• Polymer(Korea)
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• v.27 no.1
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• pp.9-16
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• 2003

Ipriflavone (IP) stimulates proliferation and differentiation of osteoblast and also enhances calcitonin secretion in the presence of estrogen. Poly(lactide-co-glycolide) (PLCA) due to its controllable biodegradability and relatively good biocompatibility is one of the most significant candidates for the study of drug controlled release system. In this study, IP-loaded PLGA microspheres (MSs) was prepared by using conventional O/W solvent evaporation method. The size of MSs was in the range of 5~200 $mu extrm{m}$. The morphology of MSs was characterized by SEM. And, in vitro release amounts of IP were analyzed by HPLC. The highest encapsulation efficiency were obtained by using gelatin and polyvinyl alcohol (PVA) as emulsifiers. The morphology, size distribution, and in vitro release pattern of MSs were changed by several preparation parameters such as molecular weights (8, 20, 33 and 90 kg/mol), polymer concentrations (2.5, 5, 10 and 20%), emulsifier types (PVA, gelatin and Tween 80), initial drug loading amount (5, 10, 20 and 30%) and stirring speed (250, 500 and 1000 rpm). The release of IP in vitro was more prolonged over 30 days, with close to zero-order pattern by controlling the preparation parameters. The physicochemical properties of IP-loaded PLGA MSs were investigated by XRD and DSC.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.34 no.5
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• pp.535-544
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• 2016

Even though existing methods for orthophoto production using expensive aircraft are effective in large areas, they are drawbacks when dealing with renew quickly according to geographic features. But, as UAV(Unmanned Aerial Vehicle) technology has advanced rapidly, and also by loading sensors such as GPS and IMU, they are evaluates that these UAV and sensor technology can substitute expensive traditional aerial photogrammetry. Orthophoto production by using UAV has advantages that spatial information of small area can be updated quickly. But in the case of existing researches, images of same altitude are used in orthophoto generation, they are drawbacks about repetition of data and renewal of data. In this study, we targeted about small slope area, and by using low-end UAV, generated orthophoto and DEM(Digital Elevation Model) through different altitudinal images. The RMSE of the check points is σ_h = 0.023m on a horizontal plane and σ_v = 0.049m on a vertical plane. This maximum value and mean RMSE are in accordance with the working rule agreement for the aerial photogrammetry of the National Geographic Information Institute(NGII) on a 1/500 scale digital map. This paper suggests that generate orthophoto of high accuracy using a different altitude images. Reducing the repetition of data through images of different altitude and provide the informations about the spatial information quickly.

• Journal of the Korea Concrete Institute
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• v.13 no.2
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• pp.107-113
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• 2001

This study was conducted preliminarily to develop the crack source location technique for plain concrete beam using acoustic emission(AE). Before the main experiment, the test of virtual An source location was achieved in plain concrete block. The sensor layout was mutually compared between triangular layout and rectangular layout. As the results of test, AE source location by triangular layout was evaluated more effective than that by rectangular layout. The specimen to apply he source location technique was man in total nine specimens (each three in 40 %, 50%, 60% of W/C ratio) which the experiment variable was the compressive strength level(W/C ratio). The bending loading method is selected by cyclic loadings to evaluate the degree of concrete damage. It is seen that Kaiser effect and Felicity effect exists through analysis of AE parameters in coming failure experiment. As a result of analyzing the felicity ratio(FR) values, it is shown that this values can be used for evaluating the degree of concerto damage. AE activity is started highly at the 70% of failure load without the compressive strength level. Thus considered by a index in constructing the system of the failure warning at application of the field structure. And the results compared the real cracking location with the source location has perceived by AE monitoring before it is appeared the primary crack by visual observation.

