• 한국식품영양학회지
• /
• 제22권1호
• /
• pp.97-102
• /
• 2009

본 연구에서는 독성이 적고, 활성이 높으면서 안정한 새로운 tyrosinase 저해제를 미생물을 대상으로 얻고자 tyrosinase 저해제를 강하게 분비하는 방선균 F-97을 토양으로부터 분리하였다. 이 균의 기균사는 회색의 나뭇가지형 (tree type)이며, 포자의 끝부분이 유선형으로 회전되어 있고, 포자 표면은 구형의 smooth형으로 분류되었다. 세포벽의 DAP 성분은 LL-DAP이었으며, 세포균체의 당 성분은 검출되지 않았다. 기타 배양학적 및 생리적 특성을 종합한 결과 streptomyces aburaviensis 또는 근연균으로 추정된다.

• ALGAE
• /
• 제28권2호
• /
• pp.203-211
• /
• 2013

Dunaliella salina and Dunaliella bardawil are well known for carotenogenesis, the overproduction of carotenoids, under stress conditions. The effect of high light (HL) and low light (LL) on the growth, morphology, photosynthetic efficiency, and the ${\beta}$-carotene and zeaxanthin production of D. salina CCAP 19/18 and D. bardawil was investigated and compared. Both strains showed similar growth kinetics under LL growth condition, but D. salina CCAP 19/18 was faster. As the light intensity increased, D. salina CCAP 19/18 cells were elongated and D. bardawil cells became larger. Both strains showed decrease of the maximum quantum yield of PSII ($F_v/F_m$) and election transport rate (ETR) under HL growth condition and D. salina CCAP 19/18 was less liable to the light stress. Both strains had about 1.8 and 5 times difference in the $O_2$ evolution rate at LL and HL conditions, respectively. The ${\beta}$-carotene and zeaxanthin production were increased as the light intensity increased in both strains. D. bardawil was more sensitive to light intensity than D. salina CCAP 19/18. The possible application of D. salina CCAP 19/18 as a carotenogenic strain will be discussed.

• Asian-Australasian Journal of Animal Sciences
• /
• 제26권9호
• /
• pp.1237-1246
• /
• 2013

The objective of this study was to estimate variance components and genetic parameters for lactation milk yield (LY), lactation length (LL), average milk yield per day (YD), initial milk yield (IY), peak milk yield (PY), days to peak (DP) and parameters (ln(a) and c) of the modified incomplete gamma function (MIG) in an Ethiopian multibreed dairy cattle population. The dataset was composed of 5,507 lactation records collected from 1,639 cows in three locations (Bako, Debre Zeit and Holetta) in Ethiopia from 1977 to 2010. Parameters for MIG were obtained from regression analysis of monthly test-day milk data on days in milk. The cows were purebred (Bos indicus) Boran (B) and Horro (H) and their crosses with different fractions of Friesian (F), Jersey (J) and Simmental (S). There were 23 breed groups (B, H, and their crossbreds with F, J, and S) in the population. Fixed and mixed models were used to analyse the data. The fixed model considered herd-year-season, parity and breed group as fixed effects, and residual as random. The single and two-traits mixed animal repeatability models, considered the fixed effects of herd-year-season and parity subclasses, breed as a function of cow H, F, J, and S breed fractions and general heterosis as a function of heterozygosity, and the random additive animal, permanent environment, and residual effects. For the analysis of LY, LL was added as a fixed covariate to all models. Variance components and genetic parameters were estimated using average information restricted maximum likelihood procedures. The results indicated that all traits were affected (p<0.001) by the considered fixed effects. High grade $B{\times}F$ cows (3/16B 13/16F) had the highest least squares means (LSM) for LY ($2,490{\pm}178.9kg$), IY ($10.5{\pm}0.8kg$), PY ($12.7{\pm}0.9kg$), YD ($7.6{\pm}0.55kg$) and LL ($361.4{\pm}31.2d$), while B cows had the lowest LSM values for these traits. The LSM of LY, IY, YD, and PY tended to increase from the first to the fifth parity. Single-trait analyses yielded low heritability ($0.03{\pm}0.03$ and $0.08{\pm}0.02$) and repeatability ($0.14{\pm}0.01$ to $0.24{\pm}0.02$) estimates for LL, DP and parameter c. Medium heritability ($0.21{\pm}0.03$ to $0.33{\pm}0.04$) and repeatability ($0.27{\pm}0.02$ to $0.53{\pm}0.01$) estimates were obtained for LY, IY, PY, YD and ln(a). Genetic correlations between LY, IY, PY, YD, ln(a), and LL ranged from 0.59 to 0.99. Spearman's rank correlations between sire estimated breeding values for LY, LL, IY, PY, YD, ln(a) and c were positive (0.67 to 0.99, p<0.001). These results suggested that selection for IY, PY, YD, or LY would genetically improve lactation milk yield in this Ethiopian dairy cattle population.

