• The Journal of Internal Korean Medicine
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• v.33 no.3
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• pp.284-297
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• 2012

Objectives : This study was performed to investigate characteristic indice of heart rate variability (HRV) according to presence of metabolic syndrome (MS), pattern identification. Methods : We analyzed 167 subjects who participated in a stroke check-up. We classified the subjects into two groups as MS (n=48) and non-MS (n=119) based on NCEP ATP III. First, we investigated pattern identification of all subjects based on Korean Standard Pattern Identifications for Stroke-III. Second, we surveyed significance of HRV indices between MS and non-MS groups. Third, we investigated significance of HRV indices between classified DP of MS and classified DP of non-MS. Fourth, we investigated significance of HRV indices between classified DP of MS and non-MS. Fifth, we investigated significance between components of MS and HRV indices. Results : 1. SDNN, RMS-SD, HF, Ln(HF), and HF (NORM) were significantly lower in the MS than non-MS group. LN (TP), LF/HF were significantly higher in the MS than non-MS. 2. Ln (HF), Ln (TP), and LF/HF were statistically significant in the classified DP of MS group. 3. RMS-SD, and Ln (HF) were significantly lower in the abdominal obesity group than in the non-abdominal obesity group. SDNN, RMS-SD, TP, Ln (TP), VLF, Ln (VLF), and Ln (LF) were significantly lower in the hypertension group than in the non-hypertension group. RMS-SD was significantly lower in the diabetes group than in the non-diabetes group. Mean HRT,LF/HF were significantly higher in the hypertriglyceridemia than non-hypertriglyceridemia group, but Ln (HF), RMS-SD, and HF (NORM) were significantly lower in the hypertriglyceridemia than non-hypertriglyceridemia group. Conclusions : We found a few significant relationships between classified DP of MS and HRV indices. The resluts demonstrate that MS has potentially negative effects on the cardiovascular system, and these effects could be detected by HRV.

• Journal of Oriental Neuropsychiatry
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• v.14 no.2
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• pp.135-143
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• 2003

Objectives : The purpose of this study is to analyze and compare heart rate variability(HRV) of patient of twenties and thirties diagnosed as Kiwooljeung with healthy controls'. Methods : We measured HRV of 35 patient(20 to 39 years old, male 14, female 11) diagnosed as Kiwooljeung and 40 healthy controls(male 24, female 16). HRV was measured by SA-3000P(Medicore, Korea) for 5 minutes after 5 minutes resting. Results : 1. In time domain analysis, Mean pulse rate(PRT) in Kiwooljeung group was higher than healthy controls. Standard deviation of all normal N-N intervals (SDNN) in Kiwooljeung group was lower and the results of twenties and thirties were same. 2. In frequency domain analysis, total power(TP), very low frequency(VLF), low frequency(LF), high frequency(HF), Ln TP, Ln VLF, Ln LF, Ln HF in Kiwooljeung group were lower than healthy controls but LF/HF ratio was higher than healthy controls. 3. Comparing gender in Kiwooljeung group, LF/HF ratio in male was higher than female. Conclusions : This study suggests lower activity and imbalance of cardiac autonomous nervous system in Kiwooljeung with the age group between twenties and thirties.

• Journal of Acupuncture Research
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• v.27 no.1
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• pp.65-74
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• 2010

