• Korean Journal of Oriental Medicine
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• v.17 no.3
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• pp.77-85
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• 2011

Objectives : The purpose of this study was to develop a simulator which can analyze the anti-inflammatory effects of medical herbs based on e-cell concerning p38 MAPK signal pathway. Methods : We collected data concerning medical herbs with anti-inflammatory effects and the active compounds to provide as a fundamental databse and to validate the newly developed algorithm. At this time, we used the target database as pubmed and gathered the data by data mining tool, pathway studio. Also we have developed the web-based search system for confirming database related to anti-inflammation. We researched the mechanism of actions of proteins in p38 MAPK signal pathway when active compound has been inserted into the network. We reduced total network into TAK-MKK3-p38 and made the two types of mathematical model about active compounds' interaction. Results & Conclusion : We constructed the database which have 69 cases of medical herbs, 71 cases of active compounds, about 8,000 cases of URL(Uniform Resource Locator) related to papers and reports. We designed the ordinary differential equations for response of TAK, MKK3, p38 in e-cell's cytosol and nucleus. We used this formular as measure whether an active compound of medicinal plants which is inputted by an user would have an anti-inflammation effects. We developed the visualization program which could show the change of concentration over time.

• The Journal of the Korea Contents Association
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• v.3 no.2
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• pp.57-64
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• 2003

A Web Service is an URL addressable set of functionality that is exposed over a network to serve as a building Hock for creating distributed applications. SOAP is a protocol that Web Service consumers often use, when they request and response to a Web Service, and it is a lightweight, XML-based protocol over HTTP for exchange to information in decentralized, distributed environments. A Web Service is very useful forimplementing common functions in especially a large size business area, because it is invoked by a protocol like HTTP or SOAP that we easily use, and by an XML-based data format In this paper, we implement Web Services that process dip data by computers in enterprise accounts in order to enhance the transparency and productivity of enterprises. we analyse the structure of slip data, design dip database, implement stored procedures for manipulating data of slip database, and make thorn controlled by Web Services. The result of this paper will contribute to the standardization and activation of accounting process systems for e-business area.

• Journal of the Korean BIBLIA Society for library and Information Science
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• v.33 no.4
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• pp.139-157
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• 2022

Finding and selecting proper reviewers is a burden on the publisher of the journal. In order to solve this problem, the online submission system started to recommend appropriate reviewers automatically. It includes a variety of new features, from recommending authors in the references of submitted papers as reviewers to finding similar papers by searching the citation index and suggesting reviewer candidates extensively. This study investigated how the online submission system provides functions such as recommendation of reviewers. As a result of examining major online submission systems, ScholarOne and Editorial Manager were recommending reviewer candidates by commercial citation index and review history platform. On the other hand, JAMS, a domestic online submission system, did not have any advanced functions such as recommendation of candidates for reviewers. Sooner or later, in Korea, it seems that more efforts should be made to improve the function of online submission system, such as recommending suitable reviewers for papers.

• Journal of IKEEE
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• v.27 no.3
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• pp.213-219
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• 2023

According to statistics from the National Police Agency, smishing crimes using texts or messengers have increased dramatically since COVID-19. In addition, most of the cases of impersonation of public institutions reported to agency were related to vaccination and reward, and many methods were used to trick people into clicking on fake URLs (Uniform Resource Locators). When detecting them, URL-based detection methods cannot detect them properly if the information of the URL is hidden, and content-based detection methods are slow and use a lot of resources. In this paper, we propose a system for URL-based detection using transformer for regular URLs and content-based detection using XGBoost for shortened URLs through the process of determining shortened URLs using GRU(Gated Recurrent Units). The F1-Score of the proposed detection system was 94.86, and its average processing time was 5.4 seconds.