• Journal of the Korean Statistical Society
• /
• 제23권2호
• /
• pp.367-378
• /
• 1994

Let P and Q be probability measures of a measurable space $(\Omega, F)$, and ${F_n}_{n \geq 1}$ be a sequence of increasing sub $\sigma$-fields which generates F. For each $n \geq 1$, let $P_n$ and $Q_n$ be the restrictions of P and Q to $F_n$, respectively. Under the assumption that $Q_n \ll P_n$ for every $n \geq 1$, a zero-one condition is derived for P and Q to have the dichotomy, i.e., either $Q \ll P$ or $Q \perp P$. Then using this condition and the Kolmogorov's zero-one law, we give new and simple proofs of the dichotomy theorems for a pair of Gaussian measures and Poisson processes with examples.

• 감성과학
• /
• 제1권1호
• /
• pp.153-160
• /
• 1998

본 연구는 피부에 가해지는 직물촉각 자극에 따라 나타나는 정서와 관련된 뇌파특징을 알아보려는 기초연구이다. 실험l에서는 촉각에 의한 정서가 생리적인 측정치를 통해 구분될 수 있는지를 알아보고자, 피험자에게 물리적 특성이 극단적으로 다른 자극을 선택하여 실험을 실시하였다. 20명의 대학생 치험자 (20-25세)에게 자극이 무선적으로 제시되었고, 각 자극제시후 피험자는 제시자극에 대한 느낌을 주관적 정서척도로 평정하였다. 뇌파는 양쪽 귓볼(A1, A2)을 기준전극으로 하여 F3, F4, C3, C4, T4, P3, P4, O1, O2에서 측정되었고, 측정된 뇌파는 FFT방법으로 분석되었다. 각 피험자의 주관적 평가 결과에 따라 가장 쾌한 자극과 가장 불쾌한 자극이 제시되었을 때 측정한 뇌파의 분석결과를 비교하였다. 전두엽, 두정엽, 후두엽 영역에서 쾌자극 제시시에 alpha파가 유의미하게 높은 값을 나타내었고, 후두엽 영역에서 불쾌자극 제시시 beta가가 유의미하게 높게 나타났다. 물리적 특성이 유사한 다섯 가지 직물자극을 가진 실험 ll에서와 유사한 절차에 다섯 가지 직물자극을 가진 실험 1에서와 유사한 절차에 의해 실험ll가 실시되었다. 실험l의 결과에 근거하여 측정 부위를 F3, F4, P3, P4, O1, O2로 축소되었다. 쾌자극 제시시의 뇌파는 불쾌자극 제시시보다 slow alpha(8-10Hz)파의 출현량이 많은 반면, slow beta(13-20Hz)파의 출현량은 적었다. 결론적으로 직물촉각자극에 의해 유발되는 심리적 반응에 특정적인 뇌파반응이 존재하며, 이는 촉각에 의해 유발되는 주관적인 쾌.불쾌정서를 객관적으로 측정하기 위한 지표로서 뇌파특징을 사용할 수 있음을 의미한다.

• 한국지능시스템학회논문지
• /
• 제16권3호
• /
• pp.338-348
• /
• 2006

We classify the 3-classes In the semigroup M$_5$(F) of all 5$\times$5 Boolean matrices over F=(0,1).

• 한국소성가공학회:학술대회논문집
• /
• 한국소성가공학회 1996년도 추계학술대회논문집
• /
• pp.113-121
• /
• 1996

AI7075 alloy has been used for aircraft components since it has the advantage of high strength, high toughness, and high corrosion resistance. Many airframe components consist of various combinations of rib-web structure. In this study, various process paramenters such as die design, lubricant, ram speed, forging temperature have been investigated using the experiment and F.E.M. simulation to develop the precision forging technology for AI7075. When lubricant is applied to both material and die, shear friction factor is 0.1 which shows best effect of lubricant. It is specific corner radius of die that minimized forging load regarding process conditions, especially according to the ratio of the width of rib and web. In conclusion, optimum corner radius is 2~3mm when the width of rib and web is 3mm and 20mm respectively.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권1호
• /
• pp.489-494
• /
• 2014

