• Korean Journal of Head & Neck Oncology
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• v.17 no.2
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• pp.179-184
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• 2001

Objective: The role of chemotherapy in locally advanced head and neck cancer has been established in nasopharynx and larynx as definitive therapy and organ preserving therapy, respectively. Oral cavity cancers are relatively uncommon and local recurrence is the main cause of treatment failure. We planned this retrospective study to evaluate the role of neoadjuvant chemotherapy in locally advanced oral cavity cancer patients. Materials and Methods: From 1988 March to 2001 February, locally advanced, previously untreated oral cavity cancer patients who received neoadjuvant chemotherapy were examined. Chemotherapy had been done in the following patients: Histologically proven squamous cell or poorly differentiated carcinoma, stage 3 or 4, and performance state 0-2 patients. Chemotherapy regimen consisted of cisplatin and infusional 5-fluorouracil. Response was evaluated after 2 cycles and in case of no response, definitive local therapy was done; otherwise 3 cycles was done before local treatment. Results: 48 patients were treated and 47 patients were evaluable for responses. Complete response rate was 6.4%(3/47) and partial response 80.0%(38/47), scoring overall response rate of 87.2%. Median time to progression was 27.0 months (95% CI : 0-58months) and overall 5 year survival was 54.8%. 5-year disease-free survival in the patients in remission after local treatment was 51.9%. In multivariate analysis, contributing factor to the survival were response to neoadjuvant chemotherapy and local treatment modalities. Extensive surgery was done in 10 patients and 25 patents (52.1%) was followed up with preserved function. With median follow-up of 57.0 months, 19 recurrences were detected, most of which were local or regional type. Conclusion: Neoadjuvant chemotherapy followed by local treatment in oral cavity cancer showed high response rate and was thought to be effective therapeutic approach especially in view of organ preservation.

• Restorative Dentistry and Endodontics
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• v.31 no.4
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• pp.257-262
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• 2006

The aims of the study were to evaluate the effect of epinephrine-containing local anesthetics on pulpal blood flow (PBF) and to investigate its effect on cavity preparation-induced PBF change. PBF was recorded using a laser Doppler flowmeter (Perimed Co., Sweden) from canines of nine cats under general anesthesia before and after injection of local anesthetics and after cavity preparation. 2% lidocaine hydrochloride with 1 : 100,000 epinephrine was administered by local infiltration given apical to the mandibular canine at the vestibular area and the same volume of isotonic saline was injected on the contralateral tooth as a control. A round carbide bur was operated at slow speed with isotonic saline flushing to grind spherical cavities with increasing depth through the enamel and into the dentin on both teeth. The obtained data was analyzed with paired t-test. Cavity preparation caused significant increase of PBF (n = 9, p < 0.05). Local infiltration of lidocaine with epinephrine resulted in decreases of PBF (n = 9, p < 0.05), whereas there was no significant change of PBF with the physiologic saline as a control. Cavity preparation on tooth anesthetized with lidocaine with epinephrine caused significantly less increase of PBF than in control tooth (p < 0.05). Therefore, the result of the present study demonstrates that local infiltration of 2% lidocaine with 1 : 100,000 epinephrine effectively reduces PBF increase caused by cavity preparation.

• Bulletin of the Korean Chemical Society
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• v.16 no.2
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• pp.96-101
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• 1995

The optical properties of individual 3-to 14-micron diameter CdS crystalline spheres embedded in poly(methyl methacrylate) were studied using elastic scattering. The presence of well defined sharp peaks in the 550 to 600 nm elastic scattering spectra confirmed that each microcrystal acts as an optical cavity with cavity quality factors exceeding 104. Such natural resonator microcrystals should lead to greatly enhanced local field effects near the surface of CdS, quantum electrodynamic modification of optical transition rates of nearby species and altered photochemistry. Absorptive heating following high intensity laser irradiation was found to induce a transient washout of the high Q modes.

• Korean Journal of Head & Neck Oncology
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• v.2 no.1
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• pp.41-48
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• 1986

Tumors of the nasal cavity are rare and are usually classified and reported jointly with tumors of the paranasal sinuses. Neverthless their frequency, diagnostic problems, management, and prognosis differ considerably from the latter and justify their study as a separate entity in order to define clearly and evaluate their characteristics. Males outnumbered females in a ratio of 2 to 1. Regional lymph node metases is infrequent; only 10% of the patients presented nodes on admission. Radiation therapy is more favorable method of treatment for nasal cavity tumor secondary to good cosmetic results and high local control rate. The tumor doses are in the range of 5,000 to 6,000 rads in 5 to 6 weeks and an additional dose of 500 to 1,000 rads were given through reduced field to residual disease area. The results of two cases of nasal cavity tumor treated by radiation alone were reasonably good, and review of literature indicated that the radiation alone can give high local control rate and good cosmetics. Therefore, at present time, we recomend radiation therapy for the nasal cavity tumor.

