• 한국생물물리학회:학술대회논문집
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• 한국생물물리학회 2003년도 정기총회 및 학술발표회
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• pp.64-64
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• 2003

In growing number of diseases it has been shown that the aggregation of specific proteins has an important role in the pathogenesis of the disorder. This has been demonstrated in structural detail with the liver cirrhosis of ${\alpha}$$_1$-antitrypsin deficiency, and it is now believed that similar protein aggregation underlies many neurodegenerative disorders such as autosomal dominant Parkinson disease, prion diseases, Alzheimer disease, Huntington disease.

• 한국생물물리학회:학술대회논문집
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• 한국생물물리학회 2003년도 정기총회 및 학술발표회
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• pp.57-57
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• 2003

In growing number of diseases it has been shown that aggregation of specific proteins has an important role in pathogenesis of the disorder. This has been demonstrated in structural details with the liver cirrhosis of ${\alpha}$$_1$-antitrypsin deficiency, and it is now believed that similar protein aggregation underlies many neurodegenerative disorders such as autosomal dominant Parkinson disease, prion diseases, Alzheimer disease, and Huntington disease. ${\alpha}$$_1$-Antieypsin, a member of serine pretense inhibitor (serpin) family, functions as an inhibitor of neutrophil elastase.

• 대한인간공학회지
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• 제29권6호
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• pp.897-905
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• 2010

The purpose of this study is to identify relationships between safety and health indices in a shipbuilding industry. From the results of periodical health examination, job stress test, and health questionnaire for musculoskeletal disorders, the author stratified the 704 shipbuilding workers into categories of smoking, drinking frequency, the amount of exercise per week, obesity, blood pressure, diabetic symptoms, liver function, audibility, job stress, fatigued condition, musculoskeletal symptom, and accident. The results show that occupational injuries are highly related to smoking, drinking frequency, auditory capacity, fatigued condition, and musculoskeletal symptoms. These results can be used to develop more effective accidental occupational injury prevention programs for shipbuilding industries.

• 고려인삼학회:학술대회논문집
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• 고려인삼학회 2002년도 학술대회지
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• pp.145-158
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• 2002

Since immemorial time Panax ginseng has been known as therapeutic, tonic, prophylactic and restorative agent in ancient Korea, China and Tibet and at present time is also used as a food supplement by Western societies (6). Various ginseng preparations in a form of powders, teas, tinctures or extracts, very often mixed with other substances are recommended for attenuation of degenerative processes caused by aging or fatigue, as well as for treatment of various disorders and diseases in several organs (e.g. circulatory and nervous system, liver, kidney). One of the most commonly known properties of ginseng is its possibly positive influence on physical and mental performance and general well being. Because of these adaptogenic properties promoting vitality and resistance to stress ginseng is considered as an ergogenic aid. During almost 40 years in many laboratories attempts have been made to find out whether ginseng can be 'a remedy for today's problems'. The present work is focused on the results obtained in human studies and concerning an influence of ginseng root extracts on exercise and mental performance.

• The Korean journal of internal medicine
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• 제33권6호
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• pp.1070-1078
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• 2018

Vibrio vulnificus is a gram-negative bacterium that can cause serious, potentially fatal infections. V. vulnificus causes three distinct syndromes: an overwhelming primary septicemia caused by consuming contaminated seafood, wound infections acquired when an open wound is exposed to contaminated warm seawater, and gastrointestinal tract-limited infections. Case-fatality rates are higher than 50% for primary septicemia, and death typically occurs within 72 hours of hospitalization. Risk factors for V. vulnificus infection include chronic liver disease, alcoholism, and hematological disorders. When V. vulnificus infection is suspected, appropriate antibiotic treatment and surgical interventions should be performed immediately. Third-generation cephalosporin with doxycycline, or quinolone with or without third-generation cephalosporin, may be potential treatment options for patients with V. vulnificus infection.

• Journal of Preventive Medicine and Public Health
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• 제25권4호
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• pp.343-356
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• 1992