• Journal of Navigation and Port Research
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• v.33 no.3
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• pp.167-174
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• 2009

Recently, design technology of has been required such as catamaran yacht with high-speed according to expand a marine leisure industry. The domestic technical development for design and production of yacht is not actively than Canada, USA, Japan etc. However, with further development of yacht design & technology, it is need to develop a key technology related to increase the value of catamaran yacht. In the present paper, new guideline is suggest for catamaran yacht as like kinds of marine leisure ship in order for fundamental structure design and structural analysis for twin-hulled ship yacht and techniques for structural analysis as sea leisure ship in this research. The class of society has not been proposed formally about regulation and methodology for estimation of strength of small hight-speed craft with satisfying two conditions as noted; length less than 50meters, ratio of length to breadth less than 12. In the present study, we were adopted DNV (Yachts, Design Principles, Design Loads, Hull Structural Design) Rule and KR (FRP rule application guide) for scantling of structural members. Furthermore, ABS rule is used for structural calculation about application of loading conditions for catamaran yacht. This study can be available feedback role to manufacture of 38ft diffusion style for catamaran yacht. It is expected that this study will be a good reference in order to design of catamaran yacht with high-speed.

• Journal of the Korea institute for structural maintenance and inspection
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• v.14 no.2
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• pp.106-112
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• 2010

Due to the improvement and stabilization of the social environment, construction market in the urban region is under shrinking. According, researches to lengthen the service life of the existing building structures are under the way through the remodeling or maintenance of deteriorated structures other than the new constructions. Similar situations are widely discussed in the domestic building construction market and the social importance of the remodeling of the existing building structures is increased. Although the structural stability of the building is uncertain due to the frequent repairing and structural changing, the remodeling works are usually conducted. In general, documents such as drawings and calculations for the design of the deteriorated structure to be remodeled are not kept. Accident at the remodeling site frequently occur because of the lack of thorough understanding of changed situations such as loadings, loading paths, changing of the mechanical properties of material, etc. In this paper, using the finite element analysis method, we investigated the structural behaviors of slab in the remodeling building and the results are applied to remodeling construction, and the appropriateness of the remodeling works are evaluated.

• Journal of the Korea institute for structural maintenance and inspection
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• v.21 no.3
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• pp.76-85
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• 2017

In this study, to evaluate the mechanical properties of fiber-reinforced cement composites by strain rate, hydraulic rapid loading test system was developed. And compressive and tensile strength of the hooked steel fiber and polyamide fiber reinforced cement composite were evaluated. As a result, the compressive strength, strain capacity and elastic modulus were increased with increasing strain rate. The effect of compressive strength by type and volume fraction of fibers was not significant. The dynamic increase factor(DIF) of the compressive strength was higher than that of the CEB-FIP model code 2010 and showed a trend similar to that of ACI-349. The tensile strength and strain capacity were increased with increasing strain rate. The hooked steel fibers were drawn from the matrix. The tensile strength and strain capacity of hooked steel fiber reinforced cement composites were increased as the strain rate increased. The tensile strength and deformation capacity of the fiber reinforced cement composites were increased. And, hooked steel fibers were drawn from the matrix. On the other hand, because the bonding properties of polyamide fiber and matrix is large, polyamide fiber was cut-off with out pullout from matrix. The strain rate effect on the tensile properties of polyamide fiber reinforced cement composites was found to be strongly affected by the tensile strength of the fibers.

• Journal of Pharmaceutical Investigation
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• v.30 no.4
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• pp.241-246
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• 2000

To develop a sustained-release preparation containing ketorolac tromethamine, two sustained-release pellet formulations were evaluated with a pharmacokinetic study as compared with a conventional commercial tablets (10 mg $Tarasyn^{TM}$, Roche Korea Ltd.). Two sustained-release formulations were as follows; formulation A was composed of an inner layer containing 75% of drug coated with $Eudragit^{TM}$ RS 100 membrane and an outer layer containing 25% of drug mixed with $Eudragit^{TM}$ NE30D, and formulation B was composed of only an inner layer containing 100% of drug coated with $Eudragit^{TM}$ RS 100 membrane. The dissolution test was performed for two formulations. In case of conventional tablets, 2.5 mg of drug per a dose was administered orally into male Albino rabbit (2.0-2.3 kg of body weight) 3 times at intervals of 4 hours. In case of two sustained formulations, 7.5 mg of drug was administered once orally. Blood samples were withdrawn periodically after the administration, and the blood concentration was determined by HPLC. The conventional tablets showed very high peak-trough fluctuation between administered doses, but two sustained formulations showed less fluctuation. Formulation A with the loading dose showed the time to reach minimum effective concentration (MEC) i.e. the onset time was less than 20 min, while Formulation B had more than 1 hr of the onset time. Formulation A had the more constant plasma level than formulation B. However, formulation B had a time lag, so the plasma level was less than MEC for an initial period of 1 hr. In formulation A, the plasma level was maintained within the therapeutic window $(0.3-5\;{\mu}g/ml)$ for a long period. Formulation A was thought to be an ideal sustained-release formulation for ketorolac tromethamine oral delivery system.