Background: Psychiatric patients appear to be at lower risk of cancer. Some antipsychotic drugs might have inhibitory effects on tumor growth, including penfluridol, a strong agent. To test this, we conducted a study to determine whether penfluridol exerts cytotoxic effects on tumor cells and, if so, to explore its anti-tumor mechanisms. Methods: Growth inhibition of mouse cancer cell lines by penfluridol was determined using the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. Cytotoxic activity was determined by clonogenic cell survival and trypan blue assays. Animal tumor models of these cancer cells were established and to evaluate penfluridol for its anti-tumor efficacy in vivo. Unesterified cholesterol in cancer cells was examined by filipin staining. Serum total cholesterol and tumor total cholesterol were detected using the cholesterol oxidase/p-aminophenazone (CHOD-PAP) method. Results: Penfluridol inhibited the proliferation of B16 melanoma (B16/F10), LL/2 lung carcinoma (LL/2), CT26 colon carcinoma (CT26) and 4T1 breast cancer (4T1) cells in vitro. In vivo penfluridol was particularly effective at inhibiting LL/2 lung tumor growth, and obviously prolonged the survival time of mice bearing LL/2 lung tumors implanted subcutaneously. Accumulated unesterified cholesterol was found in all of the cancer cells treated with penfluridol, and this effect was most evident in LL/2, 4T1 and CT26 cells. No significant difference in serum cholesterol levels was found between the normal saline-treated mice and the penfluridol-treated mice. However, a dose-dependent decrease of total cholesterol in tumor tissues was observed in penfluridol-treated mice, which was most evident in B16/F10-, LL/2-, and 4T1-tumor-bearing mice. Conclusion: Our results suggested that penfluridol is not only cytotoxic to cancer cells in vitro but can also inhibit tumor growth in vivo. Dysregulation of cholesterol homeostasis by penfluridol may be involved in its anti-tumor mechanisms.

• Smart Structures and Systems
• /
• 제21권6호
• /
• pp.777-791
• /
• 2018

This paper discusses the shape control of deformable mirrors for Adaptive Optics in the dynamic range. The phenomenon of control-structure interaction appears when the mirror becomes large, lowering the natural frequencies $f_i$, and the control bandwidth $f_c$ increases to improve the performance, so that the condition $f_c{\ll}f_i$ is no longer satisfied. In this case, the control system tends to amplify the response of the flexible modes and the system may become unstable. The main parameters controlling the phenomenon are the frequency ratio $f_c/f_i$ and the structural damping ${\zeta}$. Robustness tests are developed which allow to evaluate a lower bound of the stability margin. Various passive and active strategies for damping augmentation are proposed and tested in simulation.

• Toxicological Research
• /
• 제34권4호
• /
• pp.291-296
• /
• 2018

Chemical carcinogenesis is a multistep process. Genotoxic carcinogens, which are DNA-reactive, induce DNA adduct formation and genetic alterations in target cells, thereby generating mutated cells (initiation). Subsequently, preneoplastic lesions appear through clonal proliferation of the mutated cells and transform into tumors (promotion and progression). Many factors may influence these processes in a dose-dependent manner. Therefore, quantitative analysis plays an important role in studies on the carcinogenic threshold of genotoxic carcinogens. Herein, we present data on the relationship between key carcinogenic events and their deriving point of departure (PoD). Their PoDs were also compared to those of the carcinogenesis pathway. In an experiment, the liver of rats exposed to 2-amino-3,8-dimethylimidazo-(4,5-f)quinoxaline (MeIQx) was examined to determine the formation of MeIQx-DNA adducts, generation of mutations at LacI transgene, and induction of preneoplastic glutathione S-transferase placental form (GST-P)-positive foci and tumors (benign and malignant). The PoDs of the above key events in the carcinogenicity of MeIQx were increased as the carcinogenesis advanced; however, these PoDs were lower than those of tumor induction. Thus, the order of key events during tumor induction in the liver was as follows: formation of DNA adducts ${\ll}$ Mutations ${\ll}$ GST-positive foci (preneoplasia) ${\ll}$ Tumor (adenoma and carcinoma). We also obtained similar data on the genotoxic and carcinogenic PoDs of other hepatocarcinogens, such as 2-amino-3,8-dimethylimidazo(4,5-f)quinoline. These results contribute to elucidating the existence of a genotoxic and carcinogenic threshold.