• Restorative Dentistry and Endodontics
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• v.46 no.3
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• pp.31.1-31.13
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• 2021

Objectives: To evaluate postoperative pain after endodontic treatment of necrotic teeth using large intentional foraminal enlargement (LIFE). Materials and Methods: The sample included 60 asymptomatic necrotic teeth (with or without chronic apical periodontitis), and a periodontal probing depth of 3 mm, previously accessed and referred to perform endodontic treatment. After previous procedures, the position and approximate size of the apical foramen (AF) were determined by using an apex locator and K flexo-files, respectively. The chemomechanical preparation was performed with Profile 04 files 2 mm beyond the AF to achieve the LIFE, using 2.5 mL of 2.5% NaOCl at each file change. The filling was performed by Tagger's hybrid technique and EndoFill sealer. Phone calls were made to all the patients at 24, 48 and 72 hours after treatment, to classify postoperative pain. Statistical analysis was performed by different tests with a significance level of 5%. Results: Age, gender, periradicular status and tooth type did not influence postoperative pain (p > 0.05). Only 1 patient (1.66%) reported severe pain after 72 hours. Moderate pain was reported by 7, 4 and 3 patients after 24, 48 and 72 hours, respectively (p = 0.0001). However, paired analyses showed a statistically significant difference only between 24 and 72 hours (p = 0.04). Sealer extrusion did not influence the postoperative pain (p > 0.05). Conclusions: Acute or moderate postoperative pain was uncommon after endodontic treatment of necrotic teeth with LIFE.

• The Journal of Korean Academy of Prosthodontics
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• v.54 no.3
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• pp.267-272
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• 2016

This case report describes the treatment of two fully edentulous patients with mini-implant overdentures using different implant systems on narrow mandibular alveolar bone ridge. They were complaining about discomfort and pain wearing mandibular conventional complete dentures caused by insufficient retention. Each patient received four miniimplants in the interforaminal area of the mandible using the non-submerged flapless surgical approach. One-body type implant (Slimline, Dentium, Seoul, Korea) was used for a patient and loaded immediately after surgery. Metal housings of O-ring were attached by direct technique. For the other patient, two-piece type implant (LODI, Zest Anchors, Escondido, CA, USA) was used and impressions were made for attachment connection of the Locator's metal housings after 8 weeks of surgery. Within this case report, mandibular miniimplant overdentures using different implant systems showed improvement of patient satisfaction with favorable peri-implant tissue response 6 months after attachment connection. However, long-term follow-up is needed for further evaluation.

• Journal of the Korean Geographical Society
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• v.47 no.2
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• pp.226-244
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• 2012

This paper aims to analyze the process of the evolution of Gumi electronics industrial cluster and to understand the role of governments for local industrial dynamics. Gumi was a typical satellite platform type new industrial district up to mid-1990s. At that time, Gumi industrial park was the agglomeration of branch plants headquartered in Capital Region with weak local linkages. During the last two decades, however, Gumi has evolved to an electronics industrial cluster with considerable local interfirm linkages and innovation activities of SMEs. Recognizing government industrial policies is critical in understanding the process of the evolution of Gumi electronics cluster. At the early stage, the state was the developer and locator of business activities within the confines of the Gumi industrial park. In recent years, central government's innovative cluster policy contributed to strengthening networks among firms, universities, and research centers to form local innovation networks as well as networks between large branch plants and SMEs. Gumi city and Gyungsangbuk-do promoted innovative activities of SMEs through the supports of cooperative networks between universities and SMEs. The increasing roles of SMEs and local governments in addition to the large branch plants and the central government have become the basis of the evolution of industrial cluster in Gumi.

• Journal of IKEEE
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• v.22 no.3
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• pp.638-644
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• 2018

In this paper, we develop a measurement system that uses 3D Scintillator and NaI(TI) Detector to 3-dimensionally identify the location of multiple radiation sources in moving vehicle loads. The radiation measurement system consists of radiation measurement (plastic scintillator), 2-channel Pulse Counter Board, nuclide analysis (NaI(TI) detector) and 1 channel MCA Board. The source locator algorithm calculates the coordinate value of the ratio of the CPS value($1/r^2$) of the source according to the angle(${\theta}$) in inverse proportion to the square of the distance(X, Y) through the SVM classification. The coordinate values are input every predetermined period of the spectrum, and after analyzing the spectrum per unit cycle, the position of the nuclide at the time is calculated by determining whether or not the nuclide is present in the remaining part except for the background area. As a result of the position discrimination test, the error within the international standard of ${\pm}1m$ was shown. Thus, the utility of the proposed system has been demonstrated.