• Nuclear Engineering and Technology
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• v.48 no.1
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• pp.72-86
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• 2016

A steam explosion may occur during a severe accident, when the molten core comes into contact with water. The pressurized water reactor and boiling water reactor ex-vessel steam explosion study, which was carried out with the multicomponent three-dimensional Eulerian fuel-coolant interaction code under the conditions of the Organisation for Economic Co-operation and Development (OECD) Steam Explosion Resolution for Nuclear Applications project reactor exercise, is presented and discussed. In reactor calculations, the largest uncertainties in the prediction of the steam explosion strength are expected to be caused by the large uncertainties related to the jet breakup. To obtain some insight into these uncertainties, premixing simulations were performed with both available jet breakup models, i.e., the global and the local models. The simulations revealed that weaker explosions are predicted by the local model, compared to the global model, due to the predicted smaller melt droplet size, resulting in increased melt solidification and increased void buildup, both reducing the explosion strength. Despite the lower active melt mass predicted for the pressurized water reactor case, pressure loads at the cavity walls are typically higher than that for the boiling water reactor case. This is because of the significantly larger boiling water reactor cavity, where the explosion pressure wave originating from the premixture in the center of the cavity has already been significantly weakened on reaching the distant cavity wall.

• Journal of Advanced Marine Engineering and Technology
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• v.15 no.4
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• pp.46-53
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• 1991

In the present study, Navier-Stokes equation is numerically solved by use of a Finite analytic method to obtain the 2-dimensional flow field in the square cavity. The basic idea of F.A.M. is the incorporation of local analytic solutions in the numerical solution of linear or non-linear partial differential equations. In the F.A.M., the total problem is subdivided into a number of all elements. The local analytic solution is obtained for the small element in which the governing equation, if non-linear, to be linearized. The local analytic solutions are then expressed in algebraic form and are overlapped to cover the entire region of the problem. The assembly of these local analytic solutions, which still preserve the overall nonlinearity of the governing equations, results in a system of linear algebraic equations. The system of algebraic equations is then solved to provide the numerical solutions of the total problem. The computed flow field shows the same characteristics to physical concept of flow phenomena.

• Korean Journal of Animal Reproduction
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• v.18 no.4
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• pp.245-250
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• 1995

The appearance and function of corpora lutea(CL) with a central cavity in the ovaries of Korean Native Cattle (KNC) were investigated endocrinologically and histochemically. The CL were enucleated from KNC ovaries within 2~3 hrs local slaughter house and classified with central cavity CL or not. Enzymatically dispersed luteal cell (1$\times$106 live cell/ml of Dulbecco's Modified Eagle Media) with or without cavity of CL cultured at 37$^{\circ}C$ in a humidified incubation (5% CO2 : 95% air) for 72hr. A central cavity in the CL of KNC was found in 58.8% of CL-1, 34.9% of CL 2, 39.1% of CL-3, and 11.1% of CL-4, respectively. There were no significant difference between protein content of CL with and without a central cavity. Mean progesterone secretion after 36h of in vitro luteal cell culture were significantly (p<0.05) higher in CL with central cavity than without cavity. However, the luteal cavitic wall was composed of the connective tissue band of the reticular and collagen fibers and then these connective tissue band extended into the CL with cavity. These results suggest that the central cavity of CL may be caused infertility in KNC.

• Publications of The Korean Astronomical Society
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• v.30 no.2
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• pp.89-91
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• 2015

Observed spectra of stars around the Sun have indicated that the Sun is located in a gas cavity, extending to 100pc. This gas cavity is called the "Local Bubble". The density of the interstellar medium (ISM) in the local bubble is about one tenth that of the average for the ISM in the Milky Way. Furthermore, some structures such as gas planes and strings in the local bubble are probably the result of supernovae. These, due to their low temperatures, can not be observed in the visible and infrared. The only way to do so is to measure the spectra of nearby stars so that the light of stars passing through the local bubble is absorbed by existing gas and the resulting spectral lines from absorption can be measured. In this study, we use binary stars to trace the local bubble structures through lines such as the Na I Doublet. First, we determined the observed spectral lines of stars by HARPS and FEROS echelle spectrographs. Then, we made synthetic spectra with the ATLAS9 code. Finally, the difference between the observational and synthetic spectra confirms the existence of the Na I Doublet in the local ISM.

• Journal of Korean Society for Atmospheric Environment
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• v.10 no.2
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• pp.116-123
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• 1994

The E- $\varepsilon$ turbulence numerical model was applied to a flow around triangular ridge in neutral boundary layer. Scale of cavity region, mean velocity, Reynolds stress and eddy diffusivity were investigated. The height of cavity region was in satifactory agreement with the wind tunnel data while the length of cavity region was underestimated. The man wind velocities outside the cavity region were well Predicted by the model, however in cavity region the mean wind velocities of wind tunnel data were larger than the model results Reynolds stress of cavity region was overestimated by the model. The eddy diffusivity of wake region was strongly modified under the influence of triangular ridge. The local minimum of the eddy diffusivity was occured in the lee of the ridge top.

• Journal of Welding and Joining
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• v.10 no.2
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• pp.51-62
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• 1992

A torch was designed and fabricated in order to develope the technology of "locally drying underwater welding" by water curtain method. The condition for the formation of the possible local cavity, the mechanical properties and the thermal cycle of welds were investigated in the developed welding equipment compared with in-air welding. The possibility of highly reliable and practical underwater welding was found. The proper local cavity was formed above the water flowrate of 30l/min and CO$_{2}$ gas flowrate of 100l/min. The bead width and penetration depth were increased with increasing welding current. The hardness of weldments is about 160Hv in air welding, but about 210Hv in underwater welding. The elongation and the impact value of underwater weldments are 15% and 6Kg/cm$^{2}$ respectively, which are only half as much as the values of in-air welding. The cooling time in the temperature range from 800.deg.C to 500.deg.C affecting the structure and the hardness of weldments is about 22sec. in air welding while about 10sec. in underwater welding.r welding.