Objectives : This study was to investigate the effects of Cervi Pantotrichum Cornu Pharmacopuncture and Bovis calculus Fel Ursi Pharmacopuncture on autonomic nervous system with Heart Rate Variability(HRV). Purpose of the trial was to observe what influence Cervi Pantotrichum Cornu Pharmacopuncture and Bovis calculus Fel Ursi pharmacopuncture have on the autonomic nervous system. Methods : 40 healthy male volunteers were divided into two experimental groups, such as Cervi Pantotrichum Cornu Pharmacopuncture group and Bovis calculus Fel Ursi Pharmacopuncture group. Study design was a randomized, double-blind clinical trial. 20 subjects in one experimental group were injected Cervi Pantotrichum Cornu Pharmacopuncture, 20 subjects in other experimental group were injected hydrolyzed Bovis calculus Fel Ursi Pharmacopuncture at GB21(Kyonjong). We measured HRV 7 times : baseline measurement and every 5 minutes for 30 minutes after injection. The SPSS 15.0 for Windows was used to analyze the data by the paired t-test(in group) and independent sample t-test(between the groups). Results A. Time Domain Analysis 1. Analysis of Mean HRV, SDNN and Complexity After injection of Cervi Pantotrichum Cornu Pharmacopuncture, Mean HRV was significantly decreased all the times after injection. SDNN was significantly increased at immediate and 25 minute after injection. Complexity was significantly decreased only at 15 minute after injection. After injection of Bovis calculus Fel Ursi Pharmacopuncture, Mean HRV was significantly decreased all the times after injection. Complexity was significantly decreased at 15 minutes after injection. 2. Analysis of HRV index, pNN50 After injection of Cervi Pantotrichum Cornu Pharmacopuncture, HRV index was significantly increased immediately after injection. pNN50 was significantly decreased at immediately, 20 and 25 minutes after injection. After injection of Bovis calculus Fel Ursi Pharmacopuncture, HRV index was significantly increased immediately after injection. pNN50 was significantly decreased at immediate and 25 minutes after injection. B. Frequency Domain Analysis 1. Analysis of Ln(TP), Ln(HF), Ln(LF), Ln(VLF) After injection of Cervi Pantotrichum Cornu Pharmacopuncture, Ln(TP) was significantly increased at immediate and 25 after injection. Ln(HF) was significantly increased all the times after injection. Ln(LF) was significantly increased at 15, 20 and 25 minutes after injection. Ln(VLF) was significantly increased at immediate and 25 minutes after injection. After injection of Bovis calculus Fel Ursi Pharmacopuncture, Ln(TP) was significantly increased at immediately and 25 after injection. Ln(LF) was significantly increased at 20 and 25 minutes after injection. Ln(VLF) was significantly increased at immediate and 25 minutes after injection. Conclusions : We results suggest that Cervi Pantotrichum Cornu Pharmacopuncture and Bovis calculus Fel Ursi Pharmacopuncture in healthy adult men tend to activate the autonomic nervous system and sympathetic nervous system within normal range.

• The Journal of Korean Obstetrics and Gynecology
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• v.20 no.4
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• pp.101-110
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• 2007

Purpose: Oligomenorrhea is clinically important because it can be progressed to amenorrhea. The purpose of this study is to analyse Autonomic Nerve Function of some oligomenorrheic patients by using HRV(Heart Rate Variability). Methods: We studied 35 patients visiting OO Oriental Hospital from 1st November 2006 to 31th May 2007. One woman who takes antidepressant is excluded. 17 oligomenorrheic group and 17 normal menstrual cycle group were compared with HRV. The SPSS 12.0 for windows was used to analyze the data and Mann Whitney U-test were used to verify the results. Results: Mean PR, LF norm, LF/HF ratio of oligimenorrheic group are higher than normal menstrual cycle group. But there is no statistically significance. SDNN, RMS-SD, ln TP, ln VLF, ln LF, ln HF, HF norm of oligimenorrheic group are lower than normal menstrual cycle group. But there is no statistically significance. Conclusion: It can be suggested that oligomenorrhea can be related to increased activities of sympathetic nerve and decreased activities of general autonomic nerve function. But, we need study with more subjects for settling this.