• Herbal Formula Science
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• v.18 no.2
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• pp.227-239
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• 2010

Objective : The purpose of this study was to develop the simulator which can analyze the anti-inflammatory effects of herbs based on e-cell, or the virtual cell. Method : We have ensured the medical herbs and its active compounds by investigating the oriental medicine records and NBCI(Biomedicine database). Also we have developed the web-based search system for confirming database related to anti-inflammation. We have researched the cell signal pathway related with inflammatory response control and established the mathematical model of herb interaction on selected signal pathway in e-cell. Finally we have developed the prototype which can confirm the result of this model visibly. Results : We constructed the database of 62 cases of anti-inflammatory active compounds in 61 cases of medical herbs which have been known anti-inflammation effects in the paper, 16 cases of inflammatory factors, 10 cases of signal pathways related with inflammatory response and 6,834 cases of URL(Uniform Resource Locator) of referenced papers. And we embodied the web-based research system, which can research this database. User can search basic and detailed information of medical plants related with anti-inflammatory by using information system. And user can acquire information on an active compounds, a signal pathway and a link URL of related paper. Among investigated ten pathways, we selected NF-${\kappa}B$, which plays important role in activation of immune system, and we searched the mechanisms of actions of proteins which could be components of this pathway. We reduced total network into IKK-$I{\kappa}B$ - NF-${\kappa}B$, and completed mathematic modeling by using ordinary differential equations and response variables of $I{\kappa}B-NF-{\kappa}B$ signaling model network which is suggested by Baltimore Group. We designed OED(Ordinary Differential Equation) for response of IKK, $I{\kappa}B$, $NF-{\kappa}B$ in e-cell's cytoplasm and nucleus, and measured whether an active compound of medicinal plants which is inputted by an user would have a anti-inflammation effects in obedience to change in concentration over time. The proposed model was verified by using experimental results of the papers which are listed on NCBI.

• Restorative Dentistry and Endodontics
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• v.24 no.4
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• pp.578-584
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• 1999

The purpose of this experiment was to determine: (1) the safe automatic apical reverse setting that prevents overinstrumentation of the root canal, using Tri Auto ZX$^{(R)}$ and (2) the effect of various irrigant on such instrumentation. The instrumentation was carried out with the automatic apical reverse setting of 0.5, 1.0, 1.5, and 2.0. The root canal irrigants used in usual manner were normal saline(0.9%), NaOCl(2.5%), and RC Prep$^{(R)}$. For each reverse setting and each irrigant, ten teeth were used with the total of 120 teeth. The distance between the file tip and the apical constriction was determined by stereomicroscope using the point that the file began to rotate in reverse direction. When the reverse setting mode was set to 0.5, 18 of 30 were overinstrumented. If these were discriminated by irrigant, 10 of 6 with 0.9% saline, 10 of 6 with NaOCl, and 10 of 6 with RC Prep$^{(R)}$ has the file tip located 0.57${\pm}$0.30mm, 0.73${\pm}$0.39mm, and 0.26${\pm}$0.25mm beyond the apical constriction respectively. In 1.0 setting 15 of 29 were over the apical constriction, and the distribution was 6 in saline, 5 in NaOCl, and 4 in RC Prep$^{(R)}$. The mean distance over the apical constriction was 0.28${\pm}$0.13mm with saline, 0.75${\pm}$0.61mm with NaOCl, and 0.25${\pm}$0.17mm with RC Prep$^{(R)}$. When the autoatic reverse mode was set to 1.5, and 2.0, 5, and 1 teeth were found to be overinstrumented in respective settings. But there were large variations in overinstrumented distances when an attempt was made to compare the effect of irrigants on this overinstrumentations and they were meaningless for the small sample size. When all of the autoreverse setting were combined to compare the number of overinstrumented teeth with each irrigant, there were no significant differences (14 for normal saline, 12 for NaOCl, 13 for RC Prep$^{(R)}$). When 0.5 or 1.0 automatic apical reverse setting mode was used the Tri Auto ZX$^{(R)}$ in clinical application, the possibility of overinstrumentation beyond the apical constriction exists in 55.9% of cases. Therefore 1.5 or 2.0 setting is safer for the preparation inside the canal but this type setting needs additional apical hand preparation of the root canal because the accuracy is lower than 0.5 or 1.0 setting.