Authors studied the workers' knowledge about the health problems detected through the previous workers' periodic health examination, content of follow-up management ana actions taken for their health problem detected on previous health examination. From June to September 1992, workers' periodic health examination was peformed on workers employed in 10 companies located in 2 middle-sized Korean cities. A questionnaire survey was done far 150 workers who reported to have $D_2$ result of either hypertension or liver disorder at the previous workers' periodic health examination done in 1991. The results are as follows; 1. Of 160 workers who had $D_2$ result of either hypertension or liver disorder in previous examination one year before, only 85 workers(51.3%, 43 workers with hypertension, 38 workers with live disorder) responded that they have such disorders. The other 65 workers responded to questionnaire were all those with C results. Respondents' knowledge about their diagnoses was relatively precise (95.2% in hypertension group, 94.6% in liver disorder group) but knowledge about classification of diseases was poor. 2. The main efforts to solve the health problem nab self management (20 spells, 55.3%), visiting clinic or hospital(6 spells, 12.8%), use of herb medicine (2 spells, 4.3%) and use of drug store(2 spells, 4.3%) in hypertension group. In liver disorder group, 30 spells (71.4%) relied on self management,6 spells (14.3%) on hospital or clinic and 9 spells (21.4%) had no effort to improve the health problem. Content of self management was low salt diet, quit smoking, regular exercise and quit alcohol drinking in order. Avoidance of salt in diet was high in hypertension group and quitting alcohol drinking was high in liver disorder group. In those with self management, 80.7% of hypertension group and 83.3% of liver disorder group continued previous effort. Those, however, who utilized clinic or hospital, only 16.7% and 50.0% were still visiting hospital or clinic. 3. Fifty seven percent of hypertension group and 64.3% of liver disorder group was presently smoking,8.5% and 11.9% reduced smoking and 21.3% and 14.3% stopped smoking. Forty nine percent of hypertension group and 28.6% of liver disorder group was presently drinking. Reduced alcohol intake was reported in 29.8% and 40.5%, 12.8ole and 23.8% stopped alcohol drinking. Sixty six percent of hypertension group and 73.8% of liver disorder group did no regular exercise, but 12.8% and 11.9% of each group increased their physical exercise far last one year. Forty three percent of hypertension group and 38.l% of liver disorder group was overweight (defined by bodymass index greater or equal than 25). Reduced body Weight was reported in 17.2% and 16.7% of each group. Reduced dietary salt intake was high in hypertension group (51.5%). The study results suggest that follow-up management after workers' periodic health examination is not satisfactory. In order to improve this situation, adequate information on the result of the workers' periodic health examination should be distributed to each worker group with health education and counselling.

• 한국식품영양과학회지
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• 제35권9호
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• pp.1185-1193
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• 2006

다이옥신계 TCDD에 노출된 흰쥐의 지질대사, 및 간 독성물질대사에 있어서 녹차의 방어효과를 알아보고자 Sprague-Dawley rat(수컷, 6주령)를 이용하여 녹차는 건분으로 1%, 3% 첨가식이를 공급하고 TCDD는 실험 초에 복강내 주입하여 3주간 실험하였다. 사육 종료후 혈액조성과 혈청, 간 및 변의 지질을 분석하고 간 조직에서 항산화 효소 활성도와 간 독성물질대사 관련효소의 활성도를 측정하였다. 체중증가와 식이섭취량이 TCDD투여군 모두에서 감소하였다. 간과 뇌 및 고환의 중량은 TCDD투여군에서 모두 유의적으로 증가하였는데 흉선의 무게는 TCDD투여군 모두에서 대조군의 1/3 정도로 현저하게 감소하였고 녹차에 의한 효과는 보이지 않았다. 혈액성분에서 적혈구, 백혈구의 수와 헤모글로빈, 헤마토크리트의 값은 군 간에 유의적인 차이가 없었다. 혈소판의 수와 lymphocyte%가 TCDD투여에 의해 저하되었다가 녹차 3% 첨가군에서 증가되어 개선되는 경향을 보였다. neutrophill%는 TCDD투여에 의해 상승했다가 녹차 첨가에 의해 저하되는 경향이었다. 간 기능 지표가 되는 효소인 혈청 GOT와 ALP활성도에서는 TCDD투여에 의한 상승을 녹차첨가에 의해 저하시켜 개선되었다. 혈청 총콜레스테롤과 HDL-, LDL-콜레스테롤함량은 모두 대조군보다 TCDD 투여군에서 모두 높은 경향을 보였으며 녹차의 콜레스테롤 저하효과는 나타나지 않았다. 혈청 triglyceride는 녹차 첨가식이에 의해 저하되는 경향을 보였다. 간의 콜레스테롤 및 triglyceride 함량은 TCDD투여에 의해 2배정도의 상승을 보였는데 녹차 3%첨가에 의해 억제작용이 나타났다. 변의 총 배설량과 총지질, 총콜레스테롤의 배설량이 녹차 첨가에 의해 현저하게 많았으며 특히 콜레스테롤 배설이 녹차 3% 첨가식이에 의해 유의적으로 증가하였다. 따라서 녹차의 성분이 지질흡수를 저하시키고 배설을 촉진하는 작용이 확인되었다. 항산화효소인 SOD의 활성도가 다른 군보다 녹차 3% 첨가 식이군에서 유의적으로 높아 녹차의 항산화성이 높은 것으로 나타났으며 간의 독성물질대사 효소활성도에서 TCDD투여에 의한 NADPH cytochrome p-450 reductase의 상승을 녹차 3%첨가 식이에 의해, 그리고 cytochrome p-450 의존성 monooxigenase인 BPND는 TCDD투여에 의한 상승을 녹차 1% 첨가식이에 의해 유의적으로 감소시켰다. 이상의 결과에서 녹차가 TCDD투여에 의한 간지질의 축적을 억제시키고 변으로 지질배설량을 증가시켰으며 간 기능에 관련된 효소활성도를 정상화시키는 경향이 있었고 항산화효소인 SOD 활성도를 상승시켜 항산화성을 높이는 것이 확인되었다.