• The Journal of Pediatrics of Korean Medicine
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• v.25 no.3
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• pp.77-84
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• 2011

Objectives: This study was performed to investigate the effect of hot spring therapy on children weight, body composition and heart rate variability. Methods: The study was carried out from 30 children who visited the spa from August 1, 2011 to August 31, 2011. We measured the change of weight, body composition, and heart rate variability after hot spring therapy for an hour per day. Results: The subject was consisted of 13 boys and 17 girls. This study revealed that their weight got lost from a hot spring therapy, which was statistically significant. Their body mass index(BMI) was decreased in from a hot spring therapy, which was not statistically significant. Total body water, muscle, protein, and mineral were decreased from a hot spring therapy, which was statistically significant. We measured HRV(heart rate variability) before and after the hot spring therapy. The mean HRT was increased, which was statistically insignificant. SDNN(standard deviation of the NN interval) and RMSSD(square root of the mean of the sum of the square of differences) were not different before and after the hot spring therapy. ln TP was decreased insignificantly. ln VLF was not affected before and after hot spring therapy. ln LF and ln HF was decreased, LF norm was increased, and HF norm was decreased, which were not statistically significant. Also, LF/HF ratio was increased insignificantly. Conclusions: From these results, we concluded that the weight, total body water, muscle, protein, and mineral got lost from the hot spring therapy. However, the HRV was not affected from the hot spring therapy.

• Journal of Oriental Neuropsychiatry
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• v.17 no.2
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• pp.179-185
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• 2006

Objective : This research was designed to study the characteristics of heart rate variability in postpartum women compared with normal women. Method : HRV data of postpartum women were gathered from 255 women who was hospitalized for oriental postpartum treatments(Age : 25-35). HRV data of comparison group were gathered from 327 women who visited hospital to check up their health(Age : 25-35). The SPSS 12.0 for windows was used to analyze the date and the independent samples t-test was used to verify the result. Result : 1. Mean-RR and SDNN of postpartum women group significantly decreased compared with that of normal women group. But, Heart Rate of postpartum women group significantly increased compared with that of normal women group. 2. HRV-Index, RMSSD and SDSD of postpartum women group significantly decreased compared with that of normal women group. pNN50 of postpartum women group significantly increased compared with that of normal women group. 3. Ln(TP), Ln(VLF), Ln(LF) and Ln(HF) of postpartum women group significantly increased compared with that of normal women group. 4. There were no significant differences in Normal LF, Normal HF and LF/DF Ratio between postpartum women group and normal women group. Conclusion : The result suggest that the function of heart of postpartum women group significantly decreased compared with that of normal women group. Futhermore although the ANS maintained the balance in the range of normality, the sympathetic nervous system frequently revitalized which caused increasing the heart of pulsation.

• Korean Journal of Psychosomatic Medicine
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• v.30 no.1
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• pp.7-15
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• 2022

Objectives : The purpose of this study is to identify the effect of office workers' stress level and stress vulnerability on heart rate variability (HRV), confirm the significance of objective stress indicators obtained through subjective stress and heart rate variability devices, and examine their effectiveness as an integrated stress measurement tool in community mental health projects. Methods : From June to July in 2020, 929 workers participated in the stress management and mental health promotion project carried out by K hospital, and their recorded database was used for study analysis with their agreements. Multiple linear regression analysis was performed to find out the effects of general stress level, and stress vulnerability on heart rate variability. Results : All general characteristics were found to have a significant effect on SDNN (ln), RMSSD (ln), LF (ln), and HF (ln), but work experience did not significantly affect RMSSD (ln). Stress level and stress vulnerability did not significantly affect heart rate variability, but stress perception, a sub-factor of stress level, was found to have a significant effect on RMSSD (ln) (β=0.118, p=0.023). Conclusions : In this study, stress perception, a sub-factor of stress level, was found to be a factor affecting RMSSD (ln). This indicates an association with the activity of parasympathetic nerves in stressful situations, and more follow-up studies are needed to use it as a direct indicator of chronic stress and integrated stress in the community mental health field.

