   DOI
14 Yeo BPH, Foong LC, Tam SM, Lee V, Hwang SS : Gene isolation using degenerate primers targeting protein motif: a laboratory exercise. Biochem Mol Biol Educ 46 : 47-53, 2018   DOI
15 Zhu QB, Wu GM, Li GM, et al. : Study on the relationship between single nucleotides polymorphism rs2240419 of HDAC9 gene and the susceptibility to ischemic stroke and TCM syndromes in Guangdong Han population. Chinese Journal for Clinicians 47 : 35-40, 2019
16 Zhu R, Liu X, He Z, Li Q : MiR-146a and miR-196a2 polymorphisms in patients with ischemic stroke in the northern Chinese Han population. Neurochem Res 39 : 1709-1716, 2014   DOI
17 Ferronato S, Mombello A, Posenato I, Candiani P, Scuro A, Setacci C, et al. : Expression of circulating miR-17-92 cluster and HDAC9 gene in atherosclerotic patients with unstable and stable carotid plaques. Genet Test Mol Biomarkers 21 : 402-405, 2017   DOI
18 Baird AE : Genetics and genomics of stroke: novel approaches. J Am Coll Cardiol 56 : 245-253, 2010   DOI
19 Cao Q, Rong S, Repa JJ, Clair RS, Parks JS, Mishra N : Histone deacetylase 9 represses cholesterol efflux and alternatively activated macrophages in atherosclerosis development. Arterioscler Thromb Vasc Biol 34 : 1871-1879, 2014   DOI
20 Chinese Society of Neurology : The diagnosis of cerebrovascular diseases. CHN of J Neurol 29 : 379-380, 1996
21 Han X, Han X, Wang Z, Shen J, Dong Q : HDAC9 regulates ox-LDL-induced endothelial cell apoptosis by participating in inflammatory reactions. Front Biosci (Landmark Ed) 21 : 907-917, 2016   DOI
22 Kalkonde YV, Sahane V, Deshmukh MD, Nila S, Mandava P, Bang A : High prevalence of stroke in Rural Gadchiroli, India: a community-based Study. Neuroepidemiology 46 : 235-239, 2016   DOI
23 Han Y, Sun W, Wang L, Tao S, Tian L, Hao Y, et al. : HDAC9 gene is associated with stroke risk in a Chinese population. Exp Biol Med (Maywood) 238 : 842-847, 2013   DOI
24 He M : The role and mechanism of acetylation epigenetic regulation molecule HDAC4/5 in ischemic brain injury. Jinan : Shandong University, 2012
25 International Stroke Genetics Consortium (ISGC); Wellcome Trust Case Control Consortium 2 (WTCCC2), Bellenguez C, Bevan S, Gschwendtner A, Spencer CC, et al. : Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke. Nat Genet 44 : 328-333, 2012   DOI
26 Kaluza D, Kroll J, Gesierich S, Manavski Y, Boeckel JN, Doebele C, et al. : Histone deacetylase 9 promotes angiogenesis by targeting the anti-angiogenic microRNA-17-92 cluster in endothelial cells. Arterioscler Thromb Vasc Biol 33 : 533-543, 2013   DOI
27 Markus HS, Makela KM, Bevan S, Raitoharju E, Oksala N, Bis JC, et al. : Evidence HDAC9 genetic variant associated with ischemic stroke increases risk via promoting carotid atherosclerosis. Stroke 44 : 1220-1225, 2013   DOI
28 Lahm A, Paolini C, Pallaoro M, Nardi MC, Jones P, Neddermann P, et al. : Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases. Proc Natl Acad Sci U S A 104 : 17335-17340, 2007   DOI
29 Liu WL, Lin YJ, Tao J, Peng J, Li GP, Chen LD, et al. : Study on the correlation between HDAC9 gene SNPs and large vessel atherosclerosis-induced ischemic stroke. Chin J Stroke 11 : 269-276, 2016
30 Lu S, Li H, Li K, Fan XD : HDAC9 promotes brain ischemic injury by provoking lκBα/NF-κB and MAPKs signaling pathways. Biochem Biophys Res Commun 503 : 1322-1329, 2018   DOI