• 한국식품과학회지
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• 제6권3호
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• pp.147-157
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• 1974

This study was undertaken to observe the effect of sesame in the diet of rats (Splague Dowley). Comparisons were made of weight gains, organ weights and the cholesterol, phospholipid and triglyceride content of the blood serum and liver tissue. Rats weighing 67-80 g were used for the study, while rats weighing 160-165 g were used in the study. In the both studies, the experimental animals were fed on sesame mixtures for 24 weeks. The study was conducted to determine the effect of sesame hulls which are known to contain a high proportion of oxalic acid and phytic acid, which are toxic substances causing various physical disorders. The rats were divided into four groups, a control group which was fed on a standard diet and three groups fed with 20%, 10% and 5% mixtures of sesame seed hulls respectively. The study was designed to observe the same effect, but in this case the rats were divided into two groups, one fed with a 5% mixture of whole sesame seeds and the other with a 5% mixture of dehulled seeds. The results are as follows: 1) An examination of weight gains showed that group I and II which were fed on 20% and 10% mixture of sesame hulls were significantly retarded in comparison with the control group(P<0. 05). 2) Comparisons of organ weights, group I (20% mixture) showed relatively lower weights(P<0.05). 3) The cholesterol content of the blood serum and liver tissue of group I (20% mixture) and group II (10% mixture) were significantly higher than that of the control. 4) The group fed on the whole sesame seed diet and that fed on the dehulled seed diet differed significantly from each other. 5) With the results stated above, the investigators could observe that a high content of sesame hulls in the diet caused retardation in growth and might be the cause of many physical disorders. Though these effects are not important in Korea at present, the increasing intake of sesame seeds and oils indicates that it may become an important problems.

• IMMUNE NETWORK
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• 제12권3호
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• pp.96-103
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• 2012

Obesity-induced disorders contribute to the development of metabolic diseases such as insulin resistance, fatty liver diseases, and type 2 diabetes (T2D). In this study, we evaluated whether the Aloe QDM complex could improve metabolic disorders related to blood glucose levels and insulin resistance. Male C57BL/6 obese mice fed a high-fat diet for 54 days received a supplement of Aloe QDM complex or pioglitazone (PGZ) or metformin (Met) and were compared with unsupplemented controls (high-fat diet; HFD) or mice fed a regular diet (RD). RT-PCR and western blot analysis were used to quantify the expression of obesity-induced inflammation. Dietary Aloe QDM complex lowered body weight, fasting blood glucose, plasma insulin, and leptin levels, and markedly reduced the impairment of glucose tolerance in obese mice. Also, Aloe QDM complex significantly enhanced plasma adiponectin levels and insulin sensitivity via AMPK activity in muscles. At the same time, Aloe QDM decreased the mRNA and protein of $PPAR{\gamma}/LXR{\alpha}$ and scavenger receptors in white adipose tissue (WAT). Dietary Aloe QDM complex reduces obesity-induced glucose tolerance not only by suppressing $PPAR{\gamma}/LXR{\alpha}$ but also by enhancing AMPK activity in the WAT and muscles, both of which are important peripheral tissues affecting insulin resistance. The Aloe QDM complex could be used as a nutritional intervention against T2D.

• 동의생리병리학회지
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• 제17권5호
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• pp.1141-1146
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• 2003

In order to investigate different and original theories on pathology of eyes from the past main etiology of fire and heat, two texts of Si-sheng-xin-yuan written by Huang Yuan Yu and Eui-gam-jung-ma written by Lee Gyu Jun are selected and analysed in terms of pathology and prescription. Huang explained that diseases of the eyes are usually born of functional disorders of spleen and stomach(脾胃升降失調) accompanied with turbidity change of energy and blood(氣血淸濁變化). In the meantime, Lee described that the diseases are made from disorders of activities of essence, spirit, energy and blood stored in 5 viscera. So following them, the main point of treatment for the diseases of eyes is to restore and clarify the stagnated gastrointestinal(GI) function, or to supply the clear essence and blood to eyes respectively. Also they have same opinions that the fire and heat are the secondary symptoms of the optical diseases. Therefore Huang focused on cleaning the phlegm and leaking the moisture of GI tract to treat those symptoms, and Lee emphasized on nourishing essential energy of kidney and liver on the other hand. Although they preferred to use radical therapy than symptomatic one. But it can be deduced that Huang's theory is more positive and direct therapy and Lee's one is more basic but indirect treatment.