• Journal of Energy Engineering
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• v.23 no.2
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• pp.49-56
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• 2014

It is important to keep stable effluent water quality and minimize operation cost in biological wastewater treatment plant. However, the optimal operation is difficult because of the change of influent flow rate and concentrations, the nonlinear dynamics of microbiology growth rate and other environmental factors. Therefore, many wastewater treatment plants are operated for much more redundant oxygen or chemical dosing than the necessary. In this study, the optimal control scheme for dissolved oxygen (DO) is suggested to prevent over-aeration and the reduction of the electric cost in plant operation while maintaining the dissolved oxygen (DO) concentration for the metabolism of microorganisms in oxic reactor. For optimal control, The oxygen uptake rate (OUR) is realtime measured for the identification of influent characterization and the identification of microorganisms' oxygen requirement in oxic reactor. Optimal DO seT-Point needed for the microorganism is suggested based on real time measurement of oxygen uptake of microorganism and the control of air blower. Therefore, both stable effluent quality and minimization of electric cost are satisfied with a suggested optimal setpoint decision system by providing the necessary oxygen supply requirement to the microorganisms coping with the variations of influent loading.

• Journal of Navigation and Port Research
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• v.44 no.3
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• pp.195-202
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• 2020

The production of larger of ships is a survival strategy for global shipping companies to pursue the economics of scale. According to this strategy, to respond to this situation, many containers are loading/unloading simultaneously in the hub port. Additionally, the container terminals are promoting the introduction of automation to expand the terminal facilities and increase efficiency/productivity of the container yards. European ports have introduced automation to address rising labor costs and shortages of labor. Recently, the construction of fully automated container terminals is increasing in the United States and China to resolve problems such as the slow growth of the global economy, the emergence of large ships, air pollution, and safety accidents. Domestic ports are at an early stage compared to the world's advanced container terminals, and countermeasures are being prepared to respond to the changing ports. However, research on the recognition difference analysis that examines the opinions of stakeholders is insufficient. As a result of analyzing the recognition among the groups, it was found that container terminal operators reduced labor costs, improved shipping services for shipping companies, prevented safety accidents for port union labor, and increased service for port authority and government agencies. Thus, to closely examine the perception among the groups, one-way ANOVA was performed, and then the implications were deduced as the basic data for the smooth introduction of automation.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.11 no.3
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• pp.866-872
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• 2010

In this paper, we developed a digital soldering station based on PID controller, which supply stable power by controlling the current of heater of soldering iron. The proposed system designed PID controller to converge quickly to the set up temperature by user, and regain the lost of heat by external factors quickly. PID controller, designed by Ziegler-Nichols' tuning method, decides triac's trigger timing using setting temperature and present temperature to control the phase of AC 24V power that supply to the heater. Also, we give the function that shows present temperature and setting temperature of iron, and working time by graphic LCD. And during the rest time, we decided the power saving and extension of iron tip by dropping to the optimal temperature. Two experiments had implemented in $25^{\circ}C$ laboratory to confirm the performance of proposed method. The first experiment took 12sec, 13sec, 16sec, 18sec, reaching to $200^{\circ}C$, $300^{\circ}C$, $400^{\circ}C$, $480^{\circ}C$ respectively which result showed shorten of rising time than previous method. In the loading experiment of $300^{\circ}C$, $400^{\circ}C$, $480^{\circ}C$ steady state showed temperature drop of $3.8^{\circ}C$, $4.1^{\circ}C$, $4.5^{\circ}C$ which result showed the low temperature deviation than previous method.