• Journal of Korean Medicine Rehabilitation
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• v.23 no.1
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• pp.51-64
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• 2013

Objectives : This study was performed to evaluate the effect of dry cupping treatment applied to back-shu points on the autonomic nervous system. Methods : Two groups of sympathicotonia and normal with each 30 volunteers were set up for this experiment. The sympathicotonia group was selected by the criterion for sympathicotonia by the questionnaire composed of 11 items. After 10 minutes for environmental adaptation, the first HRV(heart rate variability) test was conducted, and then, dry cupping therapy was applied to back-shu points for 5 minutes to stimulate sympathetic ganglia lying along the spine. The second HRV test was carried out just after the cupping therapy under the same condition and then, the third test was repeated after two hours based on the first test time. Results : 1. In sympathicotonia group, SDNN(standard deviation of all normal R-R intervals), RMSSD(the square root of the mean of the sum of the squares of differences between adjacent normal R-R intervals), Ln(HF)(high frequency power), nmHF(normalized high frequency power) increased and mHR(mean heart rate), nmLF(normalized low frequency power) decreased significantly right after dry cupping therapy which means dry cupping affects on autonomic nervous system. The effect lasts in these items of nmLF, Ln(HF), nmHF, rLHF(rate ratio of LF/HF). 2. In normal group, SDNN, RMSSD increased and mHR decreased significantly right after dry cupping therapy, too. But, Ln(LF)(low frequency power), nmLF, rLHF unexpectedly increased and nmLF, rLHF stay increased up to 2 hours. Conclusions : The results suggest that the dry cupping therapy has effect on the autonomic nervous system. It is effective to stabilize hyper-sympathetic tone of people diagnosed as Sympathicotonia and activate parasympathetic tone.

• Journal of Korean Medicine Rehabilitation
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• v.19 no.2
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• pp.241-250
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• 2009

Objectives : To study autonomic nervous system dysfunction of Low Back Pain(LBP) patients, using spectral analysis of Heart Rate Variability(HRV). Methods : HRV of 190 patients was measured and seperated into two groups, those with LBP(n=95) and healthy controls(n=95). HRV was measured by SA-6000(Medicore, Korea) for 5 minutes after 5 minutes' resting. Results : 1. Mean heart rate(MHRT) of the experimental group was slightly higher than that of the control group, but did not show significant difference(P=0.428). The square root of the mean squared differences of successive normal-to-normal intervals(RMSSD), logarithmic very low frequency power(Ln VLF) and low frequency power/high frequency power ratio(LH/HF ratio) were not significantly low between experimental group and control group(P=0.16, 0.130, 0.537). 2. The standard deviation of all the normal-to-normal intervals(SDNN), logarithmic total power(Ln TP), logarithmic low frequency power(Ln LF) and logarithmic high frequency power(Ln HF) were significantly low between experimental group and control group(P=0.03, 0.005, 0.001, 0.007). 3. Ln LF of acute group was significantly low compared with those of chronic group(P= 0.039). Conclusions : This study suggests the activity and imbalance of autonomic nervous system in LBP is low. Also sympathetic nervous system of acute LBP is lower than that of chronic LBP. Further study of HRV related to LBP is needed in the clinical medicine.

• The Journal of Korean Obstetrics and Gynecology
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• v.20 no.3
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• pp.164-177
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• 2007

Purpose: The purpose of this study is to analysis on the Heart Rate Variability(HRV) of some dysmenorrhoea patients. Methods : We studied 30 patients visiting Kyung Hee University East-West Neo Medical Center from 7th Febrary 2007 to 22th Febrary 2007. Women with organic disease were excluded from this study. The severity of dysmenorrhoea were measured by Multidimensional Verbal Rating scale(MVRS), Verbal Rating scale (VRS) and Visual Analog Scale(VAS). And HRV was recorded. Results : According to comparison of Means of HRV values among the groups of None, Mild and Moderate, the points of almost all values were kept by order of Moderate group-Mild group-None group. Among these, the statistically significant things are PR, SDNN, Ln (TP), Ln (VLF), Ln (LF). According to correlation analysis between dysmenorrhoea and HRV, specially, there were many correlations in VRS2. Among these, the statistically significant things are LF norm, HF norm, LF/HF ratio(p<0.05L). Conclusion : The results suggest that HRV is related to dysmenorrhoea. We may analyze that dysmenorrhoea is related to, specially, increased activities of sympathetic nerve. We need more study for settling this.